Asian Pacific journal of allergy and immunology最新文献

筛选
英文 中文
A Delphi consensus on nebulized budesonide for adults with asthma and COPD. 布地奈德雾化治疗成人哮喘和慢性阻塞性肺病的德尔菲共识
IF 2.3 4区 医学
Asian Pacific journal of allergy and immunology Pub Date : 2025-06-03 DOI: 10.12932/AP-190824-1910
Phunsup Wongsurakiat, Akrawat Rattanawongpaibul, Atikun Limsukon, Chirawat Chiewchalermsri, Kittipong Maneechotesuwan, Kittiyaporn Wiwatcharagoses, Kumpol Kornthatchapong, Narongkorn Saiphoklang, Pitsucha Sanguanwit, Pornanan Domthong, Tirachat Sewatanon, Wipa Reechaipichitkul, Theerasuk Kawamatawong
{"title":"A Delphi consensus on nebulized budesonide for adults with asthma and COPD.","authors":"Phunsup Wongsurakiat, Akrawat Rattanawongpaibul, Atikun Limsukon, Chirawat Chiewchalermsri, Kittipong Maneechotesuwan, Kittiyaporn Wiwatcharagoses, Kumpol Kornthatchapong, Narongkorn Saiphoklang, Pitsucha Sanguanwit, Pornanan Domthong, Tirachat Sewatanon, Wipa Reechaipichitkul, Theerasuk Kawamatawong","doi":"10.12932/AP-190824-1910","DOIUrl":"https://doi.org/10.12932/AP-190824-1910","url":null,"abstract":"<p><strong>Background: </strong>Inhaled corticosteroids (ICS) represent an alternative treatment option to systemic corticosteroids (SCS) in the treatment of asthma and chronic obstructive pulmonary disease (COPD); however, detailed clinical guidance on the use of nebulized ICS, such as budesonide, in the management of asthma and COPD remains scarce.</p><p><strong>Objective: </strong>To review the literature and develop Delphi consensus statements on the use of nebulized ICS for the management of asthma and COPD in adults.</p><p><strong>Methods: </strong>An expert panel of 13 respiratory physicians, comprising pulmonologists (n = 9), allergists (n = 1), and emergency department consultants (n = 3) from tertiary medical centers in Thailand, undertook a Delphi procedure with the aim of developing evidence-based consensus statements on the use of nebulized ICS in patients with asthma and COPD. Panelists used a 5-point Likert scale to score their agreement with each statement.</p><p><strong>Results: </strong>A total of 12 Delphi consensus statements pertaining to the use of nebulized ICS in the management of asthma and COPD in both acute and maintenance care were developed. The overall consensus of the panel across the 12 statements was very high (mean agreement score, 4.2-4.9/5). The panelists expressed strongest consensus agreement (84.6% strong agreement) with the following two statements: 1) inhalation devices are the cornerstone of drug delivery in patients with asthma and COPD, and 2) for adult asthma and COPD patients with severe exacerbations, nebulization is more suitable for drug delivery than a pMDI plus spacer.</p><p><strong>Conclusions: </strong>Nebulized budesonide is an effective and well tolerated treatment option for the management of asthma and COPD.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sensitization profiles of aeroallergens among allergic rhinitis patients in central China: A six-year real-world study. 中国中部变应性鼻炎患者空气过敏原的致敏特征:一项为期6年的真实世界研究。
IF 2.3 4区 医学
Asian Pacific journal of allergy and immunology Pub Date : 2025-06-03 DOI: 10.12932/AP-070125-2002
Li Le, Luo Chunhua, Chen Hao, Wang Yin, Liu Jin, Xu Qingxiu, Zhu Rongfei
