Asian Pacific journal of allergy and immunology最新文献_第10页

NLRP3 inhibition attenuates the allergic rhinitis symptoms in a mouse model. 抑制 NLRP3 可减轻小鼠模型的过敏性鼻炎症状。

IF 2.3 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-07-14 DOI: 10.12932/AP-301223-1756

Minhyung Lee, Young-Kyung Ko, Sehun Jang, Chan Hee Gil, Kyoung Mi Eun, Yu-Lian Zhang, Sung-Woo Cho, Dae Woo Kim, Hyun Jik Kim, Chae-Seo Rhee

{"title":"NLRP3 inhibition attenuates the allergic rhinitis symptoms in a mouse model.","authors":"Minhyung Lee, Young-Kyung Ko, Sehun Jang, Chan Hee Gil, Kyoung Mi Eun, Yu-Lian Zhang, Sung-Woo Cho, Dae Woo Kim, Hyun Jik Kim, Chae-Seo Rhee","doi":"10.12932/AP-301223-1756","DOIUrl":"https://doi.org/10.12932/AP-301223-1756","url":null,"abstract":"Background: Recent human and animal studies have demonstrated that Nod-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome is closely involved in the development of allergic diseases.Objective: To identify the mechanism underlying the activation of NLRP3 inflammasome signaling pathway in an ovalbumin (OVA)-induced allergic rhinitis (AR) mice model and to validate the effect of a specific inhibitor of the NLRP3, MCC950.Methods: Mice were divided into three groups and each group consisted of ten mice (saline group, the negative control group; OVA group, the OVA-induced AR model group; and OVA+MCC group, treated with 10 mg/kg MCC950). MCC950 was administered intraperitoneally every second day. Multiple parameters of AR, including NLRP3, caspase-1, interleukin (IL)-1β, and IL-18 were evaluated by using ELISA, RT-qPCR, histopathology, and immunohistochemistry.Results: The mRNA and protein levels of NLRP3, caspase-1, IL-1β and IL-18 were upregulated in the OVA group compared with those of the saline group. MCC950 significantly inhibited the mRNA and protein levels of NLRP3, caspase-1, IL-1β and IL-18 in nasal tissue. Further, AR symptoms and eosinophil count were normalized after MCC950 treatment. However, OVA-specific IgE was not restored in the OVA+MCC group.Conclusion: NLRP3 inflammasome signaling pathway may be an alternative pathway to induce AR symptoms in OVA-induced AR model. MCC950 is a specific inhibitor of NLRP3 cascade, which attenuates AR symptoms regardless of IgE.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Total airway mechanics and fractional exhaled nitric oxide levels of children living in banjihas (semi-basements). 居住在 Banjihas（半地下室）的儿童的总气道力学和呼出一氧化氮分数水平。

IF 2.3 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-07-14 DOI: 10.12932/AP-050224-1780

Ji Hee Kwak, Ju Hee Kim, Eun Kyo Ha, Hye Mi Jee, Youn Ho Shin, Hey Sung Baek, Man Yong Han

