Basic and Clinical Neuroscience最新文献_第10页

Evaluation of Anxiolytic Effects of Justicia secunda Methanol Leaf Extract and Its Chemical Constituents in Mice. 苦参甲醇叶提取物及其化学成分对小鼠抗焦虑作用的评价。

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Basic and Clinical Neuroscience Pub Date : 2024-09-01 DOI: 10.32598/bcn.2024.6335.1

Ileri Oluwa Emmanuel, Babatunde Alabi, Olasubomi Sotunde, Segun Olowoparija, Michael Obaro, Ayotunde Badejo, Olufunmilayo Ologe, Abayomi Ajayi, Ifeoluwa Oguntoye, Opeyemi Hammed, Olugbenga Iwalewa

{"title":"Evaluation of Anxiolytic Effects of Justicia secunda Methanol Leaf Extract and Its Chemical Constituents in Mice.","authors":"Ileri Oluwa Emmanuel, Babatunde Alabi, Olasubomi Sotunde, Segun Olowoparija, Michael Obaro, Ayotunde Badejo, Olufunmilayo Ologe, Abayomi Ajayi, Ifeoluwa Oguntoye, Opeyemi Hammed, Olugbenga Iwalewa","doi":"10.32598/bcn.2024.6335.1","DOIUrl":"10.32598/bcn.2024.6335.1","url":null,"abstract":"Introduction: The use of benzodiazepines and selective serotonin reuptake inhibitors to treat depression has severe adverse effects. This study aims to evaluate the effects of the methanolic leaf extract of Justicia secunda (MLEJS) on anxiety and depression in mice.Methods: In this study, animals were male Swiss mice weighing 20-25 g. Gas chromatography-mass spectroscopy (GC-MS) phytochemical analysis of MLEJS was performed to verify the different bioactive components. An acute oral toxicity study was performed based on the Organization for Economic Co-operation and Development (OECD) guideline, No.423. We investigated the antidepressant and anxiolytic effect of MLEJS (12.5, 25, and 50 mg/kg) using lipopolysaccharide (LPS)-induced depression and flumazenil/benzodiazepine interaction in GABA (gamma-amino-butyric acid) receptors. The open field test, forced swimming test, and tail suspension test were performed to evaluate the depressive-like behavior in mice. Also, hole-board, light/dark box, elevated plus maze, thiopental sodium, and rotarod motor coordination tests were used as a screening paradigm for the anxiolytic effect of MLEJS.Results: The MLEJS had an anxiolytic-like effect by increasing the exploration of the open arms and reducing the exploration of the closed arms in the elevated plus maze, light/dark box, and hole-board test. Moreover, LPS-induced depressive-like behavior in mice was reversed by the MLEJS (P<0.05). The significant attenuation of proinflammatory mediators and suppression of oxidative and nitrosative stress could be responsible for the observed effects (P<0.05).Conclusion: The MLEJS can be an efficient therapeutic option against anxiety and depression concomitantly.","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"15 5","pages":"683-702"},"PeriodicalIF":1.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of ABCB1, μ-opioid Receptor, and Cytochrome P450 Genes with Methadone Dose in Iranian Male Addicts Under Methadone Therapy. 美沙酮治疗伊朗男性依赖者ABCB1、μ-阿片受体和细胞色素P450基因与美沙酮剂量的关系

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Basic and Clinical Neuroscience Pub Date : 2024-09-01 DOI: 10.32598/bcn.2023.2756.2

Abdollah Golnezhad, Anahita Torkaman-Boutorabi, Emran Mohammad Razaghi, Mohammad Reza Zarrindast, Mohammad Reza Mahdavi, Nasim Vousooghi

