Mohammad Sayadnasiri, Mahta Moridian, Borzooyeh Naji
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引用次数: 0
Abstract
Introduction: It is not surprising that an obsessive-compulsive disorder (OCD) patient does not respond desirably to the first choice of medication, and it may last up to one year to find the best treatment. According to the consequences of failed antidepressant therapy for OCD, any factor that can predict responsiveness would be of high importance. We investigated the potential predictive value of quantitative electroencephalography (QEEG) in the responsiveness of OCD patients to fluvoxamine.
Methods: We included 40 medication-free, non-depressed OCD patients assessed before the intervention and 6 weeks after that. Five minutes of opened eyes and closed eyes QEEG records were taken. The relative power of each frequency band was calculated for all electrodes. The patients received fluvoxamine, 150-300 mg per day. We used univariate analyses and multivariate logistic regression to compare the brain waves between responders and non-responders.
Results: Responsiveness was correlated with normal relative powers in FP1, FP2, FZ, and F3 and increased relative power in O1 in closed eyes condition, increased relative power of alpha in O1 and O2, and normal relative powers in FP1 and FP2 with open eyes. Unresponsiveness was correlated with increased theta wave in FP2, FZ, and F3, no change in the alpha wave in O1 with closed eyes, and increased alpha in the O1 and O2 in opened eyes condition.
Conclusion: The electroencephalographic waves of the medial-frontal area and occipital areas can be biomarkers to predict responsiveness to treatment with fluvoxamine.
期刊介绍：
BCN is an international multidisciplinary journal that publishes editorials, original full-length research articles, short communications, reviews, methodological papers, commentaries, perspectives and “news and reports” in the broad fields of developmental, molecular, cellular, system, computational, behavioral, cognitive, and clinical neuroscience. No area in the neural related sciences is excluded from consideration, although priority is given to studies that provide applied insights into the functioning of the nervous system. BCN aims to advance our understanding of organization and function of the nervous system in health and disease, thereby improving the diagnosis and treatment of neural-related disorders. Manuscripts submitted to BCN should describe novel results generated by experiments that were guided by clearly defined aims or hypotheses. BCN aims to provide serious ties in interdisciplinary communication, accessibility to a broad readership inside Iran and the region and also in all other international academic sites, effective peer review process, and independence from all possible non-scientific interests. BCN also tries to empower national, regional and international collaborative networks in the field of neuroscience in Iran, Middle East, Central Asia and North Africa and to be the voice of the Iranian and regional neuroscience community in the world of neuroscientists. In this way, the journal encourages submission of editorials, review papers, commentaries, methodological notes and perspectives that address this scope.
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