Bangladesh Journal of Pharmacology最新文献_第9页

Antimycobacterial and anti-oxidant potential of the bioactive metabolite isolated from the endophytic fungus Daldinia eschscholtzii 内生真菌焦氏达尔迪尼亚生物活性代谢产物的抗菌和抗氧化潜力

IF 1.6 4区医学

Bangladesh Journal of Pharmacology Pub Date : 2018-11-07 DOI: 10.3329/bjp.v13i4.38593

G. Shylaja, K. Sasikumar, A. Sathiavelu

引用次数: 1

Lymphocyte active immunotherapy for unexplained recurrent spontaneous abortion 淋巴细胞主动免疫疗法治疗不明原因复发性自然流产

IF 1.6 4区医学

Bangladesh Journal of Pharmacology Pub Date : 2018-10-28 DOI: 10.3329/BJP.V13I4.37278

Xianjiang Wei, X. Fang, Ling Tong

{"title":"Lymphocyte active immunotherapy for unexplained recurrent spontaneous abortion","authors":"Xianjiang Wei, X. Fang, Ling Tong","doi":"10.3329/BJP.V13I4.37278","DOIUrl":"https://doi.org/10.3329/BJP.V13I4.37278","url":null,"abstract":"This study is to evaluate the curative effect of lymphocyte active immune treatment for unexplained recurrent spontaneous abortion. Fourteen randomized controlled trials of 994 subjects were included. Blocking antibody positive rate of patients who experienced a new pregnancy showed significant differences between immunotherapy and placebo. Moreover, live birth rate among paternal or third-party donor lymphocytes and placebo groups had significant difference [RR= 1.63, 95% CI (1.38-1.92), p＜0.05]. Trial sequential analysis showed that the Z-curve crosses the trial sequential monitoring boundaries, confirming that the clinical benefit of active immunotherapy was significant. Subgroup analysis suggests that immunotherapy with lymphocytes might be more effective for primary recurrent spontaneous abortion than for secondary recurrent miscarriage. Taken together, women with primary recurrent spontaneous abortion who are negative for blocking antibody prior to treatment seemed most likely to obtain a potential beneficial effect of lymphocyte active immunotherapy, but not secondary recurrent spontaneous abortion.","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2018-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3329/BJP.V13I4.37278","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45782396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Effect of Solanum melongena peel extract in the treatment of arsenic-induced Bowen’s disease 茄皮提取物对砷致鲍文病的治疗作用

IF 1.6 4区医学

Bangladesh Journal of Pharmacology Pub Date : 2018-10-20 DOI: 10.3329/BJP.V13I4.38273

Q. S. Sarah, M. Misbahuddin

引用次数: 6

New bioactive triaryl triglyceride esters: Synthesis, characterization and biological activities 新型生物活性三芳基甘油三酯酯的合成、表征及生物活性

IF 1.6 4区医学

Bangladesh Journal of Pharmacology Pub Date : 2018-10-14 DOI: 10.3329/BJP.V13I4.37210

Tanzila Arshad, H. Sheikh, M. Kazmi, Sadia Farheen, Tehmina Sohail, M. Lateef

{"title":"New bioactive triaryl triglyceride esters: Synthesis, characterization and biological activities","authors":"Tanzila Arshad, H. Sheikh, M. Kazmi, Sadia Farheen, Tehmina Sohail, M. Lateef","doi":"10.3329/BJP.V13I4.37210","DOIUrl":"https://doi.org/10.3329/BJP.V13I4.37210","url":null,"abstract":"Four new bioactive aryl triester derivatives of glycerol and benzoic acids were synthesized. The synthetic compounds were studied for their antimicrobial and urease inhibition activities. Esterification was carried out by using carbonyldiimidazole to enhance the acyl elimination addition reaction with benzoic acid derivatives. The structure of triglycerides were studied by EI-MS, 1H, 13C-NMR, FT-IR and elemental analysis. All synthetic compounds showed urease inhibition activity with highest value of IC50 value 22.4 ± 0.45 μM which is nearest to standard thiourea IC50 value (21.6 ± 0.12 μM). Except compound (3d), all other compounds exhibited antimicrobial activity against Streptococcus pneumoniae, Staphylococcus epidermidis, Bacillus pumilus, Escherichia coli, Pseudomonas aeruginosa and Candida albican.Video Clip of Methodology:7 min 59 sec <a href=\"https://youtube.com/v/PvGTYUxO7-4\">Full Screen</a> <a href=\"https://youtube.com/watch?v=PvGTYUxO7-4\">Alternate</a> ","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2018-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3329/BJP.V13I4.37210","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46161591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoglycemic potential of Elaeagnus angustifolia fruit polysaccharide on streptozotocin-induced type 2 diabetic mice 沙枣果实多糖对链脲佐菌素诱导的2型糖尿病小鼠的降血糖作用

