Asian Journal of Pharmaceutical Sciences最新文献

{"title":"Microneedle technology in the treatment of ocular diseases: Advances and applications","authors":"Jing Li,&nbsp;Zi Yan,&nbsp;Dengxuan Mao,&nbsp;Xiumei Liu,&nbsp;Peixin Lee,&nbsp;Yaqi Lyu,&nbsp;Nianping Feng","doi":"10.1016/j.ajps.2026.101129","DOIUrl":"10.1016/j.ajps.2026.101129","url":null,"abstract":"<div><div>Microneedle (MN) technology has emerged as a transformative approach for treating ocular diseases, addressing the limitations of conventional drug delivery methods such as low bioavailability and poor patient compliance. This review highlights the advancements and applications of MNs in managing both anterior and posterior segment ocular diseases. MNs overcome physiological barriers, enabling precise, minimally invasive drug delivery with enhanced efficacy. Various MN designs, such as solid, coated, soluble, hollow, hydrogel and cryo-MNs, are tailored for specific therapeutic needs, offering rapid or sustained drug release. Applications include treating keratitis, glaucoma, age-related macular degeneration and diabetic retinopathy, demonstrating improved drug penetration and reduced side effects. Despite challenges in manufacturing and clinical translation, MN technology holds promise for revolutionizing ocular therapeutics through innovations in materials, design, and personalized medicine.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 2","pages":"Article 101129"},"PeriodicalIF":11.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147741267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A programmable nanoreactor for photothermal immunotherapy via NIR-II triggered enzyme-catalyzed immunogenic tumor microenvironment remodeling","authors":"Jiayao Ding ,&nbsp;Long Wang ,&nbsp;Shengze Lu ,&nbsp;Jingyang Su ,&nbsp;Jingchao Li","doi":"10.1016/j.ajps.2026.101150","DOIUrl":"10.1016/j.ajps.2026.101150","url":null,"abstract":"<div><div>The complicated and immunosuppressive tumor microenvironment usually obstruct the efficiencies of various therapeutic schedules including immunotherapy. Here, we report a programmable polymer-based nanoreactor for photothermal-enhanced immunotherapy through second near-infrared (NIR-II) light-triggered enzyme‑catalyzed immunogenic tumor microenvironment remodelling. The nanoreactor system contains a thermal-responsive liposome modified on its surface with xanthine oxidase (XO), and a core co-loaded with a NIR-II-absorbing semiconducting polymer, an oxygen carrier perfluorohexane (PFH) and a hypoxanthine substrate. Under NIR-II laser irradiation, the semiconducting polymer (SP-II) generates a local photothermal effect, directly ablating tumor cells and triggering a phase transition of the liposome shells, enabling precise pulsed release of the loaded contents. The released PFH rapidly alleviates local tumor hypoxia, providing a key substrate for subsequent enzyme cascade reactions. Simultaneously, hypoxanthine is catalyzed by XO to continuously generate superoxide anions and uric acid. In this approach, superoxide anions acting as reactive oxygen species enhance immunogenic cell death and oxidative stress, while uric acid serves as an endogenous danger signal, promoting M2 to M1 repolarization of tumor-associated macrophages, thereby synergistically remodeling the immunosuppressive tumor microenvironment. This strategy potently inhibits laser-irradiated primary tumors, as well as significantly suppresses the progress of distant and metastatic tumors, and prolongs the survival of mouse. Our study provides a new approach for developing programmable anti-tumor nanoreactors with enzyme-catalyzed immunogenic tumor microenvironment remodelling capabilities.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 2","pages":"Article 101150"},"PeriodicalIF":11.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147741271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo self-assembled siRNAs targeting VEGFR2 and mTOR for renal cell carcinoma treatment","authors":"Jinyu Fu ,&nbsp;Xinyan Zhou ,&nbsp;Junjie Mi ,&nbsp;Likun Zhou ,&nbsp;Luzhen Ma ,&nbsp;Jingwei Guo ,&nbsp;Jieqiong Lei ,&nbsp;Shuang Qu ,&nbsp;Zheng Fu ,&nbsp;Tianyao Liu ,&nbsp;Xi Chen ,&nbsp;Rong Yang","doi":"10.1016/j.ajps.2026.101126","DOIUrl":"10.1016/j.ajps.2026.101126","url":null,"abstract":"<div><div>Renal cell carcinoma (RCC) is a challenging urologic malignancy characterized by its aggressive nature, including invasion, metastasis, and treatment resistance. To explore multi-targeted therapies, we established an advanced clear cell renal cell carcinoma (ccRCC) model via orthotopic tumor transplantation in mice, and established another model simulating post-surgical recurrence by performing radical nephrectomy. We engineered a genetic circuit to reprogram the host liver as a bioreactor, enabling the production and delivery of <em>in vivo</em> self-assembled siRNAs (IVSA-siRNAs) for co-targeting <em>VEGFR2</em> and <em>mTOR</em>. The efficacy and toxicity of this IVSA-siRNA system were evaluated and compared with the combination therapy of sunitinib and everolimus. In the established models, the combination therapy of sunitinib and everolimus showed efficacy but induced severe adverse effects. In contrast, IVSA-siRNAs potently silenced <em>VEGFR2</em> and <em>mTOR</em> expression, achieving therapeutic effects in both advanced and radical nephrectomy ccRCC models without discernible toxicity.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 1","pages":"Article 101126"},"PeriodicalIF":11.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Porous Baicalin-Fe(III) ICP@Propofol nanocomposites for enhanced anesthetic efficacy and reduced toxicity via neuroprotection and ultrasound assistance","authors":"Shuo Zhang ,&nbsp;Lei Shi ,&nbsp;Jiansheng He ,&nbsp;Ji Xia ,&nbsp;Shunlian Li ,&nbsp;Rong Wang ,&nbsp;Qingyan Ma ,&nbsp;Mingting Zhu ,&nbsp;Peng Tang ,&nbsp;Hao Tian ,&nbsp;Feiqian Wang ,&nbsp;Mingxi Wan ,&nbsp;Daocheng Wu ,&nbsp;Wei Gao ,&nbsp;Xiancang Ma ,&nbsp;Feng Zhu","doi":"10.1016/j.ajps.2026.101117","DOIUrl":"10.1016/j.ajps.2026.101117","url":null,"abstract":"<div><div>To enhance the anesthetic efficacy of propofol while mitigating its systemic toxicity and irreversible developmental neurotoxicity, we developed a strategy leveraging the neuroprotective effects of baicalin in combination with propofol anesthesia via baicalin-based nanocomposites. High propofol-loaded porous Baicalin-Fe(III) infinite coordination polymer@propofol nanocomposites were synthesized, wherein baicalin coordinates with Fe³⁺ ions to form porous nanoparticles that encapsulate propofol within a core-shell structure. These nanocomposites exhibited an average diameter of 92.3 ± 10.2 nm and a pore volume of 0.322 cm³/g, achieving ultra-high propofol loading (∼62%) with no detectable leakage over 100 d, attributed to their large surface area and strong molecular interactions. When combined with focused ultrasound (FUS) and microbubbles, the effective dose (ED₅₀) of propofol decreased from 10 to 4.3 mg/kg, doubling the duration of anesthesia and extending the therapeutic window by 200%. Importantly, the therapeutic index improved 1.66-fold while vital physiological parameters remained stable. Histological analyses revealed an 80% reduction in neuronal injury compared to free propofol, and behavioral tests demonstrated significant enhancements in motor and cognitive performance, alongside recovery from propofol-induced irreversible developmental neurotoxicity, indicating effective neuroprotection. Collectively, this baicalin-propofol nanocomposite, coupled with FUS-mediated delivery, represents a promising approach for safe and long-term anesthesia in clinical applications.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 1","pages":"Article 101117"},"PeriodicalIF":11.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in molecular glue degraders for targeted protein degradation: Focus on NEK7, WEE1, CDK2, GSPT1 and VAV1","authors":"Binbin Cheng ,&nbsp;Yaping Wang ,&nbsp;Yimeng Hong ,&nbsp;Yingxing Zhou ,&nbsp;Xiaopeng Peng ,&nbsp;Jianjun Chen ,&nbsp;Chunlai Zeng","doi":"10.1016/j.ajps.2026.101125","DOIUrl":"10.1016/j.ajps.2026.101125","url":null,"abstract":"<div><div>Molecular glues (MGs), a class of small-molecule degraders, exhibit drug-like properties that generally conform to Lipinski's rule of five, while uniquely mediating the stabilization or induction of protein-protein interactions. By altering the surface properties of either target proteins or E3 ligases, MGs promote the formation of a ternary complex comprising the MG, an E3 ligase, and a target protein. This interaction facilitates the polyubiquitination and subsequent degradation of the target protein via the ubiquitin-proteasome system. Owing to its distinctive mechanism of action and broad therapeutic potential, MG is offering novel approaches to disease treatment. This review summarizes recent advances in MGs targeting NIMA-related kinase 7 (NEK7), WEE1, CDK2, GSPT1 and VAV1, emphasizing the rational design, benefits, and potential limitations, highlighting rational design principles, advantages, and current limitations including challenges in achieving selectivity and rational design that provide critical insights for enhancing MG efficacy. These developments are crucial for advancing the application and optimization of molecular glues targeting NEK7, WEE1, CDK2, GSPT1 and VAV1.