Asian Journal of Pharmaceutical Sciences最新文献_第3页

Vat-based photopolymerization 3D printing: From materials to topical and transdermal applications 釜基光聚合三维打印：从材料到局部和透皮应用

IF 10.7 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2024-08-01 DOI: 10.1016/j.ajps.2024.100940

Angélica Graça , Sara Bom , Ana M. Martins, Helena M. Ribeiro, Joana Marto

{"title":"Vat-based photopolymerization 3D printing: From materials to topical and transdermal applications","authors":"Angélica Graça , Sara Bom , Ana M. Martins, Helena M. Ribeiro, Joana Marto","doi":"10.1016/j.ajps.2024.100940","DOIUrl":"10.1016/j.ajps.2024.100940","url":null,"abstract":"<div><p>Three-dimensional (3D) printing is an innovative manufacturing method with the potential to revolutionize topical and transdermal dosage forms. Nowadays, it is established that Vat-based photopolymerization (VP) 3D printing technologies offer superior printing efficiency and versatility compared to other 3D printing technologies available on the market. However, there are some limitations that impair their full application in pharmaceutical contexts, such as the lack of a range of biocompatible materials for topical and transdermal applications. This review article explores all types of VP-based 3D printing and discusses the relevance of implementing this kind of technology. We start with a detailed description of the printing process, focusing on the commercial materials available and lab-made resins proposed by different authors. We also review recent studies in this field, which mainly focus on the fabrication of transdermal devices based on microneedle arrays. In the future, it is expected that the manufacturers of 3D printers invest in modifications to the printing apparatus to allow the simultaneous printing of different resins and/or compound types, which will open frontiers to the personalization of treatment approaches.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"19 4","pages":"Article 100940"},"PeriodicalIF":10.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1818087624000576/pdfft?md5=64bef77d0edd1ff8a02ddc6a706f9983&pid=1-s2.0-S1818087624000576-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141713709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in living cell nucleic acid probes based on nanomaterials for early cancer diagnosis 基于纳米材料的活细胞核酸探针用于早期癌症诊断的最新进展

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2024-06-01 DOI: 10.1016/j.ajps.2024.100910

Xuyao Liu , Qi Shi , Peng Qi , Ziming Wang , Tongyue Zhang , Sijia Zhang , Jiayan Wu , Zhaopei Guo , Jie Chen , Qiang Zhang

{"title":"Recent advances in living cell nucleic acid probes based on nanomaterials for early cancer diagnosis","authors":"Xuyao Liu , Qi Shi , Peng Qi , Ziming Wang , Tongyue Zhang , Sijia Zhang , Jiayan Wu , Zhaopei Guo , Jie Chen , Qiang Zhang","doi":"10.1016/j.ajps.2024.100910","DOIUrl":"10.1016/j.ajps.2024.100910","url":null,"abstract":"<div><p>The early diagnosis of cancer is vital for effective treatment and improved prognosis. Tumor biomarkers, which can be used for the early diagnosis, treatment, and prognostic evaluation of cancer, have emerged as a topic of intense research interest in recent years. Nucleic acid, as a type of tumor biomarker, contains vital genetic information, which is of great significance for the occurrence and development of cancer. Currently, living cell nucleic acid probes, which enable the <em>in situ</em> imaging and dynamic monitoring of nucleic acids, have become a rapidly developing field. This review focuses on living cell nucleic acid probes that can be used for the early diagnosis of tumors. We describe the fundamental design of the probe in terms of three units and focus on the roles of different nanomaterials in probe delivery.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"19 3","pages":"Article 100910"},"PeriodicalIF":10.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1818087624000278/pdfft?md5=b86a6ad335897822d142540e1f939d93&pid=1-s2.0-S1818087624000278-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140801206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A biomimetic spore nanoplatform for boosting chemodynamic therapy and bacteria-mediated antitumor immunity for synergistic cancer treatment 一种生物仿生孢子纳米平台，可增强化学动力疗法和细菌介导的抗肿瘤免疫力，从而实现癌症的协同治疗

