Asian Journal of Pharmaceutical Sciences最新文献

Navigating the brain: Harnessing endogenous cellular hitchhiking for targeting neoplastic and neuroinflammatory diseases 为大脑导航：利用内源性细胞搭便车技术治疗肿瘤和神经炎症性疾病

IF 10.7 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2025-02-26 DOI: 10.1016/j.ajps.2025.101040

Suraj S. Wagh , Paras Famta , Saurabh Shah , Ganesh Vambhurkar , Giriraj Pandey , Anupama Sikder , Gurpreet Singh , Shalini Shukla , Abhishek Sharma , Sajja Bhanu Prasad , Akshay Shinde , Rahul Kumar , Nitin Pal Kalia , Rajeev Singh Raghuvanshi , Saurabh Srivastava

{"title":"Navigating the brain: Harnessing endogenous cellular hitchhiking for targeting neoplastic and neuroinflammatory diseases","authors":"Suraj S. Wagh , Paras Famta , Saurabh Shah , Ganesh Vambhurkar , Giriraj Pandey , Anupama Sikder , Gurpreet Singh , Shalini Shukla , Abhishek Sharma , Sajja Bhanu Prasad , Akshay Shinde , Rahul Kumar , Nitin Pal Kalia , Rajeev Singh Raghuvanshi , Saurabh Srivastava","doi":"10.1016/j.ajps.2025.101040","DOIUrl":"10.1016/j.ajps.2025.101040","url":null,"abstract":"<div><div>Cellular hitchhiking is an emerging therapeutic strategy that uses an endogenous cell migration mechanism to deliver therapeutics to specific sites in the body. Owing to the low permeability and presence of the blood-brain barrier (BBB), the targeted delivery of therapeutics is limited, leading to inadequate localization in the brain. NCs fail to extravasate significantly into the tumor microenvironment (TME), demonstrating poor accumulation and tumor penetration. The novel cellular hitchhiking concept has been utilized to promote systemic half-life and therapeutic targeting. Neoplastic and neuroinflammatory diseases of the brain, including glioblastoma and neuroinflammation, face critical hurdles for efficiently delivering therapeutic entities owing to the BBB. Cellular hitchhiking can surmount these hurdles by utilizing various cell populations, such as stem cells, monocytes/macrophages, neutrophils, and platelets, as potential functional carriers to deliver the therapeutic cargo through the BBB. These carrier cells have the innate capability to traverse the BBB, transit through the brain parenchyma, and specifically reach disease sites such as inflammatory and neoplastic lesions owing to chemotactic navigation, <em>i.e.</em>, movement attributed to chemical stimuli. Chemotherapeutic drugs delivered by cellular hitchhiking to achieve tumor-specific targeting have been discussed. This article explores various cell types for hitchhiking NCs to the TME with in-depth mechanisms and characterization techniques to decipher the backpack dissociation dynamics (nanoparticle payload detachment characteristics from hitchhiked cells) and challenges toward prospective clinical translation.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"20 2","pages":"Article 101040"},"PeriodicalIF":10.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in nanotechnology for the diagnosis and management of metabolic dysfunction-associated steatotic liver disease

IF 10.7 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2025-02-09 DOI: 10.1016/j.ajps.2025.101025

Fenfen Li , Ruyan Yuan , Jiamin Zhang , Bing Su , Xiaolong Qi

引用次数: 0

Microalgae-carrying nanomedicine for bioadhesive drug delivery for treating chemotherapy-induced intestinal injury

IF 10.7 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2025-02-08 DOI: 10.1016/j.ajps.2025.101024

