Nrf2信号传导有助于Cicadidae Periostracum对1-甲基-4-苯基-1,2,3,6-四氢吡啶毒性的神经保护作用

IF 0.9 4区医学 Q4 PHARMACOLOGY & PHARMACY

Bangladesh Journal of Pharmacology Pub Date : 2022-03-17 DOI:10.3329/bjp.v17i1.57472

Hye-Sun Lim, B. Moon, G. Park

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引用次数: 2

摘要

Cicadidae Periostracum具有多种药理作用，包括通过核受体相关-1（NURR1）蛋白信号传导的神经保护潜力。然而，目前还没有关于其抗氧化作用的研究。在帕金森病小鼠模型中，重点研究了1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）对多巴胺能神经元损伤的神经保护作用，并探讨了其抗氧化作用机制。我们在体外和体内测量了NURR1相关的神经营养信号传导和抗氧化因子的水平。Cicadidae Periostracum对MPTP诱导的神经毒性的作用与抑制神经营养信号通路和上调Nrf2通路有关。因此，Cicadidae Periostracum通过神经营养信号减轻神经毒性，不仅通过增加Nrf2活性，还通过增加抗氧化活性。

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Nrf2 signaling contributes to the neuroprotective effect of Cicadidae Periostracum against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity

Cicadidae Periostracum has various pharmacological effects, including neuroprotective potential via nuclear receptor related-1 (NURR1) protein signaling. However, there are no studies on its antioxidative effect. The neuroprotective effect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced damage to dopaminergic neurons was evaluated and explored the mechanisms of its antioxidant action, focusing on nuclear factor E2-related factor 2 (Nrf2) in a mouse model of Parkinson's disease. We measured NURR1-related neurotrophic signaling and the levels of antioxidant factors in vitro and in vivo. The effects of Cicadidae Periostracum against MPTP-induced neurotoxicity were associated with inhibition of the neurotrophic signaling pathways and up-regulation of Nrf2 pathways. Thus, Cicadidae Periostracum mitigates neurotoxicity via neurotrophic signaling not only by increasing Nrf2 activity but also by increasing antioxidant activity.

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来源期刊

Bangladesh Journal of Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

1.50

自引率

18.80%

发文量

审稿时长

>12 weeks

期刊介绍： Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS). A scholarly publication is defined ''open access'' when there are no financial, legal or technical barriers to accessing it. Anyone can read, download, copy, distribute, print or use it in educational purpose within the legal agreements. Peer review of a manuscript means the evaluation of research work by one or more people with similar competences. It can be open or blind. We do the single-blind peer review. Our readers want to know the methodology used by the researchers which is very important to get the results. The video clip of one of the methodologies is prepared by the authors and submit it to publish.