1 型自身免疫性胰腺炎和慢性鼻炎患者血清细胞因子的独特特征。

IF 2.3 4区医学 Q3 ALLERGY

Asian Pacific journal of allergy and immunology Pub Date : 2024-06-01 DOI:10.12932/AP-311020-0990

Tomoe Yoshikawa, Kosuke Minaga, Akane Hara, Ikue Sekai, Yasuo Otsuka, Ryutaro Takada, Ken Kamata, Tomohiro Watanabe, Masatoshi Kudo

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引用次数: 0

摘要

背景：1型自身免疫性胰腺炎（AIP）是IgG4相关疾病（IgG4-RD）的胰腺表现。虽然AIP和IgG4-RD的特点是多器官受累，包括唾液腺、肺和肾，但慢性鼻炎（CRS）和AIP/IgG4-RD的并发症尚未明确：我们探讨了CRS和AIP/IgG4-RD并发的分子机制：用酶联免疫吸附法测定血清中IFN-α和IL-33的浓度：我们遇到了一名同时患有1型AIP/IgG4-RD和CRS的患者。通过泼尼松龙（PSL）诱导1型AIP/IgG4-RD缓解，CRS明显好转。PSL治疗后的血清细胞因子分析显示，IFN-α和IL-33的血清浓度明显降低，而这两种细胞因子都是AIP/IgG4-RD的候选致病细胞因子：结论：鉴于IL-33是1型AIP/IgG4-RD和CRS的共同致病细胞因子之一，IL33反应增强可能会导致1型AIP/IgG4-RD和CRS并发。

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A unique profile of serum cytokines in type 1 autoimmune pancreatitis and chronic rhinosinusitis.

Background: Type 1 autoimmune pancreatitis (AIP) is a pancreatic manifestation of IgG4-related disease (IgG4-RD). Although AIP and IgG4-RD are characterized by multiple organ involvement including salivary glands, lung, and kidney, co-occurrence of chronic rhinosinusitis (CRS) and AIP/IgG4-RD has been poorly defined.

Objective: We explored molecular mechanism accounting for the co-occurrence of CRS and AIP/IgG4-RD.

Methods: Serum concentrations of IFN-α and IL-33 were measured by enzyme-linked immune-sorbent assay.

Results: We encountered a patient with concurrent type 1 AIP/IgG4-RD and CRS. Induction of remission by prednisolone (PSL) for type 1 AIP/IgG4-RD led to a marked improvement of CRS. Serum cytokine analysis after PSL treatment revealed a marked reduction in serum concentrations of IFN-α and IL-33, both of which are candidate pathogenic cytokines for AIP/IgG4-RD.

Conclusions: Given that IL-33 is shared as one of pathogenic cytokines by type 1 AIP/IgG4-RD and CRS, enhanced IL33 responses may cause concurrent type 1 AIP/IgG4-RD and CRS.

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来源期刊

Asian Pacific journal of allergy and immunology 医学-过敏

CiteScore

12.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Asian Pacific Journal of Allergy and Immunology (APJAI) is an online open access journal with the recent impact factor (2018) 1.747 APJAI published 4 times per annum (March, June, September, December). Four issues constitute one volume. APJAI publishes original research articles of basic science, clinical science and reviews on various aspects of allergy and immunology. This journal is an official journal of and published by the Allergy, Asthma and Immunology Association, Thailand. The scopes include mechanism, pathogenesis, host-pathogen interaction, host-environment interaction, allergic diseases, immune-mediated diseases, epidemiology, diagnosis, treatment and prevention, immunotherapy, and vaccine. All papers are published in English and are refereed to international standards.