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2024-06-01 DOI: 10.1016/j.ajps.2024.100912

Cuixia Zheng , Lingling Sun , Hongjuan Zhao , Mengya Niu , Dandan Zhang , Xinxin Liu , Qingling Song , Weijie Zhong , Baojin Wang , Yun Zhang , Lei Wang

{"title":"A biomimetic spore nanoplatform for boosting chemodynamic therapy and bacteria-mediated antitumor immunity for synergistic cancer treatment","authors":"Cuixia Zheng , Lingling Sun , Hongjuan Zhao , Mengya Niu , Dandan Zhang , Xinxin Liu , Qingling Song , Weijie Zhong , Baojin Wang , Yun Zhang , Lei Wang","doi":"10.1016/j.ajps.2024.100912","DOIUrl":"10.1016/j.ajps.2024.100912","url":null,"abstract":"<div><p>Bacterial-based antitumor immunity has become a promising strategy to activate the immune system for fighting cancer. However, the potential application of bacterial therapy is hindered by the presence of instability and susceptibility to infections within bacterial populations. Furthermore, monotherapy is ineffective in completely eliminating complex cancer with multiple contributing factors. In this study, based on our discovery that spore shell (SS) of <em>Bacillus coagulans</em> exhibits excellent tumor-targeting ability and adjuvant activity, we develop a biomimetic spore nanoplatform to boost bacteria-mediated antitumor therapy, chemodynamic therapy and antitumor immunity for synergistic cancer treatment. In detail, SS is separated from probiotic spores and then attached to the surface of liposome (Lipo) that was loaded with hemoglobin (Hb), glucose oxidase (GOx) and JQ1 to construct SS@Lipo/Hb/GOx/JQ1. In tumor tissue, highly toxic hydroxyl radicals (•OH) are generated via sequential catalytic reactions: GOx catalyzing glucose into H<sub>2</sub>O<sub>2</sub> and Fe<sup>2+</sup> in Hb decomposing H<sub>2</sub>O<sub>2</sub> into •OH. The combination of •OH and SS adjuvant can improve tumor immunogenicity and activate immune system. Meanwhile, JQ1-mediated down-regulation of PD-L1 and Hb-induced hypoxia alleviation synergistically reshape immunosuppressive tumor microenvironment and potentiate immune response. In this manner, SS@Lipo/Hb/GOx/JQ1 significantly suppresses tumor growth and metastasis. To summarize, the nanoplatform represents an optimum strategy to potentiate bacteria-based cancer immunotherapy.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"19 3","pages":"Article 100912"},"PeriodicalIF":10.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1818087624000291/pdfft?md5=6d76e9f0ffce2ff30af602552971af0c&pid=1-s2.0-S1818087624000291-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140785025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Charge adaptive phytochemical-based nanoparticles for eradication of methicillin-resistant staphylococcus aureus biofilms 用于消除耐甲氧西林金黄色葡萄球菌生物膜的电荷自适应植物化学纳米颗粒

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2024-06-01 DOI: 10.1016/j.ajps.2024.100923

Xilong Cui , Fanhui Liu , Shuang Cai , Tingting Wang , Sidi Zheng , Xinshu Zou , Linlin Wang , Siqi He , Yanhua Li , Zhiyun Zhang

