Basic and Clinical Neuroscience最新文献

{"title":"Synergistic Effects of Cerebrolysin and Aerobic Exercise on 6-hydroxydopamine-induced Model of Parkinson Disease in Adult Male Rats.","authors":"Seyed Zanyar Athari, Fereshteh Farajdokht, Daryoush Mohajeri, Mir Alireza Nourazar","doi":"10.32598/bcn.2025.6378.1","DOIUrl":"10.32598/bcn.2025.6378.1","url":null,"abstract":"<p><strong>Introduction: </strong>Neurotrophic factors and physical activities have beneficial effects on neurodegenerative disorders. This study assessed the impact of physical exercise (EXE) and cerebrolysin (CBL), individually or in combination, in a Parkinson's disease (PD) model caused by 6-hydroxydopamine (6-OHDA).</p><p><strong>Methods: </strong>The study utilized 62 male Wistar rats, which were divided into six groups (n=12): Sham (received intra substantia nigra [SN] injection of normal saline), PD (underwent 12.5 μg injection of 6-OHDA into the left SN), PD+levodopa (treated with levodopa; 12 mg/kg, gavage, for three weeks), PD+CBL (treated with intraperitoneal injection of CBL 2.5 mL/kg, for three weeks), PD+EXE (exercised 30 min/d for three weeks), and PD+CBL+EXE. Rotation with apomorphine and Murprogo's test was assessed 21 days after PD induction and after treatments. Ultimately, the levels of lipid peroxidation marker and total antioxidant capacity (TAC), glutathione peroxidase (GPx) activity, α-synuclein protein expression, and histopathological changes of the SN were evaluated ipsilateral to the lesioned side.</p><p><strong>Results: </strong>The results showed that CBL and exercise, alone or in combination, decreased ipsilateral apomorphine rotation and muscle rigidity in the PD animals. Moreover, these behavioral changes were associated with reduced malondialdehyde (MDA) levels and α-synuclein protein levels, increased TAC level and GPx activity, and a greater neuronal count in the SN. Notably, the combination effects were greater than single therapy and levodopa treatment.</p><p><strong>Conclusion: </strong>Our findings indicate that the combination of exercise and CBL ameliorated 6-OHDA-induced motor impairments by attenuating oxidative stress and protein expression of α-synuclein and preserving neurons in the SN.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 2","pages":"475-488"},"PeriodicalIF":1.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148359412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining Quality of Life, Mental Health, and Craving in Opioid Users, Methadone Patients, and NA Members.","authors":"Narges Dalili, Elahe Motevaseli, Mehdi Tehrani-Doost, Mohammad Reza Zarrindast, Parviz Dousti Kataj, Nasim Vousooghi","doi":"10.32598/bcn.2024.2756.3","DOIUrl":"10.32598/bcn.2024.2756.3","url":null,"abstract":"<p><strong>Introduction: </strong>Opioid use disorder (OUD) is a significant public health concern, and different treatment approaches, such as maintenance therapy or group therapy, have been proposed. The effectiveness of these therapies in improving the psychological and mental state of the patients has drawn the focus of research and evaluation. This study aimed to compare the dimensions of quality of life (QoL), depression, anxiety, stress, and substance control-related factors in OUD subjects and those who have entered methadone maintenance treatment or narcotics anonymous (NA) group therapy compared to control subjects who had never used opioids.</p><p><strong>Methods: </strong>The participants (n=80) in this cross-sectional study were all male subjects and divided into 4 groups (n=20 in each group), OUD subjects, NA members with a history of OUD, methadone-maintenance therapy (MMT) individuals previously involved with OUD and a healthy control group. The first three groups were recruited from substance use disorder treatment centers and community groups in Tehran City, Iran. All participants completed the validated Farsi version of questionnaires, the World Health Organization QoL-BREF (WHOQoL-BREF), the depression anxiety stress scale (DASS-21), and the desire for drug questionnaire (DDQ). Multivariate analysis of variance followed by the least significant difference was used to assess the differences between groups.