Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score as a biomarker for phase differentiation in Peyronie's Disease: a retrospective cohort study.

IF 2.4 3区医学 Q2 ANDROLOGY

Basic and Clinical Andrology Pub Date : 2025-06-05 DOI:10.1186/s12610-025-00269-y

Türker Soydaş, Selman Ünal, Halil Uzundal

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引用次数: 0

Abstract

Background: Peyronie's disease progresses through acute (inflammatory) and chronic (fibrotic) phases. Objective biomarkers for phase differentiation are lacking. Neutrophil-to-eosinophil ratio has been evaluated as an inflammatory marker in PD and reported as an important marker in the inflammatory phase. We evaluated the Hemoglobin, Albumin, Lymphocyte, and Platelet score as a non-invasive indicator of Peyronie's Disease phases.

Results: A retrospective cohort of 216 Peyronie's disease patients were analyzed. Blood parameters were collected at diagnosis (acute phase) and follow-up (chronic phase) in 112 patiens. Hemoglobin, Albumin, Lymphocyte, and Platelet scores were compared using receiver operating characteristic curves and paired t-tests. Hemoglobin, Albumin, Lymphocyte, and Platelet scores increased significantly from 36.8 ± 8.2 (acute) to 47.5 ± 10.4 (chronic) in 112 paired patients (p <0.001). Receiver operating characteristic analysis identified a cutoff of>41.2 for chronic phase detection (area under the curve = 0.83, sensitivity 76%, specificity 71%, positive predictive value 73.9%).

Conclusion: The Hemoglobin, Albumin, Lymphocyte, and Platelet score is a cost-effective tool for differentiating Peyronie's Disease phases, aiding clinical decision-making.

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血红蛋白、白蛋白、淋巴细胞和血小板（HALP）评分作为Peyronie病分期分化的生物标志物：一项回顾性队列研究

背景：Peyronie病的进展分为急性（炎症）期和慢性（纤维化）期。缺乏客观的相分化生物标志物。中性粒细胞与嗜酸性粒细胞的比值被认为是帕金森病的炎症标志物，并被报道为炎症期的重要标志物。我们评估血红蛋白、白蛋白、淋巴细胞和血小板评分作为Peyronie病分期的非侵入性指标。结果：对216例佩罗尼氏病患者进行回顾性队列分析。112例患者在诊断（急性期）和随访（慢性期）时采集血液参数。采用受试者工作特征曲线和配对t检验比较血红蛋白、白蛋白、淋巴细胞和血小板评分。112例配对患者的血红蛋白、白蛋白、淋巴细胞和血小板评分从36.8±8.2（急性）显著增加到47.5±10.4（慢性）(慢性期检测p为41.2（曲线下面积= 0.83，敏感性76%，特异性71%，阳性预测值73.9%）。结论：血红蛋白、白蛋白、淋巴细胞和血小板评分是鉴别Peyronie病分期的有效工具，有助于临床决策。

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来源期刊

Basic and Clinical Andrology Medicine-Urology

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

22 weeks

期刊介绍： Basic and Clinical Andrology is an open access journal in the domain of andrology covering all aspects of male reproductive and sexual health in both human and animal models. The journal aims to bring to light the various clinical advancements and research developments in andrology from the international community.