{"title":"Association of ABCB1, μ-opioid Receptor, and Cytochrome P450 Genes with Methadone Dose in Iranian Male Addicts Under Methadone Therapy.","authors":"Abdollah Golnezhad, Anahita Torkaman-Boutorabi, Emran Mohammad Razaghi, Mohammad Reza Zarrindast, Mohammad Reza Mahdavi, Nasim Vousooghi","doi":"10.32598/bcn.2023.2756.2","DOIUrl":"10.32598/bcn.2023.2756.2","url":null,"abstract":"Introduction: Treatment of opioid use disorders (OUDs) via safe and effective approaches has been investigated for years. Methadone maintenance treatment (MMT) has been considered an effective therapy for opioid addiction. It has been observed that patients with genetic polymorphisms often show variability in the optimal drug dose requirement and treatment schedule. This study aimed to investigate the relationship between single nucleotide polymorphisms (SNPs) in the ATP-binding cassette subfamily B member-1 (ABCB1), the mu-opioid receptor (OPRM1), and cytochrome P450 (CYP) genes and methadone dose in patients undergoing MMT in Mazandaran Province, Iran.Methods: In a cross-sectional study, 216 male MMT patients (20 to 45 years old) who were involved in the treatment program for at least three months were randomly recruited from six MMT clinics in Mazandaran province between 2018 and 2020. Blood samples were taken, DNA was extracted, and SNPs of CYP2B6 (G516T, A785G), CYP2C19 (-3402C>T), CYP3A4 (-392A>G), OPRM (A118G), and ABCB1 (C3435T, G2677T, G2677A, and C1236T) genes were evaluated using polymerase chain reaction-restriction fragment length polymorphism (RFLP).Results: Our results showed no significant relationship between all the studied genotypes and methadone dose requirements.Conclusion: The present study, for the first time in the Mazandaran population, reported no significant correlations between methadone dose requirement and different SNPs in the ABCB1, OPRM1, and CYP genes in MMT patients, which is consistent with other studies conducted on the Iranian population.","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"15 5","pages":"703-712"},"PeriodicalIF":1.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural Changes in Pharyngeal and Tongue Muscles as a Potential Contributor to Dysphagia in Alzheimer Disease Rat Model. 咽部和舌部肌肉的结构变化是阿尔茨海默病大鼠模型中吞咽困难的潜在因素。

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Basic and Clinical Neuroscience Pub Date : 2024-09-01 DOI: 10.32598/bcn.2023.5719.1

Ramy Abdelnaby, Yasmine H Ahmed, Dalia Zaafar, Mohamed Y Mahmoud, Eman Mohammed Elsaeed, Alexa Häger, Heba M A Khalil

{"title":"Structural Changes in Pharyngeal and Tongue Muscles as a Potential Contributor to Dysphagia in Alzheimer Disease Rat Model.","authors":"Ramy Abdelnaby, Yasmine H Ahmed, Dalia Zaafar, Mohamed Y Mahmoud, Eman Mohammed Elsaeed, Alexa Häger, Heba M A Khalil","doi":"10.32598/bcn.2023.5719.1","DOIUrl":"10.32598/bcn.2023.5719.1","url":null,"abstract":"Introduction: Alzheimer disease (AD) is a progressive neurodegenerative disease that accounts for 60% of dementia cases worldwide. Despite the lack of concrete information about the prevalence of dysphagia among AD patients, it still significantly impairs their quality of life (QoL). That outcome necessitates more investigations to understand the pathophysiology of this condition and how to manage it. In this study, we examined if AD-associated changes in pharyngeal and tongue muscles could explain dysphagia.Methods: Fourteen adult male rats were allocated into 2 groups: Group I (control) received distilled water orally, group II (AD) received aluminum chloride (AlCl3) (200 mg/kg, per os) and D-galactose (60 mg/kg, subcutaneous) daily for 45 days. Biochemical parameters were conducted, including amyloid beta-peptide (Aβ), histopathological investigation of the hippocampus, tongue, and pharynx, and immune-histochemical expression of brain glial fibrillar acidic protein (GFAP).Results: Our AD model showed marked cognitive impairment, hippocampal oxidative stress, and increased brain Aβ expression (P=0.0003) compared to controls. Dysphagia was confirmed by loss of body weight (P=0.0077) and decreased eating and drinking patterns by 25%-35% in AD versus the control group. Histopathological, immune-histochemical, and biochemical evidence, including increased levels of pharyngeal Aβ (P=0.0017), were detected in AD rats' tongue and pharyngeal muscles.Conclusion: Dysphagia in AD can result not only centrally but also due to local involvement of the tongue and pharynx. Further translational studies linking dysphagia to AD pathology will be needed.","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"15 5","pages":"671-682"},"PeriodicalIF":1.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Optimal Time for Postoperative Magnetic Resonance Imaging of the Sella in Patients With Pituitary Adenoma. 垂体腺瘤患者术后鞍区磁共振成像的最佳时机。

