Asian Pacific journal of allergy and immunology最新文献_第10页

A comparison of cell-culture plasticwares for effective human cytokine-induced killer cell culture. 细胞培养塑料器皿对人细胞因子诱导杀伤细胞培养效果的比较。

IF 5 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2023-12-01 DOI: 10.12932/AP-140720-0913

Panwadee Pluangnooch, Chaiphichit Phayangkhe, Kitipong Soontrapa

引用次数: 0

Validity and reliability of the Thai version of Food Allergy Quality of Life Questionnaire - Adult Form (FAQLQ-AF) and Food Allergy Independent Measure - Adult Form (FAIM-AF). 泰国版食品过敏生活质量问卷-成人版（FAQLQ-AF）和食品过敏独立测量-成人版的有效性和可靠性。

IF 5 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2023-10-23 DOI: 10.12932/AP-060323-1559

Chayapat Tangwiwat, Mongkhon Sompornrattanaphan, Torpong Thongngarm, Chamard Wongsa

{"title":"Validity and reliability of the Thai version of Food Allergy Quality of Life Questionnaire - Adult Form (FAQLQ-AF) and Food Allergy Independent Measure - Adult Form (FAIM-AF).","authors":"Chayapat Tangwiwat, Mongkhon Sompornrattanaphan, Torpong Thongngarm, Chamard Wongsa","doi":"10.12932/AP-060323-1559","DOIUrl":"https://doi.org/10.12932/AP-060323-1559","url":null,"abstract":"Background: Food allergy affects the patient's quality of life (QoL) and leads to anxiety and depression. In addition to routine treatment, QoL evaluation should also be performed in patients with food allergies. The validated Food Allergy Quality of Life Questionnaire - Adult Form (FAQLQ-AF) and Food Allergy Independent Measure - Adult Form (FAIM-AF) have been well accepted and available in many languages.Objective: Translate FAQLQ-AF and FAIM-AF into Thai and perform reliability and validity tests in Thai adult patients with food allergies.Methods: The translation process was performed according to the ISPOR Task Force for Translation and Cultural Adaptation. Participants 18 years or older and with physician-diagnosed food allergies were included in the study. Thai versions of FAQLQ-AF and FAIM-AF were administered to participants at baseline and after two weeks. The intraclass correlation coefficient and Cronbach's α coefficient were evaluated to demonstrate both questionnaires' test-retest reliability and internal consistency.Results: The study included 104 participants. The Thai version of FAQLQ-AF and FAIM-AF demonstrated good reliability, with intraclass correlation coefficients of 0.83 (95%CI 0.76, 0.88) and 0.85 (95%CI 0.79, 0.90), respectively. The validity was excellent, with Cronbach's α coefficient of 0.91 and 0.92, respectively. Both questionnaires were moderately correlated (r = 0.69, P < 0.001), but poorly correlated with the 36-Item Short Form Survey, which is usually used to evaluate general health status.Conclusions: To evaluate the QoL in adult patients with food allergies, the Thai versions of FAQLQ-AF and FAIM-AF are valid, reliable, and more suitable than the general questionnaire.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49688588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Benefits of mobile messenger application in caregivers of food allergy children. 移动信使应用程序在食物过敏儿童护理人员中的好处。

IF 5 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2023-10-23 DOI: 10.12932/AP-210423-1592

Kranjana Chayutimaphan, Jetsada Arnin, Adithep Sawatchai, Watcharoot Kanchongkittiphon, Wiparat Manuyakorn

