Asian Journal of Pharmaceutical Sciences最新文献

{"title":"Platycodon grandiflorus-derived exosome-like nanovesicles drive AMPK-dependent glycolytic beige remodeling to ameliorate obesity","authors":"Hye-Lin Kim,&nbsp;Harim Kim,&nbsp;Yohan Han,&nbsp;Suhyeon An,&nbsp;Mina Boo,&nbsp;Hyunyoung Choi,&nbsp;Ji In Park,&nbsp;Hyunwoo Kim,&nbsp;HyunSoo Yang,&nbsp;Jae Heon Sim,&nbsp;Dokyoung Kim,&nbsp;Kwan-Il Kim,&nbsp;Seunghoon Lee,&nbsp;Woojin Kim,&nbsp;Ji Hoon Jung,&nbsp;Jungbin Song,&nbsp;In-Seon Lee,&nbsp;Dong-Hyun Youn,&nbsp;Ki-Sun Park,&nbsp;Ke-Wu Zeng,&nbsp;Hyo In Kim","doi":"10.1016/j.ajps.2026.101198","DOIUrl":"10.1016/j.ajps.2026.101198","url":null,"abstract":"<div><div>Obesity is a pandemic with limited therapeutic options. Recent pharmacotherapies are constrained by tolerability, durability, accessibility, and incomplete resolution of adipose tissue dysfunction. Plant-derived exosome-like nanovesicles (ELNs) provide a natural nanoscale therapeutic platform. However, their anti-obesity effects and underlying mechanisms remain unexplored. In the present study, we investigated whether ELNs from <em>Platycodon grandiflorus</em> roots (P-ELNs) can mitigate obesity. P-ELNs were isolated, characterized and evaluated in high-fat diet-induced and genetic (db/db) obesity models. Analyses integrating transcriptomic profiling and metabolic flux assessment were performed to define the P-ELN-induced adipose remodeling program. Treatment with P-ELNs significantly attenuated body weight gain and reduced white adipose tissue (WAT) mass in obese mice without inducing systemic, hepatic or renal toxicity. Mechanistically, P-ELNs enhanced non-shivering thermogenesis in inguinal WAT through AMP-activated protein kinase (AMPK)-dependent remodeling toward a glycolytic beige fat state characterized by the coordinated activation of myogenic and glycolytic gene programs. Collectively, P-ELNs represent a safe and effective nanotherapeutic strategy to combat obesity through AMPK-dependent glycolytic beige fat remodeling. Therefore, P-ELNs are a first-in-class nanotherapeutic that induce this unique beige fat subtype, providing a novel strategy to treat obesity and related metabolic disorders.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 5","pages":"Article 101198"},"PeriodicalIF":12.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149255805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional vesicle-secreting bioadhesive dermatomimetic hydrogel for enhanced extensive wound healing","authors":"Jiawen Zhu,&nbsp;Xiaochuan Wu,&nbsp;Jialu Lang,&nbsp;Qi Zhu,&nbsp;Yuanyan Huang,&nbsp;Shihui Wu,&nbsp;Di Chen,&nbsp;Luwen Zhu,&nbsp;Jucong Zhang,&nbsp;Jiahao Hu,&nbsp;Jiayi Ding,&nbsp;Wei Wang,&nbsp;Yongzhong Du","doi":"10.1016/j.ajps.2026.101204","DOIUrl":"10.1016/j.ajps.2026.101204","url":null,"abstract":"<div><div>Extensive skin wounds pose significant clinical challenges due to delayed healing, persistent inflammation and insufficient tissue regeneration. Here, we develop a photocrosslinked dermatomimetic hydrogel (DA-Col/HA) with bioadhesiveness and spatiotemporal controllability, composed of dopamine-conjugated collagen type III (DA-Col) and hyaluronic acid (HA). The DA-Col/HA gel, by mimicking the native extracellular matrix, promotes wound healing through accelerating hemostasis and its antioxidant/anti-inflammatory activities, specifically by scavenging ROS and inducing macrophage M2 polarization. On the other hand, the half-life of retinoic acid (RA), a key regulator of epithelial differentiation, is increased by 1.4 times after being encapsulated in adipose-derived stem cell extracellular vesicles (ADSC-EVs). In an extensive wound rat model, the mixture of RA-loaded ADSC-EVs and DA-Col/HA gel (EVs@RA-gel) significantly accelerates wound closure and facilitates the formation of follicle-like structures through enhanced re-epithelialization, accelerated neovascularization, and collagen deposition. Altogether, this multifunctional vesicle-secreting bioadhesive dermatomimetic hydrogel offers a promising therapeutic strategy for treating extensive skin wounds.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 5","pages":"Article 101204"},"PeriodicalIF":12.