{"title":"Sensitization profiles of aeroallergens among allergic rhinitis patients in central China: A six-year real-world study.","authors":"Li Le, Luo Chunhua, Chen Hao, Wang Yin, Liu Jin, Xu Qingxiu, Zhu Rongfei","doi":"10.12932/AP-070125-2002","DOIUrl":"https://doi.org/10.12932/AP-070125-2002","url":null,"abstract":"<p><strong>Background: </strong>Environmental changes have led to shifts in allergen sensitization patterns globally.</p><p><strong>Objective: </strong>To assess changes in aeroallergen sensitization profiles among AR patients in Yichang, a city located in central China along the Yangtze River and develop an optimized allergen panel for the diagnosis of AR through specific IgE (sIgE) testing.</p><p><strong>Methods: </strong>This retrospective study encompassed all patients with suspected AR who sought care at a university hospital in Yichang between 2018 and 2023 and underwent IgE testing. Demographic and sIgE data were collected.</p><p><strong>Results: </strong>A total of 11,855 patients were included in the study, with 7,453 (62.88%) testing positive for at least one allergen. The predominant allergen identified was house dust mite (HDM), with sensitization rates of 58.65% for D. pteronyssinus and 58.63% for D. farinae. Notably, sensitization to animal dander showed a significant increase, with cat dander rising from 4.41% in 2018 to 12.50% in 2023, and dog dander from 4.41% to 10.42%. Sensitization rates for various allergens also exhibited fluctuations, with seasonal peaks observed: HDM (summer/autumn), molds (spring/autumn), and Blattella germanica (autumn/winter). A five-allergen panel (HDM, B. germanica, mixed animal dander, mixed molds) identified over 95% of sensitized patients.</p><p><strong>Conclusions: </strong>HDM remains the primary allergen among AR patients in this area, with rising sensitization to animal dander. A five-allergen panel effectively detects most sensitized patients.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TNFAIP3 regulates inflammatory arthritis through the differentiation of monocytes into macrophages. TNFAIP3通过单核细胞向巨噬细胞的分化调节炎性关节炎。
IF 2.3 4区 医学
Asian Pacific journal of allergy and immunology Pub Date : 2025-06-03 DOI: 10.12932/AP-090924-1921
Lu Zhang, Wanlan Jiang, Biqing Zhang, Ting Xu, Shiliang Zhou, Mingyuan Cai, Jinyun Chen, Min Wu
{"title":"TNFAIP3 regulates inflammatory arthritis through the differentiation of monocytes into macrophages.","authors":"Lu Zhang, Wanlan Jiang, Biqing Zhang, Ting Xu, Shiliang Zhou, Mingyuan Cai, Jinyun Chen, Min Wu","doi":"10.12932/AP-090924-1921","DOIUrl":"https://doi.org/10.12932/AP-090924-1921","url":null,"abstract":"<p><strong>Background: </strong>Rheumatoid arthritis (RA) is a disease characterized by synovitis. The synovium of RA patients is rich in macrophages, which are differentiated mainly from monocytes. The susceptibility gene of RA, tumor necrosis factor-α inducible protein 3 (tnfaip3), is considered an anti-inflammatory factor. Our previous study revealed the abnormal protein expression of TNFAIP3 in monocytes from patients with RA.</p><p><strong>Objective: </strong>In the present study, we aimed to explore the role of TNFAIP3 in monocytes in RA and its potential functions.</p><p><strong>Methods: </strong>In vivo, we injected adenoviral vectors overexpressing tnfaip3 into mice with collagen-induced arthritis (CIA) (the TNFAIP3-oe group). Arthritis scores, as well as the expression of iNOS and CD206 in the synovium, were compared between the TNFAIP3-oe group and the CIA group. In vitro, we used lentivirus transfection to upregulate/downregulate the expression of tnfaip3 in THP-1 cells. The ability of these cells to migrate, secrete cytokines and differentiate into macrophages was compared.