Asian Pacific journal of allergy and immunology最新文献

{"title":"Immunopathophysiology, biochemistry, and clinical implications of Daboia siamensis venom: A possible challenge to macrophages' immunomodulation.","authors":"Wichit Thaveekarn, Jureeporn Noiphrom, Orawan Khow, Asada Leelahavanichkul, Visith Sitprija","doi":"10.12932/AP-070126-2206","DOIUrl":"https://doi.org/10.12932/AP-070126-2206","url":null,"abstract":"<p><p>Daboia siamensis (Eastern Russell's viper) envenomation remains a major public health problem in Southeast Asia and is frequently associated with severe systemic complications, particularly coagulopathy and acute kidney injury (AKI). A complex mixture of biologically active toxins, including snake venom metalloproteinases (SVMPs), serine proteases (SVSPs), phospholipase A2 (PLA2), and other enzymes, synergistically disrupts vascular integrity, hemostasis, and organ microcirculation. Beyond the direct toxic effects of venom, secondary immune-mediated processes amplify tissue injury through endothelial activation, inflammatory mediators, and oxidative stress that contribute to microvascular dysfunction and ischemic injury, a major pathophysiology of AKI even after correction of systemic coagulation abnormalities. Although antivenom therapy remains the most effective treatment when administered early, its ability to prevent established organ damage is limited once tissue injury has occurred. Hence, immunomodulatory strategies targeting macrophage activation may be beneficial. This review integrates current knowledge on venom composition, immunopathophysiological mechanisms, and clinical manifestations of D. siamensis venom, with particular emphasis on factors contributing to renal injury. Improved understanding of the interconnected processes between venom and immune responses may support the development of adjunctive strategies to reduce organ complications and improve outcomes following Russell''s viper envenomation.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":"44 2","pages":"297-308"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148429626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A real-world data analysis of distribution and inconsistency between total serum IgE and allergen-specific IgE results in clinical practice.","authors":"Xianjie Yang, Zhiqiang Song, Shifei Li, Anqi Chen, Huan Wang, Sisi Deng, Bing Ni, Qiquan Chen","doi":"10.12932/AP-230424-1843","DOIUrl":"10.12932/AP-230424-1843","url":null,"abstract":"<p><strong>Background: </strong>The inconsistency between serum total IgE (tIgE) and allergen-specific IgE (sIgE) results is often encountered in clinical practice, but the distribution and influencing factors of the inconsistent results have not been fully understood.</p><p><strong>Objective: </strong>The aim of this study was to analyze the distribution and inconsistency between tIgE and sIgE test results.</p><p><strong>Methods: </strong>A retrospective study, from the electronic medical records of 2139 patients who underwent both tIgE and sIgE tests, from January to December 2023 was reviewed. The tIgE and sIgE results and their distribution, as well as their inconsistency, were analyzed based on sex, age, and disease subgroups.</p><p><strong>Results: </strong>36.2% of the patients had a positive sIgE, and 43.7% had an elevated tIgE level. sIgE and tIgE results were discordant in nearly 30% of patients, with no difference between genders, while individuals aged over 60 exhibited a significantly higher inconsistency rate than the other age groups, and the inconsistency rate between tIgE and sIgE results was significantly different among different tIgE levels, sIgE grades, positive allergen count and positive allergen types. In addition, patients with chronic urticaria (CU) had a higher inconsistency rate than those with other allergic diseases, but the difference was not statistically significant.</p><p><strong>Conclusion: </strong>The overall inconsistency rate between tIgE and sIgE results was about 30%. The elderly group older than 60 years old is more likely to have inconsistent results, and tIgE level, sIgE level, the number and type of positive allergens also affected the consistency of tIgE and sIgE results.