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Bangladesh Journal of Pharmacology最新文献

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Antiproliferative effect of Memecylon malabaricum leaves methanolic extract against A-431 cell lines 马来香叶甲醇提取物对A-431细胞系的抗增殖作用
IF 1.6 4区 医学
Bangladesh Journal of Pharmacology Pub Date : 2022-06-06 DOI: 10.3329/bjp.v17i2.59408
R. Gaikwad, Anilkumar Shinde
{"title":"Antiproliferative effect of Memecylon malabaricum leaves methanolic extract against A-431 cell lines","authors":"R. Gaikwad, Anilkumar Shinde","doi":"10.3329/bjp.v17i2.59408","DOIUrl":"https://doi.org/10.3329/bjp.v17i2.59408","url":null,"abstract":"<jats:p>NA</jats:p>","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47698043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antianxiety and antidepressant effects of aqueous latex extract of Euphorbia resinifera 大黄蜂乳胶水提取物的抗焦虑和抗抑郁作用
IF 1.6 4区 医学
Bangladesh Journal of Pharmacology Pub Date : 2022-06-06 DOI: 10.3329/bjp.v17i2.59258
Majda Badaoui, S. Moubtakir, Chafik Terrafe, R. Aboufatima, A. Chait
{"title":"Antianxiety and antidepressant effects of aqueous latex extract of Euphorbia resinifera","authors":"Majda Badaoui, S. Moubtakir, Chafik Terrafe, R. Aboufatima, A. Chait","doi":"10.3329/bjp.v17i2.59258","DOIUrl":"https://doi.org/10.3329/bjp.v17i2.59258","url":null,"abstract":"This study aims to examine the antianxiety and antidepressant effects of aqueous latex extract of Euphorbia resinifera in mice. Antianxiety and sedative effects were examined using the elevated plus maze test, open field test, and thiopental-induced sleeping time respectively. While the antidepressant effect was evaluated, using the forced swimming test. E. resinifera reduced the latency of sleeping and increased sleeping time significantly at 75 mg/kg. It reduced the immobility time and increased swimming significantly at all doses assessed (25, 50, and 75 mg/kg). Pretreatment with antagonists reversed these effects indicating the possible involvement of α2, 5HT2, D2, and GABAA receptors respectively. These findings confirm the traditional utilization of this plant as an antioxidant, anxiolytic, and antidepressant.","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48492714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Synthesis, in silico analysis and antidepressant activity of 1,3,4-oxadiazole derivatives 1,3,4-恶二唑衍生物的合成、计算机分析及抗抑郁活性
IF 1.6 4区 医学
Bangladesh Journal of Pharmacology Pub Date : 2022-03-31 DOI: 10.3329/bjp.v17i1.58728
B. F. D. Gatphoh, Natasha Naval Aggarwal, S. M. Kumar, M. Kumar, B. Revanasiddappa
{"title":"Synthesis, in silico analysis and antidepressant activity of 1,3,4-oxadiazole derivatives","authors":"B. F. D. Gatphoh, Natasha Naval Aggarwal, S. M. Kumar, M. Kumar, B. Revanasiddappa","doi":"10.3329/bjp.v17i1.58728","DOIUrl":"https://doi.org/10.3329/bjp.v17i1.58728","url":null,"abstract":"The compounds 1,3,4-oxadiazole derivatives (1-8) were synthesized by the cyclization of 4-hydroxy benzhydrazide (1) with various substituted aroma-tic aldehydes (2) using FeCl3 as catalyst and methanol as a solvent medium. The structures of the newly synthesized compounds were assigned based on FT-IR, 1H-NMR, and mass spectral data. In vivo antidepressant activity was performed by tail suspension test and forced swimming test models. Using the Schrodinger Maestro, the in silico analysis was performed and docked to the glycogen synthase kinase 3β binding site (PDB: 3GB2). Compounds 8 [4,4'-(1,3,4-oxadiazole-2,5-diyl)diphenol] and 3 [3-(5-(4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl) phenol] showed both potent inhibitory activity against GSK-3β with a docking score of -7.800 kcal/mol as well as good antidepressant activity in both tail suspension and forced swimming tests models. The synthesized derivatives showed good antidepressive potential.","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49534998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-MRSA activity of Pollianthes tuberosa leaf extracts 柱花草叶提取物的抗MRSA活性
IF 1.6 4区 医学
Bangladesh Journal of Pharmacology Pub Date : 2022-03-18 DOI: 10.3329/bjp.v17i1.57727
R. Sundar, Sathiavelu Arunachalam