{"title":"Charge adaptive phytochemical-based nanoparticles for eradication of methicillin-resistant staphylococcus aureus biofilms","authors":"Xilong Cui , Fanhui Liu , Shuang Cai , Tingting Wang , Sidi Zheng , Xinshu Zou , Linlin Wang , Siqi He , Yanhua Li , Zhiyun Zhang","doi":"10.1016/j.ajps.2024.100923","DOIUrl":"10.1016/j.ajps.2024.100923","url":null,"abstract":"<div><p>The intrinsic resistance of MRSA coupled with biofilm antibiotic tolerance challenges the antibiotic treatment of MRSA biofilm infections. Phytochemical-based nanoplatform is a promising emerging approach for treatment of biofilm infection. However, their therapeutic efficacy was restricted by the low drug loading capacity and lack of selectivity. Herein, we constructed a surface charge adaptive phytochemical-based nanoparticle with high isoliquiritigenin (ISL) loading content for effective treatment of MRSA biofilm. A dimeric ISL prodrug (ISL-G2) bearing a lipase responsive ester bond was synthesized, and then encapsulated into the amphiphilic quaternized oligochitosan. The obtained ISL-G2 loaded NPs possessed positively charged surface, which allowed cis-aconityl-<span>d</span>-tyrosine (CA-Tyr) binding via electrostatic interaction to obtain ISL-G2@TMDCOS-Tyr NPs. The NPs maintained their negatively charged surface, thus prolonging the blood circulation time. In response to low pH in the biofilms, the fast removal of CA-Tyr led to a shift in their surface charge from negative to positive, which enhanced the accumulation and penetration of NPs in the biofilms. Sequentially, the pH-triggered release of <span>d</span>-tyrosine dispersed the biofilm and lipase-triggered released of ISL effectively kill biofilm MRSA. An <em>in vivo</em> study was performed on a MRSA biofilm infected wound model. This phytochemical-based system led to ∼2 log CFU (>99 %) reduction of biofilm MRSA as compared to untreated wound (<em>P</em> < 0.001) with negligible biotoxicity in mice. This phytochemical dimer nanoplatform shows great potential for long-term treatment of resistant bacterial infections.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"19 3","pages":"Article 100923"},"PeriodicalIF":10.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1818087624000400/pdfft?md5=a8010c180b3afe2e2464817b9b8a723c&pid=1-s2.0-S1818087624000400-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140786781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autophagy and mitophagy as potential therapeutic targets in diabetic heart condition: Harnessing the power of nanotheranostics 自噬和丝裂噬是糖尿病心脏疾病的潜在治疗靶点：利用纳米otheranostics的力量

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2024-06-01 DOI: 10.1016/j.ajps.2024.100927

Sagnik Nag , Oishi Mitra , Bhanu Maturi , Simran Preet Kaur , Ankita Saini , Muskan Nama , Soumik Roy , Souvik Samanta , Leena Chacko , Rohan Dutta , Suresh Babu Sayana , Vetriselvan Subramaniyan , Jasvinder Singh Bhatti , Ramesh Kandimalla

{"title":"Autophagy and mitophagy as potential therapeutic targets in diabetic heart condition: Harnessing the power of nanotheranostics","authors":"Sagnik Nag , Oishi Mitra , Bhanu Maturi , Simran Preet Kaur , Ankita Saini , Muskan Nama , Soumik Roy , Souvik Samanta , Leena Chacko , Rohan Dutta , Suresh Babu Sayana , Vetriselvan Subramaniyan , Jasvinder Singh Bhatti , Ramesh Kandimalla","doi":"10.1016/j.ajps.2024.100927","DOIUrl":"10.1016/j.ajps.2024.100927","url":null,"abstract":"<div><p>Autophagy and mitophagy pose unresolved challenges in understanding the pathology of diabetic heart condition (DHC), which encompasses a complex range of cardiovascular issues linked to diabetes and associated cardiomyopathies. Despite significant progress in reducing mortality rates from cardiovascular diseases (CVDs), heart failure remains a major cause of increased morbidity among diabetic patients. These cellular processes are essential for maintaining cellular balance and removing damaged or dysfunctional components, and their involvement in the development of diabetic heart disease makes them attractive targets for diagnosis and treatment. While a variety of conventional diagnostic and therapeutic strategies are available, DHC continues to present a significant challenge. Point-of-care diagnostics, supported by nanobiosensing techniques, offer a promising alternative for these complex scenarios. Although conventional medications have been widely used in DHC patients, they raise several concerns regarding various physiological aspects. Modern medicine places great emphasis on the application of nanotechnology to target autophagy and mitophagy in DHC, offering a promising approach to deliver drugs beyond the limitations of traditional therapies. This article aims to explore the potential connections between autophagy, mitophagy and DHC, while also discussing the promise of nanotechnology-based theranostic interventions that specifically target these molecular pathways.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"19 3","pages":"Article 100927"},"PeriodicalIF":10.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1818087624000448/pdfft?md5=8e1fdf35ae6e7c29e70276be30b2b0c7&pid=1-s2.0-S1818087624000448-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141140621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunotherapeutic hydrogel for co-delivery of STAT3 siRNA liposomes and lidocaine hydrochloride for postoperative comprehensive management of NSCLC in a single application 用于联合递送 STAT3 siRNA 脂质体和盐酸利多卡因的免疫治疗水凝胶，可一次性用于 NSCLC 术后综合治疗

