Asian Pacific journal of allergy and immunology最新文献

{"title":"Children with wheat anaphylaxis and with low wheat specific IgE have a different IgE immunoblot pattern than those with high wheat specific IgE.","authors":"Nuntanut Rutrakool, Surapon Piboonpocanun, Unchalee Wangthan, Witchaya Srisuwatchari, Torpong Thongngarm, Orathai Jirapongsananuruk, Nualanong Visitsunthorn, Pakit Vichyanond, Punchama Pacharn","doi":"10.12932/AP-140622-1387","DOIUrl":"10.12932/AP-140622-1387","url":null,"abstract":"<p><strong>Background: </strong>Children with wheat anaphylaxis can present with a wide range of wheat-specific IgE (sIgE).</p><p><strong>Objective: </strong>To identify differences in clinical features and predominant wheat allergens sensitized by these patients.</p><p><strong>Methods: </strong>Children with history of wheat anaphylaxis were recruited. Skin prick test (SPT) to wheat, sIgE to wheat, omega-5 gliadin (ω5G), lipid transfer protein (LTP) were investigated. Profiles of IgE-bound wheat allergens were studied to identify predominant wheat allergens.</p><p><strong>Results: </strong>Twenty-nine children (17 males) aged 1-18 years were enrolled. Sixteen patients (55.2%) had wheat-sIgE > 100 kUA/L (WAhi) and 13 patients (44.8%) had wheat-sIgE < 34 kUA/L (WAlo). The median of peak wheat-sIgE in WAhi and WAlo were 340.5 kUA/L (IQR 184.3, 564.5) and 12.2 kUA/L (IQR 1.4, 41.3), respectively. Oral food challenge test (OFC) was carried out in 12 of 13 patients in the WAlo group, all of which had positive results. Eight of these 12 patients developed anaphylaxis during OFC despite having wheat-sIgE less than 10 kUA/L. There were no differences in clinical characteristics and atopic history between WAhi vs. WAlo. Medium to low molecular weight gliadin (< 40 kDa) and glutenin (< 60 kDa) were commonly recognized by patients with WAhi. IgE immunoblot pattern among the WAlo group was more widely dispersed than those with WAhi.</p><p><strong>Conclusions: </strong>Wheat anaphylaxis can occur in patients with low wheat-sIgE. Predominant wheat allergens recognized by patients with WAlo were different than those with WAhi. Such difference could be responsible for anaphylaxis at even low levels of wheat-sIgE.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"811-818"},"PeriodicalIF":1.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10694831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bronchoalveolar lavage fluid cytokines and chemokines changes after bronchial thermoplasty in severe asthma.","authors":"Nophol Leelayuwatanakul, Pimpayao Sodsai, Ketsupar Jirakran, Vorawut Thanthitaweewat, Virissorn Wongsrichanalai, Thitiwat Sriprasart","doi":"10.12932/AP-010523-1599","DOIUrl":"10.12932/AP-010523-1599","url":null,"abstract":"<p><strong>Background: </strong>Bronchial thermoplasty (BT) is a non-pharmacological intervention in severe asthma with a well-known mechanism of reducing airway smooth muscle. However, its effect on airway inflammation remains uncertain.</p><p><strong>Objective: </strong>To investigate the effect of BT on bronchoalveolar lavage fluid (BALF) cytokines and chemokines in severe asthma patients before BT, after the first BT, and 12 weeks after BT.</p><p><strong>Methods: </strong>Ten severe asthma patients were recruited, and BALF was obtained from right lower lobe before BT, after the first BT, and 12 weeks after BT. BALF analytes were measured and values were compared among the time points. Lung function, asthma control test (ACT), and asthma quality of life questionnaire (AQLQ) were also measured.</p><p><strong>Results: </strong>Tumor necrosis factor (TNF)-α concentration was significantly decreased after the first BT and significantly increased at 12 weeks after BT. Interleukin-6 (IL-6) and TNF-related apoptosis inducing ligand (TRAIL) concentration were significantly increased at 12 weeks after BT. There were no significant changes in Regulated upon activation, normal T-cell expressed and secreted (RANTES) and transforming growth factor-beta1 (TGF-β1) concentration over time after BT. At 12 weeks after BT, there were significantly greater improvements in the scores on AQLQ (3.93 ± 0.88 to 5.3 ± 0.99, p = 0.002) and ACT (13.6 ± 3.27 to 19 ± 4.44, p = 0.002). The lung function did not differ significantly between pre- and post-BT.</p><p><strong>Conclusions: </strong>BT has limited effect on TNF-α, IL-6, TRAIL, RANTES, and TGF- β1 in BALF suggesting that its clinical benefit is not primarily related to this local airway inflammation. The effect on long-term airway inflammation probably needs further studies.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"1045-1052"},"PeriodicalIF":1.