Basic and Clinical Neuroscience最新文献

{"title":"L-α-aminoadipic Acid-induced Astrocytes Inhibition in the Hippocampal CA1 Region, Anxiety-like Behavior, and Memory Impairment.","authors":"Mehrdad Jahanshahi, Leila Elyasi, Emsehgol Nikmahzar","doi":"10.32598/bcn.2024.93.6","DOIUrl":"10.32598/bcn.2024.93.6","url":null,"abstract":"<p><strong>Introduction: </strong>Glutamate plays a significant role in synaptic plasticity, which is important for learning and memory. Astrocytes are an important part of glial cells or neuroglia. They are involved in neuroinflammation and are key in maintaining glutamine/glutamate homeostasis. As astrocytes provide vital support to neurons in pathological conditions, we aimed to evaluate the effect of hippocampal astrocyte ablation induced by microinjection of L-α-aminoadipic acid (L-α-AAA) in this study. We intend to assess memory, anxiety, and the density of glial fibrillary acidic protein-immunoreactive (GFAP-ir) astrocytes in the hippocampus.</p><p><strong>Methods: </strong>A total of 21 adult male Wistar rats were randomly assigned to control, vehicle, and experimental groups. L-α-AAA was injected into their hippocampal CA1 subfield for 3 days. Then, their memory was evaluated by an inhibitory passive avoidance test, and anxiety-related behavior using an elevated plus maze apparatus. Hippocampal sections were immunostained for GFAP, and the density of GFAP-ir astrocytes was evaluated.</p><p><strong>Results: </strong>Microinjection of L-α-AAA into the CA1 subfield of the hippocampus significantly decreased the step-through latency time in the passive avoidance test, decreased time spent in the open arm, and increased time spent in the closed arm in the elevated plus maze test. Also, the administration of L-α-AAA significantly declined the density of GFAP-ir astrocytes in the hippocampus.</p><p><strong>Conclusion: </strong>Inhibition of astrocytes impaired memory and increased anxiety-like behavior in male rats. Hence, the current study confirmed hippocampal astrocytes' key role in memory and anxiety-like behavior, which can be considered in future therapeutic strategies.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 1","pages":"19-30"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12248182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Emotionally Focused Therapy vs Transcranial Direct Current Stimulation on Anxiety, Life Quality in CAD Patients During COVID-19.","authors":"Shahnaz Gili, Sarieh Ebrahimiasl","doi":"10.32598/bcn.2023.5003.1","DOIUrl":"10.32598/bcn.2023.5003.1","url":null,"abstract":"<p><strong>Introduction: </strong>The COVID-19 pandemic has increased psychological distress and impacted the diagnosis and treatment of noncommunicable diseases. This study aimed to examine the comparative effectiveness of emotionally focused therapy (EFT) and transcranial direct current stimulation (tDCS) on the anxiety and quality of life (QoL) in patients with coronary artery disease (CAD) during the COVID-19 pandemic.</p><p><strong>Methods: </strong>A total of 45 participants who met the criteria for a current episode of CAD, referred to Shahid-Rajaee Heart Hospital in Tehran City, Iran, were chosen by convenience sampling method. They were randomly assigned to a 9-week/60-minute EFT (n=15) group therapy, a 5-week/20-minute tDCS (n=15) experimental group, and one control group (n=15). They were assessed at pre-test, post-test, and 3-month follow-up. The study subjects completed the self-reported reliable and valid Persian version of questionnaires, Beck anxiety inventory (BAI), and health-related quality of life (HRQOL). Then, repeated measures analysis of variance was used to measure inferential statistics.</p><p><strong>Results: </strong>There were significant improvements in anxiety and QoL scores in both EFT and tDCS groups over the post-test and follow-up period (P≤0.01). However, a difference was found when EFT had a greater effect on the anxiety and QoL.</p><p><strong>Conclusion: </strong>These results showed that EFT and tDCS have effective interventions in reducing anxiety and improving the QoL of CAD patients, but improvements with EFT were greater than those with tDCS.