Basic and Clinical Andrology最新文献

{"title":"Male polycystic ovarian syndrome phenotype: a meta-analysis of endocrine-metabolic dysregulation in fathers and brothers of PCOS-affected women.","authors":"Kyana Jafarabady, Ida Mohammadi, Shahryar Rajai Firouzabadi, Fateme Mohammadifard, Sana Mohammad Soltani, Amirreza Paksaz, Mahsa Noroozzadeh, Fahimeh Ramezani Tehrani","doi":"10.1186/s12610-025-00290-1","DOIUrl":"10.1186/s12610-025-00290-1","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women with potential familial and genetic components. Emerging evidence suggests that male first-degree relatives (fathers and brothers) may exhibit endocrine and metabolic abnormalities similar to a \"male equivalent\" of PCOS, although the condition remains without clear diagnostic criteria. We conducted a systematic review and meta-analysis to investigate whether male relatives of women with PCOS show consistent patterns of metabolic and hormonal dysregulation.</p><p><strong>Results: </strong>A total of 21 studies met inclusion criteria, encompassing male first-degree relatives of women with PCOS with available data on metabolic, hormonal, and cardiovascular outcomes. Meta-analysis showed that male relatives had significantly higher fasting blood glucose (MD: 6.25; 95% CI: 1.36-11.14), body mass index (1.18; 0.35-2.02), triglycerides (17.82; 10.82-24.81), total cholesterol (18.63; 6.16-31.10), LDL-cholesterol (12.99; 1.27-24.71), and dehydroepiandrosterone sulfate (1.29; 0.66-1.92) compared with controls. They also exhibited higher prevalence of hypertension (OR: 1.88; 1.18-2.29), waist circumference > 90 cm (3.27; 1.18-9.08), and androgenetic alopecia (1.65; 1.04-2.60). Findings were consistent across studies, with low to moderate heterogeneity and minimal publication bias.</p><p><strong>Conclusion: </strong>Male first-degree relatives of women with PCOS demonstrate increased rates of metabolic abnormalities, hormonal imbalances, and androgenic features, supporting the concept of a male PCOS of equivalent. These findings underscore the familial nature of PCOS and highlight the need for improved diagnostic criteria and higher clinical awareness. Screening male relatives for metabolic and hormonal risk factors may help identify at-risk individuals and inform preventive interventions.</p><p><strong>Trial registration: </strong>IR.SBMU.ENDOCRINE.REC.1403.146.</p>","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"35 1","pages":"44"},"PeriodicalIF":2.0,"publicationDate":"2025-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12621411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145534413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the causal associations between obesity indicators and male reproductive diseases: new evidence from Mendelian randomization.","authors":"Huijuan Wei, Haoting Chen, Yifei Lin, Haibin Lu","doi":"10.1186/s12610-024-00242-1","DOIUrl":"10.1186/s12610-024-00242-1","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study was to investigate potential causal associations between indicators of obesity and male reproductive disorders using Mendelian randomization (MR) analysis.</p><p><strong>Methods: </strong>Based on summary data from the GWAS, we conducted MR analyses. Univariable MR analysis was performed to estimate the association between three obesity indicators and five male reproductive diseases. Multivariable MR analysis was conducted to account for pleiotropy observed in univariable MR analysis by including a set of covariates.</p><p><strong>Results: </strong>Univariable MR analysis revealed suggestive associations between waist-to-hip ratio (WHR) and testicular dysfunction (OR = 0.32, 95% Cl: 0.11-0.99, P_IVW = 0.049), body mass index (BMI) and erectile dysfunction (OR = 1.28, 95%CI 1.12-1.45, P_IVW = 1.84 × 10^-4). Multivariate MR analysis indicated after controlling for potential confounders, waist-to-hip ratio was suggestively associated with the decreased risk of testicular dysfunction (OR = 0.23, 95% Cl: 0.08-0.67, P_IVW = 0.008). Nevertheless, multivariate MR analysis also showed that body mass index was suggestively associated with the increased risk of erectile dysfunction (OR = 1.22, 95% Cl: 1.06-1.40, P_IVW = 0.006). Sensitivity analyses confirmed that these results were reliable.