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 1","pages":"Article 101125"},"PeriodicalIF":11.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting macrophages in OA nanomedicine: Therapeutic opportunity or delivery delusion? A pragmatic reappraisal","authors":"Qing Yao ,&nbsp;Beilin Fu ,&nbsp;Longfa Kou","doi":"10.1016/j.ajps.2026.101127","DOIUrl":"10.1016/j.ajps.2026.101127","url":null,"abstract":"","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 1","pages":"Article 101127"},"PeriodicalIF":11.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carrier-free reduction-responsive self-assembling paclitaxel dimer nanoprodrug synergizing with celastrol for enhanced chemoimmunotherapy","authors":"Yudi Lu ,&nbsp;Mei Zhou ,&nbsp;Xunfa Zhang ,&nbsp;Weijun Huang ,&nbsp;Fan Li ,&nbsp;Ning Li Zhang ,&nbsp;Nannan Lu ,&nbsp;Chenggui Wu ,&nbsp;Zhihui Feng ,&nbsp;Shuangying Gui ,&nbsp;Zhenbao Li","doi":"10.1016/j.ajps.2026.101124","DOIUrl":"10.1016/j.ajps.2026.101124","url":null,"abstract":"<div><div>Chemotherapeutic paclitaxel (PTX) formulations are widely used in clinical cancer treatment; however, they are also associated with concomitant programmed death-ligand (PD-L1) upregulation and an immunosuppressive microenvironment. Herein, we rationally designed carrier-free, reduction-sensitive PTX dimer self-assembling nanoprodrugs (diPC NPs), composed of a glutathione (GSH)-responsive PTX dimer prodrug (diPTX) and the PD-L1 downregulator celastrol (Cel) for combinational chemoimmunotherapy. Following intravenous administration, the diPC NPs exhibited prolonged blood circulation and preferential tumor accumulation by exploiting the enhanced permeability and retention effect. Subsequently, the elevated GSH levels in tumor cells cleaved the disulfide bonds, triggering the rapid release of PTX and Cel. The released PTX elicited potent cytotoxic effects and induced immunogenic cell death (ICD), whereas the released Cel synergistically enhanced ICD and downregulated PD-L1 expression in tumor cells. Together, these effects resulted in remarkable antitumor efficacy with exhibited a favorable safety profile within the therapeutic window in both Lewis lung carcinoma cells and B16F10 tumor-bearing mice. Our findings highlight a promising strategy for highly efficient combination chemoimmunotherapy.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 1","pages":"Article 101124"},"PeriodicalIF":11.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial biosurfactant-reinforced chitooligosaccharide/polyvinyl alcohol hydrogels accelerate methicillin-resistant Staphylococcus aureus-infected wound healing by attenuating its virulence factors","authors":"Geum-Jae Jeong ,&nbsp;Dong-Joo Park ,&nbsp;Ju-Hong Kang ,&nbsp;Se-Chang Kim ,&nbsp;Yu-Jin Ahn ,&nbsp;Kyung-Jin Cho ,&nbsp;Fazlurrahman Khan ,&nbsp;Won-Kyo Jung ,&nbsp;Young-Mog Kim","doi":"10.1016/j.ajps.2026.101118","DOIUrl":"10.1016/j.ajps.2026.101118","url":null,"abstract":"<div><div>Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) causes widespread infections and poses serious public health concerns. Its high level of resistance to multiple antibiotics has garnered growing interest in identifying and applying novel antibacterial compounds derived from natural sources. In this study, we purified a biosurfactant (BS) from <em>Bacillus rugosus</em> HH2 to develop a natural antibacterial agent. This agent was then reinforced with chitooligosaccharide (COS) and polyvinyl alcohol (PVA) to create a hydrogel that promoted healing in MRSA-infected wounds. The COS/PVA/BS hydrogel was readily fabricated <em>via</em> the freeze-thaw method and demonstrated excellent mechanical strength, biological activity, and biocompatibility. <em>In vitro</em> assays confirmed that the hydrogel significantly enhanced the proliferation, migration, angiogenesis, and extracellular matrix deposition of fibroblasts, keratinocytes, and endothelial cells. Moreover, it exhibited strong bacteriostatic and bactericidal activities against MRSA, along with potent antibiofilm activity and inhibition of virulence factors relevant to MRSA-induced wound infections. Its anti-virulence effects have been linked to the downregulation of quorum sensing and virulence-related genes in MRSA. In an <em>in vivo</em> model of MRSA-induced infection, the COS/PVA/BS hydrogel significantly accelerated wound healing and markedly reduced the MRSA burden. Immunofluorescence staining confirmed enhanced neovascularization and regulated macrophage responses, underscoring the angiogenic and immunomodulatory effects of the hydrogel. Overall, the COS/PVA/BS hydrogel represents a promising therapeutic strategy for addressing antibiotic-resistant bacterial infections and promoting wound repair, supported by the use of common raw materials, a simple fabrication process, and high-yield production of natural antibacterial agents.