Asian Journal of Pharmaceutical Sciences最新文献

{"title":"Chimeric biohybrid nanovesicles induce immunogenic cell death for targeted and immune-potentiated glioblastoma therapy","authors":"Xiaojing Zhu ,&nbsp;Yutong Xing ,&nbsp;Wenrui Jin ,&nbsp;Haoran Geng ,&nbsp;Fan Li ,&nbsp;Yeying Li ,&nbsp;Hongtao Zhang ,&nbsp;Chengjun Wu ,&nbsp;Chen Chen ,&nbsp;Zhenyong Wu","doi":"10.1016/j.ajps.2026.101167","DOIUrl":"10.1016/j.ajps.2026.101167","url":null,"abstract":"<div><div>Glioblastoma (GBM) is shielded by both the blood-brain barrier (BBB) and an immunosuppressive tumor microenvironment. Here, we develop a chimeric biohybrid nanovesicle (BEV-RVG29-PTX) that integrates viral tropism, bacterial vesiculation, and chemotherapeutic cytotoxicity into a single genetically programmable platform. Genetic fusion of rabies virus glycoprotein 29 (RVG29) to the AIDA1 autotransporter translocator domain enables robust, autonomous surface expression on bacterial extracellular vesicles (BEVs) without the need for chemical conjugation. The BEV-RVG29-PTX drives receptor-dependent BBB transcytosis and achieves efficient glioma accumulation. Encapsulated paclitaxel (PTX), otherwise restricted by BBB impermeability, is effectively delivered to intracranial tumors and induces reactive oxygen species-driven immunogenic cell death. Bone marrow-derived dendritic cells immune-activation experiments further confirmed an approximately 2-fold increase in CD80/CD86 activation. Synergizing with the pathogen-mimetic characteristics of BEVs, these signals also elicit an approximately 2-fold increase in intratumoral CD8⁺ T-cell infiltration, overcome immune exclusion, and achieve durable tumor control with extended survival in orthotopic GBM models. Accordingly, this virus-bacteria-drug biohybrid strategy enables targeted brain delivery while simultaneously amplifying antitumor immunity, offering a promising and translatable approach for GBM treatment.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 3","pages":"Article 101167"},"PeriodicalIF":11.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148245900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic antimicrobial nanocomposite: Protamine-loaded PVP-capped silver nanoparticles for combating multidrug-resistant infections","authors":"Mohammad Jaafreh ,&nbsp;Walhan Alshaer ,&nbsp;Mahmoud Alkawareek ,&nbsp;Zalina Zahari ,&nbsp;Shrouq Alsotari ,&nbsp;Dana A. Alqudah ,&nbsp;Hazem Choukaife ,&nbsp;Manal A. Abbas ,&nbsp;Yasser Bustanji ,&nbsp;Mulham Alfatama","doi":"10.1016/j.ajps.2026.101160","DOIUrl":"10.1016/j.ajps.2026.101160","url":null,"abstract":"<div><div>The emergence of multidrug-resistant (MDR) bacterial infections has become a critical global health concern, driving the urgent need for innovative therapeutic strategies beyond conventional antibiotics. In this study, we developed a novel nanotherapeutic platform comprising protamine-loaded poly(N-vinyl-2-pyrrolidone)-stabilized silver nanoparticles (PVP-AgNPs) designed to enhance antimicrobial efficacy while improving biocompatibility. AgNPs were synthesized via chemical reduction using silver nitrate and sodium borohydride, with PVP serving as a stabilizing and capping agent. Protamine sulfate, a cationic antimicrobial peptide, was subsequently incorporated to exploit its strong affinity for bacterial membranes and synergistic bactericidal effects. The resulting nanoparticles exhibited spherical morphology with an average diameter of 70.96 ± 0.27 nm, a PDI of 0.25 ± 0.002, a zeta potential of +10.4 ± 0.15 mV, and a protamine loading efficiency of 66.2% ± 3.2%, indicating excellent colloidal stability and drug incorporation. <em>In vitro</em> antimicrobial testing demonstrated a two- to four-fold reduction in minimum inhibitory concentration values compared to blank PVP–AgNPs and free protamine, with disk diffusion assays confirming significantly enhanced activity against both Gram-positive (<em>Staphylococcus aureus</em>) and Gram-negative (<em>Escherichia coli, Pseudomonas aeruginosa</em>) bacteria. Furthermore, <em>in vivo</em> evaluation using a murine wound infection model showed effective bacterial clearance, accelerated wound closure, and improved tissue regeneration. These findings demonstrate that protamine-loaded PVP-AgNPs offer multimodal antibacterial activity, enhanced cytocompatibility, and the potential to overcome resistance mechanisms. Collectively, this work introduces a promising nanotherapeutic strategy for managing MDR infections and promoting wound healing, with significant implications for future biomedical applications.