Mulberrofuran G通过灭活JAK2/STAT3信号抑制肺癌细胞的增殖和迁移

IF 0.9 4区医学 Q4 PHARMACOLOGY & PHARMACY

Bangladesh Journal of Pharmacology Pub Date : 2021-12-26 DOI:10.3329/bjp.v16i4.55198

Haifeng Guo, Xiao-xiao Liu, X. Zhu, Zhe Yu

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引用次数: 2

摘要

本研究探讨了mulberrofuran G如何影响肺腺癌和鳞状细胞癌的增殖、侵袭和迁移。采用4种不同浓度的mulberrofuran G(1、5、10和100 μmol/L)模拟人肺腺癌细胞(A549细胞)和鳞状细胞癌(NCI-H226细胞)。结果表明，mulberrofuran G对A549和NCI-H226细胞的增殖、侵袭和迁移均有显著抑制作用，且呈剂量效应关系。mulberrofuran G对A549细胞和NCI-H226细胞的IC50分别为22.5 μmol/L和30.6 μmol/L。在A549细胞和NCI-H226细胞中，CDK4和MMP9的表达增强，p27的表达明显减弱。此外，p-JAK2和p-STAT3的表达在药物治疗中显著下调。综上所述，mulberrofuran G可以通过灭活JAK2/STAT3信号通路抑制肺癌细胞的增殖、迁移和侵袭。

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Mulberrofuran G inhibits proliferation and migration by inactivating JAK2/STAT3 signaling in lung cancer cells

The present study has investigated how mulberrofuran G affects prolifera-tion, invasion, and migration of the lung adenocarcinoma and squamous cell carcinoma. Four different concentrations of mulberrofuran G (1, 5, 10, and 100 μmol/L) were used to simulate human lung adenocarcinoma cells (A549 cells) and squamous-cell carcinoma (NCI-H226 cells). The results showed that mulberrofuran G significantly inhibited the proliferation, invasion, and migration of both A549 and NCI-H226 cells, with a dose-effect relationship. The IC50 inhibited the growth of A549 cells and NCI-H226 cells by mulberrofuran G were 22.5 and 30.6 μmol/L, respectively. It strengthened the expression of CDK4 and MMP9 but significantly weakened the expression of p27 in both A549 cells and NCI-H226 cells. Furthermore, the expression of p-JAK2 and p-STAT3 was significantly down-regulated in drug treatments. In conclusion, mulberrofuran G could inhibit proliferation, migration, and invasion of lung cancer cells via inactivating JAK2/STAT3 signaling.

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来源期刊

Bangladesh Journal of Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

1.50

自引率

18.80%

发文量

审稿时长

>12 weeks

期刊介绍： Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS). A scholarly publication is defined ''open access'' when there are no financial, legal or technical barriers to accessing it. Anyone can read, download, copy, distribute, print or use it in educational purpose within the legal agreements. Peer review of a manuscript means the evaluation of research work by one or more people with similar competences. It can be open or blind. We do the single-blind peer review. Our readers want to know the methodology used by the researchers which is very important to get the results. The video clip of one of the methodologies is prepared by the authors and submit it to publish.