Asian Pacific journal of allergy and immunology最新文献_第9页

Efficacy of drug therapies in antihistamine refractory chronic spontaneous urticaria: Real life data. 药物疗法对抗组胺药难治性慢性自发性荨麻疹的疗效：真实生活数据。

IF 5 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-06-01 DOI: 10.12932/AP-270820-0948

Mehmet Unsel

{"title":"Efficacy of drug therapies in antihistamine refractory chronic spontaneous urticaria: Real life data.","authors":"Mehmet Unsel","doi":"10.12932/AP-270820-0948","DOIUrl":"10.12932/AP-270820-0948","url":null,"abstract":"Background: Omalizumab is a safe and effective treatment for antihistamine-refractory chronic spontaneous urticaria (CSU) but is insufficient in one-third of patients. For serious cases in which omalizumab is ineffective, cyclosporine or methotrexate may be preferred. Most drug trials in CSU have focused on omalizumab or cyclosporine monotherapy.Objective: This retrospective study evaluated responses to monotherapy or combined therapy and real-life data on the effectiveness and safety of omalizumab in antihistamine-refractory CSU.Methods: A total of 133 patients who received omalizumab due to antihistamine-refractory CSU were evaluated in terms of 7-day urticaria activity score, total IgE, anti-thyroid peroxidase, C-reactive protein, skin prick test with aeroallergens and disease duration. Partial or nonresponders to omalizumab monotherapy were given antihistamine, omalizumab, cyclosporine, and methotrexate as combined or monotherapy.Results: Ninety-eight (73.7%) of the 133 patients were female and the mean age was 40.7 ± 14.4 years; 70.6% of the patients received omalizumab monotherapy and the others received combined or non-omalizumab monotherapy. Omalizumab monotherapy was effective in 66.9% of the patients. Of those with complete response to omalizumab monotherapy, 65.4% had early recurrence after discontinuing treatment. Treatment response was significantly better in patients who had high total IgE (p = 0.001). Patients with longer disease duration had significantly higher likelihood of early recurrence (p = 0.035).Conclusions: Omalizumab monotherapy was as effective in real life as in placebo-controlled trials. Omalizumab was well tolerated by all patients. Treatment responses were comparable in patients treated with combined therapy and those who received monotherapy.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"138-146"},"PeriodicalIF":5.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25411606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative analysis of asian carps parvalbumin reveals the divergence pattern of major fish allergen. 亚洲鲤鱼副卵磷脂的比较分析揭示了主要鱼类过敏原的分化模式。

IF 5 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-05-06 DOI: 10.12932/AP-200823-1673

Judy Kin Wing Ng, Qing Xiong, Ling Shi, Christine Yee Yan Wai, Soo Kyung Shin, Fu Kiu Ao, Agnes Sze Yin Leung, Nicki Yat Hin Leung, Ting Fan Leung, Stephen Kwok Wing Tsui

{"title":"Comparative analysis of asian carps parvalbumin reveals the divergence pattern of major fish allergen.","authors":"Judy Kin Wing Ng, Qing Xiong, Ling Shi, Christine Yee Yan Wai, Soo Kyung Shin, Fu Kiu Ao, Agnes Sze Yin Leung, Nicki Yat Hin Leung, Ting Fan Leung, Stephen Kwok Wing Tsui","doi":"10.12932/AP-200823-1673","DOIUrl":"https://doi.org/10.12932/AP-200823-1673","url":null,"abstract":"Background: Asian carps, a popular freshwater fish globally, are valued for their flavor and serve as a crucial protein source, especially for infants. However, grass carp parvalbumin is highly allergenic, surpassing the allergenicity of fish like salmon and cod. The allergenic potential of parvalbumin in other Asian carps remains unknown, underscoring the need for allergen identification to improve the precision of fish allergy diagnosis and treatment.Objective: To identify all parvalbumin homologs in Asian carps and investigate the role of gene divergence in allergenic homolog formation.Methods: Three annotated genomes of Asian carp, including grass carp, black carp and bighead carp, were constructed using a hybrid assembly approach. Through sequence homology at the genomic level, all the homologs of major fish allergens were identified. Bioinformatics tools were then employed to reveal the gene structures, expression levels, and protein conformations of parvalbumin.Results: Grass carp genome analysis showed nine parvalbumin homologs, with Cid_PV2 most similar to Cten i 1. Bighead and black carp genomes had ten homologs, including potentially allergenic Mpi_PV7 and Hno_PV7. Tissue-specific expression patterns revealed alternative usage of parvalbumin homologs. Gene duplication events expanded parvalbumin copies in bony fish, with two gene clusters identified in Asian carp genomes.Conclusion: All the homologs of Asian carps' parvalbumin were accurately identified and gene divergence contributed to the formation of allergenic homologs. Together with a comprehensive gene sequence profile of carps' parvalbumin, those could be applied to achieve a more precise clinical diagnostic test.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140853080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical significance of a basophil activation test for Japanese beekeepers naturally sensitized to honey bee venom. 针对对蜜蜂毒液天然致敏的日本养蜂人的嗜碱性粒细胞活化测试的临床意义。

