Basic and Clinical Neuroscience最新文献

{"title":"Effect of Anticholinergic Medications on the Risk of Dementia: A Systematic Review and Meta-analysis Protocol.","authors":"Elham Maraghi, Ali Reza Safarpour, Maryam Hajmohammadi, Ali Akbar Oroojan, Amal Saki Malehi, Hadis Ashrafizadeh","doi":"10.32598/bcn.2022.3823.1","DOIUrl":"10.32598/bcn.2022.3823.1","url":null,"abstract":"<p><strong>Introduction: </strong>The most frequent dementia is senile dementia or Alzheimer disease. Meanwhile, anticholinergic drugs can potentially modify the risk factors. As different studies have achieved dissimilar results and the clinical findings of these interventions have not been conclusive, the objective of this research will be to evaluate the effect of anticholinergic drugs on the risk of dementia.</p><p><strong>Methods: </strong>This systematic review and meta-analysis with no language limitation will search WoS, EMBASE, and MEDLINE via PubMed, Scopus, ProQuest electronic databases, and Grey Literature between December 15, 1988, and December 15, 2021. Our search strategy with suitability criteria covers cohort, case-control, nested case-control, randomized, and non-randomized clinical trial studies evaluating the effect of anticholinergic drugs on the risk of dementia. Two authors will independently implement the selection phase, data extraction, and quality assessment. The reviewers will evaluate the risk of bias using the Newcastle-Ottawa, Cochrane risk of bias tool and ROBINS-I (risk of bias in non-randomized studies - of interventions) quality assessment scale. We will conduct a meta-analysis with a random or fixed effect model according to the severity of methodological heterogeneity. The results will be presented via the forest plot for the final studies' data composition, demonstrating the separated and combined frequency and their corresponding 95% CIs, summary tables, and narrative summaries.</p><p><strong>Conclusion: </strong>The results of different studies in this field are various. This study's findings and other studies will help physicians and other health professionals before prescribing these drugs. Older people, especially those with polypharmacy, should be carefully assessed for the risk of dementia, Alzheimer or a variety of cognitive disorders.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 1","pages":"55-64"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12248178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statistical Method for Identification of Alzheimer Disease With Multimodal Predictive Markers Mild Cognitive Impairment.","authors":"Soheil Zarei, Reza Shalbaf, Ahmad Shalbaf","doi":"10.32598/bcn.2024.2034.7","DOIUrl":"10.32598/bcn.2024.2034.7","url":null,"abstract":"<p><strong>Introduction: </strong>Predicting the progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD) is crucial for early intervention. Identifying reliable predictive markers can enhance diagnostic accuracy and improve clinical decision-making. This study aimed to explore multimodal predictive markers to distinguish stable MCI (sMCI) from progressive MCI (pMCI) to AD using statistical analysis.</p><p><strong>Methods: </strong>We analyzed data from the Alzheimer's disease neuroimaging initiative (ADNI), categorizing 487 individuals as sMCI and 348 as pMCI. The study incorporated multiple assessment modalities, including demographics, positron emission tomography (PET), genotyping, magnetic resonance imaging (MRI), and neurocognitive tests. A rigorous data preprocessing approach was applied, including cleaning and feature selection. The area under the curve (AUC) and the Wilcoxon test were used to evaluate the discriminative power of predictive markers.</p><p><strong>Results: </strong>Our findings showed the strong predictive potential of PET, particularly florbetaben (FBB), which achieved an AUC of 0.84. Neurocognitive tests, including the Alzheimer's disease assessment scale (ADAS13), ADNI-modified preclinical Alzheimer cognitive composite (mPACCtrailsB and mPACCdigit), logical memory delayed recall total (LDELTOTAL), and ADAS cognitive subscale question 4 (ADASQ4), also demonstrated high discriminatory power with AUC values ranging from 0.82 to 0.83. These results indicated that a combination of neuroimaging and cognitive assessments can significantly differentiate between sMCI and pMCI.</p><p><strong>Conclusion: </strong>The results emphasize the importance of multimodal assessments, particularly PET imaging and neurocognitive tests, in distinguishing sMCI from pMCI. These findings contribute to early AD diagnosis strategies and personalized intervention planning..