</p><p><strong>Conclusion: </strong>Our two-sample MR analysis suggests generalized obesity in was suggestively associated with the increased risk of erectile dysfunction, while central obesity obesity is associated with an decreased risk of testicular dysfunction.</p>","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"35 1","pages":"43"},"PeriodicalIF":2.0,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12604271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145494433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Density gradient centrifugation specifically improves sperm motility in hyperuricemia: evidence from intrauterine insemination cycles - retrospective cohort study.","authors":"Jinqiang Peng, Lingjuan Wu, Zhimin Li, Qiongying Huang, Lixian Li","doi":"10.1186/s12610-025-00292-z","DOIUrl":"10.1186/s12610-025-00292-z","url":null,"abstract":"<p><strong>Background: </strong>Hyperuricemia (HUA) impairs sperm function via oxidative stress and metabolic dysregulation. This retrospective cohort study aimed to investigate the therapeutic effect of density gradient centrifugation (DGC) on HUA-associated sperm dysfunction.</p><p><strong>Results: </strong>A total of 490 couples undergoing their first intrauterine insemination (IUI) were stratified into the HUA group (200 cycles) and control group (290 cycles) based on male serum uric acid levels. At baseline, the percentage of progressively motile sperm (PR%) in the HUA group was significantly lower than that in the control group (39.55% ± 11.29% vs. 41.76% ± 11.89%, P = 0.040). Following DGC processing, PR% in both groups exceeded 90% with no significant intergroup difference; however, the increase in PR% (ΔPR%) was significantly greater in the HUA group (52.34% ± 10.62% vs. 50.29% ± 11.02%, P = 0.040). No significant difference was observed in the clinical pregnancy rate between the two groups (11.0% vs. 13.4%, P = 0.230).</p><p><strong>Conclusions: </strong>DGC specifically improves sperm motility in patients with HUA. While direct measurement of mechanistic markers (e.g., oxidative stress, metabolic factors) was not performed in this study, this motility-improving effect may correlate with DGC's known capacity to scavenge reactive oxygen species and optimize energy supply-an inference supported by prior mechanistic studies. However, improving sperm motility alone is insufficient to significantly enhance clinical pregnancy rates. These findings provide insights to optimize semen preparation strategies in HUA-associated male infertility.</p>","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"35 1","pages":"42"},"PeriodicalIF":2.0,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12593767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145470289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compound heterozygous REC114 variants in dizygotic twins causes meiotic arrest and non-obstructive azoospermia.","authors":"Wanze Ni, Chenwang Zhang, Shuai Xu, Wenbo Li, Dewei Qian, Haowei Bai, Yifan Sun, Zizhou Meng, Na Li, Chencheng Yao, Zheng Li, Peng Li, Yuxiang Zhang","doi":"10.1186/s12610-025-00291-0","DOIUrl":"10.1186/s12610-025-00291-0","url":null,"abstract":"","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"35 1","pages":"41"},"PeriodicalIF":2.0,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12577098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145407955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quercetin ameliorates nicotine-induced spermatogenesis damage via modulation of sperm miR-151a-5p and testicular Cep72 gene expression.","authors":"Masoumeh Faghani, Mahmoud Alijani, Aghil Esmaeili-Bandboni, Fahimeh Mohammadghasemi","doi":"10.1186/s12610-025-00288-9","DOIUrl":"10.1186/s12610-025-00288-9","url":null,"abstract":"<p><strong>Background: </strong>Smoking impairs spermatogenesis by disrupting gene and miRNA expression profiles. This study aims to explore the protective effects of quercetin against nicotine-induced testicular damage, with a specific focus on its regulatory role on sperm miR-151a-5p and testicular Cep72 gene expression, as potential molecular mechanisms involved in male reproductive dysfunction. Male BALB/c mice (N = 32) were randomly divided into four groups of: control, nicotine, quercetin, and quercetin + nicotine combined groups. Treatments lasted 35 days. Spermatogenesis was evaluated through histopathological studies of the testicles. TAC and SOD levels were evaluated as markers of antioxidant activity using colorimetric methods in testicular homogenates. Sex hormones were measured using the ELISA method. Relative expression of Cep72 and miR-151a-5p genes in testicular tissue and epididymal sperm was assessed by real-time PCR. Androgen receptor (AR) and estrogen receptor alpha (ERα) expression in testicular tissue were evaluated by immunohistochemical methods.