{"title":"Immediate allergic reaction to thiocolchicoside confirmed by skin testing and basophil activation test: A case report and literature review.","authors":"Nucera Eleonora, Inchingolo Riccardo, Ferraironi Manuela, Aruanno Arianna, Chini Raffaella, Rizzi Angela","doi":"10.12932/AP-250320-0793","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Thiocolchicoside is a muscle relaxant, anti-inflammatory, and analgesic. Administered orally, intramuscularly, or topically, this drug is used in the symptomatic treatment of muscular spasms and rheumatologic disorders. Despite its extensive use, thiocolchicoside is a very rare sensitizer.</p><p><strong>Objective: </strong>To evaluate IgE-mediated reaction to thiocolchicoside by basophil activation test.</p><p><strong>Methods: </strong>Allergological work-up with skin prick tests, intradermal tests and basophil activation test with thiocolchicoside.</p><p><strong>Results: </strong>We report the first case of immediate reaction to thiocolchicoside confirmed by basophil activation test in addition to positive skin tests.</p><p><strong>Conclusions: </strong>BAT can be considered a complementary diagnostic tool to demonstrate an IgE-mediated reaction also for muscle relaxant drugs.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.12932/AP-250320-0793","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Thiocolchicoside is a muscle relaxant, anti-inflammatory, and analgesic. Administered orally, intramuscularly, or topically, this drug is used in the symptomatic treatment of muscular spasms and rheumatologic disorders. Despite its extensive use, thiocolchicoside is a very rare sensitizer.
Objective: To evaluate IgE-mediated reaction to thiocolchicoside by basophil activation test.
Methods: Allergological work-up with skin prick tests, intradermal tests and basophil activation test with thiocolchicoside.
Results: We report the first case of immediate reaction to thiocolchicoside confirmed by basophil activation test in addition to positive skin tests.
Conclusions: BAT can be considered a complementary diagnostic tool to demonstrate an IgE-mediated reaction also for muscle relaxant drugs.
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