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2024-06-01 DOI: 10.1016/j.ajps.2024.100925

Xianglei Fu , Yanbin Shi , Zili Gu , Hengchang Zang , Lian Li , Qingjie Wang , Yongjun Wang , Xiaogang Zhao , Hang Wu , Shengnan Qiu , Yankun Zhang , Jiamin Zhou , Xiangqin Chen , Hua Shen , Guimei Lin

{"title":"Immunotherapeutic hydrogel for co-delivery of STAT3 siRNA liposomes and lidocaine hydrochloride for postoperative comprehensive management of NSCLC in a single application","authors":"Xianglei Fu , Yanbin Shi , Zili Gu , Hengchang Zang , Lian Li , Qingjie Wang , Yongjun Wang , Xiaogang Zhao , Hang Wu , Shengnan Qiu , Yankun Zhang , Jiamin Zhou , Xiangqin Chen , Hua Shen , Guimei Lin","doi":"10.1016/j.ajps.2024.100925","DOIUrl":"10.1016/j.ajps.2024.100925","url":null,"abstract":"<div><p>Despite standard treatment for non-small cell lung cancer (NSCLC) being surgical resection, cancer recurrence and complications, such as induction of malignant pleural effusion (MPE) and significant postoperative pain, usually result in treatment failure. In this study, an alginate-based hybrid hydrogel (SOG) is developed that can be injected into the resection surface of the lungs during surgery. Briefly, endoplasmic reticulum-modified liposomes (MSLs) pre-loaded with the signal transducer and activator of transcription 3 (STAT3) small interfering RNA and lidocaine hydrochloride are encapsulated in SOG. Once applied, MSLs strongly downregulated STAT3 expression in the tumor microenvironment, resulting in the apoptosis of lung cancer cells and polarization of tumor-associated macrophages towards the M1-like phenotype. Meanwhile, the release of lidocaine hydrochloride (LID) was beneficial for pain relief and natural killer cell activation. Our data demonstrated MSL@LID@SOG not only efficiently inhibited tumor growth but also potently improved the quality of life, including reduced MPE volume and pain relief in orthotopic NSCLC mouse models, even with a single administration. MSL@LID@SOG shows potential for comprehensive clinical management upon tumor resection in NSCLC, and may alter the treatment paradigms for other cancers.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"19 3","pages":"Article 100925"},"PeriodicalIF":10.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1818087624000424/pdfft?md5=af9866fa79376685878ba98645ec3d3b&pid=1-s2.0-S1818087624000424-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140932646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A PET probe targeting polyamine transport system for precise tumor diagnosis and therapy 用于肿瘤精确诊断和治疗的多胺转运系统正电子发射计算机断层显像探针

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2024-06-01 DOI: 10.1016/j.ajps.2024.100924