</p><p><strong>Results: </strong>The combined treatment of quercetin and nicotine enhanced sperm quality, caused significant changes in LH and estradiol hormone levels, increased anti-oxidants in testicular homogenates, and increased AR expression in Sertoli cells without affecting ERα, compared to the nicotine group. In addition, the combined therapy improved spermatogenesis by increasing the number of germ cells and Leydig cells. Furthermore, combined therapy increased testicular Cep72 gene expression and reduced sperm miR-151a-5p.</p><p><strong>Conclusions: </strong>This study demonstrates that quercetin may protect against nicotine-induced testicular damage by maintaining hormonal balance, enhancing AR expression, improving antioxidant enzyme activity, and normalizing the miR-151a-5p/Cep72 regulatory axis, ultimately supporting sperm quality and spermatogenesis. These results establish a foundation for future mechanistic and translational research.</p>","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"35 1","pages":"40"},"PeriodicalIF":2.0,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12542156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L-Proline supplementation preserves sperm function and chromatin integrity in asthenozoospermic patients during cryopreservation.","authors":"Mojtaba Moradi, Masoumeh Golestan Jahromi, Elham Ghanbari, Amir Hossein Hashemian, Azita Faramarzi","doi":"10.1186/s12610-025-00286-x","DOIUrl":"10.1186/s12610-025-00286-x","url":null,"abstract":"<p><strong>Background: </strong>Asthenozoospermia is a major cause of male infertility, accounting for approximately 18% of infertility cases. L-Proline, a natural antioxidant and osmoprotectant, has gained attention for its potential applications in semen cryopreservation. This study aimed to evaluate the beneficial effects of L-proline on sperm quality in samples from asthenozoospermic patients during cryopreservation.</p><p><strong>Results: </strong>This in vitro experimental study utilized semen samples from 30 men (aged 27-40 years) diagnosed with asthenozoospermia. Each sample was divided into three aliquots for cryopreservation: (1) a control group using a standard unsupplemented freezing medium; (2) a group supplemented with 2 mM L-proline; and (3) a group supplemented with 4 mM L-proline. Following thawing, samples were assessed for sperm count, motility, viability, morphology, and chromatin quality. Additionally, levels of malondialdehyde (MDA), total antioxidant capacity (TAC), and nitric oxide (NO) were assessed. Supplementation with 2 mM L-proline resulted in significantly higher post-thaw progressive motility, viability, and chromatin integrity compared to the control group (p < 0.05). These functional improvements were associated with a more favorable antioxidant status, evidenced by significantly lower levels of MDA and NO and higher levels of TAC (p < 0.05). While the 4 mM L-proline group showed some protection, the effects were less pronounced than those observed with the 2 mM concentration.</p><p><strong>Conclusions: </strong>The results suggest that adding 2 mM L-proline into the freezing medium effectively protects human sperm quality and chromatin integrity in asthenozoospermic samples by mitigating cryopreservation-induced nitro-oxidative stress. This strategy holds promise for improving assisted reproductive technology (ART) outcomes in men with asthenozoospermia.