</p><p><strong>Results: </strong>Compared with that in the CIA group, arthritis in the TNFAIP3-oe group was ameliorated (p = 0.030). Moreover, the joints of these mice presented more CD206+ cells and fewer iNOS+ cells (both p < 0.001), indicating the anti-inflammatory effect of TNFAIP3 and its regulation of macrophage polarization. In vitro, the tnfaip3-depleted cells (the TNFAIP3-i group) had greater migration and differentiated into M1 macrophages, and more cells overexpressing tnfaip3 (the TNFAIP3-oe group) differentiated into M2 macrophages. Furthermore, cells in the TNFAIP3-i group showed increased secretion of the proinflammatory cytokines IL-6 and MMPs.</p><p><strong>Conclusions: </strong>Taken together, these findings suggest that TNFAIP3 in monocytes can regulate inflammatory arthritis by modulating monocyte migration, differentiation, and cytokine secretion.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Allergenicity potential of protein extract from freshwater and saltwater fish based on heat stability and antibody-binding frequency. 基于热稳定性和抗体结合频率的淡水和咸水鱼蛋白提取物致敏性潜力。
IF 2.3 4区 医学
Asian Pacific journal of allergy and immunology Pub Date : 2025-06-03 DOI: 10.12932/AP-221024-1958
Atika H Falihah, Zulfi Azizah, Bayu Ba Santoso, Ika P Sari, Muhammad Na Sahid
{"title":"Allergenicity potential of protein extract from freshwater and saltwater fish based on heat stability and antibody-binding frequency.","authors":"Atika H Falihah, Zulfi Azizah, Bayu Ba Santoso, Ika P Sari, Muhammad Na Sahid","doi":"10.12932/AP-221024-1958","DOIUrl":"https://doi.org/10.12932/AP-221024-1958","url":null,"abstract":"<p><strong>Background: </strong>Saltwater fish are associated with more allergic reactions compared to freshwater fish. However, the factors contributing to this difference remain unclear.</p><p><strong>Objective: </strong>To compare the heat stability of freshwater and saltwater fish proteins, and assess their binding affinity to allergen-specific antibodies.</p><p><strong>Methods: </strong>Protein extracts were isolated from saltwater fish-Selar crumenophthalmus, Euthynnus affinis, Ambassis urotaenia, and freshwater fish i.e., Rasbora argyrotaenia, Monopterus albus, and Poecilia reticulata. Protein extract from Penaeus monodon served as a standard allergen source. Both raw and heat-treated protein extracts were subjected to SDS-PAGE analysis. The number of protein bands, their molecular sizes, and intensities were evaluated. Protein binding frequencies to anti-tropomyosin antibodies and IgE-containing serum from allergic patients were measured using ELISA.</p><p><strong>Results: </strong>The P. monodon protein extract < 100 kDa demonstrated heat stability, while A. urotaenia proteins < 40 kDa were also heat-stable. Raw protein extracts from R. argyrotaenia and M. albus exhibited binding frequencies to anti-tropomyosin IgG of 28.18 ± 1.05% and 14.79 ± 0.91%, respectively. In saltwater fish, raw protein extracts from A. urotaenia and S. crumenophthalmus showed binding frequencies of 61.74 ± 1.87% and 34.68 ± 1.39%, respectively. Freshwater and saltwater fish heat-treated protein extracts displayed binding frequencies below 10%. All heat-treated protein samples exhibited higher binding frequencies to polyclonal IgE in patient sera compared to their raw counterparts.</p><p><strong>Conclusions: </strong>Proteins smaller than 20 kDa exhibit significant heat stability. Raw protein extracts show higher binding frequencies to monoclonal IgG against crustacean tropomyosin, while heat-treated samples have increased binding frequency to IgE-containing human serum.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recurrent chronic spontaneous urticaria in a tropical country: Clinical characteristics and associated factors. 热带国家复发性慢性自发性荨麻疹:临床特征和相关因素。
IF 2.3 4区 医学
