Asian Pacific journal of allergy and immunology最新文献_第3页

NLRP3 inhibition attenuates the allergic rhinitis symptoms in a mouse model. 抑制 NLRP3 可减轻小鼠模型的过敏性鼻炎症状。

IF 2.3 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-07-14 DOI: 10.12932/AP-301223-1756

Minhyung Lee, Young-Kyung Ko, Sehun Jang, Chan Hee Gil, Kyoung Mi Eun, Yu-Lian Zhang, Sung-Woo Cho, Dae Woo Kim, Hyun Jik Kim, Chae-Seo Rhee

{"title":"NLRP3 inhibition attenuates the allergic rhinitis symptoms in a mouse model.","authors":"Minhyung Lee, Young-Kyung Ko, Sehun Jang, Chan Hee Gil, Kyoung Mi Eun, Yu-Lian Zhang, Sung-Woo Cho, Dae Woo Kim, Hyun Jik Kim, Chae-Seo Rhee","doi":"10.12932/AP-301223-1756","DOIUrl":"https://doi.org/10.12932/AP-301223-1756","url":null,"abstract":"Background: Recent human and animal studies have demonstrated that Nod-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome is closely involved in the development of allergic diseases.Objective: To identify the mechanism underlying the activation of NLRP3 inflammasome signaling pathway in an ovalbumin (OVA)-induced allergic rhinitis (AR) mice model and to validate the effect of a specific inhibitor of the NLRP3, MCC950.Methods: Mice were divided into three groups and each group consisted of ten mice (saline group, the negative control group; OVA group, the OVA-induced AR model group; and OVA+MCC group, treated with 10 mg/kg MCC950). MCC950 was administered intraperitoneally every second day. Multiple parameters of AR, including NLRP3, caspase-1, interleukin (IL)-1β, and IL-18 were evaluated by using ELISA, RT-qPCR, histopathology, and immunohistochemistry.Results: The mRNA and protein levels of NLRP3, caspase-1, IL-1β and IL-18 were upregulated in the OVA group compared with those of the saline group. MCC950 significantly inhibited the mRNA and protein levels of NLRP3, caspase-1, IL-1β and IL-18 in nasal tissue. Further, AR symptoms and eosinophil count were normalized after MCC950 treatment. However, OVA-specific IgE was not restored in the OVA+MCC group.Conclusion: NLRP3 inflammasome signaling pathway may be an alternative pathway to induce AR symptoms in OVA-induced AR model. MCC950 is a specific inhibitor of NLRP3 cascade, which attenuates AR symptoms regardless of IgE.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Total airway mechanics and fractional exhaled nitric oxide levels of children living in banjihas (semi-basements). 居住在 Banjihas（半地下室）的儿童的总气道力学和呼出一氧化氮分数水平。

IF 2.3 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-07-14 DOI: 10.12932/AP-050224-1780

Ji Hee Kwak, Ju Hee Kim, Eun Kyo Ha, Hye Mi Jee, Youn Ho Shin, Hey Sung Baek, Man Yong Han

{"title":"Total airway mechanics and fractional exhaled nitric oxide levels of children living in banjihas (semi-basements).","authors":"Ji Hee Kwak, Ju Hee Kim, Eun Kyo Ha, Hye Mi Jee, Youn Ho Shin, Hey Sung Baek, Man Yong Han","doi":"10.12932/AP-050224-1780","DOIUrl":"https://doi.org/10.12932/AP-050224-1780","url":null,"abstract":"Background: The ISAAC phase III study in Korea found a higher incidence of wheezing illnesses among residents in basements or semi-basements.Objective: This study investigates the link between living in banjihas (semi-basements) and airway resistance and Th2 airway inflammation in Korean children, compared to those on higher floors.Methods: We assessed 575 fifth- and sixth-grade students (aged 10-12) in an inner-city area of South Korea. The study utilized impulse oscillometry to measure small and total airway resistance (Rrs20-5 and Rrs0, respectively) and Fractional Exhaled Nitric Oxide (FeNO) measurements to evaluate airway inflammation. We also considered a range of biological and environmental factors, including allergen sensitization, serum 25-hydroxyvitamin D levels, and urinary metabolites like VOCs, bisphenol, and triclosan. Participants were categorized by living floors: banjihas, first-fifth floors, and sixth floors or higher.Results: Twenty-five children (4.3%) lived in banjihas, 311 (54.1%) on the first to fifth floor, and 239 (41.6%) on the sixth floor or above. Despite similar levels of allergen sensitization and urinary pollutant metabolite levels across all groups, banjiha dwellers showed significantly higher total airway resistance (adjusted &1: 0.633, 95%CI: 0.156, 1.109; P = 0.009) and a greater prevalence of elevated FeNO levels (> 35 ppb) (P = 0.033). These findings persisted after adjusting for critical factors like height, gender, BMI z-score, and birth conditions.Conclusion: Children in banjihas exhibit elevated airway resistance and FeNO levels independently of allergen sensitization or pollution exposure, underscoring the necessity for enhanced focus on their respiratory health in such living conditions.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Home-based up-dosing of wheat oral immunotherapy: Real-world effectiveness and predictive factor analysis. 基于家庭的小麦口服免疫疗法：实际效果和预测因素分析。