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 3","pages":"Article 101160"},"PeriodicalIF":11.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148245914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesoporous polydopamine nanoplatform enhances IL-2 immunotherapy for hepatocellular carcinoma via mild photothermal therapy and lactate regulation","authors":"Fengkai Qiu ,&nbsp;Xiaoxiao Chen ,&nbsp;Qianhui He ,&nbsp;Kai Li ,&nbsp;Xinlong Chai ,&nbsp;Shiji Fang ,&nbsp;Fazong Wu ,&nbsp;Dengke Zhang ,&nbsp;Liyun Zheng ,&nbsp;Zhongwei Zhao ,&nbsp;Minjiang Chen ,&nbsp;Jin Su ,&nbsp;Jiansong Ji ,&nbsp;Gaofeng Shu","doi":"10.1016/j.ajps.2026.101165","DOIUrl":"10.1016/j.ajps.2026.101165","url":null,"abstract":"<div><div>Hepatocellular carcinoma (HCC) is commonly diagnosed at intermediate or advanced stages. While transcatheter arterial embolization (TAE) is the accepted locoregional therapy, embolization inevitably induces severe intratumoral hypoxia, leading to excessive lactate accumulation, metabolic reprogramming and the formation of an immunosuppressive tumor microenvironment (TME), factors that collectively limit durable therapeutic efficacy and promote tumor recurrence. Although immunotherapy has shown promise in HCC, the efficacy of combining TAE with immune-based strategies remains suboptimal, largely due to metabolic constraints and T cell dysfunction within the post-embolization TME. Interleukin-2 (IL-2) therapy can stimulate effector T cells but suffers from the drawbacks of systemic toxicity, a short half-life and TME-induced dysfunction. Recent evidence indicates that lactate-rich, acidic TMEs impair IL-2 stability and signaling, suppress CD8⁺ T cell function, and promote Treg cell activity, thereby further compromising IL-2-based immunotherapy following TAE. Here, we developed a nano-immunotherapy platform (Syr/IL-2@MPDA) using mesoporous polydopamine (MPDA) nanoparticles co-loaded with His-tagged IL-2 and the monocarboxylate transporter inhibitor Syrosingopine (Syr). Syr-mediated lactate regulation alleviates TME acidity and restores IL-2 activity, while MPDA enables mild photothermal therapy (mPTT) to transform immunologically “cold” tumors into “hot” phenotypes, thereby enhancing the immune response. This integrated strategy significantly enhanced antitumor immunity, achieving a tumor growth inhibition rate of 70.87% in a murine subcutaneous tumor model. In an orthotopic N1S1 HCC rat model, the treatment demonstrated strong therapeutic efficacy in combination with αPD-L1 and TAE, overcoming the hazards of TAE-induced lactate accumulation and immune suppression. Overall, this study demonstrates a safe and effective strategy that enhances IL-2 immunotherapy through mPTT and metabolic modulation, offering a promising combination treatment for advanced HCC.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 3","pages":"Article 101165"},"PeriodicalIF":11.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148245915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photothermal-detonated functional macrophage membrane-camouflaged nano-crackers induce tumor cell wandering-anoikis","authors":"Shengjie Sun,&nbsp;Simin Wen,&nbsp;Ruiqi Zhang,&nbsp;Yanan Fu,&nbsp;Huisong Hao,&nbsp;You Li,&nbsp;Yingfei Wen,&nbsp;Ying Huo,&nbsp;Yixuan Fang,&nbsp;Shihao Zhuang,&nbsp;Jia Tang,&nbsp;Yanglong Hou,&nbsp;Tianqi Wang,&nbsp;Meiying Wu","doi":"10.1016/j.ajps.2026.101171","DOIUrl":"10.1016/j.ajps.2026.101171","url":null,"abstract":"<div><div>Cancer-associated fibroblasts (CAFs) are the primary source of collagen I, which contributes to the formation of a dense tumor extracellular matrix (ECM). Non-selective targeting of collagen I through CAF inhibition may inadvertently promote tumor cell detachment and metastasis by triggering anoikis resistance. To address