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"309-317"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IgE-sensitization and cross-reactivity of Der f 23 and Der p 23 in Korean patients with allergy.","authors":"Myung-Hee Yi, Tai-Soon Yong, Chung-Ryul Kim, Kyoung Yong Jeong, Ju Yeong Kim","doi":"10.12932/AP-120924-1924","DOIUrl":"10.12932/AP-120924-1924","url":null,"abstract":"<p><strong>Background: </strong>House dust mites (HDM) are a major source of allergens, and more than 30 HDM allergens have been identified to date. Recently, Der p 23 was reported to be a major allergen that is related to the severity of allergic responses.</p><p><strong>Objective: </strong>This study aimed to characterize IgE-sensitization and cross-reactivity between Der f 23 and Der p 23 in Korean patients with allergy.</p><p><strong>Methods: </strong>We produced recombinant Der f 23 and Der p 23 using a yeast Pichia expression system. The IgE binding activity of Der f 23 and Der p 23 was evaluated by enzyme-linked immunosorbent assay (ELISA) using sera from 194 Korean HDM-sensitized patients. The cross-reactivity between Der f 23 and Der p 23 was then assayed using competitive ELISA.</p><p><strong>Results: </strong>Among the 194 HDM-allergic patients, IgE reactivity to rDer f 23 and rDer p 23 was observed in 45.36% (88/194) and 43.81% (85/194) of the samples, respectively. Competitive ELISA with pooled serum from 10 patients revealed that rDer p 23 inhibited 86.1% of the rDer f 23 IgE reactivity and rDer f 23 inhibited 61.1% of the rDer p 23 IgE reactivity.</p><p><strong>Conclusions: </strong>Group 23 HDM allergens, Der f 23 and Der p 23, show moderate sensitization, with 45.36% and 43.81% of Korean patients with allergy reacting to them, respectively. Significant IgE cross-reactivity was observed between the two allergens. These findings can facilitate the development of component-resolved diagnosis and allergen-specific immunotherapy in the future.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"399-405"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Binding specificity of HuScFv to cholangiocarcinoma cells; New avenues for diagnosis and treatment.","authors":"Nathawadee Sawatpiboon, Monrat Chulanetra, Wanpen Chaicumpa, Sunisa Duang Sa-Ard, Kanda Kasetsinsombat, Adisak Wongkajornsilp","doi":"10.12932/AP-210624-1877","DOIUrl":"10.12932/AP-210624-1877","url":null,"abstract":"<p><strong>Background: </strong>Cholangiocarcinoma (CCA) is a very aggressive cancer of the bile ducts. Recent advances in immunotherapy, particularly with human single-chain variable fragments (HuScFv), have shown promise in the treatment of solid tumors by targeting cancer cells or improving the immune response.</p><p><strong>Objective: </strong>This study aimed to select and produce human single-chain antibody fragments (HuScFv) specific to CCA cells (HubCCA1, RMCCA) from phage display HuScFv libraries with minimum or no binding to cholangiocytes (MMNK1).</p><p><strong>Methods: </strong>Phages that displayed HuScFv to CCA cells were selected by bio-panning and each phagemid was transduced to HB2151 E. coli. The presence of huscfv was determined by direct colony PCR. HuScFv was produced in the E. coli and detected by Western blot analysis and confirmed their specificity and binding capacity to CCA by flow cytometry.</p><p><strong>Results: </strong>From biopanning, 196 of 350 colonies (56%) of HB2151 E. coli harboring the huscfv gene, and 106 of these (30%) produced the protein. Flow cytometry testing with 14 clones confirmed the presence of the HuScFv protein. The result showed that five HuScFv clones (25, 33, 61, 68, and 80) exhibited stronger binding to CCA cell lines (HubCCA1, RMCCA) compared to cholangiocytes. Furthermore, each clone possessed a distinct amino acid sequence, suggesting unique binding specificities.</p><p><strong>Conclusions: </strong>HuScFv specific to CCA cells were successfully selected from phage display HuScFv libraries which offer new revenues to develop a pan-CCA immunotherapy and diagnosis of CCA.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"328-338"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropsychiatric adverse effects of antihistamine: A nationwide data-based epidemiological study in South Korea.","authors":"Jin Youp Kim, Dong Wook Shin, Zio Kim, Su Hwan Kim, Kyung-Lak Son, Su Hwan Kim, Hyung-Jin Yoon","doi":"10.12932/AP-100724-1889","DOIUrl":"10.12932/AP-100724-1889","url":null,"abstract":"<p><strong>Background: </strong>Despite concerns on the major neuropsychiatric side effects for long-term use of H1-receptor antagonist (anti-histamine, AH), one of the major therapeutic tools for allergic diseases, their association has not been investigated well.