Asian Pacific journal of allergy and immunology最新文献_第2页

Do aggravating rhinologic symptoms at work indicate occupational exposure? A cross-sectional outpatient clinic study. 工作时鼻部症状加重是否表明存在职业暴露？一项横断面门诊研究。

IF 2.3 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2025-06-01 DOI: 10.12932/AP-070621-1151

Maija Ylivuori, Liisa Airaksinen, Harri Sintonen, Risto P Roine, Maija Hytönen, Paula Virkkula

{"title":"Do aggravating rhinologic symptoms at work indicate occupational exposure? A cross-sectional outpatient clinic study.","authors":"Maija Ylivuori, Liisa Airaksinen, Harri Sintonen, Risto P Roine, Maija Hytönen, Paula Virkkula","doi":"10.12932/AP-070621-1151","DOIUrl":"10.12932/AP-070621-1151","url":null,"abstract":"Background: Air impurities can exacerbate or cause rhinologic diseases. However, only a few studies have assessed rhinologic patients' symptoms at work.Objective: This study surveys the impact of work on rhinology clinic patients' quality of life in relation to work-related respiratory exposures. In addition, we surveyed patients' sick leave periods.Methods: We recruited adult employed rhinology patients referred to the otorhinolaryngology clinic. A total of 177 patients were included. We collected data on patients' medical history, rhinologic disease-specific and generic quality of life, current or most recent job title, a description of current work, nasal symptoms, possible worked-related symptom triggers and sick leave periods during the preceding year.Results: In total, 101 (57.1%) patients reported exacerbated rhinologic symptoms at work and reported more severe rhinologic disease and a lower disease-specific quality of life compared to non-work-related rhinologic patients (P = 0.008). A minority, 24.3% of our patients were exposed to any specific occupational respiratory sensitizer or irritant at work. The mean sick leave period due to rhinologic disease was 7.7 days per year.Conclusions: Exposure to specific occupational sensitizers or irritants did not associate with increasing symptoms at work or quality of life amongst our patients. Most rhinology patients reported exacerbated symptoms at work. They appeared to be more symptomatic than the rest of the patients and, therefore, possibly hyperreactive to unspecific respiratory triggers at work. Rhinologic diseases caused our patients a marked burden with high work absenteeism.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"227-233"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39763038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anxiety and depression are associated with reduced quality of life and increased cough severity in chronic cough. 慢性咳嗽患者的焦虑和抑郁与生活质量下降和咳嗽严重程度增加有关。

IF 2.3 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2025-06-01 DOI: 10.12932/AP-110721-1184

Yiting Li, Chao Cao, Yunxin Ji, Suling Xu

{"title":"Anxiety and depression are associated with reduced quality of life and increased cough severity in chronic cough.","authors":"Yiting Li, Chao Cao, Yunxin Ji, Suling Xu","doi":"10.12932/AP-110721-1184","DOIUrl":"10.12932/AP-110721-1184","url":null,"abstract":"Background: Chronic cough has led to a substantial socioeconomic burden globally. Psychiatric comorbidities are reported in many chronic diseases. However, the relationship between mental disorders and chronic cough remains unclear.Objective: This study aims to explore the relationship between anxiety, depression and chronic cough.Methods: 238 patients (96 males and 142 females) with chronic cough were enrolled in this study. Responses were collected using the Cough Visual Analog Scale, the Hospital Anxiety and Depression Scale (HADS), and the Leicester Cough Questionnaire.Results: According to the HADS, 9.2% and 6.3% of patients were identified as having anxiety and depression, respectively. Patients with anxiety and depression were more likely to have a reduced quality of life. Cough duration, cough severity and history of anaphylaxis were found to be positively associated with reduced quality of life in patients with chronic cough. Cough severity was considered as a dependent risk factor for symptoms of anxiety and depression. Also, more severe symptoms of anxiety were observed in patients reported that a history of anaphylaxis. More female patients had a history of anaphylaxis and reduced cough-related quality of life.Conclusions: Symptoms of anxiety and depression, longer cough duration, more severe cough and a history of anaphylaxis may reduce the quality of life in patients with chronic cough. Cough severity and a history of anaphylaxis are associated with symptoms of anxiety.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":"1 1","pages":"337-345"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42459439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prostaglandin E2 inhibits the differentiation of T regulatory cells by Peroxisome Proliferator-Activated Receptor-Gamma during allergic rhinitis. 前列腺素 E2 通过过氧化物酶体增殖激活受体-γ抑制过敏性鼻炎期间 T 调节细胞的分化。