IF 2.3 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-07-14 DOI: 10.12932/AP-130224-1783

Jiwon Kim, Minyoung Jung, Sehun Jang, Sanghee Shin, Jeongmin Song, Sukyung Kim, Ji Young Lee, Hyun Mi Kim, Yeonghee Kim, Min Hee Lee, Su Jin Lee, Minji Kim, Jihyun Kim, Kangmo Ahn

{"title":"Home-based up-dosing of wheat oral immunotherapy: Real-world effectiveness and predictive factor analysis.","authors":"Jiwon Kim, Minyoung Jung, Sehun Jang, Sanghee Shin, Jeongmin Song, Sukyung Kim, Ji Young Lee, Hyun Mi Kim, Yeonghee Kim, Min Hee Lee, Su Jin Lee, Minji Kim, Jihyun Kim, Kangmo Ahn","doi":"10.12932/AP-130224-1783","DOIUrl":"10.12932/AP-130224-1783","url":null,"abstract":"Background: Wheat allergy is one of the most prevalent allergens in Korea, decreasing quality of life and causing nutritional repercussions.Objective: We aimed to investigate the efficacy and safety of the home-based wheat oral immunotherapy (OIT) using wheat noodles in children with a wheat allergy.Methods: We conducted a retrospective study involving 72 children aged 3 to 17 years diagnosed with a wheat allergy. Patients received wheat OIT using wheat noodles (n = 50) and were compared with a historical control group (n = 22). Baseline characteristics, adverse events, and immunological changes were assessed. Predictors of successful desensitization were identified using logistic regression analysis.Results: Among 50 patients completing the up-dosing phase, 82.0% achieved desensitization to 2,400 mg of wheat protein, compared to 4.5% in the control group (p < 0.001). During the up-dosing period, the median number of adverse reactions per person was 2, and anaphylaxis occurred in 30.0% (15/50). However, there were no life-threatening adverse events. In multivariable analysis, the presence of asthma (adjusted odds ratio [aOR], 8.88; 95% confidence interval [CI], 1.10-71.97; p = 0.041) and a higher ratio of specific IgE (sIgE) to ω-5-gliadin and total IgE (aOR 19.09, 95%CI 1.21-300.80, p = 0.036) were significantly associated with treatment outcomes of wheat OIT.Conclusion: Our study showed the safety and efficacy of home-based wheat OIT using boiled noodles in Korean children with wheat allergies. Careful consideration is warranted for patients with elevated baseline sIgE to ω-5-gliadin to total IgE ratio and a history of asthma.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-sensitization between inhalant allergens and food allergens: the extent, intensity, and age-related shifts. 吸入性过敏原和食物过敏原之间的交叉致敏：程度、强度和与年龄有关的转变。

IF 2.3 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-07-14 DOI: 10.12932/AP-240324-1826