{"title":"Anti-MRSA activity of Pollianthes tuberosa leaf extracts","authors":"R. Sundar, Sathiavelu Arunachalam","doi":"10.3329/bjp.v17i1.57727","DOIUrl":"https://doi.org/10.3329/bjp.v17i1.57727","url":null,"abstract":"<jats:p>NA</jats:p>","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46464776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cost-effectiveness analysis of intradermal versus classical intramuscular COVID-19 vaccine administration 皮内注射与传统肌肉注射COVID-19疫苗的成本-效果分析
IF 1.6 4区 医学
Bangladesh Journal of Pharmacology Pub Date : 2022-03-17 DOI: 10.3329/bjp.v17i1.57593
P. Sookaromdee, V. Wiwanitkit
{"title":"Cost-effectiveness analysis of intradermal versus classical intramuscular COVID-19 vaccine administration","authors":"P. Sookaromdee, V. Wiwanitkit","doi":"10.3329/bjp.v17i1.57593","DOIUrl":"https://doi.org/10.3329/bjp.v17i1.57593","url":null,"abstract":"<jats:p>n/a</jats:p>","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45933209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Nrf2 signaling contributes to the neuroprotective effect of Cicadidae Periostracum against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity Nrf2信号传导有助于Cicadidae Periostracum对1-甲基-4-苯基-1,2,3,6-四氢吡啶毒性的神经保护作用
IF 1.6 4区 医学
Bangladesh Journal of Pharmacology Pub Date : 2022-03-17 DOI: 10.3329/bjp.v17i1.57472
Hye-Sun Lim, B. Moon, G. Park
{"title":"Nrf2 signaling contributes to the neuroprotective effect of Cicadidae Periostracum against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity","authors":"Hye-Sun Lim, B. Moon, G. Park","doi":"10.3329/bjp.v17i1.57472","DOIUrl":"https://doi.org/10.3329/bjp.v17i1.57472","url":null,"abstract":"Cicadidae Periostracum has various pharmacological effects, including neuroprotective potential via nuclear receptor related-1 (NURR1) protein signaling. However, there are no studies on its antioxidative effect. The neuroprotective effect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced damage to dopaminergic neurons was evaluated and explored the mechanisms of its antioxidant action, focusing on nuclear factor E2-related factor 2 (Nrf2) in a mouse model of Parkinson's disease. We measured NURR1-related neurotrophic signaling and the levels of antioxidant factors in vitro and in vivo. The effects of Cicadidae Periostracum against MPTP-induced neurotoxicity were associated with inhibition of the neurotrophic signaling pathways and up-regulation of Nrf2 pathways. Thus, Cicadidae Periostracum mitigates neurotoxicity via neurotrophic signaling not only by increasing Nrf2 activity but also by increasing antioxidant activity.","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49146677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Mulberrofuran G inhibits proliferation and migration by inactivating JAK2/STAT3 signaling in lung cancer cells Mulberrofuran G通过灭活JAK2/STAT3信号抑制肺癌细胞的增殖和迁移
IF 1.6 4区 医学
Bangladesh Journal of Pharmacology Pub Date : 2021-12-26 DOI: 10.3329/bjp.v16i4.55198
Haifeng Guo, Xiao-xiao Liu, X. Zhu, Zhe Yu
{"title":"Mulberrofuran G inhibits proliferation and migration by inactivating JAK2/STAT3 signaling in lung cancer cells","authors":"Haifeng Guo, Xiao-xiao Liu, X. Zhu, Zhe Yu","doi":"10.3329/bjp.v16i4.55198","DOIUrl":"https://doi.org/10.3329/bjp.v16i4.55198","url":null,"abstract":"The present study has investigated how mulberrofuran G affects prolifera-tion, invasion, and migration of the lung adenocarcinoma and squamous cell carcinoma. Four different concentrations of mulberrofuran G (1, 5, 10, and 100 μmol/L) were used to simulate human lung adenocarcinoma cells (A549 cells) and squamous-cell carcinoma (NCI-H226 cells). The results showed that mulberrofuran G significantly inhibited the proliferation, invasion, and migration of both A549 and NCI-H226 cells, with a dose-effect relationship. The IC50 inhibited the growth of A549 cells and NCI-H226 cells by mulberrofuran G were 22.5 and 30.6 μmol/L, respectively. It strengthened the expression of CDK4 and MMP9 but significantly weakened the expression of p27 in both A549 cells and NCI-H226 cells. Furthermore, the expression of p-JAK2 and p-STAT3 was significantly down-regulated in drug treatments. In conclusion, mulberrofuran G could inhibit proliferation, migration, and invasion of lung cancer cells via inactivating JAK2/STAT3 signaling.","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2021-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42608369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Pharmacological activities and volatile organic compounds from the endophytic bacteria from the leaves of Rhizophora apiculata 尖根霉叶片内生细菌的药理活性和挥发性有机物
