Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine最新文献_第9页

MONITORING RADIATION LOADS AND QUALITY FACTOR OF IONIZING SPACE RADIATION IN THE ISS SERVICE MODULE WITH THE USE OF RESEARCH EQUIPMENT "TRITEL" 利用“tritel”研究设备监测国际空间站服务舱电离空间辐射负荷和质量因子

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-4-89-94

A. Lishnevskii, O. A. Ivanova, K. O. Inozemtsev, A. Hirn, I. Apáthy, B. Zábori, A. Csőke, S. Deme, T. Pázmándi, P. Szántó, D. Kartashov, R. Tolochek, I. Kartsev, V. Shurshakov

引用次数: 0

ROLE OF AMP-ACTIVATED PROTEIN KINASE IN REGULATION OF CALCIUM-DEPENDENT AND UBIQUITIN/PROTEASOME SIGNALING PATHWAYS DURING MUSCLE FUNCTIONAL DISLOADING amp激活的蛋白激酶在肌肉功能卸荷过程中钙依赖性和泛素/蛋白酶体信号通路调控中的作用

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-5-65-76

S. Belova, К.А. Zaripova, К.А. Sharlo, B. Shenkman, T. Nemirovskaya

{"title":"ROLE OF AMP-ACTIVATED PROTEIN KINASE IN REGULATION OF CALCIUM-DEPENDENT AND UBIQUITIN/PROTEASOME SIGNALING PATHWAYS DURING MUSCLE FUNCTIONAL DISLOADING","authors":"S. Belova, К.А. Zaripova, К.А. Sharlo, B. Shenkman, T. Nemirovskaya","doi":"10.21687/0233-528x-2022-56-5-65-76","DOIUrl":"https://doi.org/10.21687/0233-528x-2022-56-5-65-76","url":null,"abstract":"We tested the hypothesis that in unloaded skeletal muscles the calcium-dependent signaling pathways and E3-ligase expression are controlled by regulation of phosphorylation of AMP-activated protein kinase (AMPK). For a 3-d experiment 32 Wister male rats were divided into 4 groups: placebo control (С), metformin control (300 mg/kg of body, per oral, MC), suspension and placebo (SP), suspension and metformin (SM). Object of the investigation was m. soleus. In comparison to group C, rAMPK in group MC reduced 46 % and ATP increased 49 % (p < 0.05); pCaMK II showed an increase and expression of mRNA CaN, SERCA2a and Calpain 1 grew 483 %, 87 %, 41 % and 62 %, respectively; p < 0.05). In group SP, MuRF1, MAFbx E3-ligase expression and ubiquitin increased 167 %, 146 % and 191 %, respectively (p < 0.05). Per oral metformin prevented these changes in the suspended rats. During 3 days of suspension, metformin prevented changes in rAMK and ATP; also, it influenced regulation of the calcium-dependent signaling pathways through expression and phosphorylation of such markers as CaMK, CaN, SERCA2a and Calpain-1, and prevented to a degree growth in expression of key markers of ubuquitin-proteasome pathway – MuRF1, MAFbx, and uniquitin.","PeriodicalId":8683,"journal":{"name":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67956401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CHARACTERIZATION OF A HEALTHY HUMAN BLOOD COMPOSITION IN THE COURSE OF A YEAR-LONG STAY ON THE ANTARCTIC STATION «VOSTOK» 在“沃斯托克”南极站停留一年的过程中对健康人类血液成分的表征

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-6-31-36

L.Kh. Pastuhkova, A. Goncharova, D. N. Kashirina, A.N. Chebotok, A. Kononikhin, A. G. Brzhozovsky, I. Larina, Е.А. Ilyin, O. I. Orlov

{"title":"CHARACTERIZATION OF A HEALTHY HUMAN BLOOD COMPOSITION IN THE COURSE OF A YEAR-LONG STAY ON THE ANTARCTIC STATION «VOSTOK»","authors":"L.Kh. Pastuhkova, A. Goncharova, D. N. Kashirina, A.N. Chebotok, A. Kononikhin, A. G. Brzhozovsky, I. Larina, Е.А. Ilyin, O. I. Orlov","doi":"10.21687/0233-528x-2022-56-6-31-36","DOIUrl":"https://doi.org/10.21687/0233-528x-2022-56-6-31-36","url":null,"abstract":"Chromatography-mass spectrometry of dried blood spots sampled during the year-long wintering of the 65th Russian expedition to the Antarctic station Vostok identified 6798 peptides. The maximal confidence level made possible the classification of 1239 proteins. Named were proteins that changed concentrations by months 4 and 12 of wintering. Crude proteins typical for these periods were identified, too. Methods of bioinformatics established period-specific as well as common changes in proteins on the level of confidentiality. The proteomic data allow discussion of signaling pathways and ways the organism adapts to extreme life environments. Our results suggest that professional activities in the conditions of long-term hypobaric hypoxia, isolation and hypokinesia on Antarctic station «Vostok» are accompanied by changes in the blood proteome affecting first and foremost the processes that control chemical and energy homeostasis on the molecular, cell, tissue, organ and system levels.","PeriodicalId":8683,"journal":{"name":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67956582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SMOOTH MUSCLE TISSUE – A POTENTIAL TARGET OF TRANSLATIONAL RESEARCHES IN SPACE BIOMEDICINE 平滑肌组织——空间生物医学转化研究的潜在靶点

