Immediate allergic reaction to thiocolchicoside confirmed by skin testing and basophil activation test: A case report and literature review.

IF 2.3 4区 医学 Q3 ALLERGY
Eleonora Nucera, Riccardo Inchingolo, Manuela Ferraironi, Arianna Aruanno, Raffaella Chini, Angela Rizzi
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引用次数: 0

Abstract

Background: Thiocolchicoside is a muscle relaxant, anti-inflammatory, and analgesic. Administered orally, intramuscularly, or topically, this drug is used in the symptomatic treatment of muscular spasms and rheumatologic disorders. Despite its extensive use, thiocolchicoside is a very rare sensitizer.

Objective: To evaluate IgE-mediated reaction to thiocolchicoside by basophil activation test.

Methods: Allergological work-up with skin prick tests, intradermal tests and basophil activation test with thiocolchicoside.

Results: We report the first case of immediate reaction to thiocolchicoside confirmed by basophil activation test in addition to positive skin tests.

Conclusions: BAT can be considered a complementary diagnostic tool to demonstrate an IgE-mediated reaction also for muscle relaxant drugs.

经皮肤测试和嗜碱性粒细胞活化测试证实的硫代胆碱苷即刻过敏反应:病例报告和文献综述。
背景介绍硫代小檗苷是一种肌肉松弛剂、消炎药和镇痛药。该药可口服、肌肉注射或局部使用,用于肌肉痉挛和风湿病的对症治疗。尽管硫代小檗苷被广泛使用,但它是一种非常罕见的致敏物质:通过嗜碱性粒细胞活化试验评估 IgE 介导的硫代小檗苷反应:方法:通过皮肤点刺试验、皮内试验和嗜碱性粒细胞活化试验进行过敏学检查:结果:我们报告了第一例嗜碱性粒细胞活化试验证实的硫代水杨酸即刻反应病例:结论:嗜碱性粒细胞活化试验可被视为一种辅助诊断工具,用于证明肌肉松弛剂药物也会引起 IgE 介导的反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
12.80
自引率
0.00%
发文量
74
审稿时长
>12 weeks
期刊介绍: The Asian Pacific Journal of Allergy and Immunology (APJAI) is an online open access journal with the recent impact factor (2018) 1.747 APJAI published 4 times per annum (March, June, September, December). Four issues constitute one volume. APJAI publishes original research articles of basic science, clinical science and reviews on various aspects of allergy and immunology. This journal is an official journal of and published by the Allergy, Asthma and Immunology Association, Thailand. The scopes include mechanism, pathogenesis, host-pathogen interaction, host-environment interaction, allergic diseases, immune-mediated diseases, epidemiology, diagnosis, treatment and prevention, immunotherapy, and vaccine. All papers are published in English and are refereed to international standards.
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