</p><p><strong>Objective: </strong>This study aimed to assess the association between AH usage and neuropsychiatric disorder (NPD) incidence using the National Health Insurance Service Database.</p><p><strong>Methods: </strong>This study was conducted using data from the National Health Insurance Service Database from January 1st 2002 through December 31th 2017. To enroll the participants who may have history of long-term use of AH, participants having common allergic diseases were enrolled. We defined NPD as diagnosed by a psychiatrist occurring during and after antihistamine use to 6 months thereafter.</p><p><strong>Results: </strong>A total of 1,488,075 participants were enrolled. No significant association was found between increased AH usage and NPD incidence after adjusting for potential confounding factors in the health screening data. Notably, the 30-89 day AH usage group showed a significantly lower NPD risk in the subgroup analysis in participants aged over 60 years. No other groups within this age category showed a significant increase in risk.</p><p><strong>Conclusions: </strong>This study suggests that long-term AH use does not significantly increase NPD risk. While this study lacked evaluation of mild neuropsychiatric side effects not requiring psychiatric visits, this study may contribute real-world evidence to the understanding of AHs' long-term neuropsychiatric side effects.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"392-398"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Denatonium benzoate promotes IgE-mediated mast cell degranulation and ovalbumin-induced allergic diarrhea in BALB/c mice.","authors":"Ju Liu, Huaping Xu, Shaotong Feng, Xiaoyun Shi, Xin Li, Jiexin Zou, Linbo Shi","doi":"10.12932/AP-250424-1845","DOIUrl":"10.12932/AP-250424-1845","url":null,"abstract":"<p><strong>Background: </strong>Denatonium benzoate (DB), one of the most bitter compounds known to man, is used for alcohol denaturation. Some reports have demonstrated that asthmatic symptoms are associated with DB exposure, but the possible links between DB and immunoglobulin E (IgE)-mediated allergy susceptibility have not yet been examined.</p><p><strong>Objective: </strong>This study investigated the effects of DB on in vitro IgE-mediated mast cell degranulation and food allergy in BALB/c mice.</p><p><strong>Methods: </strong>IgE-sensitized rat RBL-2H3 cells (a basophilic leukemia mast cell line) and human KU812 cells (a basophilic cell line) and mice with ovalbumin (OVA)-induced allergy were treated with DB. Histamine release, calcium ion (Ca²⁺) influx, phosphorylated spleen tyrosine kinase (p-Lyn) and phosphorylated phospholipase C-γ (p-PLCγ) levels, OVA-specific IgE, anaphylactic symptoms, and the cell-surface expression of the high-affinity IgE receptor α-subunit (FcεRIα) on mast cells were evaluated.</p><p><strong>Results: </strong>DB increased histamine release, Ca²⁺ mobilization, and p-Lyn and p-PLCγ levels in IgE-mediated activated RBL-2H3 and KU812 cells, and enhanced the cell-surface expression of FcεRIα messenger RNA (mRNA). In mice, DB increased the severity of OVA-induced anaphylactic and diarrheic symptoms, the mucus thickness in the jejunum, histamine and OVA-specific IgE levels, and FcεRIα mRNA in isolated mucosal mast cells.</p><p><strong>Conclusions: </strong>Our work indicates that DB promotes IgE-mediated mast cell degranulation and OVA-induced allergic diarrhea in BALB/c mice, providing evidence that exposure to DB promotes allergy susceptibility.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"416-424"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of a basophil activation test for Japanese beekeepers naturally sensitized to honey bee venom.","authors":"Hisanori Hirokawa, Hirokuni Hirata, Masafumi Arima, Yasuo Haruyama, Yasutsugu Fukushima","doi":"10.12932/AP-030124-1759","DOIUrl":"10.12932/AP-030124-1759","url":null,"abstract":"<p><strong>Background: </strong>The basophil activation test (BAT) has high sensitivity and specificity for diagnosing Hymenoptera venom allergy and is useful for predicting the clinical sensitivity of bee venom-allergic patients after venom immunotherapy. Patients sensitized to Hymenoptera venom are at risk for systemic reactions (SRs) to subsequent stings. Therefore, a tool that can predict the occurrence of SRs and the severity of Hymenoptera stings is needed.