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 1","pages":"Article 101118"},"PeriodicalIF":11.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146098728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in nano-delivery systems for overcoming the challenges of applying siRNA drugs in tumor therapy","authors":"Xiaoxin Yan ,&nbsp;Jinhu Liu ,&nbsp;Jie Liu,&nbsp;Suyun Wei,&nbsp;Ruixin Li,&nbsp;Weiwei Mu,&nbsp;Na Zhang,&nbsp;Yongjun Liu","doi":"10.1016/j.ajps.2026.101119","DOIUrl":"10.1016/j.ajps.2026.101119","url":null,"abstract":"<div><div>Tumors pose a serious threat to human life and health. In recent years, gene therapy against tumors has garnered considerable attention. Small interfering RNAs (siRNAs), an important class of nucleic acid drugs, can silence the mRNAs of tumor-associated genes with high specificity through RNA interference (RNAi), inhibiting tumor-related signaling pathways or protein expression and thereby exerting anti-tumor effects. However, anti-tumor siRNA drugs are currently in the clinical research stage, and none of these drugs have been approved for marketing, mainly because of the challenges in terms of safety, efficacy and targeted delivery. Nano-delivery systems can enhance siRNA stability and improve siRNA pharmacokinetics and biodistribution, while increasing their uptake by target cells to achieve precise delivery and controlled release, thereby serving as a promising solution to overcome the challenges of siRNA drug application. This review summarizes the existing research on the nano-delivery systems currently available to help siRNAs achieve organ-targeted delivery and enhance the anti-tumor efficacy of siRNAs, discussing the characteristics of siRNA action and the unique advantages of different types of nano-delivery systems. The aim was to provide novel ideas for the design and optimization of siRNA-based drug delivery and the development of novel anti-tumor formulations to promote the clinical translation and application of siRNA drugs.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 1","pages":"Article 101119"},"PeriodicalIF":11.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Freezing shock monocytes deliver antisense oligonucleotides via liposomes for the treatment of idiopathic pulmonary fibrosis","authors":"Hailong Li ,&nbsp;Xi Wu ,&nbsp;Jinhe Li ,&nbsp;Liqing Han ,&nbsp;Hongting Liu ,&nbsp;Qiuyan Jiang ,&nbsp;Bowen Liu ,&nbsp;Qin Xia ,&nbsp;Zherui Li ,&nbsp;Xiaohe Li ,&nbsp;Songtao Gu ,&nbsp;Aiguo Xu ,&nbsp;Honggang Zhou ,&nbsp;Xiaoting Gu ,&nbsp;Zuojun Xu ,&nbsp;Xiaoyu Ai ,&nbsp;Cheng Yang","doi":"10.1016/j.ajps.2026.101128","DOIUrl":"10.1016/j.ajps.2026.101128","url":null,"abstract":"<div><div>Connective tissue growth factor (CTGF) is a key driver in the pathogenesis of idiopathic pulmonary fibrosis (IPF). This study presents a groundbreaking supramolecular cryo-shock bone marrow mononuclear cell system for targeted drug delivery in IPF. We incorporated antisense oligonucleotides (ASO) to inhibit CTGF and simultaneously encapsulated nintedanib using the ZMO-E5-NPs carrier for synergistic delivery. The cryo-shock treatment enhances cellular structural integrity and preserves receptor functionality, thereby extending cell viability. By modifying the E5 peptide and conjugating it with DSPE-PEG-MAL, we developed a composite carrier, ZMO-E5-NPs, which demonstrates efficient lung-targeting capability. This system enables rapid nanoparticle capture by fibroblasts through matrix metalloproteinase 2 (MMP2) recognition, ensuring precise delivery of both ASO and nintedanib. In a bleomycin-induced pulmonary fibrosis mouse model, ZMO-E5-NPs-ASO (nintedanib-containing group) significantly attenuated fibrosis progression, improved lung function, and exhibited excellent biocompatibility and safety, highlighting its potential as a novel therapeutic strategy for respiratory diseases.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 1","pages":"Article 101128"},"PeriodicalIF":11.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}