Recurrent chronic spontaneous urticaria in a tropical country: Clinical characteristics and associated factors.

IF 2.3 4区医学 Q3 ALLERGY

Asian Pacific journal of allergy and immunology Pub Date : 2025-05-05 DOI:10.12932/AP-261124-1984

Pichaya Limphoka, Sukhum Jiamton, Leena Chularojanamontri, Kanokvalai Kulthanan, Papapit Tuchinda

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引用次数: 0

Abstract

Background: Limited data exist regarding recurrent chronic spontaneous urticaria (RCSU) following complete disease remission.

Objective: This study investigated the clinical characteristics and factors associated with RCSU.

Methods: We retrospectively reviewed data from chronic spontaneous urticaria (CSU) patients who actively visited the Urticaria Center of Reference and Excellence, Siriraj Hospital, between January 2021 and December 2023. Medical records were analyzed through May 2024. The RCSU was defined as a new CSU episode occurring after a 6-month symptom-free period without treatment.

Results: Among 179 CSU patients, 19 (10.6%) developed RCSU. These patients had a mean age of 40 (SD 14.9) years, with a female predominance. The mean time to RCSU recurrence was 1.96 (SD 2.05) years. The UAS7 and medication scores were not significantly different between the recurrence and nonrecurrence groups (P = 0.675, P = 0.77). Multivariate analysis revealed that a shorter disease remission time from the first episode onset (< 3 years) was significantly associated with RCSU (odds ratio 5.13, 95%CI 1.83-14.29; P = 0.002).

Conclusions: The RCSU rate was 10.6%. The time to disease remission from the first episode onset significantly associated with RCSU. Several clinical characteristics may corelate with the recurrence: younger age at onset, the presence of angioedema, chronic inducible urticaria comorbidity, systemic corticosteroid use, and positive antinuclear antibody status.

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热带国家复发性慢性自发性荨麻疹：临床特征和相关因素。

背景：关于疾病完全缓解后复发性慢性自发性荨麻疹（RCSU）的数据有限。目的：探讨RCSU的临床特点及相关因素。方法：我们回顾性回顾了2021年1月至2023年12月期间积极访问Siriraj医院荨麻疹参考和卓越中心的慢性自发性荨麻疹（CSU）患者的数据。他们分析了截至2024年5月的医疗记录。RCSU被定义为在无症状6个月后未经治疗出现新的CSU发作。结果：179例CSU患者中，19例（10.6%）发生了RCSU。这些患者的平均年龄为40岁（SD 14.9），以女性为主。RCSU复发的平均时间为1.96年（SD 2.05）。复发组与非复发组UAS7评分及用药评分差异无统计学意义（P = 0.675, P = 0.77）。多因素分析显示，从首次发作开始疾病缓解时间较短（< 3年）与RCSU显著相关(优势比5.13,95%CI 1.83-14.29；P = 0.002)。结论：RCSU发生率为10.6%。从首次发作到疾病缓解的时间与RCSU显著相关。一些临床特征可能与复发相关：发病年龄较小，血管性水肿，慢性诱导性荨麻疹合并症，全身使用皮质类固醇，抗核抗体阳性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Pacific journal of allergy and immunology 医学-过敏

CiteScore

12.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Asian Pacific Journal of Allergy and Immunology (APJAI) is an online open access journal with the recent impact factor (2018) 1.747 APJAI published 4 times per annum (March, June, September, December). Four issues constitute one volume. APJAI publishes original research articles of basic science, clinical science and reviews on various aspects of allergy and immunology. This journal is an official journal of and published by the Allergy, Asthma and Immunology Association, Thailand. The scopes include mechanism, pathogenesis, host-pathogen interaction, host-environment interaction, allergic diseases, immune-mediated diseases, epidemiology, diagnosis, treatment and prevention, immunotherapy, and vaccine. All papers are published in English and are refereed to international standards.