Jae Hoon Cho, Jeffrey D Suh, Jin Kook Kim, Marn Joon Park, Ji Ho Choi

{"title":"Cross-sensitization between inhalant allergens and food allergens: the extent, intensity, and age-related shifts.","authors":"Jae Hoon Cho, Jeffrey D Suh, Jin Kook Kim, Marn Joon Park, Ji Ho Choi","doi":"10.12932/AP-240324-1826","DOIUrl":"https://doi.org/10.12932/AP-240324-1826","url":null,"abstract":"Background: Encountering individuals sensitized to both inhalant and food allergens is challenging in clinical practice. Despite its rarity, studies have documented cross-sensitization between these allergens. However, the extent, diversity, and age-related variations of this phenomenon remain unclear.Objective: Hence, our objective was to investigate a substantial quantity of allergy sensitivity test results in which both inhalant and food allergens were concurrently examined. The primary goal of our study is to calculate the cross-sensitization ratio, with a secondary objective of analyzing this phenomenon across four age groups.Methods: A retrospective analysis was conducted on a multiple-antigen simultaneous test (MAST) obtained from a domestic laboratory medicine facility and comprising 55 food allergens and 49 inhalant allergens from 368,156 individuals aged 1 to 89. By calculating the cross-sensitization ratio, the degree of cross-sensitization between each food allergen and inhalant allergen was determined. Further subgroup analysis was conducted to ascertain the cross-sensitization ratio between the four subgroups categorized by age.Results: The median cross-sensitization ratio between food and inhalant allergens was 5.14, indicating a significant level of cross-sensitization. The cross-sensitization ratio was greatest among pollen allergens and plant-derived food allergens, followed by between some animal aeroallergens and meat/fish/dairy/poultry food allergens. The degree of overall cross-sensitization was least prominent in adolescents, greater in adults and children, and most pronounced in the elderly.Conclusion: Our findings reveal that various inhalant and dietary allergens have considerable cross-sensitivity, with the elderly having the highest degree of cross-sensitivity and adolescents the lowest.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Level of asthma control in children and adolescents before and during the COVID-19 pandemic. COVID-19 大流行之前和期间儿童和青少年的哮喘控制水平。

IF 2.3 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-07-14 DOI: 10.12932/AP-180124-1770

Warinda Panichaporn, Kamolthip Boonard, Kantima Kanchanapoomi, Witchaya Srisuwatchari, Orathai Jirapongsananuruk, Nualanong Visitsunthorn, Punchama Pacharn

{"title":"Level of asthma control in children and adolescents before and during the COVID-19 pandemic.","authors":"Warinda Panichaporn, Kamolthip Boonard, Kantima Kanchanapoomi, Witchaya Srisuwatchari, Orathai Jirapongsananuruk, Nualanong Visitsunthorn, Punchama Pacharn","doi":"10.12932/AP-180124-1770","DOIUrl":"10.12932/AP-180124-1770","url":null,"abstract":"Background: During the COVID-19 pandemic, national lockdowns were implemented worldwide. Asthma control was reported to have improved. However, some patients lost follow-up from the clinic because they intended to avoid crowds at the hospital.Objective: To evaluate the level of asthma control during the COVID-19 pandemic and explore factors influencing asthma outcomes.Methods: Subjects 8-18 years old from our previous study in 2019 were recruited. The data during the pandemic period were collected between June 2021 - May 2023. The level of asthma control was compared before and during the pandemic. We also evaluated inhaled corticosteroid (ICS) adherence and factors related to poor asthma control during the COVID-19 pandemic.Results: One hundred and three subjects were enrolled. Asthma control levels remained relatively stable during the pandemic. However, an asthma exacerbation was significantly decreased from 36 (36.3%) in 2019 to 19 (19.2%)and 15 (15.1%) in 2021 and 2022 (p = 0.012, p < 0.001), respectively. Spirometry results demonstrated improved pre-bronchodilator FEV1 (89.91 ± 11.02 vs. 101.91 ± 14.11, p < 0.001). The factors related to the poor asthma outcome were not wearing a face mask (aOR = 8.52, 95%CI 1.26-57.79) and previously poor-controlled by the ACT score (aOR = 2.55, 95%CI 1.41-4.63). The median adherence rate during the pandemic was 85%. The main reasons for poor adherence were hectic lifestyle and misunderstandings of disease.Conclusion: Asthma exacerbation was significantly decreased during the lockdown. Not wearing a face mask and previously poorly controlled by the ACT score are related to poor asthma outcomes.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of anaphylaxis from tertiary-care hospital in lower northern Thailand: A ten-year retrospective cross-sectional study. 泰国下北部三级医院过敏性休克的特征：一项为期十年的回顾性横断面研究。

IF 2.3 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-07-14 DOI: 10.12932/AP-010424-1831

Suwannee Uthaisangsook, Nichayada Hirunwattana, Chayanis Kajornrojanaruk, Nadda Padsee

