Ji Hee Kwak, Ju Hee Kim, Eun Kyo Ha, Hye Mi Jee, Youn Ho Shin, Hey Sung Baek, Man Yong Han
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We also considered a range of biological and environmental factors, including allergen sensitization, serum 25-hydroxyvitamin D levels, and urinary metabolites like VOCs, bisphenol, and triclosan. Participants were categorized by living floors: banjihas, first-fifth floors, and sixth floors or higher.</p><p><strong>Results: </strong>Twenty-five children (4.3%) lived in banjihas, 311 (54.1%) on the first to fifth floor, and 239 (41.6%) on the sixth floor or above. Despite similar levels of allergen sensitization and urinary pollutant metabolite levels across all groups, banjiha dwellers showed significantly higher total airway resistance (adjusted &1: 0.633, 95%CI: 0.156, 1.109; P = 0.009) and a greater prevalence of elevated FeNO levels (> 35 ppb) (P = 0.033). These findings persisted after adjusting for critical factors like height, gender, BMI z-score, and birth conditions.</p><p><strong>Conclusion: </strong>Children in banjihas exhibit elevated airway resistance and FeNO levels independently of allergen sensitization or pollution exposure, underscoring the necessity for enhanced focus on their respiratory health in such living conditions.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Total airway mechanics and fractional exhaled nitric oxide levels of children living in banjihas (semi-basements).\",\"authors\":\"Ji Hee Kwak, Ju Hee Kim, Eun Kyo Ha, Hye Mi Jee, Youn Ho Shin, Hey Sung Baek, Man Yong Han\",\"doi\":\"10.12932/AP-050224-1780\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The ISAAC phase III study in Korea found a higher incidence of wheezing illnesses among residents in basements or semi-basements.</p><p><strong>Objective: </strong>This study investigates the link between living in banjihas (semi-basements) and airway resistance and Th2 airway inflammation in Korean children, compared to those on higher floors.</p><p><strong>Methods: </strong>We assessed 575 fifth- and sixth-grade students (aged 10-12) in an inner-city area of South Korea. 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引用次数: 0
摘要
背景:韩国的 ISAAC III 期研究发现,地下室或半地下室居民的喘息病发病率更高:韩国的 ISAAC III 期研究发现,地下室或半地下室居民的喘息病发病率较高:本研究调查了与较高楼层相比,居住在banjihas(半地下室)与韩国儿童气道阻力和Th2气道炎症之间的联系:我们对韩国市内地区的 575 名五、六年级学生(10-12 岁)进行了评估。研究采用脉冲振荡测量法测量小气道阻力和总气道阻力(分别为 Rrs20-5 和 Rrs0),并采用分量呼出一氧化氮(FeNO)测量法评估气道炎症。我们还考虑了一系列生物和环境因素,包括过敏原致敏、血清 25- 羟维生素 D 水平以及尿液代谢物,如挥发性有机化合物、双酚和三氯生。参与者按居住楼层分类:班吉哈斯、一至五楼、六楼或六楼以上:25名儿童(4.3%)住在班吉哈斯,311名儿童(54.1%)住在一至五楼,239名儿童(41.6%)住在六楼或六楼以上。尽管各组的过敏原致敏水平和尿液污染物代谢物水平相似,但班吉哈居民的总气道阻力明显更高(调整后&1:0.633,95%CI:0.156,1.109;P = 0.009),FeNO 水平升高(> 35 ppb)的发生率更高(P = 0.033)。在对身高、性别、体重指数 z 分数和出生条件等关键因素进行调整后,这些结果依然存在:结论:班吉哈儿童表现出较高的气道阻力和 FeNO 水平,与过敏原致敏或污染暴露无关。
Total airway mechanics and fractional exhaled nitric oxide levels of children living in banjihas (semi-basements).
Background: The ISAAC phase III study in Korea found a higher incidence of wheezing illnesses among residents in basements or semi-basements.
Objective: This study investigates the link between living in banjihas (semi-basements) and airway resistance and Th2 airway inflammation in Korean children, compared to those on higher floors.
Methods: We assessed 575 fifth- and sixth-grade students (aged 10-12) in an inner-city area of South Korea. The study utilized impulse oscillometry to measure small and total airway resistance (Rrs20-5 and Rrs0, respectively) and Fractional Exhaled Nitric Oxide (FeNO) measurements to evaluate airway inflammation. We also considered a range of biological and environmental factors, including allergen sensitization, serum 25-hydroxyvitamin D levels, and urinary metabolites like VOCs, bisphenol, and triclosan. Participants were categorized by living floors: banjihas, first-fifth floors, and sixth floors or higher.
Results: Twenty-five children (4.3%) lived in banjihas, 311 (54.1%) on the first to fifth floor, and 239 (41.6%) on the sixth floor or above. Despite similar levels of allergen sensitization and urinary pollutant metabolite levels across all groups, banjiha dwellers showed significantly higher total airway resistance (adjusted &1: 0.633, 95%CI: 0.156, 1.109; P = 0.009) and a greater prevalence of elevated FeNO levels (> 35 ppb) (P = 0.033). These findings persisted after adjusting for critical factors like height, gender, BMI z-score, and birth conditions.
Conclusion: Children in banjihas exhibit elevated airway resistance and FeNO levels independently of allergen sensitization or pollution exposure, underscoring the necessity for enhanced focus on their respiratory health in such living conditions.
期刊介绍:
The Asian Pacific Journal of Allergy and Immunology (APJAI) is an online open access journal with the recent impact factor (2018) 1.747
APJAI published 4 times per annum (March, June, September, December). Four issues constitute one volume.
APJAI publishes original research articles of basic science, clinical science and reviews on various aspects of allergy and immunology. This journal is an official journal of and published by the Allergy, Asthma and Immunology Association, Thailand.
The scopes include mechanism, pathogenesis, host-pathogen interaction, host-environment interaction, allergic diseases, immune-mediated diseases, epidemiology, diagnosis, treatment and prevention, immunotherapy, and vaccine. All papers are published in English and are refereed to international standards.