</p><p><strong>Objective: </strong>We performed BATs on Japanese beekeepers naturally sensitized to honey bee venom (HBV) and analyzed the positive threshold concentration for the occurrence of SRs following honey bee stings (HBS).</p><p><strong>Methods: </strong>Sixty-one beekeepers were interviewed and blood samples were taken. Data including history of HBS and the occurrence and severity of SRs to HBS were recorded. Blood samples were exposed to HBV-specific IgE antibodies (sIgE) and BAT was performed. Participants with HBV-sIgE ≥ class 1 were considered sensitized to HBV. The positive threshold for BAT scored as 0.0001, 0.001, 0.01, 0.1, and 1 μg/ml was classified as classes 5, 4, 3, 2, and 1, respectively. Samples negative at 1 μg/ml were classified as class 0.</p><p><strong>Results: </strong>About 40% of beekeepers with a positive BAT threshold ≤ 0.1 μg/ml had SRs after HBS. The mean score of the BAT positivity threshold for beekeepers who developed SRs was significantly lower than that for beekeepers with no history of SRs (2.6 ± 0.8 vs 1.4 ± 1.1, P < 0.01).</p><p><strong>Conclusion: </strong>Analysis of the positive threshold of BAT in Japanese beekeepers naturally sensitized to HBV may be a useful tool for predicting the occurrence of SRs.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"374-382"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140850386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the uncommon: Insights into thymoma associated immunodeficiency.","authors":"Xin Rong Lim, Bernard Pui Lam Leung, Evan Tsien Ming Tan, Faith Li-Ann Chia, Grace Yin Lai Chan, Sze-Chin Tan, Khai Pang Leong, Claire Min-Li Teo, Samuel Shang Ming Lee, Justina Wei Lynn Tan, Bernard Yu-Hor Thong","doi":"10.12932/AP-080724-1887","DOIUrl":"10.12932/AP-080724-1887","url":null,"abstract":"<p><strong>Background: </strong>Thymoma-associated immunodeficiency (TAI) is a rare, acquired adult-onset immunodeficiency. It includes the classic form of Good syndrome (GS), characterized by thymoma and hypogammaglobulinemia, as well as a non-classic form of GS. This condition leads to specific or combined deficiencies in both B- and T-cells, causing considerable morbidity and mortality, although the underlying immunopathology is still not well understood.</p><p><strong>Objective: </strong>In this study, we examine the clinical features, laboratory investigations, immunological analysis and treatment outcomes of 21 patients with TAI in our institution, and its associated comorbidities and complications.</p><p><strong>Methods: </strong>Patients with thymoma and recurrent infections who were followed up in our immunodeficiency clinic between 1 January 1999 and 1 December 2023 were identified. Clinical information, laboratory, treatment and outcome data were extracted from the medical records. Seven patients agreed to provide additional blood samples for anti-cytokine antibodies profiling.</p><p><strong>Results: </strong>Of the 21 TAI patients, 12 (57.1%) were females and the mean age at diagnosis of TAI was 61.3 ± 9.2 years. 19 patients had classic GS. 12 (57.1%) had underlying bronchiectasis, 5 (23.8%) had sinusitis and 5 (23.8%) developed malignancy other than thymic carcinoma after diagnosis of thymoma. 10 patients (47.6%) developed autoimmune conditions including myasthenia gravis, polymyositis, lichen planus, vasculitis and ulcerative colitis. One patient was found to have high titre of neutralizing anti-interferon alpha antibodies as well as medium titre of neutralizing anti-interleukin 17 antibodies. 9 patients died at a median of 4.2 (IQR 1.98 - 4.9) years after diagnosis of TAI.</p><p><strong>Conclusions: </strong>TAI is associated with significant morbidity and mortality. The syndrome leads to a plethora of opportunistic infections, autoimmune complications and malignancy.