{"title":"Characteristics of anaphylaxis from tertiary-care hospital in lower northern Thailand: A ten-year retrospective cross-sectional study.","authors":"Suwannee Uthaisangsook, Nichayada Hirunwattana, Chayanis Kajornrojanaruk, Nadda Padsee","doi":"10.12932/AP-010424-1831","DOIUrl":"https://doi.org/10.12932/AP-010424-1831","url":null,"abstract":"Background: The prevalence and etiology of anaphylaxis vary based on geographic regions, study design, and definition used. Anaphylaxis leading to emergency department visits and hospitalizations has increased worldwide.Objective: The prevalence and etiology of anaphylaxis vary based on geographic regions, study design, and definition used. Anaphylaxis leading to emergency department visits and hospitalizations has increased worldwide.Methods: A cross-sectional retrospective analysis of medical records from patients with ICD-10 confirmed anaphylaxis was performed at Naresuan University Hospital between March 2011 and February 2021.Results: We identified 439 anaphylaxis episodes in 381 patients within 10 years. The average annual occurrence rates of anaphylactic episodes were 25.0 per 100,000 outpatient and emergency department visits and 11.2 per 100,000 inpatient visits. Both pediatric and adult anaphylaxis events increased annually, from 13.3 (children: 20.5, adults: 12.4) in 2012 to 46.6 (children: 52.6, adults: 46.1) episodes per 100,000 visits in 2021. Peak incidence was observed in adolescents and young adults. Food was the most common trigger, with shrimp and fried insects being predominant. Risk factors for severe anaphylaxis were underlying cardiovascular diseases, drug triggers, and wheezing. Epinephrine was administered in 98.4% of all episodes. Although, there were no fatalities, only 11.4% of patients received prescriptions for self-injectable epinephrine.Conclusion: The study underscores an increasing trend of anaphylaxis affecting both children and adults in lower northern Thailand, with shrimp and fried insects as common triggers.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prostaglandin E2 inhibits the differentiation of T regulatory cells by Peroxisome Proliferator-Activated Receptor-Gamma during allergic rhinitis. 前列腺素 E2 通过过氧化物酶体增殖激活受体-γ抑制过敏性鼻炎期间 T 调节细胞的分化。

IF 5 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-06-15 DOI: 10.12932/AP-210923-1695

Yurong Ju, Lisha Li, Ye Zhao, Zhifeng Yang, Ziheng Zhao, Zhaofei Wu, Xuewen Pang, Wei Wang

{"title":"Prostaglandin E2 inhibits the differentiation of T regulatory cells by Peroxisome Proliferator-Activated Receptor-Gamma during allergic rhinitis.","authors":"Yurong Ju, Lisha Li, Ye Zhao, Zhifeng Yang, Ziheng Zhao, Zhaofei Wu, Xuewen Pang, Wei Wang","doi":"10.12932/AP-210923-1695","DOIUrl":"https://doi.org/10.12932/AP-210923-1695","url":null,"abstract":"Background: Allergic rhinitis (AR) represents a significant global health concern that can give rise to numerous diseases and result in labor productivity. T regulatory (Treg) cells are pivotal players in the pathogenesis of AR, and their deficiencies are closely related to Prostaglandin E2 (PGE2). However, the downstream mechanisms of this relationship remain poorly understood.Objective: This study aims to investigate the inhibitory mechanisms through which PGE2 impacts the differentiation of Treg cells.Methods: We compared the differentiation of Treg cells from naïve CD4+ T cells of AR patients and healthy controls, with or without the presence of PGE2 by flow cytometry. Intracellular cAMP concentration, mRNA and protein levels of cyclic-AMP dependent protein kinase A (PKA), as well as their downstream target, Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) were examined in Treg cells from AR and healthy donors. AR mouse model was established by pollen administration.Results: PGE2 suppressed the differentiation of Treg cells from human naïve CD4+ T cells through the EP4 receptor. Furthermore, in AR patients and AR mouse, the expression of EP4 receptor were observed enhanced. The PGE2-EP4 signal was carried out by activating cAMP-PKA signaling pathway. Subsequently, phospholated PKA would suppress PPAR-γ expression. Treatment of Pioglitazone, a PPAR-γ agonist, was demonstrated to rescue the differentiation of Treg and help alleviate inflammation in the AR mouse model.Conclusion: In AR disease, the PGE2-EP4 signaling exerts an inhibitory effect on Treg differentiation by influencing the cAMP-PKA pathway and its downstream target PPAR-γ.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141327187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the clinical performance of multiple serum sIgE detection systems based on component-resolved diagnosis. 基于成分分辨诊断的多种血清 sIgE 检测系统临床性能评估。

IF 5 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-06-15 DOI: 10.12932/AP-290923-1702

Zhifeng Huang, Aoli Li, Ziyu Yin, Tong Chen, Hui Gan, Zhiwei Lin, Mingshan Xue, Huimin Huang, Baoqing Sun