</p><p><strong>Results: </strong>Data showed that for the DASS-21 scale, the differences between OUD subjects and the other three groups for all scale variables were statistically significant, except for the difference between OUD and MMT subjects for the stress variable, which was not significant. For the DDQ and WHOQoL-BREF scales, the differences between the OUD group and NA or control subjects for all variables of the scales were significant. However, no significant differences were observed between OUD and MMT groups regarding these variables.</p><p><strong>Conclusion: </strong>The results of our study suggest that entering NA programs may be a more effective treatment option than consuming methadone for individuals with OUD in terms of improvement in the mental and psychological state of the patient, which may need to be further evaluated in the future.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 2","pages":"417-428"},"PeriodicalIF":1.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148359369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Role of MicroRNAs and Associated Proteins in Multiple Sclerosis.","authors":"Melika Abrishami, Mostafa Rezaei-Tavirani","doi":"10.32598/bcn.2024.6141.1","DOIUrl":"10.32598/bcn.2024.6141.1","url":null,"abstract":"<p><strong>Introduction: </strong>Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (CNS). The diagnosis and follow-up of MS progression are challenging because of its complex pathogenesis and the lack of specific biomarkers. This study aims to introduce related microRNAs (miRNAs) and associated proteins with MS.</p><p><strong>Methods: </strong>MS-related miRNA data of 4 peripheral blood profiles from relapsing-remitting MS patients and 8 healthy controls were extracted from the GEO database. Their related proteins were analyzed using bioinformatics methods, such as protein-protein interaction (PPI) network and action map.</p><p><strong>Results: </strong>Eighteen differential microRNA were detected, discriminating the patient samples from controls. Then, 31 related proteins were identified and assessed via PPI network analysis and action map evaluation.</p><p><strong>Conclusion: </strong>In conclusion, a protein panel of NCL, NOP58, SNRNP70, U2AF2, YBX1, PRPF8, BOP1, and PIK3K as the crucial individuals associated with MS are suggested for further investigation.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 2","pages":"449-460"},"PeriodicalIF":1.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148359419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auditory Efferent System Influencing the Auditory Overshoot Phenomenon: An Auditory Brainstem Response Study in Guinea Pigs.","authors":"Hassan Haddadzade Niri, Nariman Rahbar, Akram Pourbakht, Hamid Haghani","doi":"10.32598/bcn.16.2.1939.1","DOIUrl":"10.32598/bcn.16.2.1939.1","url":null,"abstract":"<p><strong>Introduction: </strong>Detection of a brief tonal signal at the beginning of a longer masking noise is difficult, but it becomes easier when the onset of the signal is delayed. This phenomenon is known as overshoot or temporal effect. Our study investigates the impact of the auditory efferent nerves (AENs) function on the auditory electrophysiological overshoot, further introducing an objective tool examining one of the AENs performances. Therefore, the effect and the trend of changes induced by low- and high-frequency stimuli on electrophysiological overshoot were studied in different delay onset times (DOTs) between the signal and the noise before and after dissecting the AENs.</p><p><strong>Methods: </strong>Right internal auditory canals were exposed in 16 young male guinea pigs weighing 250 to 350 g. The inferior and posterior vestibular nerves known to carry AENs were transected in half of the subjects. Then, the ABR waveforms were recorded at 16 and 8 kHz tone burst stimuli at 0, 30, 60, and 100 ms DOTs relative to wideband noise. The latency values of auditory brainstem response (ABR) waves I and III were compared among the different DOTs and 5 signal-to-noise ratios (SNRs) before and after the surgery.</p><p><strong>Results: </strong>By increasing DOTs, ABR waves I and III latency decreased in the control group before and after the surgery and in the case group before surgery at 16 kHz. However, the observed overshoot-like effect disappeared after the surgery in the case group. The wave's latency I and III increased from 0 to 30 ms, remained approximately constant from 30 to 60 ms, and then decreased toward 100 ms DOTs. However, none of the measurements at 8 kHz before and after surgery in both groups showed an overshoot effect.