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 Spec","pages":"265-272"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relational Impact of Emotional Stimuli on Putative Mirror Neuron Activity: A Transcranial Magnetic Stimulation Study.","authors":"Atefeh Zabihi, Mohammad-Ali Mazaheri, Reza Rostami, Mansoureh Sadat Sadeghi, Narjes Hosein-Zadehbahreini, Amir-Homayoun Hallajian, Vahid Nejati","doi":"10.32598/bcn.2023.1060.2","DOIUrl":"10.32598/bcn.2023.1060.2","url":null,"abstract":"<p><strong>Introduction: </strong>Mirror neurons' function is thought to be enhanced by emotion processing. There is some evidence that the valence of an emotional presentation (positive or negative) can influence subsequent mirror neuron activity differently. Additionally, mirror neurons are claimed to provide the mechanism necessary for the embodied simulation of others' mental states. Therefore, there is an assumption that relational emotion processing may manipulate mirror neuron functions.</p><p><strong>Methods: </strong>Via transcranial magnetic stimulation (TMS) of the primary motor cortex (PMC) and electromyography recording from contralateral hand muscles, 20 participants viewed videos of either a static hand or a transitive hand action preceded by either neutral or general (negative and positive) and relational (negative and positive) images.</p><p><strong>Results: </strong>Corticospinal excitability facilitation during action observation was significantly greater following the positive general than negative general emotion stimuli. Regarding relational emotions, we observed an increased mirror neuron system (MNS) activity following relational negative compared to relational positive, relational negative compared to general negative, and general positive compared to relational positive stimuli.</p><p><strong>Conclusion: </strong>This finding supports the assumption that relational content interferes with mentalizing capacity.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 Spec","pages":"193-204"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural Balance of Resting-state Brain Network in Attention Deficit Hyperactivity Disorder.","authors":"Ruzbeh Fakhari, Alireza Moradi, Reza Ebrahimpour, Reza Khosrowabadi","doi":"10.32598/bcn.2024.276.3","DOIUrl":"10.32598/bcn.2024.276.3","url":null,"abstract":"<p><strong>Introduction: </strong>The study of brain functional networks in attention deficit hyperactivity disorder (ADHD) has provided useful information about the hyper- or hypo-connectivity between distinct brain regions. Nevertheless, the impact of negative links (antisynchrony) and their topology on the stability of the network still must be investigated.</p><p><strong>Methods: </strong>In this study, we hypothesized that the effect of dysconnectivity and antisynchrony should mainly be local and may not influence the overall stability and flexibility of the network in ADHD. Therefore, differences in brain functional organization of ADHD individuals were compared to a typically developed group using the structural balance theory.</p><p><strong>Results: </strong>Our results did not show any significant differences in the balance-energy of the resting-state network between healthy individuals and three subtypes of ADHD. However, a negative correlation was found between behavioral measures of ADHD and balance energy, highlighting that the higher disorder index may push the network to a less flexible (more balanced) state.</p><p><strong>Conclusion: </strong>We hope these findings enhance our understanding of the systemic mechanism behind ADHD.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 Spec","pages":"299-308"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Physical Activity on the Orexin and Brain-derived Neurotrophic Factor Expression on the Kindling Model of Epileptic Rats.","authors":"Taha Ghantabpour, Mansoureh Soleimani, Reza Ahadi, Fariba Karimzadeh, Alireza Moradi","doi":"10.32598/bcn.2023.5909.1","DOIUrl":"10.32598/bcn.2023.5909.1","url":null,"abstract":"<p><strong>Introduction: </strong>Epilepsy is characterized by recurrent seizures associated with cognitive, mental, and social issues. Exercise has been well known as a non-pharmacological or complementary remedy that reduces the effective dose and side effects of pharmacological therapies. Orexin signaling pathway and brain-derived neurotrophic factor (BDNF) have an essential role in the pathogenesis of epilepsy. In this study, we investigated the effect of exercise on the modulation of the orexin-A (OXA) and BDNF signaling pathways in epileptic rats.