</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 Spec","pages":"233-250"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amygdala Network Dynamics During Drug Cue Processing in Methamphetamine Use Disorder.","authors":"Peyman Ghobadi-Azbari, Hossein Moslemi, Mitra Yousefpour, Yasaman Hosseini","doi":"10.32598/bcn.2023.5833.1","DOIUrl":"10.32598/bcn.2023.5833.1","url":null,"abstract":"<p><strong>Introduction: </strong>Methamphetamine use disorder (MUD) has substantial societal and individual implications, necessitating a comprehensive understanding of its neural underpinnings for effective intervention. Key to addiction is the amygdala, implicated in emotion processing and reward systems, which interacts with the prefrontal cortex in addictive behaviors.</p><p><strong>Methods: </strong>We conducted a study involving 54 male individuals with MUD (age range: 22-44 years) to examine amygdala-cortical connectivity during methamphetamine cue reactivity, aiming to uncover effective neural pathways. We combined generalized psychophysiological interaction (gPPI) analysis and dynamic causal modeling (DCM) to elucidate connectivity dynamics and effective neural pathways. We delved deeper into neuro-behavioral connections using the Pearson correlation and group factor analysis (GFA).</p><p><strong>Results: </strong>Our findings revealed increased functional connectivity within the amygdala-posterior cingulate cortex (PCC) and amygdala-dorsolateral prefrontal cortex (dlPFC) networks during methamphetamine cue reactivity. DCM revealed a neural network characterized by positive bidirectional connections among the amygdala, dlPFC, and PCC, along with negative intrinsic connections. Interestingly, we observed that the intrinsic self-inhibition of the dlPFC was negatively correlated with post-task positive affect, suggesting its role in emotional regulation. Nonetheless, utilizing GFA, we did not discover any noteworthy cross-unit latent factors between the neural group and variables related to behavior, psychology, or demographics.</p><p><strong>Conclusion: </strong>These discoveries enrich our comprehension of the neural mechanisms at play in methamphetamine cue reactivity and addiction-related processes. The increased amygdala-cortical connectivity underscores the role of these networks in drug cue processing, potentially contributing to craving and relapse. Effective connectivity analysis highlights the interconnectedness of the amygdala, dlPFC, and PCC, revealing potential pathways for neural signaling during cue reactivity. Our results contribute to the growing body of knowledge about addiction's neurobiological basis, offering insights that may inform targeted interventions to mitigate the impact of methamphetamine cue reactivity on addiction progression.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 Spec","pages":"283-298"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric Analysis of Craving in Drug and Behavioral Addiction During the Last Decade.","authors":"Roghayeh Najafi-Dehjalali, Mohsen Dadashi, Peyman Hassani Abharian, Hojjatullah Farahani, Ali Reza Faridi","doi":"10.32598/bcn.2023.194.6","DOIUrl":"10.32598/bcn.2023.194.6","url":null,"abstract":"<p><strong>Introduction: </strong>According to the review studies, the growing knowledge of craving and the relevant causal factors that have led to the accumulation of solid theoretical frameworks over the past few years make it necessary to carry out a bibliometric review of this literature.</p><p><strong>Methods: </strong>In this study, by examining the papers published during the last decade in the Scopus database, the largest citation database functional in mapping and content analysis of citation data, the researchers tried to clarify the research direction in the coming years.</p><p><strong>Results: </strong>In craving research, multi-authored articles, such as Boswell's (2016) study, garnered the highest number of citations. Boswell (2016) and Wolff (2016) have emerged as prominent figures in this field. Li X and the journal of addictive behaviors are leading producers of research in the craving domain. The highest volume of scientific output originates from the Department of Psychiatry, Yale University School of Medicine, with significant contributions from the United States, China, Germany, Italy, and England. The term \"craving\" exhibits the highest frequency of use. The co-authorship network illustrates that the most significant collaborations occur between the United States and other countries, where the majority of scientific output in this field is concentrated.