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Bangladesh Journal of Pharmacology最新文献

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Antibacterial activity of Alternanthera versicolor 云芝的抗菌活性
IF 1.6 4区 医学
Bangladesh Journal of Pharmacology Pub Date : 2021-08-11 DOI: 10.3329/bjp.v16i3.54940
Gayathri Segaran, Mythili Sathiavelu
{"title":"Antibacterial activity of Alternanthera versicolor","authors":"Gayathri Segaran, Mythili Sathiavelu","doi":"10.3329/bjp.v16i3.54940","DOIUrl":"https://doi.org/10.3329/bjp.v16i3.54940","url":null,"abstract":"","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2021-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49213286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Abutilon indicum in thyroxine-induced hyperthyroidism in rat 阿布蒂龙对甲状腺素所致大鼠甲状腺功能亢进的影响
IF 1.6 4区 医学
Bangladesh Journal of Pharmacology Pub Date : 2021-08-08 DOI: 10.3329/bjp.v16i3.54174
Q. Jabeen, Muhammad Sohaib Khan, Abdul Wahid Qureshi, Hafiz Muhammad Farhan Rasheed
{"title":"Effect of Abutilon indicum in thyroxine-induced hyperthyroidism in rat","authors":"Q. Jabeen, Muhammad Sohaib Khan, Abdul Wahid Qureshi, Hafiz Muhammad Farhan Rasheed","doi":"10.3329/bjp.v16i3.54174","DOIUrl":"https://doi.org/10.3329/bjp.v16i3.54174","url":null,"abstract":"The study was designed to investigate the antithyroid activity of the crude methanolic (70%) extract of aerial parts of Abutilon indicum in male albino rats. The extract was prepared and analyzed for the presence of phytochemical constituents through preliminary chemical analysis, antioxidant assay and GC-MS. The in vivo antithyroid activities in thyroxine-induced hyperthyroidism were studied. Phytochemical analysis showed the presence of alkaloids, flavonoids and phenols, also verified by the data obtained from GC-MS. Thyroxine increased the levels of triiodothyronine (4.9 ± 0.1 ng/mL) and total thyroxine (9.4 ± 0.2 μg/dL); while, A. indicum at the doses of 300 and 500 mg/kg, showed significant decrease in the elevated levels of triiodothyronine (3.0 ± 0.1 and 2.6 ± 0.2 ng/mL) and thyroxine (7.7 ± 0.2 and 7.1 ± 0.2 μg/dL), respectively. Histopathological studies showed the restoration of filled follicular colloids in extract-treated animals. The results show that A. indicum exhibits dose-dependent antithyroid effects.","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2021-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46171893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
NF-κB signaling contributes to the inhibitory effects of Bombyx batryticatus on neuroinflammation caused by MPTP toxicity NF-κB信号传导参与家蚕对MPTP毒性引起的神经炎症的抑制作用
IF 1.6 4区 医学
Bangladesh Journal of Pharmacology Pub Date : 2021-08-05 DOI: 10.3329/BJP.V16I3.53611
Hye-Sun Lim, Yumi Jang, B. Moon, G. Park
{"title":"NF-κB signaling contributes to the inhibitory effects of Bombyx batryticatus on neuroinflammation caused by MPTP toxicity","authors":"Hye-Sun Lim, Yumi Jang, B. Moon, G. Park","doi":"10.3329/BJP.V16I3.53611","DOIUrl":"https://doi.org/10.3329/BJP.V16I3.53611","url":null,"abstract":"Bombyx batryticatus, the dried larvae of Bombyx mori infected by Beauveria bassiana, is a renowned traditional medicine. Previous report shows that B. batryticatus improved behavioral impairments, protected dopaminergic neurons, and maintained dopamine levels by inhibiting oxidative signaling in murine Parkinson’s disease  model. In this study, the inhibitory effects of B. batryticatus on 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson’s disease in mice was investigated and explored the corresponding molecular mechanisms, while focusing on NF-κB signaling. Consequently, it was found that B. batryticatus inhibited glial and microglial activation and the levels of neuroinflammatory mediators, such as Cox-2, iNOS, and NF-kB, in the substantia nigra pars compacta. Moreover, pre-inhibition of NF-κB by BAY 11-7082, a κB kinase inhibitor, could neutralize the inhibitory effects of B. batryticatus against the activation of glia and microglia formerly induced by MPTP. It can be considered that B. batryticatus holds implications in providing anti-inflammatory neuroprotection by regulating NF-κB signaling.","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2021-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48161555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Antibacterial activity of Cathormion umbellatum 伞花菌的抑菌活性
IF 1.6 4区 医学
Bangladesh Journal of Pharmacology Pub Date : 2021-07-12 DOI: 10.3329/bjp.v16i3.53420
Surachai Rattanasuk, Rujirek Boongapim, Tannatorn Phiwthong