IF 1.6 4区 医学
Bangladesh Journal of Pharmacology Pub Date : 2021-12-02 DOI: 10.3329/bjp.v16i4.56682
T. T. H. Dat, P. T. Oanh
{"title":"Pharmacological activities and volatile organic compounds from the endophytic bacteria from the leaves of Rhizophora apiculata","authors":"T. T. H. Dat, P. T. Oanh","doi":"10.3329/bjp.v16i4.56682","DOIUrl":"https://doi.org/10.3329/bjp.v16i4.56682","url":null,"abstract":"","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46175465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanism of anti-cancer effect of β-glucan on SH-SY5Y cell line β-葡聚糖对SH-SY5Y细胞的抗癌作用机制
IF 1.6 4区 医学
Bangladesh Journal of Pharmacology Pub Date : 2021-10-01 DOI: 10.3329/bjp.v16i4.54872
A. Filiz, Ziad Joha, Fatih Yulak
{"title":"Mechanism of anti-cancer effect of β-glucan on SH-SY5Y cell line","authors":"A. Filiz, Ziad Joha, Fatih Yulak","doi":"10.3329/bjp.v16i4.54872","DOIUrl":"https://doi.org/10.3329/bjp.v16i4.54872","url":null,"abstract":"Anti-cancer property of fungi derived β-glucan (Lentinula edodes) on several cancer cell lines have been reported. In this work, the SH-SY5Y cell lines were treated with various concentrations of β-glucan (62.5, 125, 250 and 500 μg/mL) and the viability of the cells was tested using the XTT assay after 24 hours. Cleaved PARP, BCL-2, 8-hydroxy-desoxyguanosine (8-oxo-dG), cleaved caspase 3, Bax, total oxidant, and total antioxidant levels in the cells were measured by commercial kits. β-Glucan significantly decreased the cell viability in SH-SY5Y cells. ELISA tests demonstrated that β-glucan therapy dramatically increased 8-oxo-dG, cleaved caspase 3, Bax, cleaved PARP, total oxidant. However, β-glucan treatment did not change the BCL-2 protein level. Altogether, β-glucan caused significant cytotoxicity in SH-SY5Y cells by inducing oxidative stress, increasing DNA damage, and ultimately increasing apoptosis.","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44160510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Application of selected components of “SPICES” model as teaching-learning method in pharmacology “香料”模型在药理学教学中的应用
IF 1.6 4区 医学
Bangladesh Journal of Pharmacology Pub Date : 2021-10-01 DOI: 10.3329/bjp.v16i4.55620
Mohosina Sultana Setu, M. Rahman
{"title":"Application of selected components of “SPICES” model as teaching-learning method in pharmacology","authors":"Mohosina Sultana Setu, M. Rahman","doi":"10.3329/bjp.v16i4.55620","DOIUrl":"https://doi.org/10.3329/bjp.v16i4.55620","url":null,"abstract":"This study was to compare the performance of the students (future pres-cribers) of four medical colleges using three modules on rational prescribing. Marks obtained (out of 35) in ‘student-centered learning’ approach in first and second assessment were 28.3 ± 3.4 and 23.7 ± 4.2 respectively, which is significantly (p<0.01) higher than the control (12.9 ± 6.4 and 10.0 ± 6.1). Marks obtained (out of 40) in ‘problem-based learning’ approach in first and second assessment were 38.2 ± 1.5 and 32.0 ± 2.4 respectively, which is significantly (p<0.01) higher than the control (23.2 ± 3.8 and 22.7 ± 2.4). Marks obtained (out of 40) in ‘integrated learning’ approach in first and second assessment were 32.0 ± 1.8 and 28.8 ± 2.0 respectively, which is significantly (p<0.01) higher than the control (20.9 ± 2.09 and 14.3 ± 3.7). Though the marks obtained in control and all three intervention groups in first assessment was significantly (p<0.05) reduced in the second assessment. Thus, student-centered, problem based and integrated learning approaches are more effective than traditional method.  ","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45096154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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