{"title":"Benefits of mobile messenger application in caregivers of food allergy children.","authors":"Kranjana Chayutimaphan, Jetsada Arnin, Adithep Sawatchai, Watcharoot Kanchongkittiphon, Wiparat Manuyakorn","doi":"10.12932/AP-210423-1592","DOIUrl":"https://doi.org/10.12932/AP-210423-1592","url":null,"abstract":"Background: Unintentional exposure is common in children with food allergies.Objective: To assess the benefits of newly developed food allergy application.Methods: Caregivers of children with confirmed immediate reactions to food were enrolled to use the \"Kinchew\" application for one month. Kinchew provides the detail of food allergens after typing the name of specific food in the chat box. Then, the app provides the product image and detail of food allergens. Kinchew also has a menu for recording food diaries and videos on managing food allergies. Kinchew users were asked to assess their confidence in dealing with food allergies assessed by the questionnaire using 5 points Likert scale. The number of patients who experienced allergic reactions from unintentional food exposure was recorded after using Kinchew.Results: Seventy caregivers were enrolled. Wheat was the most common causative food in 67% of the participants. All participants used Kinchew with a total use of 1,754 times, classified as food items searching 1080 times (62%), and recorded their food diary 674 times (38%). The number of patients who experienced allergic reactions from unintentional exposure significantly decreased from 61 (87%) to 31 (44%), p < 0.001.The user's confidence in choosing food improved significantly compared to the baseline score. In the subgroup analysis of the type of causative food, a significant improvement in confidence in food choosing was demonstrated in wheat and multiple food allergy groups.Conclusions: Well-designed food allergy mobile applications could improve caregivers' confidence in dealing with food allergies and reduce unintentional food exposure.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49688584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Articular involvement in Henoch-Schönlein Purpura: A review of literature. Henoch Schönlein Purpura的关节受累：文献综述。

IF 5 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2023-10-23 DOI: 10.12932/AP-220523-1622

Victor Gonzalez-Uribe, Ricardo Martínez-Tenopala, Ana Paula Solórzano-Anduiza, María Fernández-De La Torre, Zaira S Mojica-Gonzalez

{"title":"Articular involvement in Henoch-Schönlein Purpura: A review of literature.","authors":"Victor Gonzalez-Uribe, Ricardo Martínez-Tenopala, Ana Paula Solórzano-Anduiza, María Fernández-De La Torre, Zaira S Mojica-Gonzalez","doi":"10.12932/AP-220523-1622","DOIUrl":"https://doi.org/10.12932/AP-220523-1622","url":null,"abstract":"Background: Henoch-Schönlein purpura (HSP), the most typical kind of pediatric vasculitis, can also affect adults. Over the last 10 years, research has been increasing on improvements in HSP diagnosis, physiopathology, symptoms, and therapy. Joint involvement is highly frequent in this condition; however, it typically undergoes spontaneous resolution and does not lead to long-term complications.Objective: To provide a deeper understanding of the constituting pathogenic mechanisms and clinical presentation of articular involvement, focusing on the effect of neutrophil activation on systemic small vessels.Methods: This literature review utilized a systematic search of academic databases, employing specific keywords to select recent peer-reviewed articles and scholarly sources on the topic.Results: The manifestations of joint involvement in HSP can vary in severity and frequency. Non-steroidal anti-inflammatory medications or acetaminophen are considered the first-line treatment for joint pain; however, corticosteroids may help achieve quick remission. In cases where standard treatment fails or manifestations persist, immunosuppressive drugs like rituximab, methotrexate, cyclophosphamide, or azathioprine have been used.Conclusions: While it tends to resolve without lasting joint damage, accurate diagnosis and appropriate management are crucial to ensure optimal patient outcomes.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49688583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bronchoalveolar lavage fluid cytokines and chemokines changes after bronchial thermoplasty in severe asthma. 严重哮喘支气管热成形术后支气管肺泡灌洗液细胞因子和趋化因子的变化。

IF 5 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2023-10-23 DOI: 10.12932/AP-010523-1599

Nophol Leelayuwatanakul, Pimpayao Sodsai, Ketsupar Jirakran, Vorawut Thanthitaweewat, Virissorn Wongsrichanalai, Thitiwat Sriprasart