Asian Pacific journal of allergy and immunology Pub Date : 2025-05-05 DOI: 10.12932/AP-261124-1984
Pichaya Limphoka, Sukhum Jiamton, Leena Chularojanamontri, Kanokvalai Kulthanan, Papapit Tuchinda
{"title":"Recurrent chronic spontaneous urticaria in a tropical country: Clinical characteristics and associated factors.","authors":"Pichaya Limphoka, Sukhum Jiamton, Leena Chularojanamontri, Kanokvalai Kulthanan, Papapit Tuchinda","doi":"10.12932/AP-261124-1984","DOIUrl":"https://doi.org/10.12932/AP-261124-1984","url":null,"abstract":"<p><strong>Background: </strong>Limited data exist regarding recurrent chronic spontaneous urticaria (RCSU) following complete disease remission.</p><p><strong>Objective: </strong>This study investigated the clinical characteristics and factors associated with RCSU.</p><p><strong>Methods: </strong>We retrospectively reviewed data from chronic spontaneous urticaria (CSU) patients who actively visited the Urticaria Center of Reference and Excellence, Siriraj Hospital, between January 2021 and December 2023. Medical records were analyzed through May 2024. The RCSU was defined as a new CSU episode occurring after a 6-month symptom-free period without treatment.</p><p><strong>Results: </strong>Among 179 CSU patients, 19 (10.6%) developed RCSU. These patients had a mean age of 40 (SD 14.9) years, with a female predominance. The mean time to RCSU recurrence was 1.96 (SD 2.05) years. The UAS7 and medication scores were not significantly different between the recurrence and nonrecurrence groups (P = 0.675, P = 0.77). Multivariate analysis revealed that a shorter disease remission time from the first episode onset (< 3 years) was significantly associated with RCSU (odds ratio 5.13, 95%CI 1.83-14.29; P = 0.002).</p><p><strong>Conclusions: </strong>The RCSU rate was 10.6%. The time to disease remission from the first episode onset significantly associated with RCSU. Several clinical characteristics may corelate with the recurrence: younger age at onset, the presence of angioedema, chronic inducible urticaria comorbidity, systemic corticosteroid use, and positive antinuclear antibody status.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of patients with suspected vaccine allergies in Singapore. 新加坡疑似疫苗过敏患者的评估。
IF 2.3 4区 医学
Asian Pacific journal of allergy and immunology Pub Date : 2025-05-05 DOI: 10.12932/AP-140724-1891
Zi Teng Chai, Jia Yi Goh, Karen Jui Lin Choo, Kheng Yong Ong, Vivian Tan, Chiara Jiamin Chong, Chaw Su Naing, Haur Yueh Lee
{"title":"Evaluation of patients with suspected vaccine allergies in Singapore.","authors":"Zi Teng Chai, Jia Yi Goh, Karen Jui Lin Choo, Kheng Yong Ong, Vivian Tan, Chiara Jiamin Chong, Chaw Su Naing, Haur Yueh Lee","doi":"10.12932/AP-140724-1891","DOIUrl":"https://doi.org/10.12932/AP-140724-1891","url":null,"abstract":"<p><strong>Background: </strong>Hypersensitivity reaction to vaccines has been reported to occur in 5 per 100,000 doses. Although hypersensitivity reactions can occur to either the active vaccine component or other components such as excipients, outcome data from skin testing and provocation remains limited.</p><p><strong>Objective: </strong>To evaluate the role of skin testing and vaccine provocation in patients with an allergy label to vaccine.</p><p><strong>Methods: </strong>This is a single centre, prospective study between March 2021 and November 2021 of adults with known allergy to non-COVID vaccine. All participants underwent skin prick testing (SPT) and intradermal testing (IDT) to vaccine and excipients. A subset of patients with negative skin testing underwent graded vaccine provocation.