吸入性过敏原和食物过敏原之间的交叉致敏:程度、强度和与年龄有关的转变。

IF 2.3 4区 医学 Q3 ALLERGY
Jae Hoon Cho, Jeffrey D Suh, Jin Kook Kim, Marn Joon Park, Ji Ho Choi
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引用次数: 0

摘要

背景:在临床实践中,遇到同时对吸入剂和食物过敏原过敏的患者是一项挑战。尽管这种情况很少见,但已有研究证实了这些过敏原之间的交叉过敏现象。因此,我们的目标是调查大量同时检测吸入剂和食物过敏原的过敏敏感性测试结果。我们研究的主要目的是计算交叉致敏比率,其次是分析四个年龄组的交叉致敏现象:方法:我们对从国内一家实验医学机构获得的多抗原同时检测(MAST)进行了回顾性分析,该检测包括 55 种食物过敏原和 49 种吸入剂过敏原,样本来自 368,156 名 1 至 89 岁的个体。通过计算交叉致敏比率,确定了每种食物过敏原和吸入剂过敏原之间的交叉致敏程度。研究人员还进一步进行了分组分析,以确定按年龄划分的四个分组之间的交叉致敏比率:结果:食物过敏原和吸入物过敏原之间的交叉致敏比率中位数为 5.14,表明交叉致敏程度显著。花粉过敏原和植物性食物过敏原之间的交叉致敏比率最大,其次是某些动物性空气过敏原和肉类/鱼类/乳制品/禽类食物过敏原之间的交叉致敏比率。总体交叉过敏程度在青少年中最不突出,在成人和儿童中较高,而在老年人中最明显:我们的研究结果表明,各种吸入剂和食物过敏原具有相当高的交叉敏感性,其中老年人的交叉敏感性最高,而青少年的交叉敏感性最低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cross-sensitization between inhalant allergens and food allergens: the extent, intensity, and age-related shifts.

Background: Encountering individuals sensitized to both inhalant and food allergens is challenging in clinical practice. Despite its rarity, studies have documented cross-sensitization between these allergens. However, the extent, diversity, and age-related variations of this phenomenon remain unclear.

Objective: Hence, our objective was to investigate a substantial quantity of allergy sensitivity test results in which both inhalant and food allergens were concurrently examined. The primary goal of our study is to calculate the cross-sensitization ratio, with a secondary objective of analyzing this phenomenon across four age groups.

Methods: A retrospective analysis was conducted on a multiple-antigen simultaneous test (MAST) obtained from a domestic laboratory medicine facility and comprising 55 food allergens and 49 inhalant allergens from 368,156 individuals aged 1 to 89. By calculating the cross-sensitization ratio, the degree of cross-sensitization between each food allergen and inhalant allergen was determined. Further subgroup analysis was conducted to ascertain the cross-sensitization ratio between the four subgroups categorized by age.

Results: The median cross-sensitization ratio between food and inhalant allergens was 5.14, indicating a significant level of cross-sensitization. The cross-sensitization ratio was greatest among pollen allergens and plant-derived food allergens, followed by between some animal aeroallergens and meat/fish/dairy/poultry food allergens. The degree of overall cross-sensitization was least prominent in adolescents, greater in adults and children, and most pronounced in the elderly.

Conclusion: Our findings reveal that various inhalant and dietary allergens have considerable cross-sensitivity, with the elderly having the highest degree of cross-sensitivity and adolescents the lowest.

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来源期刊
CiteScore
12.80
自引率
0.00%
发文量
74
审稿时长
>12 weeks
期刊介绍: The Asian Pacific Journal of Allergy and Immunology (APJAI) is an online open access journal with the recent impact factor (2018) 1.747 APJAI published 4 times per annum (March, June, September, December). Four issues constitute one volume. APJAI publishes original research articles of basic science, clinical science and reviews on various aspects of allergy and immunology. This journal is an official journal of and published by the Allergy, Asthma and Immunology Association, Thailand. The scopes include mechanism, pathogenesis, host-pathogen interaction, host-environment interaction, allergic diseases, immune-mediated diseases, epidemiology, diagnosis, treatment and prevention, immunotherapy, and vaccine. All papers are published in English and are refereed to international standards.
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