</p><p><strong>Methods: </strong>Male Wistar rats were divided into 5 groups: Normal saline (NS), seizure, physical activity (PA), PA + pentylenetetrazol (PTZ), and PA-PTZ. Assessment of seizure behaviors was done 30 min after each PTZ injection in the seizure, PA+PTZ, and PA-PTZ groups. Seizure behavior score (SBS) was monitored in seizure, PA+PTZ, and PA-PTZ. The expression of the OXA and BDNF in the CA1, CA3, and cortex was assayed by immunohistochemistry staining. The correlations between the OXA and BDNF were evaluated in the study groups.</p><p><strong>Results: </strong>SBC was reduced in the epileptic rats that had exercised. Seizure and PA increased the OXA expression in the seizure and PA groups. Compared to the seizure group, the OXA expression decreased in the CA1 and CA3 of the PA+PTZ, PA-PTZ, and cortex of the PA+PTZ group. OXA was up-expressed in the PA-PTZ group compared to the PA+PTZ group. Seizure decreased the BDNF expression in the seizure group compared to the NS group. PA elevated the BDNF expression in the CA1, CA3, and cortex of the PA group. BDNF was up-expressed in the cortex of the PA+PTZ and the CA1, CA3, and cortex of PA-PTZ. BDNF expression increased in the CA1 and CA3 of the PA-PTZ compared to the PA+PTZ group. There was a significant correlation between the OXA and BDNF expression in the CA1, CA3, and cortex of the NS and seizure groups and the CA1 and cortex of the PA group.</p><p><strong>Conclusion: </strong>Our results indicate that PA had an amelioration effect on the severity of the seizure. Our findings suggest that the effect of PA on seizure might not arise from the interaction of the OXA and BDNF expression in epileptic rats.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 1","pages":"115-130"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12248180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Serotonin 5HT-1B Receptor Expression Regulate Sex-dependent Difference for Stress and Anxiety.","authors":"Sarfraj Ahmad Siddiqui, Sanjay Singh, Mohammad Kaleem Ahmad, Md Arshad","doi":"10.32598/bcn.2024.4222.1","DOIUrl":"10.32598/bcn.2024.4222.1","url":null,"abstract":"<p><strong>Introduction: </strong>Stress disorders have multidimensional effects. How we respond to these situations is different, depending on our individual differences and gender. Reports suggest that females are more susceptible to stress disorders compared to males in the same age group. The serotonin receptor system is an important mechanism involved in the regulation of stress and anxiety in males and females.</p><p><strong>Methods: </strong>The current study incorporates a rodent model to study the sex-dependent role of serotonin receptors under chronic restrained stress conditions. A chronic restrained stress protocol was used to find the stress difference between male and female Sprague-Dawley (SD) rats. The molecular identification was done using quantitative real-time PCR and immunohistochemistry for serotonin 5HT-1B receptor in rat brains.</p><p><strong>Results: </strong>Interestingly, the 5HT-1B receptor, one of the most important serotonin receptors, exhibits a sex-dependent difference in stress response in male and female rats. Most importantly, the trio partners (amygdala, hippocampus, and prefrontal cortex) exhibit a region-specific sex dependent difference in 5HT-1B receptor expression, which was correlated with the difference in the level of stress response. This biased serotonin 5HT-1B receptor function might be why females face more stress than males.</p><p><strong>Conclusion: </strong>Overall, the results exhibit a sex-dependent difference for stress conditions in male and female rats, which was correlated with the spatial expression of the serotonin 5HT-1B receptor in the brain.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 1","pages":"81-94"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12248184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Anticholinergic Medications on the Risk of Dementia: A Systematic Review and Meta-analysis Protocol.","authors":"Elham Maraghi, Ali Reza Safarpour, Maryam Hajmohammadi, Ali Akbar Oroojan, Amal Saki Malehi, Hadis Ashrafizadeh","doi":"10.32598/bcn.2022.3823.1","DOIUrl":"10.32598/bcn.2022.3823.1","url":null,"abstract":"<p><strong>Introduction: </strong>The most frequent dementia is senile dementia or Alzheimer disease. Meanwhile, anticholinergic drugs can potentially modify the risk factors. As different studies have achieved dissimilar results and the clinical findings of these interventions have not been conclusive, the objective of this research will be to evaluate the effect of anticholinergic drugs on the risk of dementia.