</p><p><strong>Results: </strong>A total of 264 adults were evaluated. The most common index vaccine reactions were nonspecific rash (47.7%), angioedema (32.2%) and itch (25.0%). All patients had negative SPT to vaccines and excipients. Thirty patients (11.4%) had positive IDT to Hepatitis A, Hepatitis B, Human Papilloma Virus (HPV), Influenza, Measles-Mumps-Rubella (MMR), Pneumococcal, Rabies, Diphteria, Tetanus and Pertussis (DTaP). Out of 234 patients with negative IDT, 32 patients (12.1%) underwent vaccine provocation. Three patients (9.4%) developed reaction to influenza and MMR vaccine. One patient required systemic corticosteroids, one required antihistamine, and another patient did not require any treatment. None required admission or attendance at emergency department.</p><p><strong>Conclusions: </strong>The majority of allergy labels to vaccine are inaccurate based on low skin test positivity and low reaction rates on vaccine provocation. Vaccine provocation is safe. Excipients are unlikely to be the main cause of hypersensitivity reactions in vaccines.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IgE-sensitization and cross-reactivity of Der f 23 and Der p 23 in Korean patients with allergy. 韩国过敏患者Der f23和Der p23的ige致敏性和交叉反应性。
IF 2.3 4区 医学
Asian Pacific journal of allergy and immunology Pub Date : 2025-05-05 DOI: 10.12932/AP-120924-1924
Myung-Hee Yi, Tai-Soon Yong, Chung-Ryul Kim, Kyoung Yong Jeong, Ju Yeong Kim
{"title":"IgE-sensitization and cross-reactivity of Der f 23 and Der p 23 in Korean patients with allergy.","authors":"Myung-Hee Yi, Tai-Soon Yong, Chung-Ryul Kim, Kyoung Yong Jeong, Ju Yeong Kim","doi":"10.12932/AP-120924-1924","DOIUrl":"https://doi.org/10.12932/AP-120924-1924","url":null,"abstract":"<p><strong>Background: </strong>House dust mites (HDM) are a major source of allergens, and more than 30 HDM allergens have been identified to date. Recently, Der p 23 was reported to be a major allergen that is related to the severity of allergic responses.</p><p><strong>Objective: </strong>This study aimed to characterize IgE-sensitization and cross-reactivity between Der f 23 and Der p 23 in Korean patients with allergy.</p><p><strong>Methods: </strong>We produced recombinant Der f 23 and Der p 23 using a yeast Pichia expression system. The IgE binding activity of Der f 23 and Der p 23 was evaluated by enzyme-linked immunosorbent assay (ELISA) using sera from 194 Korean HDM-sensitized patients. The cross-reactivity between Der f 23 and Der p 23 was then assayed using competitive ELISA.</p><p><strong>Results: </strong>Among the 194 HDM-allergic patients, IgE reactivity to rDer f 23 and rDer p 23 was observed in 45.36% (88/194) and 43.81% (85/194) of the samples, respectively. Competitive ELISA with pooled serum from 10 patients revealed that rDer p 23 inhibited 86.1% of the rDer f 23 IgE reactivity and rDer f 23 inhibited 61.1% of the rDer p 23 IgE reactivity.</p><p><strong>Conclusions: </strong>Group 23 HDM allergens, Der f 23 and Der p 23, show moderate sensitization, with 45.36% and 43.81% of Korean patients with allergy reacting to them, respectively. Significant IgE cross-reactivity was observed between the two allergens. These findings can facilitate the development of component-resolved diagnosis and allergen-specific immunotherapy in the future.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunoglobulin E binding capacity to various types of Korean soy sauces among children sensitized to wheat and soybean. 对小麦和大豆敏感的儿童对各种韩国酱油的免疫球蛋白E结合能力。
IF 2.3 4区 医学
Asian Pacific journal of allergy and immunology Pub Date : 2025-05-05 DOI: 10.12932/AP-110924-1922
