Protective effect of Aurelia aurita against free radicals and streptozotocin-induced diabetes

IF 0.9 4区医学 Q4 PHARMACOLOGY & PHARMACY

Bangladesh Journal of Pharmacology Pub Date : 2018-09-28 DOI:10.3329/BJP.V13I3.36907

M. R. Talluri, Alekhya Ketha, G. Battu, Rajananda Swamy Tadi, V. B. Tatipamula

引用次数: 18

Abstract

The present work was carried out to identify the anti-oxidant and anti-diabetic activities of Aurelia aurita. The chemical profiling analysis showed that it possess different biologically active secondary metabolites like phenols, alakoids, steroids etc. The methanolic extract showed different free radical scavenging activity as ascorbic acid with IC50 values 202, 205, 153 µg on DPPH, hydroxyl and superoxide free radicals. The extract significantly reduced the hyperglycemic conditions with percentage of reduction 18.7 ± 1.3 to 53.5 ±1.5 of streptozotocin-induced animals and the positive result of in-vitro aldose reductase enzyme inhibition with IC50 value 163 µg suggests that A. aurita have potential to cure the diabetic complications.

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白刺对自由基和链脲佐菌素诱导的糖尿病的保护作用

本研究旨在鉴定auria aurita的抗氧化和抗糖尿病活性。化学谱分析表明，其具有酚类、生物碱、类固醇等多种具有生物活性的次生代谢产物。甲醇提取物对DPPH、羟基和超氧自由基的IC50值分别为202、205、153µg，具有不同的抗坏血酸清除活性。该提取物显著降低了链脲佐菌素诱导动物的高血糖状态，降低率为18.7±1.3 ~ 53.5±1.5，体外醛糖还原酶抑制阳性，IC50值为163µg，提示金耳木耳具有治疗糖尿病并发症的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bangladesh Journal of Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

1.50

自引率

18.80%

发文量

审稿时长

>12 weeks

期刊介绍： Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS). A scholarly publication is defined ''open access'' when there are no financial, legal or technical barriers to accessing it. Anyone can read, download, copy, distribute, print or use it in educational purpose within the legal agreements. Peer review of a manuscript means the evaluation of research work by one or more people with similar competences. It can be open or blind. We do the single-blind peer review. Our readers want to know the methodology used by the researchers which is very important to get the results. The video clip of one of the methodologies is prepared by the authors and submit it to publish.