Jie Chen , Bing Wang , Lan Shen , Yongzhuo Huang

{"title":"Microalgae-carrying nanomedicine for bioadhesive drug delivery for treating chemotherapy-induced intestinal injury","authors":"Jie Chen , Bing Wang , Lan Shen , Yongzhuo Huang","doi":"10.1016/j.ajps.2025.101024","DOIUrl":"10.1016/j.ajps.2025.101024","url":null,"abstract":"<div><div>Gastrointestinal tract toxicity represents a serious adverse effect of chemotherapy, leading to reduced quality of life and survival. For instance, irinotecan (CPT-11) usually causes severe gastrointestinal toxicity, with a lack of effective therapeutic interventions, making treatment often unsustainable. Therefore, development of an effective and safe therapy is crucial for improving chemotherapy efficacy and the patients’ quality of life. In this work, we developed a novel approach involving the helical-shaped cyanobacterium microalgae, <em>Spirulina platensis</em> (SP), to carry the bornyl acetate (BA)-loaded chitosan nanoparticles to enhance drug retention in the small intestine. We demonstrated the protection effect of BA against chemotherapy-induced intestinal injury using an epithelial cell model. In a mouse model, orally administered BA-ChNPs@SP accumulated in the small intestine and attenuated inflammation by reducing dsDNA release and oxidative stress. This was concomitant with the restoration of the intestinal barrier and modulation of the immune microenvironment. This work suggests the promise of the microalgae-carrying nanomedicine strategy for treatment of intestinal diseases, emphasizing its potential in addressing chemotherapy-induced gastrointestinal complications.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"20 2","pages":"Article 101024"},"PeriodicalIF":10.7,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implantable devices for resected glioblastoma therapy

IF 10.7 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2025-02-08 DOI: 10.1016/j.ajps.2025.101034

Xiaoyu Chang , Hui Guo , Yunqian Li , Jianxun Ding

引用次数: 0

Tailoring carrier-free nanoparticles based on natural small molecule assembly for synergistic anti-tumor efficacy

IF 10.7 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2025-02-01 DOI: 10.1016/j.ajps.2024.100992

Di Wu , Bin Zhou , Ying Liu , Xiao Zhu , Bin Li , Hongshan Liang

{"title":"Tailoring carrier-free nanoparticles based on natural small molecule assembly for synergistic anti-tumor efficacy","authors":"Di Wu , Bin Zhou , Ying Liu , Xiao Zhu , Bin Li , Hongshan Liang","doi":"10.1016/j.ajps.2024.100992","DOIUrl":"10.1016/j.ajps.2024.100992","url":null,"abstract":"<div><div>Interfacial modular assemblies of versatile polyphenols have attracted widespread interest in surface and materials engineering. In this study, natural polyphenol (tannic acid, TA) and nobiletin (NOB) can directly form binary carrier-free spherical nanoparticles (NT NPs) through synergistically driven by a variety of interactions (such as hydrogen bonding, oxidative reactions, etc.). The synthesis involves polyphenolic deposition on hydrophobic NOB nanoaggregates, followed by <em>in situ</em> oxidative self-polymerization. Interestingly, the assembled NT NPs exhibit controllable and dynamic changes in particle size during the initial stage. Ultimately, uniform and spherical NT NPs appear stable, with high loading capability, enabling incorporated NOB to preserve their function. Furthermore, <em>in vitro</em> evaluations demonstrate that the rational combination of polyphenol module and NOB can induce apoptosis and inhibit tumor metastasis for both lung cancer H1299 and human fibrosarcoma HT1080 cell lines. Notably, the optimized NT48 NPs were then verified <em>in vivo</em> experiments to achieve a promising synergistic anti-tumor efficacy. These findings not only provide new opportunities for the streamlined and sensible engineering of future polyphenol-based biomaterials, but also open up new prospects for the design of small-molecule nature phytochemicals.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"20 1","pages":"Article 100992"},"PeriodicalIF":10.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymeric nanocarriers for therapeutic gene delivery

IF 10.7 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2025-02-01 DOI: 10.1016/j.ajps.2025.101015

Jiayuan Zhang , Xinyu Yang , Zhichao Chang , Wenwei Zhu , Yuhua Ma , Haisheng He

引用次数: 0

Hyaluronic acid conjugates with controlled oleic acid substitution as new nanomaterials for improving ocular co-delivery of cyclosporine A and oleic acid

IF 10.7 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2025-02-01 DOI: 10.1016/j.ajps.2024.101009