</p><p><strong>Methods: </strong>This systematic review and meta-analysis with no language limitation will search WoS, EMBASE, and MEDLINE via PubMed, Scopus, ProQuest electronic databases, and Grey Literature between December 15, 1988, and December 15, 2021. Our search strategy with suitability criteria covers cohort, case-control, nested case-control, randomized, and non-randomized clinical trial studies evaluating the effect of anticholinergic drugs on the risk of dementia. Two authors will independently implement the selection phase, data extraction, and quality assessment. The reviewers will evaluate the risk of bias using the Newcastle-Ottawa, Cochrane risk of bias tool and ROBINS-I (risk of bias in non-randomized studies - of interventions) quality assessment scale. We will conduct a meta-analysis with a random or fixed effect model according to the severity of methodological heterogeneity. The results will be presented via the forest plot for the final studies' data composition, demonstrating the separated and combined frequency and their corresponding 95% CIs, summary tables, and narrative summaries.</p><p><strong>Conclusion: </strong>The results of different studies in this field are various. This study's findings and other studies will help physicians and other health professionals before prescribing these drugs. Older people, especially those with polypharmacy, should be carefully assessed for the risk of dementia, Alzheimer or a variety of cognitive disorders.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 1","pages":"55-64"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12248178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statistical Method for Identification of Alzheimer Disease With Multimodal Predictive Markers Mild Cognitive Impairment.","authors":"Soheil Zarei, Reza Shalbaf, Ahmad Shalbaf","doi":"10.32598/bcn.2024.2034.7","DOIUrl":"10.32598/bcn.2024.2034.7","url":null,"abstract":"<p><strong>Introduction: </strong>Predicting the progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD) is crucial for early intervention. Identifying reliable predictive markers can enhance diagnostic accuracy and improve clinical decision-making. This study aimed to explore multimodal predictive markers to distinguish stable MCI (sMCI) from progressive MCI (pMCI) to AD using statistical analysis.</p><p><strong>Methods: </strong>We analyzed data from the Alzheimer's disease neuroimaging initiative (ADNI), categorizing 487 individuals as sMCI and 348 as pMCI. The study incorporated multiple assessment modalities, including demographics, positron emission tomography (PET), genotyping, magnetic resonance imaging (MRI), and neurocognitive tests. A rigorous data preprocessing approach was applied, including cleaning and feature selection. The area under the curve (AUC) and the Wilcoxon test were used to evaluate the discriminative power of predictive markers.</p><p><strong>Results: </strong>Our findings showed the strong predictive potential of PET, particularly florbetaben (FBB), which achieved an AUC of 0.84. Neurocognitive tests, including the Alzheimer's disease assessment scale (ADAS13), ADNI-modified preclinical Alzheimer cognitive composite (mPACCtrailsB and mPACCdigit), logical memory delayed recall total (LDELTOTAL), and ADAS cognitive subscale question 4 (ADASQ4), also demonstrated high discriminatory power with AUC values ranging from 0.82 to 0.83. These results indicated that a combination of neuroimaging and cognitive assessments can significantly differentiate between sMCI and pMCI.</p><p><strong>Conclusion: </strong>The results emphasize the importance of multimodal assessments, particularly PET imaging and neurocognitive tests, in distinguishing sMCI from pMCI. These findings contribute to early AD diagnosis strategies and personalized intervention planning..</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 Spec","pages":"233-250"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amygdala Network Dynamics During Drug Cue Processing in Methamphetamine Use Disorder.","authors":"Peyman Ghobadi-Azbari, Hossein Moslemi, Mitra Yousefpour, Yasaman Hosseini","doi":"10.32598/bcn.2023.5833.1","DOIUrl":"10.32598/bcn.2023.5833.1","url":null,"abstract":"<p><strong>Introduction: </strong>Methamphetamine use disorder (MUD) has substantial societal and individual implications, necessitating a comprehensive understanding of its neural underpinnings for effective intervention. Key to addiction is the amygdala, implicated in emotion processing and reward systems, which interacts with the prefrontal cortex in addictive behaviors.