this, a “wandering tumor cells” strategy is proposed, combining the induction of tumor cell deadhesion with the reversal of anoikis resistance. For heterologous targeted drug delivery, thermosensitive lipids and a photosensitizer are incorporated into M1-type macrophage membranes (TMs) to enable laser-responsive activation. Based on this approach, we designed a photothermally triggered, functional macrophage membrane-camouflaged nano-cracker (TM@cP/siF-ErN) with a particle size of 162.20 ± 0.54 nm for the co-delivery of erianin (Er) and focal adhesion kinase small interfering RNA (siFAK). Er is encapsulated in anisamide (AA)-modified nanodiscs (ErN) with hydrodynamic diameter of 15.07 ± 7.24 nm to selectively inhibit collagen I synthesis in CAFs by targeting pyruvate carboxylase, thereby inducing tumor cell deadhesion. siFAK is delivered to tumor cells using cinnamaldehyde-modified polyethyleneimine (cP/siF) to formed complexes with a particle size of 98.57 ± 1.47 nm and enhance transfection efficiency, enabling effective FAK knockdown and reversal of tumor anoikis resistance. Furthermore, TMs are fragmented into debris to amplify M2-type macrophage repolarization. Experimental results show that the nano-cracker efficiently targets orthotopic 4T1 breast tumors and, upon laser-triggered detonation, releases ErN, cP/siF and M1-type macrophage membrane fragments, which collectively promote tumor anoikis by suppressing collagen I synthesis in CAFs and reversing tumor cell anoikis resistance. Moreover, it promotes the repolarization of M2-type macrophages, which synergizes with collagen I downregulation-induced infiltration of CD8⁺ T lymphocytes to enhance the antitumor immune response, collectively resulting in pronounced breast cancer suppression. This nano-cracker implements the “wandering tumor cells” strategy, offering a promising approach for improving tumor therapy and enabling heterologous targeted delivery.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 3","pages":"Article 101171"},"PeriodicalIF":12.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13284475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148306777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cascade-activatable small-molecule theranostic nanomicelles for photodynamic-immunotherapy of immune-cold lung tumors","authors":"Young-Chan Yoon ,&nbsp;Hyoung-Jun Kim ,&nbsp;Yongdoo Choi","doi":"10.1016/j.ajps.2026.101152","DOIUrl":"10.1016/j.ajps.2026.101152","url":null,"abstract":"<div><div>Lung cancer is the most frequently diagnosed malignancy worldwide and remains the leading cause of cancer-related mortality. Effective treatment of immune-cold lung tumors remains particularly challenging due to poor immune activation and the off-target toxicity of conventional therapies. Here, we present a small-molecule–based self-assembled nanotheranostic micelle (FRANT) that employs cascade activation via folate receptor–mediated endocytosis and subsequent cathepsin B–specific cleavage, enabling tumor-selective near-infrared (NIR) fluorescence imaging and photodynamic therapy (PDT). FRANT maintains a serum-stable quenched state, thereby suppressing background fluorescence and minimizing off-target phototoxicity during systemic circulation. With an optimal hydrodynamic size of 13.7 nm, FRANT achieves deep tumor penetration, precise NIR fluorescence recovery, and robust singlet oxygen generation selectively in cancer cells. Importantly, FRANT-mediated PDT transformed immune-cold lung tumors by inducing immunogenic cell death and synergizing with PD-1 blockade, resulting in enhanced CD8⁺ T cell infiltration and durable tumor regression without systemic toxicity. Collectively, this study introduces a novel class of serum-stable, cascade-activated small-molecule nanotheranostics that couple diagnostic precision with immunomodulatory efficacy, offering a powerful platform for next-generation lung cancer therapy.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 3","pages":"Article 101152"},"PeriodicalIF":11.