{"title":"Bronchoalveolar lavage fluid cytokines and chemokines changes after bronchial thermoplasty in severe asthma.","authors":"Nophol Leelayuwatanakul, Pimpayao Sodsai, Ketsupar Jirakran, Vorawut Thanthitaweewat, Virissorn Wongsrichanalai, Thitiwat Sriprasart","doi":"10.12932/AP-010523-1599","DOIUrl":"https://doi.org/10.12932/AP-010523-1599","url":null,"abstract":"Background: Bronchial thermoplasty (BT) is a non-pharmacological intervention in severe asthma with a well-known mechanism of reducing airway smooth muscle. However, its effect on airway inflammation remains uncertain.Objective: To investigate the effect of BT on bronchoalveolar lavage fluid (BALF) cytokines and chemokines in severe asthma patients before BT, after the first BT, and 12 weeks after BT.Methods: Ten severe asthma patients were recruited, and BALF was obtained from right lower lobe before BT, after the first BT, and 12 weeks after BT. BALF analytes were measured and values were compared among the time points. Lung function, asthma control test (ACT), and asthma quality of life questionnaire (AQLQ) were also measured.Results: Tumor necrosis factor (TNF)-α concentration was significantly decreased after the first BT and significantly increased at 12 weeks after BT. Interleukin-6 (IL-6) and TNF-related apoptosis inducing ligand (TRAIL) concentration were significantly increased at 12 weeks after BT. There were no significant changes in Regulated upon activation, normal T-cell expressed and secreted (RANTES) and transforming growth factor-beta1 (TGF-β1) concentration over time after BT. At 12 weeks after BT, there were significantly greater improvements in the scores on AQLQ (3.93 ± 0.88 to 5.3 ± 0.99, p = 0.002) and ACT (13.6 ± 3.27 to 19 ± 4.44, p = 0.002). The lung function did not differ significantly between pre- and post-BT.Conclusions: BT has limited effect on TNF-α, IL-6, TRAIL, RANTES, and TGF- β1 in BALF suggesting that its clinical benefit is not primarily related to this local airway inflammation. The effect on long-term airway inflammation probably needs further studies.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49688585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulatory T cell and cytokine changes in children undergoing 3 days rush venom immunotherapy. 接受为期3天的蜂毒免疫治疗的儿童的调节性T细胞和细胞因子变化。

IF 5 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2023-09-01 DOI: 10.12932/AP-140520-0843

Tipyapa Rattanamanee, Putthapoom Lumjiaktase, Nanthisa Kemawichanura, Potjanee Kiewgnam, Wanlapa Jotikasthira, Wiparat Manuyakorn

{"title":"Regulatory T cell and cytokine changes in children undergoing 3 days rush venom immunotherapy.","authors":"Tipyapa Rattanamanee, Putthapoom Lumjiaktase, Nanthisa Kemawichanura, Potjanee Kiewgnam, Wanlapa Jotikasthira, Wiparat Manuyakorn","doi":"10.12932/AP-140520-0843","DOIUrl":"10.12932/AP-140520-0843","url":null,"abstract":"Background: Rush venom immunotherapy (VIT) is the recommended treatment for patients with Hymenoptera anaphylaxis. Specific data regarding regulatory T cell and cytokine changes in children receiving rush VIT are sparse.Objective: To study the changing of CD4+CD25+FOXP3+ regulatory T cells (Treg) and serum cytokines in children undergoing 3 days rush VIT.Methods: Children younger than 15 years with systemic reaction to Hymenoptera who had evidence of IgE sensitization to Hymenoptera were enrolled for 3 days rush VIT. Peripheral blood CD4+CD25+FOXP3+ Treg and serum IL-4, IL5, IL-13, IFN-γ, and IL-10 were measured at baseline before rush VIT, achieving maintenance dose, 6 months, and 12 months after reaching maintenance dose. Specific IgE to Hymenoptera was measured at baseline and 12 months after VIT.Results: A total of 15 children (11 boys and 4 girls) aged 6-15 years (mean age, 10 years) were enrolled. Four children were allergic to bee and 11 children were allergic to Vespid. The levels of CD4+CD25+FOXP3+ Treg were significantly increased at 6 months after maintenance dose compared with baseline (6.58% VS 4.01%, p = 0.001). Serum IL-13, IFN-γ, and IL-10 levels did not change significantly from baseline. However, there was a significant reduction of IL-4 in the serum at 12 months after MN when compared to the baseline levels. The systemic reaction requiring epinephrine intramuscular injection occurred only in 1 case who was on Vespid venoms rush VIT.Conclusions: Three days rush VIT provide acceptable systemic reaction and able to increase the number of CD4+CD25+FOXP3+ Treg in children.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38498283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Field sting reactions in patients receiving Hymenoptera venom immunotherapy: real-life experience. 接受膜翅目毒液免疫疗法的患者的野外蜇伤反应：现实生活经验。