IF 2.3 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2025-06-01 DOI: 10.12932/AP-210923-1695

Yurong Ju, Lisha Li, Ye Zhao, Zhifeng Yang, Ziheng Zhao, Zhaofei Wu, Xuewen Pang, Wei Wang

{"title":"Prostaglandin E2 inhibits the differentiation of T regulatory cells by Peroxisome Proliferator-Activated Receptor-Gamma during allergic rhinitis.","authors":"Yurong Ju, Lisha Li, Ye Zhao, Zhifeng Yang, Ziheng Zhao, Zhaofei Wu, Xuewen Pang, Wei Wang","doi":"10.12932/AP-210923-1695","DOIUrl":"10.12932/AP-210923-1695","url":null,"abstract":"Background: Allergic rhinitis (AR) represents a significant global health concern that can give rise to numerous diseases and result in labor productivity. T regulatory (Treg) cells are pivotal players in the pathogenesis of AR, and their deficiencies are closely related to Prostaglandin E2 (PGE2). However, the downstream mechanisms of this relationship remain poorly understood.Objective: This study aims to investigate the inhibitory mechanisms through which PGE2 impacts the differentiation of Treg cells.Methods: We compared the differentiation of Treg cells from naïve CD4+ T cells of AR patients and healthy controls, with or without the presence of PGE2 by flow cytometry. Intracellular cAMP concentration, mRNA and protein levels of cyclic-AMP dependent protein kinase A (PKA), as well as their downstream target, Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) were examined in Treg cells from AR and healthy donors. AR mouse model was established by pollen administration.Results: PGE2 suppressed the differentiation of Treg cells from human naïve CD4+ T cells through the EP4 receptor. Furthermore, in AR patients and AR mouse, the expression of EP4 receptor were observed enhanced. The PGE2-EP4 signal was carried out by activating cAMP-PKA signaling pathway. Subsequently, phospholated PKA would suppress PPAR-γ expression. Treatment of Pioglitazone, a PPAR-γ agonist, was demonstrated to rescue the differentiation of Treg and help alleviate inflammation in the AR mouse model.Conclusion: In AR disease, the PGE2-EP4 signaling exerts an inhibitory effect on Treg differentiation by influencing the cAMP-PKA pathway and its downstream target PPAR-γ.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"214-226"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141327187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allergic rhinitis in remission with house dust mite subcutaneous immunotherapy. 过敏性鼻炎通过屋尘螨皮下免疫疗法得到缓解。

IF 2.3 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2025-06-01 DOI: 10.12932/AP-140224-1785

Supamas Harintajinda, Natchanun Klangkalya, Watcharoot Kanchongkittiphon, Ticha Rerkpattanapipat, Saowanee Kerddonfak, Wiparat Manuyakorn