{"title":"Total airway mechanics and fractional exhaled nitric oxide levels of children living in banjihas (semi-basements).","authors":"Ji Hee Kwak, Ju Hee Kim, Eun Kyo Ha, Hye Mi Jee, Youn Ho Shin, Hey Sung Baek, Man Yong Han","doi":"10.12932/AP-050224-1780","DOIUrl":"https://doi.org/10.12932/AP-050224-1780","url":null,"abstract":"Background: The ISAAC phase III study in Korea found a higher incidence of wheezing illnesses among residents in basements or semi-basements.Objective: This study investigates the link between living in banjihas (semi-basements) and airway resistance and Th2 airway inflammation in Korean children, compared to those on higher floors.Methods: We assessed 575 fifth- and sixth-grade students (aged 10-12) in an inner-city area of South Korea. The study utilized impulse oscillometry to measure small and total airway resistance (Rrs20-5 and Rrs0, respectively) and Fractional Exhaled Nitric Oxide (FeNO) measurements to evaluate airway inflammation. We also considered a range of biological and environmental factors, including allergen sensitization, serum 25-hydroxyvitamin D levels, and urinary metabolites like VOCs, bisphenol, and triclosan. Participants were categorized by living floors: banjihas, first-fifth floors, and sixth floors or higher.Results: Twenty-five children (4.3%) lived in banjihas, 311 (54.1%) on the first to fifth floor, and 239 (41.6%) on the sixth floor or above. Despite similar levels of allergen sensitization and urinary pollutant metabolite levels across all groups, banjiha dwellers showed significantly higher total airway resistance (adjusted &1: 0.633, 95%CI: 0.156, 1.109; P = 0.009) and a greater prevalence of elevated FeNO levels (> 35 ppb) (P = 0.033). These findings persisted after adjusting for critical factors like height, gender, BMI z-score, and birth conditions.Conclusion: Children in banjihas exhibit elevated airway resistance and FeNO levels independently of allergen sensitization or pollution exposure, underscoring the necessity for enhanced focus on their respiratory health in such living conditions.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-sensitization between inhalant allergens and food allergens: the extent, intensity, and age-related shifts. 吸入性过敏原和食物过敏原之间的交叉致敏：程度、强度和与年龄有关的转变。

IF 2.3 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-07-14 DOI: 10.12932/AP-240324-1826

Jae Hoon Cho, Jeffrey D Suh, Jin Kook Kim, Marn Joon Park, Ji Ho Choi

{"title":"Cross-sensitization between inhalant allergens and food allergens: the extent, intensity, and age-related shifts.","authors":"Jae Hoon Cho, Jeffrey D Suh, Jin Kook Kim, Marn Joon Park, Ji Ho Choi","doi":"10.12932/AP-240324-1826","DOIUrl":"https://doi.org/10.12932/AP-240324-1826","url":null,"abstract":"Background: Encountering individuals sensitized to both inhalant and food allergens is challenging in clinical practice. Despite its rarity, studies have documented cross-sensitization between these allergens. However, the extent, diversity, and age-related variations of this phenomenon remain unclear.Objective: Hence, our objective was to investigate a substantial quantity of allergy sensitivity test results in which both inhalant and food allergens were concurrently examined. The primary goal of our study is to calculate the cross-sensitization ratio, with a secondary objective of analyzing this phenomenon across four age groups.Methods: A retrospective analysis was conducted on a multiple-antigen simultaneous test (MAST) obtained from a domestic laboratory medicine facility and comprising 55 food allergens and 49 inhalant allergens from 368,156 individuals aged 1 to 89. By calculating the cross-sensitization ratio, the degree of cross-sensitization between each food allergen and inhalant allergen was determined. Further subgroup analysis was conducted to ascertain the cross-sensitization ratio between the four subgroups categorized by age.Results: The median cross-sensitization ratio between food and inhalant allergens was 5.14, indicating a significant level of cross-sensitization. The cross-sensitization ratio was greatest among pollen allergens and plant-derived food allergens, followed by between some animal aeroallergens and meat/fish/dairy/poultry food allergens. The degree of overall cross-sensitization was least prominent in adolescents, greater in adults and children, and most pronounced in the elderly.Conclusion: Our findings reveal that various inhalant and dietary allergens have considerable cross-sensitivity, with the elderly having the highest degree of cross-sensitivity and adolescents the lowest.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of anaphylaxis from tertiary-care hospital in lower northern Thailand: A ten-year retrospective cross-sectional study. 泰国下北部三级医院过敏性休克的特征：一项为期十年的回顾性横断面研究。

IF 2.3 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-07-14 DOI: 10.12932/AP-010424-1831

Suwannee Uthaisangsook, Nichayada Hirunwattana, Chayanis Kajornrojanaruk, Nadda Padsee