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"383-391"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of allergic diseases in age-related macular degeneration: A nationwide cohort study in South Korea.","authors":"Je Moon Yoon, Se Young Jung, Kyung-Do Han, Dong Wook Shin, Dong Hui Lim, Yoon-Seok Chang","doi":"10.12932/AP-280524-1865","DOIUrl":"10.12932/AP-280524-1865","url":null,"abstract":"<p><strong>Background: </strong>Premorbid allergic diseases are linked with the development of age-related macular degeneration (AMD), however, the risk of allergic diseases among patients with AMD is largely unknown.</p><p><strong>Objective: </strong>To evaluate the association between AMD with or without visual disability (VD) and the risk of allergic diseases.</p><p><strong>Methods: </strong>A total of 2,744,372 Individuals 50 years or older participated in the Korean National Health Screening Program in 2009 were categorized by presence of AMD and VD. Patients were followed until December 2019, and the prospective association of AMD and related VD with incident allergic diseases cases identified during the study period was investigated using the multivariable-adjusted Cox proportional hazard model.</p><p><strong>Results: </strong>During an average follow-up period of 5.87 years, 1,783,370 individuals were diagnosed with allergic diseases. Moreover, an increased risk of allergic diseases was observed in the group of individuals with AMD as compared to the control group (adjusted HR [aHR], 1.13; 95%CI, 1.11-1.14). The risk of atopic dermatitis or allergic rhinitis was more profound than that of asthma (aHR 1.12 [95%CI 1.07-1.18], aHR 1.13 [95%CI 1.11-1.14], and aHR 1.06 [95%CI 1.04-1.09], respectively). Furthermore, patients affected by AMD with VD were at an increased risk of atopic dermatitis (aHR 1.32, 95%CI 1.12-1.56) than those without VD (aHR 1.11, 95%CI 1.05-1.16) when compared with those in the control group.</p><p><strong>Conclusions: </strong>AMD is associated with an increased risk of developing allergic diseases. Further investigations are required to elucidate the underlying mechanisms.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"406-415"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between exercise habits including exercise partner and allergic rhinitis in a Japanese population.","authors":"Junichi Watanabe, Hironobu Nakaguchi, Shinya Furukawa, Teruki Miyake, Masumi Miyazaki, Ayumi Kanamoto, Yoshimasa Murakami, Keiichiro Horiuchi, Osamu Yoshida, Aki Kato, Katsunori Kusumoto, Yoichi Hiasa","doi":"10.12932/AP-241225-2195","DOIUrl":"https://doi.org/10.12932/AP-241225-2195","url":null,"abstract":"<p><strong>Background: </strong>Evidence on the association between physical activity (PA) and allergic rhinitis (AR) remains inconsistent. While the prevalence of AR was high in Japan, no epidemiological study regarding this issue has been conducted.</p><p><strong>Objective: </strong>This study examined the association between exercise habits including exercise partner and self-reported AR among Japanese young adults.</p><p><strong>Methods: </strong>This cross-sectional study included 12,497 university students who underwent annual health checkups. Exercise habits were evaluated using a self-administered questionnaire on frequency (none, 1-2/month, 1-3/week, ≥ 4/week), intensity (none, light, moderate, intense), and exercise partner (no exercise, group, friends, alone). AR was defined as responding \"Yes\" to the question about self-reported AR. Multivariable logistic regression estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs), controlling for age, sex, body mass index, smoking, and alcohol use.</p><p><strong>Results: </strong>Of 12,497 participants (mean age 20.1 ± 3.1 years; 60.4% men), the prevalence of AR was 20.0% (n = 2,500). Compared with non-exercisers, high-frequency exercise (≥ 4/week) was independently and inversely associated with AR (adjusted OR = 0.83, 95%CI 0.72-0.96; p for trend = 0.008). Inverse associations between intense exercise (adjusted OR = 0.84, 95%CI 0.75-0.95), exercising with groups (adjusted OR = 0.83, 95%CI 0.72-0.94), and AR were also observed.</p><p><strong>Conclusions: </strong>Among Japanese young adults, frequent and intense exercise, particularly in organized settings, was independently and inversely associated with self-reported AR. These findings provide the first large-scale evidence from Japan suggesting an inverse association between habitual exercise and AR.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148142634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}