{"title":"Allergic rhinitis in remission with house dust mite subcutaneous immunotherapy.","authors":"Supamas Harintajinda, Natchanun Klangkalya, Watcharoot Kanchongkittiphon, Ticha Rerkpattanapipat, Saowanee Kerddonfak, Wiparat Manuyakorn","doi":"10.12932/AP-140224-1785","DOIUrl":"10.12932/AP-140224-1785","url":null,"abstract":"Background: House dust mite subcutaneous immunotherapy (HDM SCIT) is a therapeutic option for allergic rhinitis (AR) patients who are unable to properly manage symptoms with standard medications.Objective: This study aimed to determine long-term efficacy and identify predictive factors in the clinical remission of AR patients who completed and discontinued HDM SCIT.Methods: This study included 240 AR patients, who completed a three-year course of HDM SCIT at two tertiary hospitals and were currently being discontinued. We followed-up the patients to ask about their current symptoms and allergy medication. Clinical remission was defined by patients who no longer required daily intranasal steroid or oral antihistamine. We compared patients in clinical remission to those still taking medication.Results: The enrolled patients had a median age of 21.0 (11.0-36.0) years at the time they began HDM SCIT. The clinical remission of AR was achieved in 174 (72.5%) patients. Starting HDM SCIT before the age of 15 and not having asthma were identified as significant and independent predictors of remission (aOR 4.44; 95%CI, 1.72-11.50; p-value 0.002, and 2.67, 95%CI 1.00-7.12; p-value 0.049), respectively, as determined by multivariate logistic regression analysis. There were no significant differences in HDM SCIT duration or sensitization patterns between patients in remission and those on medication after discontinuing HDM SCIT for at least one year.Conclusion: HDM SCIT exhibited persistent long-term efficacy after treatment discontinuation. Starting HDM SCIT before the age of 15 and without asthma comorbidity might be predictors of AR remission with HDM SCIT.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"189-197"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensitization profiles of aeroallergens among allergic rhinitis patients in central China: A six-year real-world study. 中国中部变应性鼻炎患者空气过敏原的致敏特征：一项为期6年的真实世界研究。

IF 2.3 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2025-06-01 DOI: 10.12932/AP-070125-2002

Li Le, Luo Chunhua, Chen Hao, Wang Yin, Liu Jin, Xu Qingxiu, Zhu Rongfei

{"title":"Sensitization profiles of aeroallergens among allergic rhinitis patients in central China: A six-year real-world study.","authors":"Li Le, Luo Chunhua, Chen Hao, Wang Yin, Liu Jin, Xu Qingxiu, Zhu Rongfei","doi":"10.12932/AP-070125-2002","DOIUrl":"10.12932/AP-070125-2002","url":null,"abstract":"Background: Environmental changes have led to shifts in allergen sensitization patterns globally.Objective: To assess changes in aeroallergen sensitization profiles among AR patients in Yichang, a city located in central China along the Yangtze River and develop an optimized allergen panel for the diagnosis of AR through specific IgE (sIgE) testing.Methods: This retrospective study encompassed all patients with suspected AR who sought care at a university hospital in Yichang between 2018 and 2023 and underwent IgE testing. Demographic and sIgE data were collected.Results: A total of 11,855 patients were included in the study, with 7,453 (62.88%) testing positive for at least one allergen. The predominant allergen identified was house dust mite (HDM), with sensitization rates of 58.65% for D. pteronyssinus and 58.63% for D. farinae. Notably, sensitization to animal dander showed a significant increase, with cat dander rising from 4.41% in 2018 to 12.50% in 2023, and dog dander from 4.41% to 10.42%. Sensitization rates for various allergens also exhibited fluctuations, with seasonal peaks observed: HDM (summer/autumn), molds (spring/autumn), and Blattella germanica (autumn/winter). A five-allergen panel (HDM, B. germanica, mixed animal dander, mixed molds) identified over 95% of sensitized patients.Conclusions: HDM remains the primary allergen among AR patients in this area, with rising sensitization to animal dander. A five-allergen panel effectively detects most sensitized patients.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"178-188"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medication adherence, sensory attributes, and adverse effects of intranasal corticosteroids in allergic rhinitis patients: A systematic review and meta-analysis. 过敏性鼻炎患者的用药依从性、感觉属性和鼻内皮质类固醇的不良反应：系统回顾和荟萃分析。

IF 2.3 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2025-06-01 DOI: 10.12932/AP-040424-1834