IF 5 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2023-09-01 DOI: 10.12932/AP-011221-1282

Zeynep Çelebi Sözener, Reşat Kendirlinan, Pamir Çerçi, Ömür Ayd N, Dilşad Mungan, Sevim Bavbek, Yavuz Demirel, Zeynep Mısırl Gil, Betül Ayşe Sin

{"title":"Field sting reactions in patients receiving Hymenoptera venom immunotherapy: real-life experience.","authors":"Zeynep Çelebi Sözener, Reşat Kendirlinan, Pamir Çerçi, Ömür Ayd N, Dilşad Mungan, Sevim Bavbek, Yavuz Demirel, Zeynep Mısırl Gil, Betül Ayşe Sin","doi":"10.12932/AP-011221-1282","DOIUrl":"10.12932/AP-011221-1282","url":null,"abstract":"Background: Hymenoptera stings can cause systemic allergic reactions (SARs) that are prevented by venom immunotherapy (VIT). Sting challenge tests or field stings are used to evaluate the outcome of VIT.Objective: The aim of the study was to investigate the consequences of field stings in patients during or after completion of VIT, and to identify patients at higher risk.Methods: Patients treated with VIT between 1995 and 2018 were retrospectively evaluated. Contacted patients were invited to the clinic and a questionnaire was conducted regarding the history of field stings.Results: A total of 115 patients (F/M: 45/70, mean age: 38.5 ± 12 years) treated with VIT were included; 74/115 were contacted and asked about field stings after VIT cessation. A history of 73 field stings was reported in 38 patients, 25 of whom were treated with honeybee venom and 13 with common wasp venom. Eighteen of the reactions were SARs [8 with honeybees (1 grade-I, 6 grade-II, 1 grade-III) and 10 with common wasps (1 grade-I, 5 grade-II, 4 grade-III)]. There was no association between the severity of index reactions and field stings with either the honeybee or common wasp. The median duration of VIT was longer in patients showing no reaction than in patients with an SAR. Of the 7 patients on ACE inhibitors or beta-blockers, 1 asthmatic patient developed grade-II SAR due to field stings in the first year of VIT.Conclusions: This study confirms that VIT lasting at least 3 years is effective in preventing SARs after field stings.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41104030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Epoetin-alfa induced pruritic maculopapular eruption: Case report and literature review. Epoetin-alfa诱导的瘙痒性斑丘疹：病例报告和文献复习。

IF 5 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2023-09-01 DOI: 10.12932/AP-040719-0592

Rawi Rueangsri, Wannada Laisuan

{"title":"Epoetin-alfa induced pruritic maculopapular eruption: Case report and literature review.","authors":"Rawi Rueangsri, Wannada Laisuan","doi":"10.12932/AP-040719-0592","DOIUrl":"10.12932/AP-040719-0592","url":null,"abstract":"Background: Erythropoiesis-stimulating agents (ESA) are commonly used in clinical practice to improve anaemia. Despite a number of patients successfully treated without adverse events, the complications have been previously reported.Objective: To report and review the characteristics and management of ESA hypersensitivities.Methods: Case reports and related articles associated with ESA use, published between January 1999 and December 2018, were retrieved through Electronic databases (MEDLINE® and PubMed®).Results: Forty-seven ESA patients with various immediate and delayed hypersensitivity reactions caused by epoetin and pharmaceutical excipients were identified from nineteen studies and one case report in this paper. Fatal hypersensitivity to ESA and ESA-allergic cross-reactivities have been documented. Desensitization or change of EPO molecular structure has been reported as successful methods of re-introducing the drug.Conclusions: ESA hypersensitivity in the various allergic reactions and cross-reactivity have been documented. Desensitization and Epoetin structural changes could be successful methods to re-introduce the drug.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38065781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Iodinated contrast media allergy is rare in patients undergoing sialography. 碘造影剂过敏在接受唾液造影的患者中是罕见的。

IF 5 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2023-09-01 DOI: 10.12932/AP-190720-0923

Chen Nadler, Andra Rettman, Nufar Benvenisty, Yaarit Ribak, Alon Y Hershko, Yuval Tal