IF 1.6 4区医学

Bangladesh Journal of Pharmacology Pub Date : 2018-10-07 DOI: 10.3329/BJP.V13I4.37069

Ya Wang, H. Zou, Cui Sun, Tao Guo, Zaiping Feng

{"title":"Hypoglycemic potential of Elaeagnus angustifolia fruit polysaccharide on streptozotocin-induced type 2 diabetic mice","authors":"Ya Wang, H. Zou, Cui Sun, Tao Guo, Zaiping Feng","doi":"10.3329/BJP.V13I4.37069","DOIUrl":"https://doi.org/10.3329/BJP.V13I4.37069","url":null,"abstract":"In this study, the hyperglycemic potential of Elaeagnus angustifolia fruit polysaccharide in both normal healthy and streptozotocin-induced diabetic mice was investigated. Results showed no significant effect of E. angustifolia fruit polysaccharide on blood glucose level in normal control group, while E. angustifolia significantly suppressed the rise in blood glucose of diabetic mice. In addition, in the first two weeks of administration, the body weight was decreased both in negative control group and E. angustifolia groups, however, E. angustifolia (800 mg/kg) was recovered to the began weight in the fourth week. E. angustifolia (800 mg/kg) could markedly reduce the levels of total cholesterol, triglyceride and improve the level of high density lipoprotein-cholesterol. The results suggest that E. angustifolia could be considered as an ingredient of functional foods for diabetes.Video Clip of Methodology:10 min 19 sec <a href=\"https://www.youtube.com/v/a3ikXeeByP8\">Full Screen</a> <a href=\"https://www.youtube.com/watch?v=a3ikXeeByP8\">Alternate</a> ","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2018-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3329/BJP.V13I4.37069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44956661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Protective effect of Aurelia aurita against free radicals and streptozotocin-induced diabetes 白刺对自由基和链脲佐菌素诱导的糖尿病的保护作用

IF 1.6 4区医学

Bangladesh Journal of Pharmacology Pub Date : 2018-09-28 DOI: 10.3329/BJP.V13I3.36907

M. R. Talluri, Alekhya Ketha, G. Battu, Rajananda Swamy Tadi, V. B. Tatipamula

引用次数: 18

Chemical composition and antibacterial activity of Origanum ramonense essential oil on the β-lactamase and extended- spectrum β-lactamase urinary tract isolates 拉蒙花精油对β-内酰胺酶和广谱β-内酰胺酶尿路分离株的化学成分及抑菌活性研究

IF 1.6 4区医学

Bangladesh Journal of Pharmacology Pub Date : 2018-09-21 DOI: 10.3329/BJP.V13I3.36897

H. Qaralleh

{"title":"Chemical composition and antibacterial activity of Origanum ramonense essential oil on the β-lactamase and extended- spectrum β-lactamase urinary tract isolates","authors":"H. Qaralleh","doi":"10.3329/BJP.V13I3.36897","DOIUrl":"https://doi.org/10.3329/BJP.V13I3.36897","url":null,"abstract":"The aim of this study was to evaluate the antibacterial activity of Origanum ramonense essential oil extracted from the air-dried leaves against β-lactamase and extended-spectrum β-lactamase obtained from the patients with urinary tract infection. The essential oil was extracted by hydrodistillation and analyzed by GC–MS. In vitro antibacterial activity was studied using disc diffusion and microdilution methods. Twenty compounds were identified representing 97.8% of the total oil. The major components were carvacrol (84.6%), p-cymene (4.3%) and γ-terpinene (3.3%). The oil showed a broad spectrum of antibacterial activity against all tested isolates. Staphylococcus aureus, S. epidermidis, Klebsiella pneumoniae and Enterobacter aerogenes had the lowest minimum inhibitory concentration values (0.015 µg/mL) followed by Escherichia coli (0.14 µg/mL). The lowest susceptible strains to oil were Pseudomonas aeruginosa, Proteus mirabilis, E. coli 25922 and P. aeruginosa 10145. The bacteriostatic and bactericidal effects at concentrations as low as 0.015 µg/mL indicated the potent antibacterial activity of O. ramonense. Video Clip of Methodology:Disc Diffusion method: 2 min 16 sec <a href=\"https://www.youtube.com/v/HUZqSngRvmQ\">Full Screen</a> <a href=\"https://www.youtube.com/watch?v=HUZqSngRvmQ\">Alternate</a>","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2018-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3329/BJP.V13I3.36897","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43689409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Efficacy and safety of novel oral anticoagulants versus vitamin K antagonists in the treatment of venous thromboembolism 新型口服抗凝剂与维生素K拮抗剂治疗静脉血栓栓塞症的疗效和安全性