Baharudin Abdullah, Farah Dayana Zahedi, Aneeza Hamizan, Salina Husain

{"title":"Medication adherence, sensory attributes, and adverse effects of intranasal corticosteroids in allergic rhinitis patients: A systematic review and meta-analysis.","authors":"Baharudin Abdullah, Farah Dayana Zahedi, Aneeza Hamizan, Salina Husain","doi":"10.12932/AP-040424-1834","DOIUrl":"10.12932/AP-040424-1834","url":null,"abstract":"Background: Intranasal corticosteroid (INCS) remains the primary treatment for allergic rhinitis (AR). Understanding adherence, safety concerns and sensory preferences is crucial for optimal care.Objective: This review aims to determine medication adherence, sensory attributes and adverse effects of INCS in AR patients.Methods: A systematic search of PubMed, Web of Science, Scopus, and Cochrane database was conducted for English articles published from 2004 to 2023. Eligibility includes clinical trials and observational studies with adult patients (18 years old or older) receiving INCS for AR (both intermittent and persistent).Results: Thirty-one studies with 10,582 patients, comprising 10 cross-sectional studies and 21 randomized controlled trials (RCT) were included. Adherence rates ranged from 28% to 87%, with an average of 55.8%. Forgetfulness was the primary reason for non-adherence (63.1-77.8%), followed by adverse events (26.4-61.5%) and fear of adverse events (3.8-31.5%). Scent (38%), taste (28.5%), or aftertaste (24.3%) were the main differentiators for sensory attribute, with varying levels of intensity and preferences for each INCS. Common adverse events encompass epistaxis, nasal dryness/irritation, headache and nasopharyngitis. A meta-analysis of eight RCT detected no significant difference in adverse events between the INCS and control groups (risk ratio 1.05; 95% confidence interval, 0.88-1.24; p = 0.61).Conclusions: The findings of this review indicate that medication adherence to INCS is not optimal, with non-adherence mostly attributed to forgetfulness, preferences for sensory attributes, and unpleasant effects associated with INCS. The underlying factors should be addressed as part of a multimodal strategy to improve adherence.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"151-167"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compound D from Zingiber cassumunar Roxb. attenuated type 2 inflammatory cytokine-induced tight junction disruption in airway epithelial cells. 从 Zingiber cassumunar Roxb.中提取的化合物 D 可减轻 2 型炎症细胞因子诱导的气道上皮细胞紧密连接破坏。

IF 2.3 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2025-06-01 DOI: 10.12932/AP-180624-1873

Orapan Poachanukoon, Pasistha Termworasin, Phuntila Tharabenjasin, Thaweephol Dechatiwongse Na Ayudhya, Aekkacha Moonwiriyakit

{"title":"Compound D from Zingiber cassumunar Roxb. attenuated type 2 inflammatory cytokine-induced tight junction disruption in airway epithelial cells.","authors":"Orapan Poachanukoon, Pasistha Termworasin, Phuntila Tharabenjasin, Thaweephol Dechatiwongse Na Ayudhya, Aekkacha Moonwiriyakit","doi":"10.12932/AP-180624-1873","DOIUrl":"10.12932/AP-180624-1873","url":null,"abstract":"Background: Barrier disruption in the airway mucosae has been implicated in allergic type 2 inflammatory diseases such as allergic rhinitis and asthma. Zingiber cassumunar Roxb. has long been used in traditional medicine to treat allergic diseases. The active compound, namely compound D, has proven anti-inflammatory benefits. However, the effect of compound D on allergic inflammation remains unclear.Objective: This study aimed to investigate the protective effects of compound D on allergic inflammation-induced barrier disruption.Methods: Type 2 cytokine (IL-4 and IL-13)-exposed 16HBE human bronchial epithelial cells were treated with compound D. After 24, 48, and 72 h, cytotoxicity, epithelial integrity, and tight junction (TJ) disruption were determined by viability assays, transepithelial electrical resistance measurement, and immunofluorescence staining, respectively. Moreover, the mechanism of action of compound D was investigated by western blotting.Results: Compound D (100 and 200 µM) prevented IL-4/IL-13-induced barrier disruption at 24 and 48 h with no effect on cell viability. Compound D rescued the localization of ZO-1 to pericellular areas, and the barrier-protective effect of compound D was mediated by inhibiting STAT6 signaling.Conclusions: Compound D can suppress IL-4/IL-13-induced epithelial inflammation and TJ disruption through STAT6 inhibition. The agent is a promising candidate for therapeutic or adjunctive treatment of type 2 inflammation-associated diseases, including asthma.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"320-327"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atmospheric environment and persistence of pediatric asthma: A population-based cohort study. 大气环境与小儿哮喘的持续性：一项基于人群的队列研究。

