植物化学提取物对人细胞中nfe2l2, jun, sod1基因表达的影响

Q4 Biochemistry, Genetics and Molecular Biology

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Pub Date : 2022-01-01 DOI:10.21687/0233-528x-2022-56-3-40-46

A. Alkhaddur, E. V. Mashkina

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引用次数: 0

摘要

研究了石榴、葡萄籽和大蒜提取物的植物化学成分对培养的人血液细胞中NFE2L2、JUN、SOD1表达的影响，发现石榴和葡萄籽提取物增加了SOD1的转录。在高浓度葡萄籽提取物的影响下，NFE2L2和JUN的mRNA水平迅速上升。JUN mRNA水平与NFE2L2 mRNA水平相关。大蒜提取物对NFE2L2、JUN、SOD1的转录无影响。葡萄籽提取物激活所有3个基因的转录，有助于控制人体细胞中的自由基过程。

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EFFECT OF PHITOCHEMICAL EXTRACTS ON EXPRESSION OF GENES NFE2L2, JUN, SOD1 IN HUMAN CELLS

Investigations of the effects of phitochemical compounds from extracts of pomegranate, grape seeds and garlic on expression of NFE2L2, JUN, SOD1 in cultivated cells of the human blood showed that transcription of SOD1 increased in the presence of pomegranate and grape seed extracts. Level of mRNA in NFE2L2 and JUN rose briskly only under the influence of a high concentration of the grape seed extract. Level of JUN mRNA correlated with NFE2L2 mRNA. Garlic extract had no effect on transcription of NFE2L2, JUN, SOD1. Activation of the transcription of all 3 genes under study by the grape seeds extract can contribute to controlling the free radical processes in human cells.

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来源期刊

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

0.60

自引率

0.00%

发文量