IF 1.6 4区医学

Bangladesh Journal of Pharmacology Pub Date : 2018-09-14 DOI: 10.3329/BJP.V13I3.37124

Maodi Xu, Qingquan Xue, Zhichen Pu, Zijing Wu, Haitang Xie

引用次数: 0

Antibacterial activities of endophytic fungi isolated from six Sri Lankan plants of the family Cyperaceae 斯里兰卡莎草科6种植物内生真菌的抗菌活性

IF 1.6 4区医学

Bangladesh Journal of Pharmacology Pub Date : 2018-09-08 DOI: 10.3329/BJP.V13I3.36716

P. Ratnaweera, R. C. Walgama, Kinkini U. Jayasundera, Suseema D. Herath, S. Abira, David E. Williams, R. Andersen, E. D. De Silva

{"title":"Antibacterial activities of endophytic fungi isolated from six Sri Lankan plants of the family Cyperaceae","authors":"P. Ratnaweera, R. C. Walgama, Kinkini U. Jayasundera, Suseema D. Herath, S. Abira, David E. Williams, R. Andersen, E. D. De Silva","doi":"10.3329/BJP.V13I3.36716","DOIUrl":"https://doi.org/10.3329/BJP.V13I3.36716","url":null,"abstract":"In a study designed to determine the antibacterial potential of endophytic fungi inhabiting plants of Cyperaceae family, 72 morphologically distinct endophytic fungi were isolated from six plants and their antibacterial activities against two Gram positive and three Gram negative pathogenic bacterial species were examined. Two antibacterial metabolites from two endophytes were also isolated and their chemical structures and minimum inhibitory concentrations were determined. Sixty six fungal extracts (92%) were active against at least one bacterium tested. Butyrolactone I isolated from the Aspergillus terreus and 9-epi viridol isolated from Trichoderma virens exhibited MIC values in the range 128-256 µg/mL against Gram positive Bacillus subtilits, Staphylococcus aureus, methicillin resistant S. aureus (MRSA) and Escherichia coli. Both compounds were inactive against other micro-organisms tested. This study confirmed that Cyperaceae plants harbor numerous endophytes that produce antibacterial metabolites active against both Gram positive and, to a lesser extent, Gram negative bacteria.Video Clip of Methodology:Column Chromatogrpahy: 15 min 34 sec <a href=\"https://www.youtube.com/v/CqF3GmhSHN4\">Full Screen</a> <a href=\"https://www.youtube.com/watch?v=CqF3GmhSHN4\">Alternate</a>","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2018-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3329/BJP.V13I3.36716","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41437903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Effect of sevoflurane postconditioning on myocardial oncosis and autophagy in ischemia-reperfusion injury in isolated rat heart 七氟醚后处理对离体大鼠心脏缺血再灌注损伤心肌细胞膨胀和自噬的影响

IF 1.6 4区医学

Bangladesh Journal of Pharmacology Pub Date : 2018-08-28 DOI: 10.3329/BJP.V13I3.36437

Q. Tang, Yang Xie, Hong Xie, Wenqiang Jiang, Z. Fang

{"title":"Effect of sevoflurane postconditioning on myocardial oncosis and autophagy in ischemia-reperfusion injury in isolated rat heart","authors":"Q. Tang, Yang Xie, Hong Xie, Wenqiang Jiang, Z. Fang","doi":"10.3329/BJP.V13I3.36437","DOIUrl":"https://doi.org/10.3329/BJP.V13I3.36437","url":null,"abstract":"The effects of sevoflurane postconditioning on myocardial oncosis and autophagy were studied in 32 isolated rat heart of ischemia-reperfusion injury. The hearts were perfused by: a) Sham surgery group, b) simple sevoflurane group, c) simple ischemia-reperfusion group (I/R) group, and d) sevoflurane postconditioning group. The ratios between the gray density values of the target bands to the gray density value of GADPH were used to reflect the Beclin-1, LC3II/I, and porimin expression levels. The LC3II/I level in the sevoflurane postconditioning group was lower than the level in the I/R group. The porimin level in the sevoflurane postconditioning group was lower than the level in the I/R group. The myocardial infarction range in the sevoflurane postconditioning group (33 ± 5%) was significantly diminished compared with the range in the I/R group (53 ± 6%) (p<0.05). Sevoflurane decreased the occurrence of oncosis and alleviated myocardial ischemia-reperfusion injury by inhibiting MPTP opening.Video Clip of Methodology:14 min 31 sec <a href=\"https://www.youtube.com/v/i7dssx_6Jsk\">Full Screen</a> <a href=\"https://www.youtube.com/watch?v=i7dssx_6Jsk\">Alternate</a>","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2018-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3329/BJP.V13I3.36437","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49398981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0