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Basic and Clinical Neuroscience Pub Date : 2024-09-01 DOI: 10.32598/bcn.2023.5005.1

Mohammad Ghorbani, Ehsan Keykhosravi, Mohammad Hasanpour, Ali Abbasian Ardakani, Ehsan Mohammad Hosseini

{"title":"The Optimal Time for Postoperative Magnetic Resonance Imaging of the Sella in Patients With Pituitary Adenoma.","authors":"Mohammad Ghorbani, Ehsan Keykhosravi, Mohammad Hasanpour, Ali Abbasian Ardakani, Ehsan Mohammad Hosseini","doi":"10.32598/bcn.2023.5005.1","DOIUrl":"10.32598/bcn.2023.5005.1","url":null,"abstract":"Introduction: Magnetic resonance imaging (MRI) is the preferred neuroradiologic tool for evaluating the sellar region. Pituitary adenomas account for about 15% of primary intracranial tumors. The optimal time for postoperative MRI of central nervous system neoplasms is 48 hours after surgery. Nevertheless, controversy exists regarding the timing of postoperative MRI in the sellar region. This study analyzed the sellar MRI findings of patients with pituitary adenoma at different times before and after surgery. Finally, we suggest the optimal time for postoperative sellar MRI imaging in patients with pituitary adenoma.Methods: A total of 28 patients with pituitary adenoma were evaluated. All patients did four sellar MRIs. The first MRI was done before surgery, and three were done 48 hours, two weeks, and three months after the surgery. Finally, the MRI findings at different times were compared to each other.Results: The pituitary gland and adenoma signals were constant at all time points. The signal of the packing material showed no differences in T1-weighted and T1-weighted with contrast sequences but showed changes in T2-weighted sequences.Conclusion: Contrary to other intracranial neoplasms, there were no apparent changes in MRI signal intensity during the 3 months after surgery in patients with pituitary adenoma. There was also no superiority of one time point for performing follow-up imaging.","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"15 5","pages":"649-658"},"PeriodicalIF":1.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adrenomedullin and Protecting Spinal Motor Neurons Against Doxorubicin-induced Toxicity. 肾上腺髓质素和保护脊髓运动神经元免受阿霉素诱导的毒性。

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Basic and Clinical Neuroscience Pub Date : 2024-09-01 DOI: 10.32598/bcn.2022.3650.1

Mohammad Ali Takhshid, Amir Mahmoodazdeh, Sayed Mohammad Shafiee, Mohsen Sisakht, Zahra Khosdel