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49688585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergenicity potential of protein extract from freshwater and saltwater fish based on heat stability and antibody-binding frequency.","authors":"Atika H Falihah, Zulfi Azizah, Bayu Ba Santoso, Ika P Sari, Muhammad Na Sahid","doi":"10.12932/AP-221024-1958","DOIUrl":"10.12932/AP-221024-1958","url":null,"abstract":"<p><strong>Background: </strong>Saltwater fish are associated with more allergic reactions compared to freshwater fish. However, the factors contributing to this difference remain unclear.</p><p><strong>Objective: </strong>To compare the heat stability of freshwater and saltwater fish proteins, and assess their binding affinity to allergen-specific antibodies.</p><p><strong>Methods: </strong>Protein extracts were isolated from saltwater fish-Selar crumenophthalmus, Euthynnus affinis, Ambassis urotaenia, and freshwater fish i.e., Rasbora argyrotaenia, Monopterus albus, and Poecilia reticulata. Protein extract from Penaeus monodon served as a standard allergen source. Both raw and heat-treated protein extracts were subjected to SDS-PAGE analysis. The number of protein bands, their molecular sizes, and intensities were evaluated. Protein binding frequencies to anti-tropomyosin antibodies and IgE-containing serum from allergic patients were measured using ELISA.</p><p><strong>Results: </strong>The P. monodon protein extract < 100 kDa demonstrated heat stability, while A. urotaenia proteins < 40 kDa were also heat-stable. Raw protein extracts from R. argyrotaenia and M. albus exhibited binding frequencies to anti-tropomyosin IgG of 28.18 ± 1.05% and 14.79 ± 0.91%, respectively. In saltwater fish, raw protein extracts from A. urotaenia and S. crumenophthalmus showed binding frequencies of 61.74 ± 1.87% and 34.68 ± 1.39%, respectively. Freshwater and saltwater fish heat-treated protein extracts displayed binding frequencies below 10%. All heat-treated protein samples exhibited higher binding frequencies to polyclonal IgE in patient sera compared to their raw counterparts.</p><p><strong>Conclusions: </strong>Proteins smaller than 20 kDa exhibit significant heat stability. Raw protein extracts show higher binding frequencies to monoclonal IgG against crustacean tropomyosin, while heat-treated samples have increased binding frequency to IgE-containing human serum.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"946-954"},"PeriodicalIF":1.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of intramuscular HPV vaccine on recalcitrant warts: A systematic review and IPD meta-analysis.","authors":"Charussri Leeyaphan, Sumanas Bunyaratavej, Jomgriditip Laomoleethorn, Woramate Bhorntarakcharoen, Pattriya Jirawattanadon","doi":"10.12932/AP-140825-2135","DOIUrl":"10.12932/AP-140825-2135","url":null,"abstract":"<p><strong>Background: </strong>Recalcitrant warts, often unresponsive to standard treatments, lead to a significant clinical challenge. Emerging evidence suggests intramuscular HPV vaccination may offer therapeutic benefit.</p><p><strong>Objective: </strong>To evaluate the efficacy of HPV vaccination for wart resolution and identify response predictors through an individual patient data meta-analysis.</p><p><strong>Methods: </strong>This systematic review and individual patient data meta-analysis followed PRISMA-IPD guidelines and was registered in PROSPERO (CRD420251051106). Six databases were searched for studies published before March 2025 involving patients with recalcitrant warts treated with intramuscular HPV vaccines. Inclusion required reported treatment outcomes. Two reviewers independently screened, extracted, and assessed risk of bias. Outcomes were analyzed using Kaplan-Meier survival analysis with subgroup comparisons by age, wart location, immune status, and vaccine type based on cases with known time to clearance.</p><p><strong>Results: </strong>A total of 183 patients with recalcitrant warts from 27 studies (mean age 31.7 years) were included. The most common site was anogenital. Complete resolution occurred in 61.2% of cases (112/183). Among immunocompromised patients, a clinical response (complete or partial clearance) was achieved in 92.9% (13/14). Responders were significantly younger, with no outcome differences by vaccine type, concurrent treatment, sex, or comorbidities. Time-to-event analysis based on 168 patients with known time to complete clearance showed a median time to cure of 24 weeks with a 6-month cumulative cure rate of 52.4%. Reported adverse events were mild and transient.