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149255804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation-triggered andrographolide nanoprodrug platform for lung-targeted delivery and immune homeostasis recovery: A therapeutic strategy against cytokine storm","authors":"Yin Zhou,&nbsp;Jiayi Wang,&nbsp;Yi Chen,&nbsp;Zijie Li,&nbsp;Gustavo Puras,&nbsp;José Luis Pedraz,&nbsp;Zhongwei Gu,&nbsp;Yiyan He","doi":"10.1016/j.ajps.2026.101200","DOIUrl":"10.1016/j.ajps.2026.101200","url":null,"abstract":"<div><div>Acute lung injury (ALI) leads to severe pulmonary inflammation and alveolar-capillary barrier disruption, with therapy limited by poor solubility and bioavailability of anti-inflammatory agents. To address the limited aqueous solubility, insufficient lesion accumulation, and poor bioavailability of andrographolide (ANDRO) in ALI therapy, an inflammation-responsive nanoprodrug platform (NanoPro5000@ANDRO) was developed via subcomponent self-assembly using dynamic boronic ester and imine linkages, thereby enabling both chemical conjugation and physical encapsulation of ANDRO at a total drug-loading content of 30.24% with an average hydrodynamic diameter of 206.4 nm. This platform exhibited excellent biocompatibility, including a hemolysis rate of &lt;5% and protein adsorption of &lt;10%, and achieved 82.1% cumulative ANDRO release at 48 h under acidic and oxidative conditions, facilitating inflammation-associated lesion-specific drug delivery. Furthermore, the nanosystem exhibited enhanced pulmonary accumulation in inflamed lung tissues, suppressed pro-inflammatory cytokines, including tumor necrosis factor-α and interleukin (IL)-6, upregulated anti-inflammatory mediators, including IL-4 and IL-10, reduced oxidative stress, and promoted M2 macrophage polarization. These combined effects alleviated cytokine storm, restored inflammatory microenvironment homeostasis, and attenuated lipopolysaccharide-induced ALI-associated tissue damage with confirmed biosafety. Overall, this study presents a dual dynamic covalent bond-based nanoprodrug strategy featuring dual ANDRO loading and pH/reactive oxygen species-responsive release behavior, providing a promising therapeutic approach for cytokine-associated inflammatory pulmonary diseases.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 5","pages":"Article 101200"},"PeriodicalIF":12.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149255845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatiotemporal control of protein degradation: Advances in stimuli-responsive nano-PROTACs for precision cancer therapy","authors":"Aopeng Wang,&nbsp;Yujing Sang,&nbsp;Meng Zheng,&nbsp;Dongya Zhang,&nbsp;Muhammad Ismail","doi":"10.1016/j.ajps.2026.101199","DOIUrl":"10.1016/j.ajps.2026.101199","url":null,"abstract":"<div><div>Proteolysis-targeting chimeras (PROTACs) have shown great promise in recent years as a new class of drugs capable of targeting and degrading difficult-to-treat proteins. However, the clinical translation of PROTACs is hindered by their unfavorable physicochemical characteristics (e.g., high molecular weight, poor solubility) and the potential for systemic off-target toxicity due to the widespread expression of E3 ligases. To address these issues, stimuli-responsive nano-PROTACs have been developed to enable spatiotemporal control over PROTAC activation. This review critically discusses the development of nano-PROTACs and summarizes different design strategies, including early passive encapsulation and more advanced stimuli-responsive nanostructures activated by endogenous signals (e.g., pH, enzymes and redox conditions) and exogenous signals (e.g., light and ultrasound). The emerging trend of dual-response “Logic Gate” systems and carrier-free poly-PROTAC paradigms is also presented. The review also discusses the combination of nano-PROTACs with other therapeutic strategies to maximize therapeutic efficacy and minimize drug resistance, a critical aspect for clinical applications. Finally, future prospects for nano-PROTACs are introduced, with the expectation that research in this field will continue to progress. Based on the above analysis of these technological developments, the remaining challenges and possible countermeasures for achieving precise protein degradation in clinical practice can be identified.