IF 2.3 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2025-06-01 DOI: 10.12932/AP-170623-1635

Hwan Soo Kim, Kyunghoon Kim, Eun Hee Rhee, Woo Kyung Kim, Dae Jin Song, Ji Soo Park, Dong In Suh, Jisun Yoon, Eun Lee, Seung Won Lee, Jin Tack Kim, Dae Hyun Lim, Hey Sung Baek, Meeyong Shin, Ji Won Kwon, Gwang Cheon Jang, Ju Hee Seo, Sung Il Woo, Hyung Young Kim, Ju Suk Lee, Jinho Yu, Hyeon-Jong Yang, Young Yoo Yoo

{"title":"Atmospheric environment and persistence of pediatric asthma: A population-based cohort study.","authors":"Hwan Soo Kim, Kyunghoon Kim, Eun Hee Rhee, Woo Kyung Kim, Dae Jin Song, Ji Soo Park, Dong In Suh, Jisun Yoon, Eun Lee, Seung Won Lee, Jin Tack Kim, Dae Hyun Lim, Hey Sung Baek, Meeyong Shin, Ji Won Kwon, Gwang Cheon Jang, Ju Hee Seo, Sung Il Woo, Hyung Young Kim, Ju Suk Lee, Jinho Yu, Hyeon-Jong Yang, Young Yoo Yoo","doi":"10.12932/AP-170623-1635","DOIUrl":"10.12932/AP-170623-1635","url":null,"abstract":"Background: Asthma is a heterogeneous disease with different outcomes. For children with asthma at the age of 7 years, 67-75% are symptom-free as adults. Data on the important link between childhood and adult asthma are sparse.Objective: We aimed to investigate factors associated with persistence of childhood asthma over three years of follow-up by linking data between Korea childhood Asthma Study (KAS) and their matched claims data from Health Insurance Review and Assessment Service (HIRA).Methods: We analyzed data from 450 preadolescent children aged 7 to 10 years and classified them into remission or persistence groups. Baseline clinical characteristics and exposure to air pollution materials including PM2.5 and PM10 during three years of follow-up were compared. The main outcome was asthma persistence which was defined as the presence of asthma episodes with healthcare utilization and prescription of asthma medications within three years after KAS enrollment.Results: At the third year of follow-up, after stepwise regression analysis, lower age at enrollment (adjusted odds ratio (aOR): 0.79; 95% confidence interval (CI): 0.64-0.96), male sex (aOR: 1.66; 95%CI: 1.05-2.63), proximity from an air-polluting facility (aOR: 2.4; 95%CI: 1.34-4.29), higher level outdoor PM2.5 (aOR: 1.1; 95%CI: 1.02-1.20), and higher rate of doctor-diagnosed food allergy (FA) (aOR: 2.33; 95%CI: 1.06-5.12) were significantly associated with persistence.Conclusion: We discovered various independent risk factors for the persistence of childhood asthma. By linking HIRA claims data, we could clarify risk factors for persistence in a well-defined study population.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"281-289"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139110726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between MTHFR polymorphism, dietary methyl donors, and childhood asthma and atopy. MTHFR 多态性、膳食甲基供体与儿童哮喘和过敏症之间的关系。

IF 2.3 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2025-06-01 DOI: 10.12932/AP-300422-1375

Yean Jung Choi, So-Yeon Lee, Sung-Ok Kwon, Mi-Jin Kang, Ju-Hee Seo, Jisun Yoon, Hyun-Ju Cho, Sungsu Jung, Soo-Jong Hong