IF 5 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-05-06 DOI: 10.12932/AP-030124-1759

Hisanori Hirokawa, Hirokuni Hirata, Masafumi Arima, Yasuo Haruyama, Yasutsugu Fukushima

{"title":"Clinical significance of a basophil activation test for Japanese beekeepers naturally sensitized to honey bee venom.","authors":"Hisanori Hirokawa, Hirokuni Hirata, Masafumi Arima, Yasuo Haruyama, Yasutsugu Fukushima","doi":"10.12932/AP-030124-1759","DOIUrl":"https://doi.org/10.12932/AP-030124-1759","url":null,"abstract":"Background: The basophil activation test (BAT) has high sensitivity and specificity for diagnosing Hymenoptera venom allergy and is useful for predicting the clinical sensitivity of bee venom-allergic patients after venom immunotherapy. Patients sensitized to Hymenoptera venom are at risk for systemic reactions (SRs) to subsequent stings. Therefore, a tool that can predict the occurrence of SRs and the severity of Hymenoptera stings is needed.Objective: We performed BATs on Japanese beekeepers naturally sensitized to honey bee venom (HBV) and analyzed the positive threshold concentration for the occurrence of SRs following honey bee stings (HBS).Methods: Sixty-one beekeepers were interviewed and blood samples were taken. Data including history of HBS and the occurrence and severity of SRs to HBS were recorded. Blood samples were exposed to HBV-specific IgE antibodies (sIgE) and BAT was performed. Participants with HBV-sIgE ≥ class 1 were considered sensitized to HBV. The positive threshold for BAT scored as 0.0001, 0.001, 0.01, 0.1, and 1 μg/ml was classified as classes 5, 4, 3, 2, and 1, respectively. Samples negative at 1 μg/ml were classified as class 0.Results: About 40% of beekeepers with a positive BAT threshold ≤ 0.1 μg/ml had SRs after HBS. The mean score of the BAT positivity threshold for beekeepers who developed SRs was significantly lower than that for beekeepers with no history of SRs (2.6 ± 0.8 vs 1.4 ± 1.1, P < 0.01).Conclusion: Analysis of the positive threshold of BAT in Japanese beekeepers naturally sensitized to HBV may be a useful tool for predicting the occurrence of SRs.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140850386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Moonlighting glyceraldehyde-3-phosphate dehydrogenase of Lactobacillus gasseri inhibits keratinocyte apoptosis and skin inflammation in experimental atopic dermatitis. 加塞乳杆菌的月光甘油醛-3-磷酸脱氢酶可抑制实验性特应性皮炎的角质细胞凋亡和皮肤炎症。

IF 5 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-05-06 DOI: 10.12932/AP-211123-1733

Pei-Chi Chen, Miao-Hsi Hsieh, Wei-Leng Chen, Yu-Pu Hsia, Wen-Shou Kuo, Lawrence Shih-Hsin Wu, Shulhn-Der Wang, Xiao-Yu Liu, Jiu-Yao Wang, Hui-Fang Kao