</p><p><strong>Conclusion: </strong>Using the ABR paradigm, the overshoot phenomenon disappeared after the transection of AENs. The results confirmed the role of the efferent system in auditory overshooting. Therefore, an objective tool to measure auditory efferent function is provided.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 2","pages":"403-416"},"PeriodicalIF":1.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148359377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial Toxicity by 3-NP Enhanced Susceptibility to Defective Social Behaviors in Male Wistar Rats.","authors":"Fatemeh Nasehi, Fariba Khodagholi, Neda Kaveh, Ali Maleki, Arman Zeinaddini-Meymand, Maryam Alsadat Mousavi, Dariush Minai-Tehrani, Forough Foolad","doi":"10.32598/bcn.2024.6604.1","DOIUrl":"10.32598/bcn.2024.6604.1","url":null,"abstract":"<p><strong>Introduction: </strong>The impaired mitochondrial function in neurons is a principal abnormality in many medical conditions. Behavioral changes are the key aspects that emerge under these conditions. In the current study, we investigated whether social interactions are influenced by 3-nitropropionic acid (3-NP)-induced mitochondrial failure. We also assessed changes in glucocorticoid receptor (GR) and FKBP5 protein levels, cytochrome contents, and monoamine oxidase (MAO) A and B activities in the striatum (ST), hippocampus (HIP), and prefrontal cortex (PFC) of the subjects.</p><p><strong>Methods: </strong>Adult male Wistar rats were treated with 3-NP. Then, the social and non-social behaviors of 3-NP-treated rats were investigated. Different dissected brain regions were considered regarding GR and FKBP5 protein levels, cytochrome contents, and MAO-A and MAO-B.</p><p><strong>Results: </strong>We found a significantly decreased duration of social behaviors and impaired non-social behavioral tests. We detected a decreasing trend in GR and FKBP5 protein levels. Moreover, cytochrome contents and MAO A and B activities decreased in the dissected brain regions.</p><p><strong>Conclusion: </strong>Impaired social/non-social behaviors and decreased levels of investigated molecular variables in the regions mentioned above after 3-NP treatment might point to processes connecting mitochondrial failure to behavioral impairment, particularly social type.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 2","pages":"489-504"},"PeriodicalIF":1.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148359347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding the Phenotype and Genotype Spectrum of a Novel Mutation in Hypomyelinating Leukodystrophy-5 With a Review of the Literature on 42 Cases.","authors":"Sahar Bayat, Milad Gholami, Hamidreza Khodadadi, Mohammadreza Ghazavi, Jafar Nasiri, Majid Kheirollahi","doi":"10.32598/bcn.2024.6930.1","DOIUrl":"10.32598/bcn.2024.6930.1","url":null,"abstract":"<p><strong>Introduction: </strong>Hypomyelinating leukodystrophy-5 (HLD-5) is a rare multiple congenital anomaly with intellectual disability caused by an autosomal recessive mutation in the <i>FAM126A</i> gene. It is characterized by bilateral congenital cataracts, developmental delay, cerebellar ataxia, slowly progressive gait disturbance, and cognitive impairment. This study aims to contribute to a better understanding of HLD-5 by reviewing previous patients and introducing a novel variant in a new case.</p><p><strong>Methods: </strong>We subjected a case with an initial diagnosis of HLD-5 in an Iranian family. To identify the possible genetic cause(s), whole exome sequencing (WES) was conducted to detect exon mutations. Sanger sequencing was performed to verify the DNA sequence variants and co-segregation analysis. We predicted the potential deleterious effects of the novel mutation using in silico predictive tools.</p><p><strong>Results: </strong>WES identified a novel homozygous mutation (NM_032581: c.636_639del p.C213Dfs*7) in the <i>FAM126A</i> gene. The variant can cause premature termination of amino acid translation or affect mRNA expression.</p><p><strong>Conclusion: </strong>This study explained the clinical manifestations and molecular findings of HLD-5. Additionally, we reported a novel variant and some rare clinical features, such as exophthalmos and strabismus, in our proband for the first time. Further research is needed to clarify the molecular mechanisms underlying HLD-5 pathogenesis.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 2","pages":"505-518"},"PeriodicalIF":1.