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-6-5-15

T. V. Samoilenko, V. V. Shishkina, L. N. Antakova, D. A. Atyakshin

{"title":"SMOOTH MUSCLE TISSUE – A POTENTIAL TARGET OF TRANSLATIONAL RESEARCHES IN SPACE BIOMEDICINE","authors":"T. V. Samoilenko, V. V. Shishkina, L. N. Antakova, D. A. Atyakshin","doi":"10.21687/0233-528x-2022-56-6-5-15","DOIUrl":"https://doi.org/10.21687/0233-528x-2022-56-6-5-15","url":null,"abstract":"This is an overview of the current knowledge of the structural and functional organization of the smooth muscle tissue (SMT) presenting equally fundamental and applied interest for space biomedicine. SMT is a structural component of the visceral organs involved in adaptive reactions or pathological developments. According to the evidence, cell populations of visceral SMT contain smooth myocites differing in histophysiological properties. Many investigators reason that the SMT morphological and embriological origin is organ-specific and can be an area of translational researches, including space biomedicine. In spite of the multisided analysis of animal and humans tissues exposed to the spaceflight factors, no effort has been made to study SMT in space microgravity or ground-based modeling experiments. However, space gastroenterology knows facts about morphological transformations in the digestive organs in the spaceflight environment. Clearly, SMT as a structural component of the gastrointestinal tract may contribute directly in a number of organ-specific changes during orbital missions. SMT studies will unveil mechanisms of adaptive cell, and molecular changes with stromal mediation due to microgravity, and reveal targets for enhancing health control in space missions.","PeriodicalId":8683,"journal":{"name":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67957160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

ANTHROPOMETRIC PROFILE OF FEMALE STUDENTS OF A FLIGHT SCHOOL 飞行学校女学生的人体测量剖面

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-6-60-65

Yu. B. Moiseev, I. Kovalchuk, M. Rybnikova, Yu.I. Remizov

引用次数: 0

DETERMINATION OF THE EFFECT OF DIRECTED LIGHTING BY BLUE LIGHT-EMITTING DIODES ON GROWTH OF TAP ROOTS OF ARABIDOPSIS THALIANA SEEDLINGS DURING SLOW 2D-CLINOSTAT ROTATION 蓝色发光二极管定向光照对拟南芥幼苗在2d慢速旋转条件下主根生长影响的测定

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-6-79-87

A.M. Belyak, А.А. Shilovich, A. S. Krivobok, V. B. Nikitin, T. Bibikova

{"title":"DETERMINATION OF THE EFFECT OF DIRECTED LIGHTING BY BLUE LIGHT-EMITTING DIODES ON GROWTH OF TAP ROOTS OF ARABIDOPSIS THALIANA SEEDLINGS DURING SLOW 2D-CLINOSTAT ROTATION","authors":"A.M. Belyak, А.А. Shilovich, A. S. Krivobok, V. B. Nikitin, T. Bibikova","doi":"10.21687/0233-528x-2022-56-6-79-87","DOIUrl":"https://doi.org/10.21687/0233-528x-2022-56-6-79-87","url":null,"abstract":"The paper presents the results of experiments with 48-hour horizontal and vertical clinostatting of 5-day old Arabidopsis thaliana seedlings in 2 types of lighting, i.e. white light (4000 cd) and lateral blue light (450 nm). The experiments were performed in a clinostat designed to install Petri dishes with juvenile Arabidopsis thaliana in the horizontal and rotate it about the horizontal axis at a speed of 1 rev/min. Angular bend of the main root (MR) was measured as it elongated. It was demonstrated that, on the average, vertical clinostating in white light caused a more significant MR departure from the apical-basis axis than the horizontal clinostating. The proposed space experiments with Arabidopsis seedlings and laboratory controls will require extensive preliminary studies of the effects of specific light spectra and directions, and crop orientation. In blue light, there was no difference in the MR departure due to the seedlings placement in the clinostat; however, more than 75 % of the seedlings tended to bend away from the light source. Directed blue lighting in a 2D-clinostat can be an approach to root system orientation based on the negative phototropism.","PeriodicalId":8683,"journal":{"name":"Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67957558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GENOTOXICITY OF METAL-CONTAINING NANOPARTICLES 含金属纳米颗粒的遗传毒性

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-1-26-31

E. A. Kapustina, E. Titov, М.А. Novikov

引用次数: 0

EFFECT OF 21-DAY DRY IMMESRION ON EXPRESSION OF INBORN IMMUNITY GENES ASSOCIATED WITH THE TOLL-LIKE RECEPTORS' SIGNALIING PATHWAYS 21 d干浸渍对toll样受体信号通路相关先天免疫基因表达的影响

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-2-11-19

D. D. Vlasova, A. Sadova, V. Galina, N.S. Guermanov, M. Rykova, E. Antropova, O. Kutko, S. Shulguina, K. Orlova, V. A. Shmarov, E. A. Lysenko, S. Ponomarev

引用次数: 0

EFFECT OF PHITOCHEMICAL EXTRACTS ON EXPRESSION OF GENES NFE2L2, JUN, SOD1 IN HUMAN CELLS 植物化学提取物对人细胞中nfe2l2, jun, sod1基因表达的影响

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-3-40-46

A. Alkhaddur, E. V. Mashkina

引用次数: 0

PSYCHOLOGICAL SUPPORT USING VIRTUAL REALITY IN A STUDY WITH THREE-DAY DRY IMMERSION 在为期三天的干式浸泡研究中使用虚拟现实的心理支持

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI: 10.21687/0233-528x-2022-56-1-55-61

I. A. Rozanov, P. G. Kuznetsova, A. O. Savinkina, D. Shved, O. Ryumin, E. Tomilovskaya, V. Gushchin

引用次数: 4