</p><p><strong>Conclusion: </strong>This analysis leads to the conclusion that studies about cravings occupy a prominent position in global etiological research and therapeutic interventions for addictive disorders. The enduring popularity of authors and publications addressing these disorders remains noteworthy.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 Spec","pages":"159-178"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Complexity of Information Processing During Motor Imagination in Adults Versus Children.","authors":"Jahangir Mobarezpour, Zahra Latifi, Reza Ghaderi","doi":"10.32598/bcn.2023.5705.1","DOIUrl":"10.32598/bcn.2023.5705.1","url":null,"abstract":"<p><strong>Introduction: </strong>Motor imagination is a dynamic mental state that simulates a similar brain mechanism to actual physical movement. This brain mechanism could be traced using Electroencephalography (EEG) recording during motor imagination. Nevertheless, it is still unclear how development changes this mechanism. As the brain mechanism of motor imagination must gain expertise during development to enable a subject to perform better motor actions, we hypothesized that the brain mechanism of imagination in adults must have a more complex pattern of information processing than in children.</p><p><strong>Methods: </strong>We recorded the EEG signals of 10 boys and 9 male adults during right- and left-hand motor imaginations. Subsequently, the complexity of EEG signals was estimated by applying Higuchi's fractal dimension (HFD) to the cleaned EEG data.</p><p><strong>Results: </strong>The results presented a significant increase of HFD in the adults (P<0.05, family-wised error corrected) in all the EEG channels compared to the children. An increase in HFD presents a more complex pattern of information processing in adults, which advances their ability to perform motor tasks.</p><p><strong>Conclusion: </strong>This advancement in adults could be created by information compression at higher levels than in children. We hope these findings pave the way to a better understanding brain functions and mechanisms.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 Spec","pages":"323-332"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Circadian Rhythm Disturbance and Chronotype on Medical Students' Mental State.","authors":"Mohammad Niroumand Sarvandani, Behzad Garmabi, Masoud Asadi, Hamed Ghazvini, Raheleh Rafaiee, Hamid Kalalian Moghaddam","doi":"10.32598/bcn.2022.1425.6","DOIUrl":"10.32598/bcn.2022.1425.6","url":null,"abstract":"<p><strong>Introduction: </strong>Shift workers usually undergo circadian misalignment, which appears when the feeding and sleep-wake cycles are desynchronized with the temporal framework organized by the internal biological clock. People differ considerably in their tolerance to shift work depending on their chronotype. This research aimed to obtain information about circadian disorders and chronotype (as a mediating variable) on consequent mental states such as impulsivity, depression, anxiety, stress, addiction potential, and boredom in students of a medical university in northeastern Iran. We studied the mental state of individuals with circadian misalignment and compared it with the healthy control group.</p><p><strong>Methods: </strong>The study design is a double-blind, randomized, controlled clinical trial. Thirty-five participants were randomly assigned to circadian alignment/misalignment protocols. Subjects completed questionnaires as baseline data (pre-test) and the end of the interventions (post-test). The study instruments were the multidimensional state boredom scale (MSBS), addiction potential scale, depression, anxiety, and stress scale-21, and Barratt impulsiveness-11 (BIS-11). To analyze outcomes, we categorized participants based on chronotype as mediate variable within each group (circadian aligned and misaligned condition).</p><p><strong>Results: </strong>The mean age of the participants was 21.66 years (range: 18-25 years). One-way analysis of variance to compare research variables in groups based on chronotype (evening, intermediate type, and morning types) showed a significant difference between the three chronotype groups in the total and non-planning impulsivity, as well as active and passive addiction potential (P<0.001). The Bonferroni post hoc test was used to compare the mean of variables in the chronotype groups about total and non-planning impulsivity scores, as well as active and passive addiction. The results showed that non-planning (P<0.01) and active addiction (P<0.001) in people with evening and intermediate types were significantly lower than in people with morning type (P=0.02).