{"title":"Moonlighting glyceraldehyde-3-phosphate dehydrogenase of Lactobacillus gasseri inhibits keratinocyte apoptosis and skin inflammation in experimental atopic dermatitis.","authors":"Pei-Chi Chen, Miao-Hsi Hsieh, Wei-Leng Chen, Yu-Pu Hsia, Wen-Shou Kuo, Lawrence Shih-Hsin Wu, Shulhn-Der Wang, Xiao-Yu Liu, Jiu-Yao Wang, Hui-Fang Kao","doi":"10.12932/AP-211123-1733","DOIUrl":"10.12932/AP-211123-1733","url":null,"abstract":"Background: Atopic dermatitis (AD) is a chronic inflammatory skin disorder affecting up to 20% of children in developed countries. Although probiotics have shown promise as adjuvant treatments for AD, their mechanisms are not well understood.Objective: Building upon our previous studies, we investigated whether Lactobacillus gasseri and its moonlighting glyceraldehyde 3-phosphate dehydrogenase (GAPDH), namely LGp40, could be beneficial in AD management.Methods: In AD mouse models (SKH and C57BL/6J mice) with ovalbumin (OVA) and Dermatophagoides pteronyssinus (Der p) allergens, aligning with the \"outside-in\" and \"inside-out\" hypotheses, we administered L. gasseri orally and LGp40 intraperitoneally to investigate their protective effects. The evaluation involved measuring physiological, pathological, and immune function parameters. To delve deeper into the detailed mechanism of LGp40 protection in AD, additional assays were conducted using human skin keratinocytes (HaCaT) and monocytes (THP1) cell lines.Results: L. gasseri and LGp40 enhanced skin barrier function and increased skin moisture retention. They also led to reduced infiltration of Langerhans cells in the dermis and mitigated skewed Th2 and Th17 immune responses. Moreover, LGp40 inhibited allergen-induced keratinocyte apoptosis through the blockade of the caspase-3 cascade and reduced the NLR family pyrin domain containing 3 (NLRP3) inflammasome in macrophages. These inhibitions were achieved through the activation of the peroxisome proliferator-activated receptor gamma (PPARγ) pathway.Conclusion: The results of this study provide a novel insight into the mechanism of action of probiotics in the prevention and treatment for allergic disorders through the moonlighting GAPDH protein.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral administration of Lactobacillus delbrueckii subsp. lactis LDL557 attenuates airway inflammation and changes the gut microbiota in a Der p-sensitized mouse model of allergic asthma. 口服德尔布鲁贝克乳杆菌亚种 LDL557 可减轻气道炎症，并改变 Der p 致敏过敏性哮喘小鼠模型的肠道微生物群。

IF 5 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-05-06 DOI: 10.12932/AP-200823-1672

Pei-Chi Chen, Han-Yin Hsu, Yi-Chu Liao, Chia-Chia Lee, Miao-Hsi Hsieh, Wen-Shou Kuo, Lawrence Shih-Hsin Wu, Jiu-Yao Wang