</p><p><strong>Conclusions: </strong>Intramuscular HPV vaccination has shown encouraging outcomes. Although current evidence is based on uncontrolled studies, further controlled studies are warranted to confirm these findings.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":"43 4","pages":"984-996"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146200055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of low- and high-dose slow oral egg immunotherapy for hen's egg allergy: Single-center non-inferiority randomized trial.","authors":"Yuri Takaoka, Yoichi M Ito, Junko Kumon, Tomohiro Yamaguchi, Rumi Ueno, Yuki Tsurinaga, Tamana Nakano, Yohei Fukasawa, Amane Shigekawa, Yukinori Yoshida, Makoto Kameda, Satoru Doi","doi":"10.12932/AP-130722-1411","DOIUrl":"10.12932/AP-130722-1411","url":null,"abstract":"<p><strong>Background: </strong>Low-dose oral immunotherapy (OIT) is a safe treatment for hen's egg allergy; however, comparison of its therapeutic effects with those of high-dose OIT has not been reported.</p><p><strong>Objective: </strong>To compare the efficacy of low- and high-dose boiled egg-white (EW) OIT for hen's egg allergy.</p><p><strong>Methods: </strong>Patients with hen's egg allergy were randomly assigned to two groups: OIT using hard-boiled EW with a maximum maintenance dose of 2 and 20 g in the low-dose (L-D) and high-dose (H-D) groups, respectively. The intake dose was ingested twice a week, increased by approximately 20% per week until reaching the target maintenance dose (2 or 20 g hard-boiled EW), and maintained thereafter according to the schedule. The threshold was confirmed via oral food challenge (OFC) after 6 months, and the difference in the proportion of subjects passing the exit OFC between groups was evaluated.</p><p><strong>Results: </strong>Fifty-two patients (L-D, n = 23; H-D, n = 29) were enrolled. Thirty-three patients (L-D, n = 17; H-D, n = 16) completed the 6-month OIT and underwent an exit OFC. In total, three (L-D, 3/17; H-D, 3/16) patients in each group tested negative for an exit OFC with a 20-g reactive dose (p = 1.000). EW-specific IgE levels in both groups decreased significantly after OIT (L-D, p < 0.001; H-D, p = 0.002).</p><p><strong>Conclusions: </strong>A threshold-elevating effect was observed in the L-D group, not inferior to that in the H-D group. Low-dose OIT may be appropriate to treat hen's egg allergy for the first 6 months.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"839-845"},"PeriodicalIF":1.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9675881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of gut microbiome profile in children with confirmed wheat allergy.","authors":"Watcharoot Kanchongkittiphon, Saifon Nopnipa, Rubwad Mathuranyanon, Nutthawan Nonthabenjawan, Suphanich Sritournok, Wiparat SritournokManuyakorn, Pagakrong Wanapaisan","doi":"10.12932/AP-080623-1626","DOIUrl":"10.12932/AP-080623-1626","url":null,"abstract":"<p><strong>Background: </strong>Food allergies pose serious health risks, including life-threatening anaphylactic reactions, increased morbidity, and reduced quality of life. Wheat allergy is a common concern in Asia. There is growing interest in understanding the potential association between dysregulation of the gut microbiome and the development of food allergies.</p><p><strong>Objective: </strong>This study aimed to explore the gut microbiome of Thai children with wheat allergy and its potential association with allergic responses.</p><p><strong>Methods: </strong>Microbial abundance was assessed using Quantitative Insights into Microbial Ecology 2 (QIIME2) microbiome analysis based on 16S rDNA data. The correlation between microbial richness and relevant parameters was evaluated using the Spearman correlation analysis. Additionally, the microbial community functions were predicted using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt2).</p><p><strong>Results: </strong>The gut microbiome analysis revealed significant differences between the two groups at the phylum and genus levels. Firmicutes (p = 0.012) and Verrucomicrobia (p < 0.001) were enriched in wheat-allergic children, whereas specific gut microbes such as Megamonas (p = 0.04), Romboutsia (p < 0.001), Fusobacterium (p < 0.001), Clostridium senso stricto1 (p < 0.001), and Turicibacter (p < 0.001) were more abundant in healthy children. Anaerostripes (p = 0.011), Erysipelatoclostridium (p < 0.001), Prevotella 2 (p < 0.001), Ruminiclostridium 5 (p < 0.001), and Clostridium innnocuum (p < 0.001) were enriched in children with a confirmed wheat allergy. Functional analysis indicated disparities in the pathways related to arginine and polyamine biosynthesis.