Jeongmin Lee, Purevsan Gantulga, Kyunguk Jeong, Sanghwa Youm, Sooyoung Lee
{"title":"Immunoglobulin E binding capacity to various types of Korean soy sauces among children sensitized to wheat and soybean.","authors":"Jeongmin Lee, Purevsan Gantulga, Kyunguk Jeong, Sanghwa Youm, Sooyoung Lee","doi":"10.12932/AP-110924-1922","DOIUrl":"https://doi.org/10.12932/AP-110924-1922","url":null,"abstract":"<p><strong>Background: </strong>Soy sauce (SS) is made from soy or a mix of soybean and wheat proteins. With the rise in global consumption of Korean SS, understanding the allergenicity of its different types is essential.</p><p><strong>Objective: </strong>This study is the first to evaluate whether the immunoglobulin E binding capacity (IgE+) in children sensitized to soybeans or wheat varies by SS types.</p><p><strong>Methods: </strong>Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and an enzyme-linked immunosorbent assay (ELISA) using pooled and individual sera were performed with three SS types. Inhibition ELISA was performed using SS concentrate, extracts of wheat, and soybean.</p><p><strong>Results: </strong>Guk-SS showed very faint protein bands, on SDS-PAGE. ELISA (pooled sera, n = 36) indicated that all groups had the lowest IgE+ to Guk-SS. In individual ELISA, patients sensitized to both wheat and soybeans (WS; n = 4) showed significantly higher IgE+ to all SS types (Yangjo > Jin > Guk) than those sensitized to wheat (W; n = 3) or Soy (S; n = 3) alone. The W group had IgE+ similar to the control group for Guk and Jin-SS, while the S group showed slightly higher IgE+ to Yangjo-SS. When soybean was used as an inhibitor, the IgE+ to Yangjo-SS and Jin-SS was inhibited by more than 50% (Yangjo > Jin). In contrast, wheat exhibited only subtle inhibition of both SS (< 20%). Converse showed similar results.</p><p><strong>Conclusions: </strong>For pediatric patients sensitized to wheat, it is suggested that Korean SS be carefully introduced at home. For patients sensitized to soybeans, it is safest to try Guk-SS before attempting other types.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of budesonide nasal irrigation on Hypothalamic-Pituitary-Adrenal Axis in patients with chronic rhinosinusitis post endoscopic sinus surgery: A prospective study. 布地奈德鼻冲洗对慢性鼻窦炎患者内镜鼻窦手术后下丘脑-垂体-肾上腺轴的影响:一项前瞻性研究。
IF 2.3 4区 医学
Asian Pacific journal of allergy and immunology Pub Date : 2025-03-21 DOI: 10.12932/AP-121124-1968
Jesada Kanjanaumporn, Sorranut Thaweboon, Songklot Aeumjaturapat, Kornkiat Snidvongs, Supinda Chusakul, Kachorn Seresirikachorn, Lalita Prathanee
{"title":"Effect of budesonide nasal irrigation on Hypothalamic-Pituitary-Adrenal Axis in patients with chronic rhinosinusitis post endoscopic sinus surgery: A prospective study.","authors":"Jesada Kanjanaumporn, Sorranut Thaweboon, Songklot Aeumjaturapat, Kornkiat Snidvongs, Supinda Chusakul, Kachorn Seresirikachorn, Lalita Prathanee","doi":"10.12932/AP-121124-1968","DOIUrl":"https://doi.org/10.12932/AP-121124-1968","url":null,"abstract":"<p><strong>Background: </strong>Corticosteroids added to high volume saline nasal irrigation have been introduced as a more effective method of delivering corticosteroids to the sinuses than nasal sprays. However, information regarding the effect of this intervention on the hypothalamic-pituitary-adrenal (HPA) axis is still limited.</p><p><strong>Objective: </strong>To evaluate the safety of long-term corticosteroid (6 months) nasal irrigation in patients with chronic rhinosinusitis (CRS) post endoscopic sinus surgery.