</p><p><strong>Conclusion: </strong>Alterations in diurnal profiles of activity, sleep, and feeding time, based on chronotype related to impulsiveness and boredom, and such circadian misalignment were associated with addiction potential.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 Spec","pages":"219-232"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing EEG Components in Adolescents With ADHD Using Transcranial Electrical Stimulation: A Randomized-active Controlled Study.","authors":"Moslem Kord, Jalil Fath-Abadi, Shahriar Gharibzadeh, Reza Khosrowabadi","doi":"10.32598/bcn.2023.2547.1","DOIUrl":"10.32598/bcn.2023.2547.1","url":null,"abstract":"<p><strong>Introduction: </strong>Transcranial electrical stimulation (tES), including transcranial direct current stimulation (tDCS) and transcranial random noise stimulation (tRNS), can improve neuropsychological and cognitive deficits in attention deficit hyperactivity disorder (ADHD). Here, we investigated the effectiveness of various tES modes combined with working memory training in children and adolescents with ADHD.</p><p><strong>Methods: </strong>Participants in this study consisted of a cohort of 13- to 17-year-old adolescents (N=45) who were diagnosed with ADHD in 2018. They were randomly assigned to three groups: tDCS, tRNS, and the active control (sham). The three groups received five sessions of tES either as an intervention or sham on the left and right prefrontal areas (F3 and F4). In addition to tES, dual n-back training was used in the three groups. The Wechsler's digit span subtest and resting state electroencephalography (EEG) data were collected before and after brain stimulation.</p><p><strong>Results: </strong>Analysis of variance showed significant differences between the groups in some EEG channels (P=0.05). The absolute power analysis of the brain waves data in the pre-test and post-test phases reveals that the tDCS group has the greatest changes compared to the other two groups and that most changes in the absolute power related to theta, delta, and alpha bands were found in the frontal and occipital regions.</p><p><strong>Conclusion: </strong>Based on the results, we concluded that tES over the prefrontal area induced cortical changes in children and adolescents with ADHD. Thus, it seems that various methods of tES can be used in combination with other common types of intervention to treat ADHD.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 Spec","pages":"353-356"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Intensive Short-term Dynamic Psychotherapy, Laser Acupuncture, and the Combination in Major Depression.","authors":"Arista Shojaeddin, Fariba Jafarian Namini, Zahra Razzaghi, Allan Abbass, Nima Ghorbani","doi":"10.32598/bcn.2024.5960.2","DOIUrl":"10.32598/bcn.2024.5960.2","url":null,"abstract":"<p><strong>Introduction: </strong>While major depression has been treated with laser acupuncture (LA) and intensive short-term dynamic psychotherapy (ISTDP), the relative efficacy of these two methods and their combination is unclear. ISTDP is a form of dynamic psychotherapy that enables the experience and processing of blocked complex feelings, while LA is based on the opening of blocked energy meridians. The present study aimed to compare the effectiveness of LA and ISTDP and their combination in treating major depression.</p><p><strong>Methods: </strong>A randomized controlled trial was carried out with 45 depressed patients on three equal arms (15 patients in each group): Group I) LA, group II) ISTDP, and group III) combined LA and ISTDP. The participants were evaluated at six time points using the Hamilton rating depression scale (HDRS), structured clinical interview for structured clinical interview for DSM (SCID), and symptom checklist-90 (SCL90), including baseline, session 8, session 12, 1-month follow-up, 2-month follow-up, and 3- month follow-up.</p><p><strong>Results: </strong>HDRS and SCID ratings showed within-group reductions in SCL90 and HDRS scores in the three groups over time. At one of the follow-up times, combined LA+ISTDP showed a greater reduction than either individual treatment on the SCL-90 depression subscale but not on HDRS or SCID.</p><p><strong>Conclusion: </strong>Based on releasing blocked energies, the results of this study indicate that LA and ISTDP are effective in treating major depression. The combination of the two methods may be more effective in reducing depression symptoms.