</p><p><strong>Conclusion: </strong>These findings offer valuable insights into the gut microbiome of children with wheat allergy and its potential impact on symptom severity, laying the groundwork for further research and interventions aimed at addressing this health concern.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"933-945"},"PeriodicalIF":1.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139073290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunoglobulin E binding capacity to various types of Korean soy sauces among children sensitized to wheat and soybean.","authors":"Jeongmin Lee, Purevsan Gantulga, Kyunguk Jeong, Sanghwa Youm, Sooyoung Lee","doi":"10.12932/AP-110924-1922","DOIUrl":"10.12932/AP-110924-1922","url":null,"abstract":"<p><strong>Background: </strong>Soy sauce (SS) is made from soy or a mix of soybean and wheat proteins. With the rise in global consumption of Korean SS, understanding the allergenicity of its different types is essential.</p><p><strong>Objective: </strong>This study is the first to evaluate whether the immunoglobulin E binding capacity (IgE+) in children sensitized to soybeans or wheat varies by SS types.</p><p><strong>Methods: </strong>Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and an enzyme-linked immunosorbent assay (ELISA) using pooled and individual sera were performed with three SS types. Inhibition ELISA was performed using SS concentrate, extracts of wheat, and soybean.</p><p><strong>Results: </strong>Guk-SS showed very faint protein bands, on SDS-PAGE. ELISA (pooled sera, n = 36) indicated that all groups had the lowest IgE+ to Guk-SS. In individual ELISA, patients sensitized to both wheat and soybeans (WS; n = 4) showed significantly higher IgE+ to all SS types (Yangjo > Jin > Guk) than those sensitized to wheat (W; n = 3) or Soy (S; n = 3) alone. The W group had IgE+ similar to the control group for Guk and Jin-SS, while the S group showed slightly higher IgE+ to Yangjo-SS. When soybean was used as an inhibitor, the IgE+ to Yangjo-SS and Jin-SS was inhibited by more than 50% (Yangjo > Jin). In contrast, wheat exhibited only subtle inhibition of both SS (< 20%). Converse showed similar results.</p><p><strong>Conclusions: </strong>For pediatric patients sensitized to wheat, it is suggested that Korean SS be carefully introduced at home. For patients sensitized to soybeans, it is safest to try Guk-SS before attempting other types.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"783-792"},"PeriodicalIF":1.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Buckwheat allergy.","authors":"Feng Chen, Yangshuhan Xu, Kelong Ma, Yuzhu Zhang, Tengchuan Jin","doi":"10.12932/AP-171025-2165","DOIUrl":"10.12932/AP-171025-2165","url":null,"abstract":"<p><p>Buckwheat, a gluten-free pseudocereal, is a traditional staple in parts of East Asia-particularly Japan, Korea, and northern China-as well as in Russia, but is rarely consumed in Southeast Asia where rice dominates the diet. Its growing use in gluten-free products worldwide has increased exposure, raising concerns about buckwheat allergy, which can manifest as urticaria, rhinoconjunctivitis, asthma, or life-threatening anaphylaxis. Both dietary ingestion and occupational inhalation pose risks. Despite relatively high sensitization rates in endemic regions, many individuals remain asymptomatic, complicating clinical interpretation. Conventional diagnostic methods using aqueous extracts often miss lipid-soluble allergens such as oleosins (e.g., Fag t 6), potentially leading to false-negative results. Component-resolved diagnostics targeting Fag e 2-a pepsin-resistant 2S albumin recognized by IgE in up to 90% of symptomatic patients-significantly enhances diagnostic specificity. Cross-reactivity with latex, peanut, and wheat has been reported, though its clinical relevance requires individual assessment. Strict avoidance remains the cornerstone of management, as no approved immunotherapy exists. Given buckwheat's frequent inclusion in unlabeled \"gluten-free\" foods, accurate diagnosis and patient education are critical. Future efforts should focus on standardized detection protocols that include non-aqueous extraction and the development of precision diagnostic tools.