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148359385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of the Persian Writing Treatment Protocol on Communication Skills in People With Aphasia After Stroke.","authors":"Seyede Zohre Mousavi, Nahid Jalilevand, Hassan Ashayeri, Jamileh Abolghasemi","doi":"10.32598/bcn.2023.1307.2","DOIUrl":"10.32598/bcn.2023.1307.2","url":null,"abstract":"<p><strong>Introduction: </strong>Aphasia is one of the most severe post-stroke deficits affecting speech, comprehension, reading, and writing modalities. In some patients, speech is severely impaired, so choosing an alternative or complementary approach for communication seems necessary. Writing has the closest characteristics to verbal language. So, it can be a substitute or facilitate speech and improve the quality of communication. Therefore, this study aimed to design a writing treatment protocol for Persian stroke patients and investigate its effect on improving communication skills.</p><p><strong>Methods: </strong>First, the writing treatment protocol was designed by considering the characteristics of the Persian written language, and an expert panel determined its validity. Then, a single-subject study with ABA design was performed on 6 stroke patients suffering from chronic aphasia, non-fluent with limited speech. After the baseline phase, treatment sessions using the developed protocol were conducted for one hour twice weekly for 10 sessions. Finally, a follow-up was performed to evaluate the stability of the treatment.</p><p><strong>Results: </strong>The results showed that patients' improvement was limited to trained words, which were treated using the developed protocol, and no generalization was observed for untrained words. The effect size indices (improvement rate difference, percentage of non-overlapping data, and percentage of overlapping data) showed the acceptable effect of treatment, its effectiveness, and the very high impact of writing therapy in all patients.</p><p><strong>Conclusion: </strong>Writing treatment using the developed Persian protocol can improve patients' writing performance and communication. An essential outcome of this study is introducing a writing treatment approach as a new intervention for Persian patients with limited speech.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 Spec","pages":"205-218"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Functional Activity and Walking Capacity Enhancement in Children With Cerebral Palsy: A Pilot fMRI Study.","authors":"Parmida Moradi Birgani, Meghdad Ashtiyani, Seyed Behnamedin Jameie, Amin Shahrokhi, Elham Rahimian, Mohammad Reza Deevband, M Mehdi Mirbagheri","doi":"10.32598/bcn.2023.4679.1","DOIUrl":"10.32598/bcn.2023.4679.1","url":null,"abstract":"<p><strong>Introduction: </strong>Gait impairment is one of the consequences of cerebral palsy (CP) as a permanent neurological disorder. The therapy-induced neuroplasticity should be accompanied by functional improvement to have a persistent treatment effect. In this regard, we aimed to determine the correlation between brain functional activity changes and walking capacity improvement following treatments in children with hemiplegic CP (HCP).</p><p><strong>Methods: </strong>Twenty-one spastic HCP children (7-12 years old) were randomly divided into 3 groups. Occupational therapy (OT) was performed for the first group. The second group received repetitive transcranial magnetic stimulation (rTMS) treatment, and the third group underwent anti-gravity treadmill (AlterG system) training. AlterG training and OT were provided for 45 minutes, and rTMS was applied for 20 minutes per session, 3 times per week for 8 weeks. Brain functional activity while executing passive tasks involving knee flexion/extension and ankle plantarflexion/dorsiflexion over the range of motion was quantified using functional magnetic resonance imaging (fMRI). Walking capacity was indexed by clinical measures. Clinical and fMRI evaluations were performed pre- and post-training.</p><p><strong>Results: </strong>Our results indicate that intensive OT, rTMS, and AlterG training enhance brain functional activity and walking capacity in pediatrics with CP. Also, our results reveal a robust correlation between the corpus callosum (CC) functional activity changes and walking capacity improvement.