New bioactive triaryl triglyceride esters: Synthesis, characterization and biological activities

IF 0.9 4区医学 Q4 PHARMACOLOGY & PHARMACY

Bangladesh Journal of Pharmacology Pub Date : 2018-10-14 DOI:10.3329/BJP.V13I4.37210

Tanzila Arshad, H. Sheikh, M. Kazmi, Sadia Farheen, Tehmina Sohail, M. Lateef

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引用次数: 0

Abstract

Four new bioactive aryl triester derivatives of glycerol and benzoic acids were synthesized. The synthetic compounds were studied for their antimicrobial and urease inhibition activities. Esterification was carried out by using carbonyldiimidazole to enhance the acyl elimination addition reaction with benzoic acid derivatives. The structure of triglycerides were studied by EI-MS, ¹H, ¹³C-NMR, FT-IR and elemental analysis. All synthetic compounds showed urease inhibition activity with highest value of IC₅₀value 22.4 ± 0.45 μM which is nearest to standard thiourea IC₅₀value (21.6 ± 0.12 μM). Except compound (3d), all other compounds exhibited antimicrobial activity against Streptococcus pneumoniae, Staphylococcus epidermidis, Bacillus pumilus, Escherichia coli, Pseudomonas aeruginosa and Candida albican.

Video Clip of Methodology:

7 min 59 sec Full Screen Alternate

查看原文本刊更多论文

新型生物活性三芳基甘油三酯酯的合成、表征及生物活性

合成了四种新的具有生物活性的甘油和苯甲酸芳基三酯衍生物。对合成的化合物进行了抑菌活性和脲酶抑制活性的研究。采用羰基二咪唑进行酯化反应，增强了与苯甲酸衍生物的酰基消除加成反应。采用EI-MS、1H、13C-NMR、FT-IR和元素分析等方法研究了甘油三酯的结构。所有化合物均表现出脲酶抑制活性，IC50值最高为22.4±0.45 μM，最接近标准硫脲IC50值(21.6±0.12 μM)。除化合物(3d)外，其余化合物均对肺炎链球菌、表皮葡萄球菌、短小芽孢杆菌、大肠杆菌、铜绿假单胞菌和白色念珠菌具有抗菌活性。方法论视频剪辑:7分59秒全屏交替播放

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来源期刊

Bangladesh Journal of Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

1.50

自引率

18.80%

发文量

审稿时长

>12 weeks

期刊介绍： Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS). A scholarly publication is defined ''open access'' when there are no financial, legal or technical barriers to accessing it. Anyone can read, download, copy, distribute, print or use it in educational purpose within the legal agreements. Peer review of a manuscript means the evaluation of research work by one or more people with similar competences. It can be open or blind. We do the single-blind peer review. Our readers want to know the methodology used by the researchers which is very important to get the results. The video clip of one of the methodologies is prepared by the authors and submit it to publish.