</p>","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"35 1","pages":"39"},"PeriodicalIF":2.0,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12516870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity induced by a high-fat diet regulates the MYC‒PPIL1 network in the mediation of asthenozoospermia.","authors":"Menghua Shi, Lei Xu, WeiXi Zheng, Xuyao Lin, Guozheng Qin","doi":"10.1186/s12610-025-00289-8","DOIUrl":"10.1186/s12610-025-00289-8","url":null,"abstract":"<p><p>Male infertility, particularly asthenozoospermia (AZS), has become an increasingly severe global public health issue. Obesity induced by a high-fat diet (HFD) is considered a key factor in the development of AZS, although its exact molecular mechanisms remain unclear. This study employs bioinformatics analysis to explore the key genes and potential regulatory mechanisms of HFD-induced obesity in AZS, which were validated by animal experiments. First, on the basis of GEO transcriptomic data, we identified nine common differentially expressed genes (DEGs) between HFD-induced obesity and AZS. Using LASSO regression and support vector machine methods, we subsequently identified C1QBP and PPIL1 as critical genes associated with HFD-induced AZS. Furthermore, a core gene‒transcription factor coexpression network revealed that MYC is likely an upstream transcriptional regulator of these two core genes. According to single-cell RNA-seq data, C1QBP and PPIL1 are predominantly expressed in spermatogonia, whereas MYC is primarily localized in stromal cells and is closely correlated with AZS. Additionally, through genome-wide enrichment analysis, we identified several key pathways regulating both HFD-induced obesity and AZS, including cell proliferation and differentiation (MYC targets and mTOR signalling), energy metabolism, cellular stress and homeostasis, and immune and inflammatory responses. The results of animal experiments demonstrated that HFD-induced obesity significantly impaired sperm motility in male rats, accompanied by decreased testosterone levels and increased oxidative stress. At the molecular level, the expression of MYC and mTOR in the HFD obesity/AZS group was significantly reduced (P < 0.01), whereas PPIL1 expression was significantly increased (P < 0.01). Moreover, L-carnitine partially reversed these changes, indicating potential therapeutic value. In conclusion, our study suggests that HFD-induced obesity may lead to AZS through the upregulation of PPIL1 levels and the inhibition of the MYC and mTOR signalling pathways.</p>","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"35 1","pages":"38"},"PeriodicalIF":2.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of male sleep quality with semen parameters and pregnancy outcomes in infertile couple.","authors":"Rong Zhou, Ming Zhang, Caiyun Ge, Yao Xiong, Mei Wang, Kejia Wu, Yuanzhen Zhang","doi":"10.1186/s12610-025-00287-w","DOIUrl":"10.1186/s12610-025-00287-w","url":null,"abstract":"<p><strong>Background: </strong>Sleep quality has been increasingly recognized as an important determinant of overall health, yet its influence on male fertility remains underexplored. This study investigated the association between male sleep quality and reproductive outcomes, including semen characteristics, hormone profiles, and partner pregnancy success, in infertile couples.</p><p><strong>Results: </strong>A total of 727 male partners from infertile couples were evaluated between October 2023 and February 2025. Sleep quality was assessed using Pittsburgh Sleep Quality Index and categorized as good or poor. Poor sleep quality was reported in 75.1 percent of participants. Men with poor sleep quality showed significantly lower sperm concentration (β = -1.39, 95% confidence interval = -2.11 to -0.67, p < 0.001), reduced progressive motility (β = -1.25, 95% confidence interval = -1.61 to -0.88, p < 0.001), and decreased total motility compared with those reporting good sleep. No significant associations were observed between sleep quality and hormone concentrations, including follicle-stimulating hormone, luteinizing hormone, estradiol, prolactin, and testosterone. Poor male sleep quality was also linked to a lower probability of achieving clinical pregnancy (odds ratio = 4.67, 95% confidence interval = 3.08 to 7.09, p < 0.0001).</p><p><strong>Conclusions: </strong>Poor male sleep quality is associated with impaired semen quality and reduced chances of pregnancy in couples with infertility. These findings highlight the potential value of improving sleep as a modifiable factor to enhance male reproductive health and fertility outcomes.</p>","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"35 1","pages":"37"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of long-term patient reported outcomes of excisional and incisional corporoplasties for Peyronie's disease.","authors":"Patrick Daniel Preece, Varun Sahdev, Paul Gerard Davis, Rowland Wyn Rees","doi":"10.1186/s12610-025-00280-3","DOIUrl":"10.1186/s12610-025-00280-3","url":null,"abstract":"<p><strong>Background: </strong>To compare surgical and long-term patient-reported outcomes (PRO) between excisional (Nesbit) and incisional (Yachia) corporoplasty for correction of uncomplicated Peyronie's-related penile curvature in a large, single-surgeon cohort. A retrospective audit identified men who underwent Nesbit or Yachia corporoplasty (2015-2021). Operative data was extracted from records. A structured telephone survey captured long-term PRO.