{"title":"Adrenomedullin and Protecting Spinal Motor Neurons Against Doxorubicin-induced Toxicity.","authors":"Mohammad Ali Takhshid, Amir Mahmoodazdeh, Sayed Mohammad Shafiee, Mohsen Sisakht, Zahra Khosdel","doi":"10.32598/bcn.2022.3650.1","DOIUrl":"10.32598/bcn.2022.3650.1","url":null,"abstract":"Introduction: In the present study, the culture of embryonic spinal motor neurons (SMNs) was used to assess the impacts of adrenomedullin (AM) on the neurotoxic effects of doxorubicin (DOX).Methods: To prepare the culture of rat embryonic SMNs, spinal cords were isolated from the rat embryos, digested enzymatically, and triturated to obtain spinal cell suspension. Then, the SMNs were purified from the cell suspension using a single OptiPrep gradient and cultured. The SMNs were treated with DOX (0.0-100 μM) and AM (3.125-100 nM), and their viability and apoptosis were evaluated using MTT and annexin V flow cytometric assays. Oxidative stress was assessed through the measurement of cellular reactive oxygen species (ROS), nitric oxide (NO), malondialdehyde (MDA), and 8-iso-prostaglandin F2α (iPF2α) levels. Finally, qPCR was employed to determine the expressions of interleukin1-β (IL-1β), inducible NO synthase (iNOS), tumor necrosis factor-α (TNF-α), SRY-related protein 9 (SOX9), matrix metalloproteinase (MMP)-3 and -13.Results: The viability of SMNs decreased following DOX treatment dose-dependently (IC50=10.54 μM). DOX increased the cellular ROS, MDA, NO, and iPF2α levels (P<0.001). Additionally, AM reduced DOX-induced cell death dose-dependently (P<0.001). AM (50 nM) pretreatment also reduced the DOX-induced oxidative stress (P<0.01) and gene expression (P<0.01).Conclusion: Based on the results, AM might be a protective factor against chemotherapy-induced toxicity in SMNs.","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"15 5","pages":"617-630"},"PeriodicalIF":1.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interference Control Under the Stroop Task and Brain Oscillatory Activity among Internet Addicts Compared to Non-addicts. 网瘾者与非网瘾者在Stroop任务下的干扰控制及脑振荡活动。

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Basic and Clinical Neuroscience Pub Date : 2024-09-01 DOI: 10.32598/bcn.2023.4974.1

Farzad Rostami, Ali Esteki, Atiye Sarabi-Jamab

{"title":"Interference Control Under the Stroop Task and Brain Oscillatory Activity among Internet Addicts Compared to Non-addicts.","authors":"Farzad Rostami, Ali Esteki, Atiye Sarabi-Jamab","doi":"10.32598/bcn.2023.4974.1","DOIUrl":"10.32598/bcn.2023.4974.1","url":null,"abstract":"Introduction: It is common for individuals with internet addiction disorder (IAD) to demonstrate impairments in interference and inhibitory control. A primary objective of this study was to explore how interference control is related to event-related spectral perturbations (ERSPs) and whether participants with IAD experience changes in these spectral dynamics.Methods: Twenty-one IAD participants and 20 healthy controls (HCs) were administered a Stroop task while their brains' electroencephalographic (EEG) activity was recorded. ERSPs were extracted from the EEG, and a cluster-based random permutation test was conducted to compare the power between the two groups at each time-frequency level.Results: In the IAD group, the Stroop effect was significantly less for theta than in the HC group in an earlier time window. According to these results, IADs could not successfully inhibit their brain activation for stimulus conflict detection. Furthermore, IAD participants displayed a significant ERSP Stroop effect at beta2 and gamma frequencies, with the main contribution coming from bilateral dorsal frontal and parietal cortex over the scalp compared to HC participants.Conclusion: In our study, IADs displayed reduced conflict detection and response selection compared to HCs, as measured by theta band indices, as well as impaired conflict resolution, as revealed by altered interaction dynamics between beta2 and gamma bands. Among the first studies investigating oscillatory dynamics in conflict resolution for IAD groups, this study uses cluster-based random permutation tests.","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"15 5","pages":"631-648"},"PeriodicalIF":1.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Percutaneous vs Transcutaneous Posterior Tibial Nerve Stimulation in Overactive Bladder Syndrome: A Randomized Clinical Trial. 经皮与经皮胫后神经刺激治疗膀胱过度活动综合征的疗效对比：随机临床试验。

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Basic and Clinical Neuroscience Pub Date : 2024-07-01 DOI: 10.32598/bcn.2023.4896.1

Tannaz Ahadi, Ismaeel Noori, Shayesteh Khalifeh Soltani, Pouya Ghaboosi, Gholam Reza Raissi