</p><p><strong>Conclusion: </strong>Regardless of the type of treatment, the improvement in gait function in children with CP may reflect an increase in brain functional activity in callosal neurons, which may reveal an increase in interhemispheric coupling.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 Spec","pages":"309-322"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Bumetanide on Neural Correlates of Emotion Recognition in Youth With Autism Spectrum Disorder: An Event-related Potential Study.","authors":"Raheleh Mollajani, Mohamad Taghi Joghataei, Mehdi Tehrani-Doost, Reza Khosrowabadi","doi":"10.32598/bcn.2023.3978.1","DOIUrl":"10.32598/bcn.2023.3978.1","url":null,"abstract":"<p><strong>Introduction: </strong>Individuals with autism spectrum disorder (ASD) have impairments in emotion processing, including recognizing facial emotions. There is a significant need for medication to improve core symptoms of ASD. Bumetanide is one of the most recently used drugs in some studies of ASD to address this need. This study aimed to evaluate the effect of bumetanide on the brain response of youth with ASD while they were recognizing facial emotions using the event-related potentials (ERPs).</p><p><strong>Methods: </strong>Fifteen children with ASD aged between 7 to 16 years were evaluated using the childhood autism rating scale (CARS), schedule for affective disorders and schizophrenia for school-age children-present and lifetime version, social responsiveness scale, Wechsler intelligence scale for children-revised form, and standard blood tests. The electrical brain response was measured while they were doing a facial emotion recognition task (FERT). After 3 months of treatment, they were assessed again regarding core symptoms and ERPs.</p><p><strong>Results: </strong>The behavioral problems of the participants decreased significantly based on CARS. With regard to behavioral performance on FERT, the accuracy of detecting emotions increased, and reaction time decreased significantly. The amplitude of N170, EPN, and N250 increased, and latency for N170 and N250 decreased significantly in some electrodes. There were no serious side effects.</p><p><strong>Conclusion: </strong>In this study, bumetanide improved behavioral symptoms and recognition of facial emotions. Also, brain function was improved based on the ERP components. So, bumetanide can be used safely in children and adolescents with ASD to improve the main symptoms of the disorder.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 1","pages":"65-80"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12248174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eye Movements During Sentence Processing in High-functioning Autistic Children Compared to Neurotypical Peers: An Eye Tracking Study.","authors":"Faezeh Dehghan, Mehdi Alizadeh Zarei, Reza Khosro Abadi, Hashem Farhangdost, Amir Ali Soltani Tehrani, Mohamad Taghi Joghataei","doi":"10.32598/bcn.2023.5678.1","DOIUrl":"10.32598/bcn.2023.5678.1","url":null,"abstract":"<p><strong>Introduction: </strong>Autism spectrum disorder (ASD) is a neurodevelopmental disorder. The pattern of eye movements during reading can significantly impact reading quality. This study aimed to examine the eye movement patterns, which are essential for reading, in children with ASD compared to their neurotypical peers.</p><p><strong>Methods: </strong>This study focused on two crucial indicators influencing reading: Eye fixation time and saccade movement. A comparison of parameters of saccade movements and eye fixation in a sentence reading task was done between two groups using an eye tracker device. Autistic children (15 children, mean age: 102.33 months) and their neurotypical peers (17 children, mean age: 101.69 months) participated in this study.</p><p><strong>Results: </strong>Compared to their neurotypical peers, children with ASD had lower amplitude while reading sentences (P=0.02). These children used more fixations to read the words in the sentence (P=0.02). Comparing the total time spent reading a sentence between the two groups shows that autistic children need more time to read a sentence (P=0.02).</p><p><strong>Conclusion: </strong>These results suggest that low-level sensorimotor processes in generating accurate eye movements, such as the dorsal visual pathway and cerebellum, can significantly impact the reading quality of children with ASD.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 Spec","pages":"273-282"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}