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 1","pages":"131-142"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12248179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chilling and Blurring Negative Memories: An Experimental Memory Training Study.","authors":"Fatemeh Azar, Tara Rezapour, Hossein Karsazi, Javad Hatami","doi":"10.32598/bcn.2023.5539.2","DOIUrl":"10.32598/bcn.2023.5539.2","url":null,"abstract":"<p><strong>Introduction: </strong>The present study examined how broadening attentional scope (BAS) during acquisition and working memory interference (WMI) during reconsolidation could influence memory formation.</p><p><strong>Methods: </strong>A total of 95 participants were randomly assigned to inactive control (n=30), BAS (n=33), and WMI (n=32) groups. While watching a traumatic film, the participants in the BAS group were instructed to allocate their attention to the peripheral details of the film, while participants in the WMI group performed a spatial working memory task. Memory vividness and emotionality were assessed before and after the intervention using a visual analog scale, and valence, arousal, and dominance were measured by self-assessment manikin immediately after watching the film. Moreover, all participants were asked to record their intrusive memory for 3 days after the experiment. The statistical software package SPSS was used to make group comparisons.</p><p><strong>Results: </strong>Our results suggested that interfering with visuospatial working memory during retrieving emotionally valenced memories could significantly reduce the vividness of mental images from pre- to post-assessments (P=0.004). However, we found no significant differences between the three groups regarding emotionality, arousal, dominance, and the number of intrusive memories.</p><p><strong>Conclusion: </strong>Participants in the WMI group outperformed in blurring the negatively valenced memory at the posttest. In contrast with our primary assumption, BAS made no significant changes compared to the other two groups. Future studies with larger sample sizes and objective measurements may provide additional evidence on the efficacy of these methods, specifically in the context of clinical implications.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 1","pages":"95-106"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12248183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Predictive Role of Quantitative Electroencephalography in Evaluation of Responsiveness of Obsessive-compulsive Disorder Patients to Fluvoxamine.","authors":"Mohammad Sayadnasiri, Mahta Moridian, Borzooyeh Naji","doi":"10.32598/bcn.2023.4565.1","DOIUrl":"10.32598/bcn.2023.4565.1","url":null,"abstract":"<p><strong>Introduction: </strong>It is not surprising that an obsessive-compulsive disorder (OCD) patient does not respond desirably to the first choice of medication, and it may last up to one year to find the best treatment. According to the consequences of failed antidepressant therapy for OCD, any factor that can predict responsiveness would be of high importance. We investigated the potential predictive value of quantitative electroencephalography (QEEG) in the responsiveness of OCD patients to fluvoxamine.</p><p><strong>Methods: </strong>We included 40 medication-free, non-depressed OCD patients assessed before the intervention and 6 weeks after that. Five minutes of opened eyes and closed eyes QEEG records were taken. The relative power of each frequency band was calculated for all electrodes. The patients received fluvoxamine, 150-300 mg per day. We used univariate analyses and multivariate logistic regression to compare the brain waves between responders and non-responders.</p><p><strong>Results: </strong>Responsiveness was correlated with normal relative powers in FP₁, FP₂, FZ, and F₃ and increased relative power in O₁ in closed eyes condition, increased relative power of alpha in O₁ and O₂, and normal relative powers in FP₁ and FP₂ with open eyes. Unresponsiveness was correlated with increased theta wave in FP₂, FZ, and F₃, no change in the alpha wave in O₁ with closed eyes, and increased alpha in the O₁ and O₂ in opened eyes condition.</p><p><strong>Conclusion: </strong>The electroencephalographic waves of the medial-frontal area and occipital areas can be biomarkers to predict responsiveness to treatment with fluvoxamine.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 Spec","pages":"333-352"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}