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":"43 4","pages":"753-761"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146199993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-wide association study of hypersensitivity skin reactions induced by nonionic iodinated contrast media.","authors":"Min-Rou Lin, Ting-Yuan Liu, Hsing-Yu Hsu, Yow-Wen Hsieh, Poppy Diah Palupi, Pei-Pei Lau, Wei-Chiao Chang, Fuu-Jen Tsai","doi":"10.12932/AP-300424-1850","DOIUrl":"10.12932/AP-300424-1850","url":null,"abstract":"<p><strong>Background: </strong>In Taiwan, nonionic iodinated contrast media (ICMs) are commonly used but can occasionally cause severe side effects. The infrequency of these adverse events, coupled with the complexities in establishing direct causality, poses significant challenges for genetic research.</p><p><strong>Objective: </strong>: To investigate the genetic factors associated with skin reactions mediated by nonionic ICMs on a genome-wide scale.</p><p><strong>Methods: </strong>A hospital-based cohort from the China Medical University Hospital biobank was utilized to conduct a comprehensive genome-wide association study (GWAS) using PLINK v1.9. The study incorporated two distinct cohorts: one based on adverse drug reaction (ADR) reports, capturing immediate reactions, and the other based on self-reports, which primarily reflected delayed reactions. Known loci were determined by the GWAS catalog. Fine mapping was conducted by FINEMAP to predict causal variants. Pathway enrichment analysis was performed by clusterProfiler to reveal the biological function of the identified genetic signatures.</p><p><strong>Results: </strong>The ADR-based cohort included 120 cases and 3640 controls. GWAS identified 6 candidate risk loci, namely rs150515068, rs6847491, rs192044153, rs191908641, rs376660317, and rs368821335. The self-report-based cohort, consisting of 275 cases and 8338 controls, revealed 36 additional candidate risk loci. Fine mapping further identified 4 causal variants within each cohort. Pathway analysis showed that immediate HSR-related genes are linked to growth hormone response and signaling, while non-immediate HSR genes are involved in neurotransmission.</p><p><strong>Conclusion: </strong>This study offers new perspectives on the genetic foundation of nonionic ICM-induced skin reactions within the Taiwanese population, suggesting that the genes contributing to immediate and non-immediate HSRs might have different functional roles.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"590-603"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human milk oligosaccharides in Chinese lactating mothers and relationship with allergy development in offspring.","authors":"Yehao Chen, Amber Jiachi Chiou, Agnes Sze Yin Leung, Kate Ching Ching Chan, Mei Kam Chang, Nam Sze Cheng, Paul Kay Sheung Chan, Man Sau Wong, Wing Hung Tam, Ting Fan Leung","doi":"10.12932/AP-110922-1453","DOIUrl":"10.12932/AP-110922-1453","url":null,"abstract":"<p><strong>Background: </strong>The health benefits of breastfeeding are partly contributed by human milk oligosaccharides (HMOs), but there is limited data on breast milk (BM) HMO composition in Chinese.</p><p><strong>Objective: </strong>This study investigated the association between early-life HMO intake and allergy occurrence in Chinese children.</p><p><strong>Methods: </strong>103 healthy Chinese pregnant women regardless of allergy history were recruited into this birth cohort. Their babies were followed until 24 months old. Concentrations of 2'-fucosyllactose (2'-FL), lacto-N-neotetraose (LNnT), -sialyllactose (3'-SL) and 6'-sialyllactose (6'-SL) in BM collected at 1-month postpartum were measured by liquid chromatography-mass spectrometry. The associations between these HMOs and allergy occurrence by 24 months were analyzed by multivariate regression analyses.</p><p><strong>Results: </strong>Twenty-nine percent and 19% of participants had eczema at 12 and 24 months old respectively. Eighty BM samples were analyzed, with 2'-FL being the most abundant HMO (median 1447 ppm, interquartile range [IQR] 291-1906 ppm), and median (IQR) levels of LNnT, 6'-SL and 3'-SL in ppm were 738 (580-950), 20.5 (12.7-38.8) and 23.0 (17.8-27.6) respectively. Participants with eczema by 24 months consumed BM with higher 2'-FL concentration at 1-month (P = 0.008), and also lower 6'-SL concentration in exclusively breastfed infants (P = 0.012) but higher 6'-SL concentration for those with mixed feeding at 1 month (P = 0.043). Food allergic children at 12 months consumed BM with higher 2'-FL concentrations at 1 month (P = 0.048).</p><p><strong>Conclusions: </strong>BM 2'-FL concentration is higher in children who develops eczema by 24 months and food allergy during infancy. The relationship for 6'-SL is divergent depending on mode of feeding in infants.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"620-628"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9661265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}