{"title":"Evaluation of the clinical performance of multiple serum sIgE detection systems based on component-resolved diagnosis.","authors":"Zhifeng Huang, Aoli Li, Ziyu Yin, Tong Chen, Hui Gan, Zhiwei Lin, Mingshan Xue, Huimin Huang, Baoqing Sun","doi":"10.12932/AP-290923-1702","DOIUrl":"https://doi.org/10.12932/AP-290923-1702","url":null,"abstract":"Background: Serum allergen-specific IgE (sIgE) detection is an important tool in the diagnosis of allergic diseases. However, the absence of international standards for sIgE detection systems raises questions about the comparability of different systems.Objective: This study aims to evaluate three common allergen sIgE detection systems, with a primary focus on detecting dust mite allergens.Methods: We recruited 85 children with rhinitis and 15 healthy control children. The subjects underwent testing with three different sIgE detection systems, including magnetic particle flow fluorescence, magnetic particle chemiluminescence, and protein chip, to detect sIgE levels to HDM extracts. In addition, skin prick testing (SPT) was conducted, and protein chip technology was performed to measure sIgE levels to component proteins.Results: Our findings reveal strong consistency between SPT and the three in vitro detection systems, with consistency exceeding 71.76% for dust mite allergens. Moreover, there was excellent consistency and RAST class consistency among the three in vitro detection systems, with scores exceeding 94.12% and 89.00%, respectively. And for the 13 additional allergens crude extracts sIgE simultaneously detected by systems 1 and 2, the results showed that the consistency of both systems was above 87.00%, and the RAST class consistency was above 82.00%.Conclusion: The three serum sIgE detection systems exhibited an approximate 80% concordance rate with SPT in identifying dust mite allergens. Furthermore, these systems demonstrated excellent consistency and RAST class consistency among themselves. These findings suggest that the three assays introduced in this study are interchangeable in allergen diagnosis.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141327185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the Immunogenetics of STAT Proteins: Clinical Perspectives on Gain-of-Function and Loss-of-Function Variants. 揭示 STAT 蛋白的免疫遗传学：功能增益和功能缺失变异的临床视角。

IF 2.3 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-06-01 DOI: 10.12932/AP-270124-1776

Kornvalee Meesilpavikkai, Nattiya Hirankarn, Virgil A S H Dalm, P Martin van Hagen, Willem A Dik, Hanna IJspeert

引用次数: 0

Effect of fexofenadine/pseudoephedrine combination tablet on nasal obstruction in patients with allergic rhinitis using rhinomanometry: A randomized controlled trial. 非索非那定/伪麻黄碱复方片对过敏性鼻炎患者鼻阻塞的影响：随机对照试验。

IF 2.3 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-06-01 DOI: 10.12932/AP-160920-0963

Yosuke Nakamura, Yuko Yokoyama, Satoshi Koyama, Kazunori Fujiwara, Motoki Nakamori, Taihei Fujii, Tadao Enomoto, Hiromi Takeuchi

{"title":"Effect of fexofenadine/pseudoephedrine combination tablet on nasal obstruction in patients with allergic rhinitis using rhinomanometry: A randomized controlled trial.","authors":"Yosuke Nakamura, Yuko Yokoyama, Satoshi Koyama, Kazunori Fujiwara, Motoki Nakamori, Taihei Fujii, Tadao Enomoto, Hiromi Takeuchi","doi":"10.12932/AP-160920-0963","DOIUrl":"10.12932/AP-160920-0963","url":null,"abstract":"Background: A fexofenadine/pseudoephedrine combination tablet (F/P) is an optimal product for nasal obstruction. It contains fexofenadine hydrochloride, a histamine H1-receptor antagonist for sneezing and rhinorrhea and pseudoephedrine hydrochloride, an α-adrenergic agonist. The effect of an antihistamine-decongestant on nasal obstruction has been demonstrated in previous studies, but onset of action and efficacy data on nasal obstruction are limited.Objective: We estimated the efficacy of F/P on nasal obstruction in patients with house dust mite-induced allergic rhinitis (AR) versus fexofenadine (F) using objective methods.Methods: In this single-center, single-dose, prospective, randomized, parallel-group study, 24 adult patients with a history of at least 2 years of AR and nasal obstruction were randomized to receive F/P or F. The effect on nasal obstruction was evaluated using nasal airflow and visual analog scale (VAS) score measured at 30-minute intervals before and for 8 hours after dosing. The primary end point was onset of action, based on a comparison of absolute change from baseline in nasal airflow between F/P and F. The protocol was registered in a clinical trial registry as UMIN 000041845.Results: The onset of action for F/P was 30 minutes based on nasal airflow and 60 minutes based on VAS. F/P maintained a significant beneficial effect after onset of effect, while F showed no significant change during the test period.Conclusions: We found F/P had a clear effect on nasal obstruction associated with perennial AR when compared with F. There was a time lag in nasal airflow improvement and nasal obstruction relief.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25411602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0