</p><p><strong>Methods: </strong>Seventeen patients with CRS were included. After undergoing endoscopic sinus surgery, the patients were prescribed budesonide nasal irrigations (250 ml via squeeze bottle) twice daily (1 mg/day) for six months. The serum morning cortisol levels of these patients were then evaluated at 3 and 6 months post-operatively.</p><p><strong>Results: </strong>Median serum morning cortisol levels were 10.5 mcg% at pre-operative baseline; 10.3 mcg% at 3 months; and 11.2 mcg% at 6 months on post-operative follow-up. There were no significant changes in the serum morning cortisol levels (P value = 0.71 and 0.63 respectively). Three of 17 patients (17.65%) had mildly abnormal serum morning cortisol levels (4, 4.3 and 4.9 mcg%) at 3 months. However, these levels were within a normal range at 6 months.</p><p><strong>Conclusions: </strong>Serum morning cortisol levels were not significantly changed after usage of budesonide nasal irrigation for 6 months.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of pre-existing immunity on humoral and cellular responses to CoronaVac in SARS-CoV-2 variants: A focus on common human Coronaviruses. 原有免疫力对 SARS-CoV-2 变体对 CoronaVac 的体液和细胞反应的影响:聚焦常见人类冠状病毒。
IF 2.3 4区 医学
Asian Pacific journal of allergy and immunology Pub Date : 2025-03-21 DOI: 10.12932/AP-201124-1979
Nawamin Pinpathomrat, Bunya Seeyankem, Ratchanon Sophonmanee, Jomkwan Ongarj, Smonrapat Surasombatpattana
{"title":"Impact of pre-existing immunity on humoral and cellular responses to CoronaVac in SARS-CoV-2 variants: A focus on common human Coronaviruses.","authors":"Nawamin Pinpathomrat, Bunya Seeyankem, Ratchanon Sophonmanee, Jomkwan Ongarj, Smonrapat Surasombatpattana","doi":"10.12932/AP-201124-1979","DOIUrl":"https://doi.org/10.12932/AP-201124-1979","url":null,"abstract":"<p><strong>Background: </strong>The global COVID-19 pandemic, caused by SARS-CoV-2, has highlighted the importance of understanding immune responses elicited by vaccines.</p><p><strong>Objective: </strong>This study evaluated antibody and T cell responses to the inactivated CoronaVac vaccine, as well as the role of pre-existing immunity to common human coronaviruses (HCoVs) in shaping vaccine-induced immunity.</p><p><strong>Methods: </strong>We enrolled 64 participants (17 males and 47 females) and measured IgG levels against HCoVs before and after vaccination. T cell responses were analysed by stimulating peripheral blood mononuclear cells (PBMCs) with wild-type, Delta, and Omicron spike peptides.</p><p><strong>Results: </strong>We found pre-existing antibodies against HCoV-229E, HCoV-HKU1, HCoV-NL63, and HCoV-OC43 were present before vaccination. Notably, a positive correlation was observed between pre-existing antibodies to HCoV-229E and HCoV-HKU1 and anti-RBD IgG levels post-vaccination. Pre-existing CD4+ T cell responses were observed for the wild-type strain before vaccination, with a significant reduction in IFN-γ secretion after Delta re-stimulation and partial restoration after Omicron re-stimulation. IL-4 production by CD4+ T cells was significantly reduced upon re-stimulation with Delta and Omicron compared to wild-type. CD8+ T cells again showed a reduction of IL-4 production after Delta re-stimulation compared to the original strain.</p><p><strong>Conclusions: </strong>This work demonstrate that CoronaVac induces robust humoral and cellular immune responses, though variant-specific responses vary. Pre-existing immunity to certain HCoVs may influence vaccine-induced antibody responses, underscoring the importance of monitoring immunity to emerging SARS-CoV-2 variants and informing future vaccine design.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信