{"title":"Characteristics of anaphylaxis from tertiary-care hospital in lower northern Thailand: A ten-year retrospective cross-sectional study.","authors":"Suwannee Uthaisangsook, Nichayada Hirunwattana, Chayanis Kajornrojanaruk, Nadda Padsee","doi":"10.12932/AP-010424-1831","DOIUrl":"https://doi.org/10.12932/AP-010424-1831","url":null,"abstract":"Background: The prevalence and etiology of anaphylaxis vary based on geographic regions, study design, and definition used. Anaphylaxis leading to emergency department visits and hospitalizations has increased worldwide.Objective: The prevalence and etiology of anaphylaxis vary based on geographic regions, study design, and definition used. Anaphylaxis leading to emergency department visits and hospitalizations has increased worldwide.Methods: A cross-sectional retrospective analysis of medical records from patients with ICD-10 confirmed anaphylaxis was performed at Naresuan University Hospital between March 2011 and February 2021.Results: We identified 439 anaphylaxis episodes in 381 patients within 10 years. The average annual occurrence rates of anaphylactic episodes were 25.0 per 100,000 outpatient and emergency department visits and 11.2 per 100,000 inpatient visits. Both pediatric and adult anaphylaxis events increased annually, from 13.3 (children: 20.5, adults: 12.4) in 2012 to 46.6 (children: 52.6, adults: 46.1) episodes per 100,000 visits in 2021. Peak incidence was observed in adolescents and young adults. Food was the most common trigger, with shrimp and fried insects being predominant. Risk factors for severe anaphylaxis were underlying cardiovascular diseases, drug triggers, and wheezing. Epinephrine was administered in 98.4% of all episodes. Although, there were no fatalities, only 11.4% of patients received prescriptions for self-injectable epinephrine.Conclusion: The study underscores an increasing trend of anaphylaxis affecting both children and adults in lower northern Thailand, with shrimp and fried insects as common triggers.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the clinical performance of multiple serum sIgE detection systems based on component-resolved diagnosis. 基于成分分辨诊断的多种血清 sIgE 检测系统临床性能评估。

IF 5 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-06-15 DOI: 10.12932/AP-290923-1702

Zhifeng Huang, Aoli Li, Ziyu Yin, Tong Chen, Hui Gan, Zhiwei Lin, Mingshan Xue, Huimin Huang, Baoqing Sun

{"title":"Evaluation of the clinical performance of multiple serum sIgE detection systems based on component-resolved diagnosis.","authors":"Zhifeng Huang, Aoli Li, Ziyu Yin, Tong Chen, Hui Gan, Zhiwei Lin, Mingshan Xue, Huimin Huang, Baoqing Sun","doi":"10.12932/AP-290923-1702","DOIUrl":"https://doi.org/10.12932/AP-290923-1702","url":null,"abstract":"Background: Serum allergen-specific IgE (sIgE) detection is an important tool in the diagnosis of allergic diseases. However, the absence of international standards for sIgE detection systems raises questions about the comparability of different systems.Objective: This study aims to evaluate three common allergen sIgE detection systems, with a primary focus on detecting dust mite allergens.Methods: We recruited 85 children with rhinitis and 15 healthy control children. The subjects underwent testing with three different sIgE detection systems, including magnetic particle flow fluorescence, magnetic particle chemiluminescence, and protein chip, to detect sIgE levels to HDM extracts. In addition, skin prick testing (SPT) was conducted, and protein chip technology was performed to measure sIgE levels to component proteins.Results: Our findings reveal strong consistency between SPT and the three in vitro detection systems, with consistency exceeding 71.76% for dust mite allergens. Moreover, there was excellent consistency and RAST class consistency among the three in vitro detection systems, with scores exceeding 94.12% and 89.00%, respectively. And for the 13 additional allergens crude extracts sIgE simultaneously detected by systems 1 and 2, the results showed that the consistency of both systems was above 87.00%, and the RAST class consistency was above 82.00%.Conclusion: The three serum sIgE detection systems exhibited an approximate 80% concordance rate with SPT in identifying dust mite allergens. Furthermore, these systems demonstrated excellent consistency and RAST class consistency among themselves. These findings suggest that the three assays introduced in this study are interchangeable in allergen diagnosis.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141327185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the Immunogenetics of STAT Proteins: Clinical Perspectives on Gain-of-Function and Loss-of-Function Variants. 揭示 STAT 蛋白的免疫遗传学：功能增益和功能缺失变异的临床视角。