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148245547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the complex role of intestinal microbiota in drug permeability: Insights from N-acetylcysteine","authors":"Chutong Tian ,&nbsp;Zhonggui He","doi":"10.1016/j.ajps.2026.101164","DOIUrl":"10.1016/j.ajps.2026.101164","url":null,"abstract":"","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 3","pages":"Article 101164"},"PeriodicalIF":11.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148245548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional nanotherapeutics for targeted modulation of endoplasmic reticulum stress to potentiate cancer therapy","authors":"Shuang Tian,&nbsp;Jingying Wang,&nbsp;Yitong Yu,&nbsp;Yueyuan Liu,&nbsp;Yi Liu,&nbsp;Jiameng Li,&nbsp;Yanfei Shang,&nbsp;Yueyuan Zhao,&nbsp;Yu Zhang,&nbsp;Yan Fang,&nbsp;Kai Shi","doi":"10.1016/j.ajps.2026.101170","DOIUrl":"10.1016/j.ajps.2026.101170","url":null,"abstract":"<div><div>Endoplasmic reticulum stress (ERS), arising from the disruption of proteostasis within the tumor microenvironment, represents a fundamental driver of tumorigenesis, immune evasion and resistance against conventional therapies. In recent years, the precise modulation of ERS through the application of nanotechnology has emerged as a promising strategy to enhance the efficacy of cancer immunotherapy. This review provides a comprehensive analysis of the molecular mechanisms underlying ERS and discusses how engineered nanotherapeutics can selectively target the endoplasmic reticulum through approaches such as ligand conjugation, peptide modification or membrane fusion to induce sustained ERS. These nanotherapeutics initiate ERS by mechanisms including calcium ion dysregulation, overproduction of reactive oxygen species and direct activation of unfolded protein response signaling pathways. Persistent ERS subsequently facilitates immunogenic cell death by promoting the release of damage-associated molecular patterns, which enhance the maturation of dendritic cell and promote the activation of cytotoxic T lymphocytes. Moreover, combining ER-targeted nanotherapeutics with established therapeutic modalities, such as photodynamic therapy, photothermal therapy and chemodynamic therapy, has demonstrated synergistic antitumor efficacy and improved immune responses. Despite these advances, several critical challenges remain, particularly in terms of delivery efficiency, targeting specificity and systemic biocompatibility. Future research should emphasize the integration of nanotechnology with systems immunology and cancer metabolism, as well as the incorporation of artificial intelligence and single-cell omics to optimize the design and translational potential of ER-targeted nanotherapeutics. Collectively, these interdisciplinary strategies offer considerable potential to overcome therapeutic resistance and to promote the advancement of precision oncology.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 3","pages":"Article 101170"},"PeriodicalIF":12.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13285659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148306800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An opposite pH-responsiveness “gating” strategy: Intelligent sporopollenin exine armor for targeted therapy of colitis","authors":"Jun Liu,&nbsp;Zifang Ding,&nbsp;Jianxiong Wei,&nbsp;Yuanqing Li,&nbsp;Xiaoqing Wang,&nbsp;Xiaodan Yan,&nbsp;Dan Li,&nbsp;Tiantian Ye,&nbsp;Shujun Wang,&nbsp;Jin Sun","doi":"10.1016/j.ajps.2026.101172","DOIUrl":"10.1016/j.ajps.2026.101172","url":null,"abstract":"<div><div>Conventional therapy for ulcerative colitis (UC) is often limited by insufficient colonic targeting, short local retention and poor cellular drug uptake at lesion sites. Here, we develop a biomimetic colon-targeted delivery system based on an opposite pH-responsive “gating” strategy. <em>Chrysanthemum</em> sporopollenin (spo) microcapsules with a characteristic spiny architecture serve as the core carrier. Spo exhibits acid-induced contraction and alkali-induced expansion, with germinal apertures opening progressively as pH increases. In contrast, chitosan-butyrate complex (CBC) swells into a gel under acidic conditions but contracts and precipitates in alkaline environments. After drug loading into the spo, surface coating with CBC seals the germinal