Ming Zhou , Xiaoqin Yin , Bei Chen , Shuo Hu , Wenhu Zhou

{"title":"A PET probe targeting polyamine transport system for precise tumor diagnosis and therapy","authors":"Ming Zhou , Xiaoqin Yin , Bei Chen , Shuo Hu , Wenhu Zhou","doi":"10.1016/j.ajps.2024.100924","DOIUrl":"10.1016/j.ajps.2024.100924","url":null,"abstract":"<div><p>Polyamine metabolism dysregulation is a hallmark of many cancers, offering a promising avenue for early tumor theranostics. This study presents the development of a nuclear probe derived from spermidine (SPM) for dual-purpose tumor PET imaging and internal radiation therapy. The probe, radiolabeled with either [<sup>68</sup>Ga]Ga for diagnostic applications or [<sup>177</sup>Lu]Lu for therapeutic use, was synthesized with exceptional purity, stability, and specific activity. Extensive testing involving 12 different tumor cell lines revealed remarkable specificity towards B16 melanoma cells, showcasing outstanding tumor localization and target-to-non-target ratio. Mechanistic investigations employing polyamines, non-labeled precursor, and polyamine transport system (PTS) inhibitor, consistently affirmed the probeʼs targetability through recognition of the PTS. Notably, while previous reports indicated PTS upregulation in various tumor types for targeted therapy, this study observed no positive signals, highlighting a concentration-dependent discrepancy between targeting for therapy and diagnosis. Furthermore, when labeled with [<sup>177</sup>Lu], the probe demonstrated its therapeutic potential by effectively controlling tumor growth and extending mouse survival. Investigations into biodistribution, excretion, and biosafety in healthy humans laid a robust foundation for clinical translation. This study introduces a versatile SPM-based nuclear probe with applications in precise tumor theranostics, offering promising prospects for clinical implementation.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"19 3","pages":"Article 100924"},"PeriodicalIF":10.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1818087624000412/pdfft?md5=157f1e7aca3e72950e4a7d25d1af5d05&pid=1-s2.0-S1818087624000412-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140756333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing ophthalmic delivery of flurbiprofen via synergistic chiral resolution and ion-pairing strategies 通过手性解析和离子配对协同策略推进氟比洛芬的眼科给药

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2024-06-01 DOI: 10.1016/j.ajps.2024.100928

Zhining Ma , Yuequan Wang , Huiyang He , Tong Liu , Qikun Jiang , Xiaohong Hou

{"title":"Advancing ophthalmic delivery of flurbiprofen via synergistic chiral resolution and ion-pairing strategies","authors":"Zhining Ma , Yuequan Wang , Huiyang He , Tong Liu , Qikun Jiang , Xiaohong Hou","doi":"10.1016/j.ajps.2024.100928","DOIUrl":"10.1016/j.ajps.2024.100928","url":null,"abstract":"<div><p>Flurbiprofen (FB), a nonsteroidal anti-inflammatory drug, is widely employed in treating ocular inflammation owing to its remarkable anti-inflammatory effects. However, the racemic nature of its commercially available formulation (Ocufen®) limits the full potential of its therapeutic activity, as the (<em>S</em>)-enantiomer is responsible for the desired anti-inflammatory effects. Additionally, the limited corneal permeability of FB significantly restricts its bioavailability. In this study, we successfully separated the chiral isomers of FB to obtain the highly active (<em>S</em>)-FB. Subsequently, utilizing ion-pairing technology, we coupled (<em>S</em>)-FB with various counter-ions, such as sodium, diethylamine, trimethamine (TMA), and l-arginine, to enhance its ocular bioavailability. A comprehensive evaluation encompassed balanced solubility, octanol-water partition coefficient, corneal permeability, ocular pharmacokinetics, tissue distribution, and <em>in vivo</em> ocular anti-inflammatory activity of each chiral isomer salt. Among the various formulations, S-FBTMA exhibited superior water solubility (about 1–12 mg/ml), lipid solubility (1< lg P<sub>ow</sub> < 3) and corneal permeability. In comparison to Ocufen®, S-FBTMA demonstrated significantly higher <em>in vivo</em> anti-inflammatory activity and lower ocular irritability (such as conjunctival congestion and tingling). The findings from this research highlight the potential of chiral separation and ion-pair enhanced permeation techniques in providing pharmaceutical enterprises focused on drug development with a valuable avenue for improving therapeutic outcomes.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"19 3","pages":"Article 100928"},"PeriodicalIF":10.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S181808762400045X/pdfft?md5=d713cf3b9937b0a72348e2d4c6af4318&pid=1-s2.0-S181808762400045X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141139770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances on thermosensitive hydrogels-mediated precision therapy 热敏水凝胶介导的精准治疗最新进展

