CHARACTERIZATION OF A HEALTHY HUMAN BLOOD COMPOSITION IN THE COURSE OF A YEAR-LONG STAY ON THE ANTARCTIC STATION «VOSTOK»

Abstract

Chromatography-mass spectrometry of dried blood spots sampled during the year-long wintering of the 65th Russian expedition to the Antarctic station Vostok identified 6798 peptides. The maximal confidence level made possible the classification of 1239 proteins. Named were proteins that changed concentrations by months 4 and 12 of wintering. Crude proteins typical for these periods were identified, too. Methods of bioinformatics established period-specific as well as common changes in proteins on the level of confidentiality. The proteomic data allow discussion of signaling pathways and ways the organism adapts to extreme life environments. Our results suggest that professional activities in the conditions of long-term hypobaric hypoxia, isolation and hypokinesia on Antarctic station «Vostok» are accompanied by changes in the blood proteome affecting first and foremost the processes that control chemical and energy homeostasis on the molecular, cell, tissue, organ and system levels.