</p><p><strong>Results: </strong>The cohort comprised 101 men (Nesbit = 31, Yachia = 70). Nesbit patients were younger (55 vs 59.7 yr; p = 0.02) and had greater baseline curvature (55° vs 45°; p = 0.01). Every case was surgically successful (residual curvature < 20° in 100%, < 10° in 58% overall, p = 0.66). Yachia procedures were shorter (45 vs 71 min; p < 0.05) but required > 2 plications more often (41% vs 7%; p = 0.01). The PRO survey had a 74.3% response rate, with a median follow-up of 5 years. 'Patient Global Impression of Improvement' scores reflected strong improvement with median scores of 1 (\"very much better\") and 2 (\"much better\") in the Nesbit and Yachia groups respectively (p = 0.35). However, this perceived improvement did not translate uniformly into long-term satisfaction. Only 66.7% of respondents reported being \"completely\" or \"mostly\" satisfied with the overall outcome (p = 0.60). The most frequent cause of dissatisfaction was perceived penile shortening, reported by 85% of men. Erectile function declined postoperatively in 30% of Yachia and 15% of Nesbit patients (p = 0.03), though this is possibly confounded by the older age of the Yachia cohort. Bothersome curvature recurrence and post-operative cosmesis did not significantly impact satisfaction in either group.</p><p><strong>Conclusions: </strong>Both Nesbit and Yachia corporoplasties provide effective and durable results with comparable long-term patient satisfaction. Regardless of technique, subjective reporting of penile shortening was particularly pervasive and was highly bothersome. This underscores the need for meticulous pre-operative counselling.</p>","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"35 1","pages":"36"},"PeriodicalIF":2.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12418631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ureaplasma parvum impaired semen quality improves after doxycycline treatment in selected patients: a cohort study.","authors":"Harm-Henning Lindhof, Bernhard Homey","doi":"10.1186/s12610-025-00284-z","DOIUrl":"10.1186/s12610-025-00284-z","url":null,"abstract":"<p><strong>Background: </strong>Infections of the urogenital tract are recognized as potential contributors to male subfertility or infertility. Ureaplasma parvum is frequently detected in semen samples, yet its specific impact on semen quality and the potential benefit of antibiotic treatment remain uncertain.</p><p><strong>Results: </strong>In a retrospective cohort of 3,464 semen samples collected for fertility evaluation, Ureaplasma parvum was identified in 12.4% of cases using a multiplex PCR assay. Semen volume was significantly lower in infected individuals compared to uninfected controls. However, no significant differences were observed in sperm concentration, motility, morphology, or inflammatory markers. Among 124 men with documented pathogen eradication and follow-up semen analysis, doxycycline treatment led to a significant increase in sperm concentration (4.01 ± 4.69 to 9.20 ± 15.63 million/ml, p = 0.01) and motility (18.97 ± 16.04% to 29.66 ± 22.18%, p = 0.002). Peroxidase-positive leukocytes declined (1.84 ± 0.74 to 0.68 ± 0.79 million/ml, p = 0.005). In contrast, no significant changes were observed in men with normal baseline semen parameters.</p><p><strong>Conclusion: </strong>The mere detection of Ureaplasma parvum does not appear to compromise semen quality and may not warrant routine antibiotic treatment. Nevertheless, in Ureaplasma parvum-positive patients with abnormal semen parameters and elevated inflammatory markers, targeted antibiotic therapy may improve sperm quality. These findings support a selective treatment strategy, emphasizing clinical context and inflammatory status rather than routine screening or treatment of all infected individuals.</p>","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"35 1","pages":"35"},"PeriodicalIF":2.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}