IF 2.3 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-06-01 DOI: 10.12932/AP-270124-1776

Kornvalee Meesilpavikkai, Nattiya Hirankarn, Virgil A S H Dalm, P Martin van Hagen, Willem A Dik, Hanna IJspeert

引用次数: 0

Effect of fexofenadine/pseudoephedrine combination tablet on nasal obstruction in patients with allergic rhinitis using rhinomanometry: A randomized controlled trial. 非索非那定/伪麻黄碱复方片对过敏性鼻炎患者鼻阻塞的影响：随机对照试验。

IF 2.3 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-06-01 DOI: 10.12932/AP-160920-0963

Yosuke Nakamura, Yuko Yokoyama, Satoshi Koyama, Kazunori Fujiwara, Motoki Nakamori, Taihei Fujii, Tadao Enomoto, Hiromi Takeuchi

{"title":"Effect of fexofenadine/pseudoephedrine combination tablet on nasal obstruction in patients with allergic rhinitis using rhinomanometry: A randomized controlled trial.","authors":"Yosuke Nakamura, Yuko Yokoyama, Satoshi Koyama, Kazunori Fujiwara, Motoki Nakamori, Taihei Fujii, Tadao Enomoto, Hiromi Takeuchi","doi":"10.12932/AP-160920-0963","DOIUrl":"10.12932/AP-160920-0963","url":null,"abstract":"Background: A fexofenadine/pseudoephedrine combination tablet (F/P) is an optimal product for nasal obstruction. It contains fexofenadine hydrochloride, a histamine H1-receptor antagonist for sneezing and rhinorrhea and pseudoephedrine hydrochloride, an α-adrenergic agonist. The effect of an antihistamine-decongestant on nasal obstruction has been demonstrated in previous studies, but onset of action and efficacy data on nasal obstruction are limited.Objective: We estimated the efficacy of F/P on nasal obstruction in patients with house dust mite-induced allergic rhinitis (AR) versus fexofenadine (F) using objective methods.Methods: In this single-center, single-dose, prospective, randomized, parallel-group study, 24 adult patients with a history of at least 2 years of AR and nasal obstruction were randomized to receive F/P or F. The effect on nasal obstruction was evaluated using nasal airflow and visual analog scale (VAS) score measured at 30-minute intervals before and for 8 hours after dosing. The primary end point was onset of action, based on a comparison of absolute change from baseline in nasal airflow between F/P and F. The protocol was registered in a clinical trial registry as UMIN 000041845.Results: The onset of action for F/P was 30 minutes based on nasal airflow and 60 minutes based on VAS. F/P maintained a significant beneficial effect after onset of effect, while F showed no significant change during the test period.Conclusions: We found F/P had a clear effect on nasal obstruction associated with perennial AR when compared with F. There was a time lag in nasal airflow improvement and nasal obstruction relief.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"147-153"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25411602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A unique profile of serum cytokines in type 1 autoimmune pancreatitis and chronic rhinosinusitis. 1 型自身免疫性胰腺炎和慢性鼻炎患者血清细胞因子的独特特征。

IF 5 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-06-01 DOI: 10.12932/AP-311020-0990

Tomoe Yoshikawa, Kosuke Minaga, Akane Hara, Ikue Sekai, Yasuo Otsuka, Ryutaro Takada, Ken Kamata, Tomohiro Watanabe, Masatoshi Kudo