Hai V. Ngo , Hy D. Nguyen , Beom-Jin Lee

{"title":"Hyaluronic acid conjugates with controlled oleic acid substitution as new nanomaterials for improving ocular co-delivery of cyclosporine A and oleic acid","authors":"Hai V. Ngo , Hy D. Nguyen , Beom-Jin Lee","doi":"10.1016/j.ajps.2024.101009","DOIUrl":"10.1016/j.ajps.2024.101009","url":null,"abstract":"<div><div>A structural conjugate (HOC) of polysaccharide, hyaluronic acid (HA) with different ratios of oleic acid (OA) via cystamine (CYS) linker as a new ocular biomaterial was developed. The HOCs with controlled degrees of substitution of OA (4.6 %, 8.3 % and 12.2 %) were synthesized to form self-assembled HA-CYS-OA nanoparticles (HONs, HON1, HON2, HON3). A poorly water-soluble cyclosporine A (CsA) to be used for the treatment of multifactorial dry eye disease (DED) was chosen as model drug. CsA-loaded HONs exhibited improved solution transparency via solubilizing capacity of HON, and increased <em>in vitro</em> drug permeation compared to Restasis®. The physicochemical properties of CsA-loaded HONs such as nano behaviors, solution transparency, drug release, drug permeation and ocular cytocompatibility were highly variable according to the ratios of OA substitution. Interestingly, this CsA-loaded HON1 as optimal ocular nanoformulation showed markedly augmented macrophage polarization into the M2 phenotype, downregulated the expression of proinflammatory cytokines levels in LPS-induced M1 macrophage, and effectively inhibited VEGF-induced endothelial cell proliferation and capillary-like tube formation by the synergistic effect of CsA and HON1 containing OA at the same time. Collectively, the current fatty acid conjugated to HA, named fattigation platform, providing the roles and physicochemical properties via structural features of HA could be a promising co-delivery strategy of drug and fatty acid for DED and other ophthalmic disease treatments.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"20 1","pages":"Article 101009"},"PeriodicalIF":10.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in zeolitic imidazolate frameworks as drug delivery systems for cancer therapy

IF 10.7 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2025-02-01 DOI: 10.1016/j.ajps.2025.101017

Yuhan Wang , Yixin Tang , Lei Guo , Xi Yang , Shanli Wu , Ying Yue , Caina Xu

{"title":"Recent advances in zeolitic imidazolate frameworks as drug delivery systems for cancer therapy","authors":"Yuhan Wang , Yixin Tang , Lei Guo , Xi Yang , Shanli Wu , Ying Yue , Caina Xu","doi":"10.1016/j.ajps.2025.101017","DOIUrl":"10.1016/j.ajps.2025.101017","url":null,"abstract":"<div><div>Biological nanotechnologies based on functional nanoplatforms have synergistically catalyzed the emergence of cancer therapies. As a subtype of metal-organic frameworks (MOFs), zeolitic imidazolate frameworks (ZIFs) have exploded in popularity in the field of biomaterials as excellent protective materials with the advantages of conformational flexibility, thermal and chemical stability, and functional controllability. With these superior properties, the applications of ZIF-based materials in combination with various therapies for cancer treatment have grown rapidly in recent years, showing remarkable achievements and great potential. This review elucidates the recent advancements in the use of ZIFs as drug delivery agents for cancer therapy. The structures, synthesis methods, properties, and various modifiers of ZIFs used in oncotherapy are presented. Recent advances in the application of ZIF-based nanoparticles as single or combination tumor treatments are reviewed. Furthermore, the future prospects, potential limitations, and challenges of the application of ZIF-based nanomaterials in cancer treatment are discussed. We except to fully explore the potential of ZIF-based materials to present a clear outline for their application as an effective cancer treatment to help them achieve early clinical application.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"20 1","pages":"Article 101017"},"PeriodicalIF":10.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosome-membrane and polymer-based hybrid-complex for systemic delivery of plasmid DNA into brains for the treatment of glioblastoma

IF 10.7 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2025-02-01 DOI: 10.1016/j.ajps.2024.101006

Youngki Lee , Subin Kang , Le Thi Thuy , Mincheol Son , Jae Young Park , Sung Bin Ahn , Minji Kang , Jihun Oh , Joon Sig Choi , Minhyung Lee