{"title":"Antibacterial activity of Cathormion umbellatum","authors":"Surachai Rattanasuk, Rujirek Boongapim, Tannatorn Phiwthong","doi":"10.3329/bjp.v16i3.53420","DOIUrl":"https://doi.org/10.3329/bjp.v16i3.53420","url":null,"abstract":"The aim of this study was to determine the antibacterial activity of Cathormion umbellatum extracts against seven antibiotic-resistant bacteria. The pods, leaves and branches of C. umbellatum were extracted with ethanol and methanol. The disc diffusion assay was used to screen the antibacterial activity and broth microdilution and colorimetric assay were used to measure the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values. The result indicated that the highest inhibition zone (11 mm) was presented in ethanolic pods extract against multidrug resistance Klebsiella pneumoniae. The lowest MIC value of 0.05 mg/mL was obtained from branch extracted with ethanol against colistin resistant Pseudomonas aeruginosa. The lowest MBC values of 1.56 mg/mL were obtained when using C. umbellatum leaves extracted with methanol against all test antibiotic-resistant bacteria. This is the first report presented C. umbellatum extracts have the potential to eliminate antibiotic-resistant bacteria in patients. These findings show the antibacterial effect of C. umbellatum.","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2021-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46157490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Antibacterial activity of Dracaena lisa 龙血龙的抗菌活性
IF 1.6 4区 医学
Bangladesh Journal of Pharmacology Pub Date : 2021-07-02 DOI: 10.3329/bjp.v16i3.53018
Saranya Shankar, Mythili Sathiavelu
{"title":"Antibacterial activity of Dracaena lisa","authors":"Saranya Shankar, Mythili Sathiavelu","doi":"10.3329/bjp.v16i3.53018","DOIUrl":"https://doi.org/10.3329/bjp.v16i3.53018","url":null,"abstract":"","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2021-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47363441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Experimental models for vascular endothelial dysfunction 血管内皮功能障碍的实验模型
IF 1.6 4区 医学
Bangladesh Journal of Pharmacology Pub Date : 2021-07-01 DOI: 10.3329/bjp.v16i3.52948
Anchal Garg, Vardan Gupta, Ritu Tomar, M. Arora
{"title":"Experimental models for vascular endothelial dysfunction","authors":"Anchal Garg, Vardan Gupta, Ritu Tomar, M. Arora","doi":"10.3329/bjp.v16i3.52948","DOIUrl":"https://doi.org/10.3329/bjp.v16i3.52948","url":null,"abstract":"Vascular endothelial dysfunction is characterized by apoptosis of endothelial cells, an imbalance between vasoconstrictory and vasodilatory substances, the imbalance between ROS and antioxidants, vascular remodeling, loss of vascular integrity which leads to an increased risk of cardiovascular complications. To date, no therapeutic intervention is available as a promising agent. This may be due to a poor understanding of the underlying mechanism involved in vascular endothelial dysfunction in the pathogenesis. Animal models sharing identical features as that of humans are paramount to understand fundamental physiology, mechanism and to explore new targets for developing therapeutic agents. Thus, it becomes mandatory to re-explore the available animal models for a better understanding of molecular pathways involving vascular endothelial dysfunction. The purpose of this paper is to review different models for vascular endothelial dysfunction to the outlook for developing new drugs to treat vascular endothelial dysfunction.","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46354124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Antibacterial activity of an ornamental plant Hippeastrum fosteri 观赏植物马尾草的抗菌活性研究
IF 1.6 4区 医学
Bangladesh Journal of Pharmacology Pub Date : 2021-04-08 DOI: 10.3329/bjp.v16i2.52655
Gayathri Segaran, Mythili Sathiavelu
{"title":"Antibacterial activity of an ornamental plant Hippeastrum fosteri","authors":"Gayathri Segaran, Mythili Sathiavelu","doi":"10.3329/bjp.v16i2.52655","DOIUrl":"https://doi.org/10.3329/bjp.v16i2.52655","url":null,"abstract":"","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":"16 1","pages":"49-51"},"PeriodicalIF":1.6,"publicationDate":"2021-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46187958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bufalin inhibits the growth and epithelial to mesenchymal transition of human gastric cancer cells via modulation of MEK/ERK pathway 蟾毒灵通过调节MEK/ERK通路抑制人胃癌细胞的生长和上皮向间质转化
IF 1.6 4区 医学
Bangladesh Journal of Pharmacology Pub Date : 2021-01-04 DOI: 10.3329/BJP.V16I1.50548
Yi Zhou, Liguo Wang, Hui Lin, Yunxia Wang, Ke-zhu Hou