apertures, constructing an intelligent gate. In gastric fluid, the CBC layer gels and blocks apertures to prevent premature drug release. In intestinal fluid, CBC contracts and precipitates to open the gate; meanwhile, spo expands to further widen germinal apertures and facilitate drug release. The spiny morphology of spo, combined with the mucoadhesive properties of chitosan and active targeting of butyrate, collectively enhances intestinal adhesion and retention, enabling precise colonic drug release and accumulation. Mesalazine is formulated into liposomes to improve aqueous solubility and stability, which enhances cellular uptake and bioavailability, thereby exerting synergistic anti-inflammatory effects with butyric acid at inflamed sites. The <em>chrysanthemum</em> sporopollenin-based gated microcapsules exhibit favorable pH-responsive release, enhanced mucoadhesion and potent synergistic anti-inflammatory activity. This work provides a promising multifunctional targeted delivery strategy for UC therapy and establishes a novel, versatile design concept termed the opposite pH-responsive dual-gating mechanism, which supports the development of oral colon-targeted carriers capable of navigating complex gastrointestinal environments.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 3","pages":"Article 101172"},"PeriodicalIF":12.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13312463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controlled release of berberine modulates the wound microbiome to accelerate wound healing","authors":"Zeyu Xu ,&nbsp;Lixiang Zhang ,&nbsp;Juntong Guo ,&nbsp;Qing Xia ,&nbsp;Zhengping Ge ,&nbsp;Ziyu Wang ,&nbsp;Ruoyu Mu ,&nbsp;Jie Dong ,&nbsp;Zhiguo Qin ,&nbsp;Jun Chen ,&nbsp;Yiwei Wang","doi":"10.1016/j.ajps.2026.101148","DOIUrl":"10.1016/j.ajps.2026.101148","url":null,"abstract":"<div><div>The wound microbiome has been shown to play a significant role in influencing the wound healing process. <em>Coptis chinensis</em>, a traditional Chinese medicine (TCM) known for its heat-clearing properties, contains berberine (BER) as major active ingredient, which exhibits notable antibacterial activity. In this study, we investigated the effect of BER on wound healing and wound microbiome through three distinct delivery strategies, including solution form, burst-release scaffolds (PCL/BER), and sustained-release scaffolds (PCL/PLGA/BER), compared with an untreated negative control (NC) group. Drug release studies confirmed that PCL/BER caused a pronounced burst release, while the incorporation of PLGA enabled sustained release of BER for up to 120 h. Further <em>in vivo</em> studies showed that the sustained BER release from the PCL/PLGA/BER resulted in the most effective improvement in wound healing. Microbiome analysis using 16S rRNA sequencing identified <em>Staphylococcus xylosus</em> (<em>S. xylosus</em>) as the key species influencing wound healing outcomes in response to BER delivery. <em>S. xylosus</em> overabundance in the NC group and its depletion in the BER solution and burst BER release groups impaired wound healing. In contrast, sustained BER delivery maintained an optimal <em>S. xylosus</em> abundance that promoted a favorable immune microenvironment by modulating CXCL10 and (IFN-α) expression. Our findings emphasize the importance of coordinating drug release kinetics with microbiome dynamics for optimal wound healing outcomes and provide valuable insights for developing future delivery systems for heat-clearing TCMs, with a focus on microbiome-modulation therapeutic strategies.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 2","pages":"Article 101148"},"PeriodicalIF":11.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147741204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microneedle Vaccine Printer Enables Decentralized and Thermostable mRNA Vaccine Delivery","authors":"","doi":"10.1016/j.ajps.2026.101115","DOIUrl":"10.1016/j.ajps.2026.101115","url":null,"abstract":"","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 2","pages":"Article 101115"},"PeriodicalIF":11.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147741272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}