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2024-06-01 DOI: 10.1016/j.ajps.2024.100911

Hao Chen , Jiangmei Xu , Jiangwei Sun , Yongxin Jiang , Wang Zheng , Wei Hu , Haisheng Qian

{"title":"Recent advances on thermosensitive hydrogels-mediated precision therapy","authors":"Hao Chen , Jiangmei Xu , Jiangwei Sun , Yongxin Jiang , Wang Zheng , Wei Hu , Haisheng Qian","doi":"10.1016/j.ajps.2024.100911","DOIUrl":"10.1016/j.ajps.2024.100911","url":null,"abstract":"<div><p>Precision therapy has become the preferred choice attributed to the optimal drug concentration in target sites, increased therapeutic efficacy, and reduced adverse effects. Over the past few years, sprayable or injectable thermosensitive hydrogels have exhibited high therapeutic potential. These can be applied as cell-growing scaffolds or drug-releasing reservoirs by simply mixing in a free-flowing sol phase at room temperature. Inspired by their unique properties, thermosensitive hydrogels have been widely applied as drug delivery and treatment platforms for precision medicine. In this review, the state-of-the-art developments in thermosensitive hydrogels for precision therapy are investigated, which covers from the thermo-gelling mechanisms and main components to biomedical applications, including wound healing, anti-tumor activity, osteogenesis, and periodontal, sinonasal and ophthalmic diseases. The most promising applications and trends of thermosensitive hydrogels for precision therapy are also discussed in light of their unique features.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"19 3","pages":"Article 100911"},"PeriodicalIF":10.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S181808762400028X/pdfft?md5=9e1a9f4505e3f11dd3f195e4a27aff17&pid=1-s2.0-S181808762400028X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140778325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucocorticoids-based prodrug design: Current strategies and research progress 基于糖皮质激素的原药设计：当前策略与研究进展

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2024-06-01 DOI: 10.1016/j.ajps.2024.100922

Hongbing Liu , Muse Ji , Peifu Xiao , Jingxin Gou , Tian Yin , Haibing He , Xing Tang , Yu Zhang

{"title":"Glucocorticoids-based prodrug design: Current strategies and research progress","authors":"Hongbing Liu , Muse Ji , Peifu Xiao , Jingxin Gou , Tian Yin , Haibing He , Xing Tang , Yu Zhang","doi":"10.1016/j.ajps.2024.100922","DOIUrl":"10.1016/j.ajps.2024.100922","url":null,"abstract":"<div><p>Attributing to their broad pharmacological effects encompassing anti-inflammation, antitoxin, and immunosuppression, glucocorticoids (GCs) are extensively utilized in the clinic for the treatment of diverse diseases such as lupus erythematosus, nephritis, arthritis, ulcerative colitis, asthma, keratitis, macular edema, and leukemia. However, long-term use often causes undesirable side effects, including metabolic disorders-induced Cushing's syndrome (buffalo back, full moon face, hyperglycemia, etc.), osteoporosis, aggravated infection, psychosis, glaucoma, and cataract. These notorious side effects seriously compromise patients' quality of life, especially in patients with chronic diseases. Therefore, glucocorticoid-based advanced drug delivery systems for reducing adverse effects have received extensive attention. Among them, prodrugs have the advantages of low investment, low risk, and high success rate, making them a promising strategy. In this review, we propose the strategies for the design and summarize current research progress of glucocorticoid-based prodrugs in recent decades, including polymer-based prodrugs, dendrimer-based prodrugs, antibody-drug conjugates, peptide-drug conjugates, carbohydrate-based prodrugs, aliphatic acid-based prodrugs and so on. Besides, we also raise issues that need to be focused on during the development of glucocorticoid-based prodrugs. This review is expected to be helpful for the research and development of novel GCs and prodrugs.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"19 3","pages":"Article 100922"},"PeriodicalIF":10.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1818087624000394/pdfft?md5=1a86498bf675c0b810b1b5ce25a9df62&pid=1-s2.0-S1818087624000394-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140781057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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