{"title":"Bufalin inhibits the growth and epithelial to mesenchymal transition of human gastric cancer cells via modulation of MEK/ERK pathway","authors":"Yi Zhou, Liguo Wang, Hui Lin, Yunxia Wang, Ke-zhu Hou","doi":"10.3329/BJP.V16I1.50548","DOIUrl":"https://doi.org/10.3329/BJP.V16I1.50548","url":null,"abstract":"This study was designed to evaluate the anti-cancer effects of bufalin against the human gastric cancer cells and unveil the underlying mechanism. The results showed that bufalin inhibited the proliferation and colony formation of the MGC-803 gastric cancer cells and exhibited an IC50 of 10 μM. These antiproliferative effects were found to be due to the induction of G2/M cell cycle arrest. The G2/M cell cycle arrest was also concomitant with inhibition of cdc2, cdc25 and cyclin B1. Furthermore, bufalin suppressed the epithelial-to-mesenchymal transition, migration, and invasion of the MGC-803 gastric cancer cells. The Western blot analysis revealed that bufalin exerted its effects via deactivation of EK/ERK signaling pathway. Taken together, these results suggest the potential of bufalin as the lead molecule for the development of chemotherapy for gastric cancer.","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":"16 1","pages":"27-33"},"PeriodicalIF":1.6,"publicationDate":"2021-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49178017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Efficacy of beta-blockers in the treatment of sepsis β受体阻滞剂治疗败血症的疗效
IF 1.6 4区 医学
Bangladesh Journal of Pharmacology Pub Date : 2021-01-03 DOI: 10.3329/BJP.V16I1.46001
Peng Jin, Ting Zhao, Yueyue Wei, Fang Zhao
{"title":"Efficacy of beta-blockers in the treatment of sepsis","authors":"Peng Jin, Ting Zhao, Yueyue Wei, Fang Zhao","doi":"10.3329/BJP.V16I1.46001","DOIUrl":"https://doi.org/10.3329/BJP.V16I1.46001","url":null,"abstract":"This meta-analysis is to systematically evaluate the efficacy and safety of beta-blockers in the treatment of sepsis. A total of 17 articles that met the inclusion criteria were included, and 10,385 cases were obtained. The meta-analysis results showed that patients with sepsis with beta-blocker usage had a significantly lower 28-day mortality. The heart rate decreased over time in patients with sepsis using beta-blocker. Moreover, central venous blood oxygen saturation increased after 24, 48, 72 hours of treatment; lactic acid and cardiac troponin I decreased after 48, 72 hours of treatment; and tumor necrosis factor-α, interleukin-1β levels decreased significantly after 12, 24, 48, 72 hours of treatment (p<0.05).  In conclusion, beta-blockers reduce 28-day mortality and heart rate.","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":"1 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2021-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41886823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Expression of HOXC10 gene regulates the growth and invasion of prostate cancer cells HOXC10基因表达对前列腺癌症细胞生长和侵袭的调控
IF 1.6 4区 医学
Bangladesh Journal of Pharmacology Pub Date : 2021-01-03 DOI: 10.3329/BJP.V16I1.50244
Hong-jun Song, Xuxiao Ye, T. Liang, Dongliang Yan, Zuowei Li
{"title":"Expression of HOXC10 gene regulates the growth and invasion of prostate cancer cells","authors":"Hong-jun Song, Xuxiao Ye, T. Liang, Dongliang Yan, Zuowei Li","doi":"10.3329/BJP.V16I1.50244","DOIUrl":"https://doi.org/10.3329/BJP.V16I1.50244","url":null,"abstract":"The present study was undertaken to decipher the role of HOXC10 gene in regulating the growth and metastasis of prostate cancer. The results revealed significant (p<0.05) up-regulation of HOXC10 gene in human prostate cancer tissues and cell lines. The silencing of HOXC10 transcript level significantly (p<0.05) inhibited the growth and colony formation of DU145 and 22Rv1 prostate cancer cells. The DAPI staining revealed that inhibition of DU145 and 22Rv1 prostate cancer cell viability was due to the induction of apoptosis. The transwell assay showed that HOXC10 significantly (p<0.05) inhibits the invasion of prostate cancer cells. The Western blotting revealed that HOXC10 gene exerts its effects via modulation of Ras/Raf/MEK/ERK signaling cascade. Collectively, the results point towards the therapeutic potential of HOXC10 in the treatment of prostate cancer.","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":"16 1","pages":"19-26"},"PeriodicalIF":1.6,"publicationDate":"2021-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49402510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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