Seminal vesicle status and its association with semen parameters in congenital bilateral absence of the vas deferens (CBAVD).

IF 2.4 3区 医学 Q2 ANDROLOGY
Iman Shamohammadi, Abdolreza Haghpanah, Ali Eslahi, Mohammad Ali Sadighi Gilani, Ali Adib, Seyyed Sadra Kashfi
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引用次数: 0

Abstract

Background: Congenital bilateral absence of the vas deferens (CBAVD) is a rare condition associated with male infertility. CBAVD is often accompanied by other genitourinary anomalies, including abnormalities or agenesis of the seminal vesicles and kidneys. While it is expected that CBAVD always coexists with seminal vesicle agenesis due to a shared embryologic origin, some studies report the presence of seminal vesicles in certain CBAVD patients. This study aims to assess the status of seminal vesicles in CBAVD patients and explore the relationship between seminal vesicle presence and semen parameters.

Methods: In this multi-center, retrospective cross-sectional study, we reviewed data from 47 CBAVD patients diagnosed between 1994 and 2024. Data collected included demographic information (age, height, weight, BMI), physical examination findings (vas palpation), and imaging results (trans-rectal ultrasound for seminal vesicle status, abdominal and pelvic ultrasound for kidney status). Laboratory data included serum FSH, LH, and testosterone levels, as well as semen analysis results (pH, fructose, and volume). Patients were classified into three groups based on seminal vesicle status: bilateral agenesis, unilateral agenesis, and bilateral presence.

Results: Among the 47 CBAVD patients, 29 had bilateral agenesis of the seminal vesicles, 9 had unilateral agenesis, and 9 had bilateral presence. No significant differences were found between the groups regarding weight, height, BMI, or serum levels of LH, FSH, and testosterone. Additionally, semen analysis revealed that 89.4% of patients had abnormal pH, 93.6% had abnormal volume, and all patients had abnormal semen fructose. There were no significant differences between the groups in semen pH, fructose, or volume.

Conclusion: Our findings suggest that the presence or absence of seminal vesicles in CBAVD patients does not significantly affect semen parameters. This may be due to dysfunction of the seminal vesicles in those with a present organ.

先天性双侧输精管缺失(CBAVD)的精囊状态及其与精液参数的关系。
背景:先天性双侧输精管缺失(cavd)是一种罕见的与男性不育相关的疾病。cavd通常伴有其他泌尿生殖系统异常,包括精囊和肾脏的异常或发育不全。由于有共同的胚胎起源,我们认为CBAVD总是与精囊发育共存,但一些研究报道在某些CBAVD患者中存在精囊。本研究旨在评估CBAVD患者的精囊状态,探讨精囊存在与精液参数的关系。方法:在这项多中心、回顾性横断面研究中,我们回顾了1994年至2024年间诊断的47例CBAVD患者的数据。收集的数据包括人口统计信息(年龄、身高、体重、BMI)、体格检查结果(输精管触诊)和影像学结果(经直肠超声检查精囊状况,腹部和盆腔超声检查肾脏状况)。实验室数据包括血清FSH、LH和睾酮水平,以及精液分析结果(pH值、果糖和体积)。患者根据精囊状态分为三组:双侧发育不全、单侧发育不全和双侧存在。结果:47例CBAVD患者中,29例双侧精囊发育不全,9例单侧精囊发育不全,9例双侧存在。在体重、身高、身体质量指数或血清LH、FSH和睾酮水平方面,两组之间没有发现显著差异。此外,精液分析显示89.4%的患者pH值异常,93.6%的患者体积异常,所有患者精液果糖异常。两组之间精液的pH值、果糖和体积没有显著差异。结论:我们的研究结果表明,CBAVD患者的精囊存在与否对精液参数没有显著影响。这可能是由于有当前器官的人的精囊功能障碍所致。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Basic and Clinical Andrology
Basic and Clinical Andrology Medicine-Urology
CiteScore
3.50
自引率
0.00%
发文量
21
审稿时长
22 weeks
期刊介绍: Basic and Clinical Andrology is an open access journal in the domain of andrology covering all aspects of male reproductive and sexual health in both human and animal models. The journal aims to bring to light the various clinical advancements and research developments in andrology from the international community.
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