{"title":"Exosome-membrane and polymer-based hybrid-complex for systemic delivery of plasmid DNA into brains for the treatment of glioblastoma","authors":"Youngki Lee , Subin Kang , Le Thi Thuy , Mincheol Son , Jae Young Park , Sung Bin Ahn , Minji Kang , Jihun Oh , Joon Sig Choi , Minhyung Lee","doi":"10.1016/j.ajps.2024.101006","DOIUrl":"10.1016/j.ajps.2024.101006","url":null,"abstract":"<div><div>Herpes simplex virus thymidine kinase (HSVtk) gene therapy is a promising strategy for glioblastoma therapy. However, delivery of plasmid DNA (pDNA) encoding HSVtk into the brain by systemic administration is a challenge since pDNA can hardly penetrate the blood-brain barrier. In this study, an exosome-membrane (EM) and polymer-based hybrid complex was developed for systemic delivery of pDNA into the brain. Histidine/arginine-linked polyamidoamine (PHR) was used as a carrier. PHR binds to pDNA by electrostatic interaction. The pDNA/PHR complex was mixed with EM and subjected to extrusion to produce pDNA/PHR-EM hybrid complex. For glioblastoma targeting, T7 peptide was attached to the pDNA/PHR-EM complex. Both pDNA/PHR-EM and T7-decorated pDNA/PHR-EM (pDNA/PHR-EM-T7) had a surface charge of –5 mV and a size of 280 nm. Transfection assays indicated that pDNA/PHR-EM-T7 enhanced the transfection to C6 cells compared with pDNA/PHR-EM. Intravenous administration of pHSVtk/PHR-EM-T7 showed that pHSVtk/PHR-EM and pHSVtk/PHR-EM-T7 delivered pHSVtk more efficiently than pHSVtk/lipofectamine and pHSVtk/PHR into glioblastoma <em>in vivo</em>. pHSVtk/PHR-EM-T7 had higher delivery efficiency than pHSVtk/PHR-EM. As a result, the HSVtk expression and apoptosis levels in the tumors of the pHSVtk/PHR-EM-T7 group were higher than those of the other control groups. Therefore, the pDNA/PHR-EM-T7 hybrid complex is a useful carrier for systemic delivery of pHSVtk to glioblastoma.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"20 1","pages":"Article 101006"},"PeriodicalIF":10.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biofunctional supramolecular injectable hydrogel with spongy-like metal-organic coordination for effective repair of critical-sized calvarial defects

IF 10.7 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2025-02-01 DOI: 10.1016/j.ajps.2024.100988

Yingqi Chen , Zuocheng Qiu , Xueling Hu , Tiehua Wang , Guoqing Li , Ziling Tang , Chongzhou Fang , Weibei Sheng , Jin Zhao , Fei Yu , Jian Weng , Anjaneyulu Udduttula , Geetha Manivasagam , Hui Zeng

{"title":"Biofunctional supramolecular injectable hydrogel with spongy-like metal-organic coordination for effective repair of critical-sized calvarial defects","authors":"Yingqi Chen , Zuocheng Qiu , Xueling Hu , Tiehua Wang , Guoqing Li , Ziling Tang , Chongzhou Fang , Weibei Sheng , Jin Zhao , Fei Yu , Jian Weng , Anjaneyulu Udduttula , Geetha Manivasagam , Hui Zeng","doi":"10.1016/j.ajps.2024.100988","DOIUrl":"10.1016/j.ajps.2024.100988","url":null,"abstract":"<div><div>In clinical settings, regenerating critical-sized calvarial bone defects presents substantial problems owing to the intricacy of surgical methods, restricted bone growth medications, and a scarcity of commercial bone grafts. To treat this life-threatening issue, improved biofunctional grafts capable of properly healing critical-sized bone defects are required. In this study, we effectively created anti-fracture hydrogel systems using spongy-like metal-organic (magnesium-phosphate) coordinated chitosan-modified injectable hydrogels (CPMg) loaded with a bioinspired neobavaisoflavone (NBF) component. The CPMg-NBF hydrogels showed outstanding anti-fracture capabilities during compression testing and retained exceptional mechanical stability even after 28 d of immersion in phosphate-buffered saline. They also demonstrated prolonged and stable release profiles of Mg<sup>2+</sup> and NBF. Importantly, CPMg-NBF hydrogels revealed robust biphasic mineralization and were non-toxic to MC3T3-E1 cells. To better understand the underlying mechanism of Mg<sup>2+</sup> and NBF component, as well as their synergistic effect on osteogenesis, we investigated the expression of key osteogenic proteins in the p38 MAPK and NOTCH pathways. Our results showed that CPMg-NBF hydrogels greatly increased the expression of osteogenic proteins (Runx2, OCN, OPN, BMPS and ALP). <em>In vivo</em> experiments showed that the implantation of CPMg-NBF hydrogels resulted in a significant increase in new bone growth within critical-sized calvarial defects. Based on these findings, we expect that the CPMg-NBF supramolecular hydrogel has tremendous promise for use as a therapeutic biomaterial for treating critical-sized calvarial defects.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"20 1","pages":"Article 100988"},"PeriodicalIF":10.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0