</p><p><strong>Methods: </strong>We conducted a study involving 54 male individuals with MUD (age range: 22-44 years) to examine amygdala-cortical connectivity during methamphetamine cue reactivity, aiming to uncover effective neural pathways. We combined generalized psychophysiological interaction (gPPI) analysis and dynamic causal modeling (DCM) to elucidate connectivity dynamics and effective neural pathways. We delved deeper into neuro-behavioral connections using the Pearson correlation and group factor analysis (GFA).</p><p><strong>Results: </strong>Our findings revealed increased functional connectivity within the amygdala-posterior cingulate cortex (PCC) and amygdala-dorsolateral prefrontal cortex (dlPFC) networks during methamphetamine cue reactivity. DCM revealed a neural network characterized by positive bidirectional connections among the amygdala, dlPFC, and PCC, along with negative intrinsic connections. Interestingly, we observed that the intrinsic self-inhibition of the dlPFC was negatively correlated with post-task positive affect, suggesting its role in emotional regulation. Nonetheless, utilizing GFA, we did not discover any noteworthy cross-unit latent factors between the neural group and variables related to behavior, psychology, or demographics.</p><p><strong>Conclusion: </strong>These discoveries enrich our comprehension of the neural mechanisms at play in methamphetamine cue reactivity and addiction-related processes. The increased amygdala-cortical connectivity underscores the role of these networks in drug cue processing, potentially contributing to craving and relapse. Effective connectivity analysis highlights the interconnectedness of the amygdala, dlPFC, and PCC, revealing potential pathways for neural signaling during cue reactivity. Our results contribute to the growing body of knowledge about addiction's neurobiological basis, offering insights that may inform targeted interventions to mitigate the impact of methamphetamine cue reactivity on addiction progression.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 Spec","pages":"283-298"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric Analysis of Craving in Drug and Behavioral Addiction During the Last Decade.","authors":"Roghayeh Najafi-Dehjalali, Mohsen Dadashi, Peyman Hassani Abharian, Hojjatullah Farahani, Ali Reza Faridi","doi":"10.32598/bcn.2023.194.6","DOIUrl":"10.32598/bcn.2023.194.6","url":null,"abstract":"<p><strong>Introduction: </strong>According to the review studies, the growing knowledge of craving and the relevant causal factors that have led to the accumulation of solid theoretical frameworks over the past few years make it necessary to carry out a bibliometric review of this literature.</p><p><strong>Methods: </strong>In this study, by examining the papers published during the last decade in the Scopus database, the largest citation database functional in mapping and content analysis of citation data, the researchers tried to clarify the research direction in the coming years.</p><p><strong>Results: </strong>In craving research, multi-authored articles, such as Boswell's (2016) study, garnered the highest number of citations. Boswell (2016) and Wolff (2016) have emerged as prominent figures in this field. Li X and the journal of addictive behaviors are leading producers of research in the craving domain. The highest volume of scientific output originates from the Department of Psychiatry, Yale University School of Medicine, with significant contributions from the United States, China, Germany, Italy, and England. The term \"craving\" exhibits the highest frequency of use. The co-authorship network illustrates that the most significant collaborations occur between the United States and other countries, where the majority of scientific output in this field is concentrated.</p><p><strong>Conclusion: </strong>This analysis leads to the conclusion that studies about cravings occupy a prominent position in global etiological research and therapeutic interventions for addictive disorders. The enduring popularity of authors and publications addressing these disorders remains noteworthy.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 Spec","pages":"159-178"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}