{"title":"The association between MTHFR polymorphism, dietary methyl donors, and childhood asthma and atopy.","authors":"Yean Jung Choi, So-Yeon Lee, Sung-Ok Kwon, Mi-Jin Kang, Ju-Hee Seo, Jisun Yoon, Hyun-Ju Cho, Sungsu Jung, Soo-Jong Hong","doi":"10.12932/AP-300422-1375","DOIUrl":"10.12932/AP-300422-1375","url":null,"abstract":"Background: Studies investigating the genetic association of the C677T methylenetetrahydrofolate reductase (MTHFR) genotype and dietary methyl donors with asthma and atopy are limited, and have variable results.Objective: To investigate the effect of dietary methyl donor intake on the risk of childhood asthma and atopy, based on the C677T polymorphism in the MTHFR gene.Methods: This cross-sectional study included 2,333 elementary school children aged 6-8 years across Korea during 2005 and 2006, as part of the first Children's Health and Environmental Research survey. Genotyping for the MTHFR (rs1801133) polymorphism was performed using the TaqMan assay. Multivariable-adjusted logistic regression analysis was performed to determine a descriptive association between the dietary methyl donor intake, MTHFR polymorphism, and childhood asthma and atopy.Results: Intake of dietary methyl donors like folates was significantly associated with a decreased risk of the wheezing symptom, in the past 12 months, and \"ever asthma\" diagnosis, respectively. Vitamin B6 intake was also associated with a decreased atopy risk. The T allele of the MTHFR (rs1801133) gene was significantly associated with a decreased risk of atopy. Increased intakes of folate, vitamin B2, and vitamin B6 were protective factors against atopy, especially in children with the T allele on the MTHFR gene, compared to those with lower intakes and the CC genotype.Conclusions: High intakes of dietary methyl donors were associated with reduced risk of atopy and asthma symptoms. These may have additive effects related to the susceptibility alleles of the MTHFR gene. The clinical implications require evaluation.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"244-253"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10452117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenotype characterization and biomarker evaluation in moderate to severe type 2-high asthma. 中至重度2型高哮喘的表型特征和生物标志物评价。

IF 2.3 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2025-06-01 DOI: 10.12932/AP-021222-1510

Sahoko Imoto, Maho Suzukawa, Yuma Fukutomi, Nobuyuki Kobayashi, Masami Taniguchi, Takahide Nagase, Ken Ohta

{"title":"Phenotype characterization and biomarker evaluation in moderate to severe type 2-high asthma.","authors":"Sahoko Imoto, Maho Suzukawa, Yuma Fukutomi, Nobuyuki Kobayashi, Masami Taniguchi, Takahide Nagase, Ken Ohta","doi":"10.12932/AP-021222-1510","DOIUrl":"10.12932/AP-021222-1510","url":null,"abstract":"Background: There are two major pathological phenotypes of asthma, type 2 (T2)-high and T2-low asthma, which are important in determining treatment strategies. However, the characteristics and phenotypes of T2-high asthma have not yet been fully identified.Objective: This study aimed to identify the clinical characteristics and phenotypes of patients with T2-high asthma.Methods: This study used data from a nationwide asthma cohort study in Japan, NHOM Asthma Study. T2-high asthma was defined as a blood eosinophils count ≥ 300 /μL and/or fractional exhaled nitric oxide level ≥ 25 ppb, and the clinical characteristics and biomarkers were compared between T2-high and T2-low asthma. Furthermore, T2-high asthma was phenotyped via hierarchical cluster analysis using Ward's method.Results: Patients with T2-high asthma were older, less likely to be female, had longer asthma duration, had lower pulmonary function, and had more comorbidities, including sinusitis and SAS. Patients with T2-high asthma showed higher serum thymus and activation-regulated chemokine and urinary leukotriene E4 levels and lower serum ST2 levels than those with T2-low asthma. There were four phenotypes among patients with T2-high asthma: Cluster 1 (youngest, early-onset, and atopic), Cluster 2 (long duration, eosinophilic, and low lung function), Cluster 3 (elderly, female-dominant, and late-onset), and Cluster 4 (elderly, late-onset, and asthma-COPD overlap-dominant).Conclusions: Patients with T2-high asthma have distinct characteristics and four distinct phenotypes, in which eosinophil-dominant Cluster 2 is the most severe phenotype. The present findings may be useful in precision medicine for asthma treatment in the future.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"254-265"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9986738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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