{"title":"Efficacy of Percutaneous vs Transcutaneous Posterior Tibial Nerve Stimulation in Overactive Bladder Syndrome: A Randomized Clinical Trial.","authors":"Tannaz Ahadi, Ismaeel Noori, Shayesteh Khalifeh Soltani, Pouya Ghaboosi, Gholam Reza Raissi","doi":"10.32598/bcn.2023.4896.1","DOIUrl":"10.32598/bcn.2023.4896.1","url":null,"abstract":"Introduction: Overactive bladder (OAB) is a symptom syndrome consisting of urgency, frequency, and nocturia. It is a common urologic disorder. Percutaneous posterior tibial nerve stimulation (PTNS) is a minimally invasive, well-tolerated, and effective treatment of OAB. Recently, transcutaneous PTN stimulation (TTNS) with surface electrodes has been used, which is non-invasive. This study examines and compares the efficacy of these two therapy methods.Methods: In this randomized clinical trial, 44 patients with OAB were randomly assigned to PTNS and TTNS groups. In both groups, the therapeutic interventions were performed thrice a week for four weeks, 12 sessions. Incontinence quality of life questionnaire (I-QOL) and OAB symptom score (OABSS) were evaluated before the intervention, then one week and four weeks after completing the sessions.Results: Of 44 patients (41 females and 3 males), the mean age of the subjects was 51.95 years in the PTNS group and 56.86 years in the TTNS group (P=0.9). In our study, the patients' urinary symptoms and QOL improved in both groups over time. Both interventions had no significant difference (P=0.796, P=0.372, respectively).Conclusion: PTNS and TTNS effectively improved patients' symptoms of OAB and their QOL. TTNS can be considered as effective as conventional PTNS and a less invasive alternative for PTNS in OAB treatment.","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"15 4","pages":"499-508"},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavioral and Biological Bases of Herding and Conformity. 从行为学和生物学角度看群居性和顺从性。

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Basic and Clinical Neuroscience Pub Date : 2024-07-01 DOI: 10.32598/bcn.2022.4654.1

Mostafa Deldoost

{"title":"Behavioral and Biological Bases of Herding and Conformity.","authors":"Mostafa Deldoost","doi":"10.32598/bcn.2022.4654.1","DOIUrl":"10.32598/bcn.2022.4654.1","url":null,"abstract":"Humans are inherently complex creatures, and this issue became even more complicated when they decided to construct social relationships. Research into human behavior is an interdisciplinary and multifaceted endeavor studied by various disciplines, such as psychology, economics, sociology, anthropology, and neurosciences. Today, with the cooperation of researchers in different fields, it is possible to link the cellular dynamic of neurons to brain function and human behavior. Cognitive science and neurosciences, along with other disciplines, can enrich our knowledge about mechanisms of social influence, which may assist policymakers in influencing public behaviors toward creating a better society. This review aims to describe previous research on social influence's behavioral, cognitive, and neural basis and provide more understanding of human behavior in society. I review and evaluate the relevant literature from multiple databases of peer-reviewed journals, books, and conferences and hand-searching reference lists of relevant studies that consider conformity from psychological, economic, neurobiological, and neurochemical aspects. This paper has been divided into four parts. First, I start by defining and describing two kinds of social influences. The second section focuses on psychological and economic evidence of social influence. It will then explore the neurobiological and neurochemical approaches to studying social influence. Finally, the conclusion summarizes and highlights three points I believe social neuroscience as an interdisciplinary and vibrant field should consider for future developments.","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"15 4","pages":"433-442"},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The PCSK9 Protein Is Not Necessarily a Risk Factor for Major Depressive Disorder. PCSK9蛋白并不一定是重度抑郁症的风险因素。

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Basic and Clinical Neuroscience Pub Date : 2024-07-01 DOI: 10.32598/bcn.2022.4044.1

Elahe Habibitabar, Shima Khanverdiloo, Mona Doostizadeh, Leila Jahangard, Jamshid Karimi, Gholamreza Shafiee