{"title":"Oral administration of Lactobacillus delbrueckii subsp. lactis LDL557 attenuates airway inflammation and changes the gut microbiota in a Der p-sensitized mouse model of allergic asthma.","authors":"Pei-Chi Chen, Han-Yin Hsu, Yi-Chu Liao, Chia-Chia Lee, Miao-Hsi Hsieh, Wen-Shou Kuo, Lawrence Shih-Hsin Wu, Jiu-Yao Wang","doi":"10.12932/AP-200823-1672","DOIUrl":"10.12932/AP-200823-1672","url":null,"abstract":"Background: Lactic acid bacteria may be used as probiotics to prevent or treat various diseases, and Lactobacillus delbrueckii has an inhibitory effect on the development of atopic diseases.Objective: This study explored the effects of L. delbrueckii subsp. lactis strain LDL557 administration on a mouse asthma model resulting from Dermatophoides pteronyssinus (Der p) sensitization and investigated the associated gut microbiota.Methods: Der p-sensitized and challenged BALB/c mice were orally administered with three different doses of live (low, 10⁷ colony-forming units (CFU); medium, 10⁸ CFU; high, 10⁹ CFU) and heat-killed (10⁹ cells) LDL557 in 200 μL of PBS daily, starting 2 weeks before Der p sensitization and lasting 4 weeks. After the allergen challenge, airway responsiveness to methacholine and the influx of inflammatory cells to the lungs were assessed. The gut microbiome was obtained by sequencing the V3-V4 region of the 16S rRNA gene from mice stool samples.Results: LDL557 in the live (10⁹ CFU) and heat-killed (10⁹ cells) conditions reduced the airway hyper-responsiveness after stimulation with methacholine, inflammatory cell infiltration, and mucus production. These effects were similar to those in groups treated with dexamethasone. No significant change in the gut microbiota was observed after LDL557 treatment, except for the tendency of heat-killed LDL557 to change the gut microbial profile to a greater extent than live LDL557.Conclusion: In summary, we found that live and heat-killed LDL557 had the beneficial effect of preventing Der p-induced allergic inflammation in a mouse model of asthma.","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary function characteristics in children with suspected asthma: implications for asthma diagnosis. 疑似哮喘儿童的肺功能特征：对哮喘诊断的影响。

IF 5 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-04-20 DOI: 10.12932/ap-020523-1601

Mireu Park, Yun Young Roh, Ha Min Kim, Jae Hwa Jung, Soo Yeon Kim, Jong Deok Kim, Yong Ju Lee, Min Jung Kim, Yoon Hee Kim, Kyung Won Kim, Myung Hyun Sohn

引用次数: 0

Incidence, predictors, and treatment outcomes of biphasic anaphylaxis in the emergency department of a tertiary hospital:A 5-year retrospective study. 一家三级医院急诊科双相过敏性休克的发病率、预测因素和治疗结果：一项为期 5 年的回顾性研究。

IF 5 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-04-20 DOI: 10.12932/ap-101223-1745

Waratchaya Uawattanasakul, Ploylarp Lertvipapath, Thanachit Krikeerati, Chamard Wongsa, Torpong Thongngarm, Mongkhon Sompornrattanaphan

引用次数: 0

Lupus exacerbation in ovalbumin-induced asthma in Fc gamma receptor IIb deficient mice, partly due to hyperfunction of dendritic cells. Fcγ 受体 IIb 缺乏的小鼠在卵清蛋白诱发的哮喘中狼疮恶化，部分原因是树突状细胞功能亢进。

IF 5 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-04-20 DOI: 10.12932/ap-290823-1677

Thansita Bhunyakarnjanarat, Jiradej Makjaroen, Wilasinee Saisorn, Kankorn Hirunsap, Jidapond Chiewchengchol, Patcharee Ritprajak, Asada Leelahavanichkul

引用次数: 0

Short-term impact of exposure to ambient air volatile organic compounds on daily clinic visits for urticaria in Kaohsiung, Taiwan. 环境空气中挥发性有机化合物对台湾高雄市荨麻疹患者每日就诊量的短期影响。

IF 5 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-04-20 DOI: 10.12932/ap-270923-1701

Hui-Wen Tseng, Ling-Ying Lu

引用次数: 0

PCR combined with lateral flow dipstick assay (PCR-LFD) for a rapid diagnosis of melioidosis. 聚合酶链式反应（PCR）与侧流滴定法（PCR-LFD）相结合，用于快速诊断类鼻疽。

IF 5 4区医学

Asian Pacific journal of allergy and immunology Pub Date : 2024-04-20 DOI: 10.12932/ap-021023-1703

Priyapa Najomtien, Wisitsak Phoksawat, Sukanya Khammanthoon, Wadcharin Klasuk, Nuttiya Srisurat, Supaksorn Chattagul, Chotima Photisap, Chonlatip Pipattanaboon, Rasana W Sermswan, Surasakdi Wongratanacheewin

引用次数: 0