{"title":"A unique profile of serum cytokines in type 1 autoimmune pancreatitis and chronic rhinosinusitis.","authors":"Tomoe Yoshikawa, Kosuke Minaga, Akane Hara, Ikue Sekai, Yasuo Otsuka, Ryutaro Takada, Ken Kamata, Tomohiro Watanabe, Masatoshi Kudo","doi":"10.12932/AP-311020-0990","DOIUrl":"10.12932/AP-311020-0990","url":null,"abstract":"Background: Type 1 autoimmune pancreatitis (AIP) is a pancreatic manifestation of IgG4-related disease (IgG4-RD). Although AIP and IgG4-RD are characterized by multiple organ involvement including salivary glands, lung, and kidney, co-occurrence of chronic rhinosinusitis (CRS) and AIP/IgG4-RD has been poorly defined.Objective: We explored molecular mechanism accounting for the co-occurrence of CRS and AIP/IgG4-RD.Methods: Serum concentrations of IFN-α and IL-33 were measured by enzyme-linked immune-sorbent assay.Results: We encountered a patient with concurrent type 1 AIP/IgG4-RD and CRS. Induction of remission by prednisolone (PSL) for type 1 AIP/IgG4-RD led to a marked improvement of CRS. Serum cytokine analysis after PSL treatment revealed a marked reduction in serum concentrations of IFN-α and IL-33, both of which are candidate pathogenic cytokines for AIP/IgG4-RD.Conclusions: Given that IL-33 is shared as one of pathogenic cytokines by type 1 AIP/IgG4-RD and CRS, enhanced IL33 responses may cause concurrent type 1 AIP/IgG4-RD and CRS.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"154-158"},"PeriodicalIF":5.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25411603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immediate allergic reaction to thiocolchicoside confirmed by skin testing and basophil activation test: A case report and literature review. 经皮肤测试和嗜碱性粒细胞活化测试证实的硫代胆碱苷即刻过敏反应：病例报告和文献综述。

IF 2.3 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-06-01 DOI: 10.12932/AP-250320-0793

Eleonora Nucera, Riccardo Inchingolo, Manuela Ferraironi, Arianna Aruanno, Raffaella Chini, Angela Rizzi

引用次数: 0

The relationship between the rs4986791 variant of the TLR4 gene and the severity of bronchial asthma in children. TLR4 基因 rs4986791 变异与儿童支气管哮喘严重程度的关系。

IF 2.3 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-06-01 DOI: 10.12932/AP-100920-0954

Xiaoqing Chen, Kai Wang, Qin Yao, Lixin Peng, Lin Wei

{"title":"The relationship between the rs4986791 variant of the TLR4 gene and the severity of bronchial asthma in children.","authors":"Xiaoqing Chen, Kai Wang, Qin Yao, Lixin Peng, Lin Wei","doi":"10.12932/AP-100920-0954","DOIUrl":"10.12932/AP-100920-0954","url":null,"abstract":"Background: Toll-like receptor 4 (TLR4) is an important receptor for lipopolysaccharide and lipid A, components of gram-negative bacteria. At present, a variant in TLR4 has been shown to be associated with asthma, but it has not been reported whether variants in TLR4 are associated with bronchial asthma in children.Objective: The objective is to determine the relationship between the rs4986791 (+1196C/T) variants of TLR4 and bronchial asthma in Chinese children.Methods: DNA extracted from peripheral blood samples was amplified and the Bi-PASA technique was carried out to identify the genotypes in 600 patients.Results: The result showed no difference between the 1196 C/T variant of TLR4 and hemoglobin level, proportion of neutrophils and lymphocytes, leukocyte, basophil and eosinophil counts, log10IgE and hsCRP in the peripheral blood of bronchial asthmatic patients. However, the eosinophil ratio, FEV1% and FEV1/FVC level of asthma patients with the CT genotype was lower than those of patients with the CC genotype, which were 1.19 ± 0.10 and 1.67 ± 0.18 (P = 0.01), 81.25 ± 0.50 and 84.99 ± 0.65 (P < 0.0001), 81.72 ± 0.568 and 5.55 ± 0.78 (P < 0.0001), respectively. The incidence of bronchial asthma in patients with the CT genotype is higher than that in patients with the CC genotype. We analysed the influence of the two genotypes on the current medical history by multiple logistic regression, performing a comparative analysis between the two genotypes and bronchial asthma (P < 0.05). Patients with moderately persistent asthma with the CT genotype are more likely to develop severely persistent asthma compared to those with the CC genotype (P < 0.01).Conclusions: This comparative analysis between rs4986791 and bronchial asthma in children indicates that this variant is associated with bronchial asthma risk in Chinese children.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"159-164"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39172755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0