{"title":"The PCSK9 Protein Is Not Necessarily a Risk Factor for Major Depressive Disorder.","authors":"Elahe Habibitabar, Shima Khanverdiloo, Mona Doostizadeh, Leila Jahangard, Jamshid Karimi, Gholamreza Shafiee","doi":"10.32598/bcn.2022.4044.1","DOIUrl":"10.32598/bcn.2022.4044.1","url":null,"abstract":"Introduction: Major depressive disorder (MDD) is one of the common psychiatric disorders that is characterized by abnormal neurobiological responses. Proprotein convertase subtilisin/kexin 9 (PCSK9) is important in cholesterol homeostasis.Methods: This study aimed to investigate PCSK9 levels and oxidative stress with MDD disease. The study included 30 patients with MDD and 30 healthy controls. Their blood samples were collected in sterile tubes, and the serum PCSK9 concentration, superoxide dismutase (SOD), and glutathione peroxidase (GPx) activity were determined by ELISA kits. Total antioxidant capacity (TAC), total oxidant status (TOS), malondialdehyde (MDA), and copper concentration were determined manually. There was a significant increase in PCSK9 levels in the patient group (P<0.05).Results: The receiver operating characteristic (ROC) curve with a sensitivity of 57% and specificity of 52% was 0.928 (95% CI, 0.86-0.996) for PCSK9 in the patient group (P<0.001). It was found that MDA (P=0.036) level was higher in the MDD group, but TAC (P=0.445) level, SOD (P=0.148), GPx (P=0.019) activities, and copper concentration were lower in the patient group compared with the control group.Conclusion: The study results confirm the relationship between oxidative stress and MDD and also suggest a link between PCSK9 and MDD disease.","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"15 4","pages":"519-530"},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142650566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Custom-made Implants for Chronic In Vivo Electrophysiological Recording From Primate's Brain Based on the Reconstructed Skull Model. 基于重建颅骨模型的定制植入体，用于灵长类动物大脑的慢性体内电生理记录。

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Basic and Clinical Neuroscience Pub Date : 2024-07-01 DOI: 10.32598/bcn.2021.600.2

Ehsan Rezayat, Farzad Shayanfar, Mostafa HajiNasrollah, Farideh Shakrian, Mohammad-Reza A Dehaqani

{"title":"Custom-made Implants for Chronic In Vivo Electrophysiological Recording From Primate's Brain Based on the Reconstructed Skull Model.","authors":"Ehsan Rezayat, Farzad Shayanfar, Mostafa HajiNasrollah, Farideh Shakrian, Mohammad-Reza A Dehaqani","doi":"10.32598/bcn.2021.600.2","DOIUrl":"10.32598/bcn.2021.600.2","url":null,"abstract":"Introduction: In vivo neural recordings from primates require the installation of implants on the skull of the animal. Despite some improvements, current routines risk predisposition to infection and failure or impose constant discomfort by placing heaviness on the top of the head.Methods: A custom-designed imaging adapter was obtained by magnetic resonance and computerized tomography (CT) imaging of the head region. Then, based on a reconstructed skull model, the implants were designed and constructed using a computer numerical control (CNC) machine. During the surgical operation, the position of each implant was sketched on the skull, and implants were slipped onto their predicted site, following their sketched boundaries without any manual reshaping.Results: We have performed this procedure on two monkeys. After surgery, the location of the implants has been verified by CT imaging. The recovery period was without significant complications with minimal infection.Conclusion: Our experiment showed that applying an image-guided design makes it possible to utilize the skull area better and gain access to brain regions. At the same time, our method reduced the possibility of gap formation between the implant and skull open skin margins. It reduces the time and cost of operation, resulting in a reduced chance of infection and failure, and provides animal-friendly operational surgery procedures. Despite some improvements, more refinements of methodology are still required. Here, we propose and report an improvement in the design and installation of low-cost biocompatible implants providing access to at least three brain regions.","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"1 1","pages":"455-462"},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69705510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0