大黄蜂乳胶水提取物的抗焦虑和抗抑郁作用

IF 0.9 4区医学 Q4 PHARMACOLOGY & PHARMACY

Bangladesh Journal of Pharmacology Pub Date : 2022-06-06 DOI:10.3329/bjp.v17i2.59258

Majda Badaoui, S. Moubtakir, Chafik Terrafe, R. Aboufatima, A. Chait

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引用次数: 1

摘要

本研究旨在研究大胡木胶乳水提物对小鼠的抗焦虑和抗抑郁作用。分别采用升高+迷宫试验、空旷场试验和硫喷妥诱导睡眠时间检测抗焦虑和镇静作用。同时使用强迫游泳试验来评估抗抑郁效果。在75 mg/kg的剂量下，松脂草显著降低了睡眠潜伏期，增加了睡眠时间。在所有评估剂量(25、50和75 mg/kg)下，它都显著减少了静止时间并增加了游泳量。拮抗剂预处理逆转了这些作用，表明可能分别与α2、5HT2、D2和GABAA受体有关。这些发现证实了这种植物作为抗氧化剂、抗焦虑剂和抗抑郁剂的传统用途。

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Antianxiety and antidepressant effects of aqueous latex extract of Euphorbia resinifera

This study aims to examine the antianxiety and antidepressant effects of aqueous latex extract of Euphorbia resinifera in mice. Antianxiety and sedative effects were examined using the elevated plus maze test, open field test, and thiopental-induced sleeping time respectively. While the antidepressant effect was evaluated, using the forced swimming test. E. resinifera reduced the latency of sleeping and increased sleeping time significantly at 75 mg/kg. It reduced the immobility time and increased swimming significantly at all doses assessed (25, 50, and 75 mg/kg). Pretreatment with antagonists reversed these effects indicating the possible involvement of α2, 5HT2, D2, and GABAA receptors respectively. These findings confirm the traditional utilization of this plant as an antioxidant, anxiolytic, and antidepressant.

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来源期刊

Bangladesh Journal of Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

1.50

自引率

18.80%

发文量

审稿时长

>12 weeks

期刊介绍： Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS). A scholarly publication is defined ''open access'' when there are no financial, legal or technical barriers to accessing it. Anyone can read, download, copy, distribute, print or use it in educational purpose within the legal agreements. Peer review of a manuscript means the evaluation of research work by one or more people with similar competences. It can be open or blind. We do the single-blind peer review. Our readers want to know the methodology used by the researchers which is very important to get the results. The video clip of one of the methodologies is prepared by the authors and submit it to publish.