{"title":"Iodinated contrast media allergy is rare in patients undergoing sialography.","authors":"Chen Nadler, Andra Rettman, Nufar Benvenisty, Yaarit Ribak, Alon Y Hershko, Yuval Tal","doi":"10.12932/AP-190720-0923","DOIUrl":"10.12932/AP-190720-0923","url":null,"abstract":"Background: Iodinated contrast media allergy is considered as a strong contra-indication for performing sialography. There is little evidence to support this approach.Objective: To evaluate the rate of iodinated contrast media (ICM) allergy in subjects undergoing sialography and to assess the risk for allergic responses in patients with a previous diagnosis of allergy.Methods: We retrospectively reviewed sialo-CBCT studies performed from 2014 to 2019. During the study period we implemented a protocol for performing sialo-CBCT in patients with a prior diagnosis of allergy: 1) Clinical data were collected from a questionnaire and medical records. 2) No premedication was administered but, instead, oxygen, epinephrine and a resuscitation cart were accessible. 3) Following the procedure, each patient was observed for one hour and contacted by telephone 24 hrs later.Results: No allergic responses were documented in the medical records of 1515 subjects following sialo-CBCT studies, including 13 individuals previously diagnosed with ICM allergy. Investigation of the subgroup with prior allergy disclosed that the range of injected volume was between 2 ml to 6.2 ml per patient and that complete secretion of ICM was detected in 7 of 13 patients. In the remainder of subjects, retention rates of 5-50% were observed.Conclusions: Allergic reactions are exceedingly rare following sialo-CBCT studies regardless of a previous diagnosis of allergy. Pre-medication with corticosteroids and antihistamines is usually not warranted.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38673745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Efficacy, patients' perception, and cost of medication in allergic rhinitis with subcutaneous immunotherapy. 皮下免疫疗法治疗过敏性鼻炎的疗效、患者认知和药物成本。

IF 5 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2023-09-01 DOI: 10.12932/AP-040320-0781

Karnsinee Thanborisutkul, Nantika Khodtecha, Prapasri Kulalert, Paskorn Sritipsukho, Orapan Poachanukoon, Sira Nanthapisal

{"title":"Efficacy, patients' perception, and cost of medication in allergic rhinitis with subcutaneous immunotherapy.","authors":"Karnsinee Thanborisutkul, Nantika Khodtecha, Prapasri Kulalert, Paskorn Sritipsukho, Orapan Poachanukoon, Sira Nanthapisal","doi":"10.12932/AP-040320-0781","DOIUrl":"10.12932/AP-040320-0781","url":null,"abstract":"Background: Allergic rhinitis (AR) is the allergic inflammation of nasal mucosa. Treatment of AR includes pharmacotherapy and allergen immunotherapy. Subcutaneous immunotherapy (SCIT) is indicated in inadequate disease control, patient's preference, or impossible allergen avoidance. SCIT is an effective treatment but its cost is comparatively high. Efficacy, patient perception, and cost of medication are rarely explored in Asia.Objective: To study efficacy, patient perception, and cost-benefit of SCIT in AR.Methods: We performed a descriptive cross-sectional study at Thammasat University Hospital, Thailand. AR patients who had been receiving SCIT were interview. Current and recall of AR total symptom score (TSS), quality of life, and perception were scored. Cost of medications before SCIT and current cost were reviewed from the medical records.Results: A total of 142 patients were enrolled. Sixty-eight patients (47.9%) received single allergen; house dust mite was the most common allergen. The median of maintenance phase was 47 months, range 15-142 months. The mean of current TSS was significantly lower than mean TSS before SCIT. Forty-two patients (29.6%) had discontinued SCIT on the day of the interview. After discontinuation of SCIT, TSS was still lower than TSS before SCIT. The average cost of medications including SCIT was lower than that of before SCIT with an average difference of 254.2 USD/year. Sixteen patients (11.3%) experienced systemic reaction, 8 of which had reaction during rush immunotherapy.Conclusions: SCIT is an effective, cost-saving and safe treatment option for AR. Rush immunotherapy can reduce duration of build-up phase but increase the risk of systemic reaction.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38290089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2