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 5","pages":"Article 101199"},"PeriodicalIF":12.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149175034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatiotemporally stratified nanoassemblies for precisely halting the immunothrombotic vicious cycle in acute lung inflammation","authors":"Cong Li,&nbsp;Yuqing Ni,&nbsp;Jianqiang Huang,&nbsp;Jing Li,&nbsp;Yuqing Zheng,&nbsp;Yifan Zhang,&nbsp;Lianrui Cao,&nbsp;Zeyu Wang,&nbsp;Lijiang Chen","doi":"10.1016/j.ajps.2026.101203","DOIUrl":"10.1016/j.ajps.2026.101203","url":null,"abstract":"<div><div>Acute lung injury and acute respiratory distress syndrome have high mortality. Extensive pulmonary microvascular thrombosis occurs in over 80% of patients who die from severe pneumonia. Inflammation and thrombosis mutually aggravate each other, forming a vicious cycle that accelerates disease progression. Nevertheless, it remains challenging to achieve safe and balanced anti-inflammatory treatment and systemic anticoagulation. These two pathological processes are spatially separated, coagulation arises on the vascular endothelial surface, while inflammatory signals are confined inside immune cells. Current therapeutic strategies fail to realize simultaneous and precise dual regulation within a single delivery system. Therefore, we developed a spatiotemporally hierarchical responsive nanoplatform called Hep-PBA/Dex@TAF. The outer Hep-PBA layer accumulates at the lesion sites by targeting P-selectin on the inflamed pulmonary endothelium. In the weakly acidic local microenvironment, boronate-ester bonds break, releasing Hep-PBA for local anticoagulation. The exposed Dex@TAF core is internalized by macrophages through the recognition between tannic acid and toll-like receptor 4. Subsequently, intracellular metal-polyphenol networks are disassembled. Relying on the proton sponge effect, dexamethasone escapes from lysosomes and is released into the cytoplasm, whereas reactive oxygen species are eliminated via the Fe²⁺/Fe³⁺ redox cycle. The released dexamethasone activates glucocorticoid receptors and suppresses proinflammatory transcription, further reducing neutrophil activation and neutrophil extracellular trap production. This synergistic regulation blocks the inflammation-thrombosis cascade by alleviating platelet activation and endothelial injury. In a mouse model of acute lung injury complicated by thrombosis, this nanoplatform markedly alleviated cytokine storms, preserved the integrity of the lung tissue structure, and inhibited microthrombus formation. In conclusion, Hep-PBA/Dex@TAF serves as a precise and dual-functional intervention strategy for comorbid inflammation and thrombosis.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 5","pages":"Article 101203"},"PeriodicalIF":12.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149255806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A barrier-crossing and immune checkpoint-blocking antibody fusion protein for enhanced glioma-targeted immunotherapy","authors":"Yanning Bao,&nbsp;Shengmin Yang,&nbsp;Yuan Ding,&nbsp;Jianfen Zhou,&nbsp;Xudong Zheng,&nbsp;Ruohan Chen,&nbsp;Zhixuan Jiang,&nbsp;Nana Meng,&nbsp;Dongsheng Pan,&nbsp;Jiasheng Lu,&nbsp;Jiacheng Guan,&nbsp;Jing Ye,&nbsp;Hongjia Zhu,&nbsp;Nan Xu,&nbsp;Cao Xie,&nbsp;Lei Yu,&nbsp;Linwei Lu,&nbsp;Weiyue Lu","doi":"10.1016/j.ajps.2026.101175","DOIUrl":"10.1016/j.ajps.2026.101175","url":null,"abstract":"<div><div>With low five-year survival estimates, poor prognosis, and high recurrence probabilities, glioma is considered one of the most intractable malignant tumors. Despite the discovery of lymphatic vascular system and immune system in the central nervous system (CNS), immune checkpoint blockade therapeutics, such as programmed death ligand 1 (PDL1, also called B7H1 or CD274) antibodies, are prevented from the CNS and glioma sites due to the existence of biological barriers including the blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB). Herein, we constructed a BBB/BBTB-crossing recombinant antibody by fusing the PDL1 antibody (αPDL1) and the targeting moiety RAP22 peptide (RAP22) through a matrix metalloproteinase 2 (MMP2)-responsive cleavable linker, abbreviated as αPDL1-mRAP22. Not only was αPDL1-mRAP22 able to block PD1/PDL1 pathway, reduce T cell apoptosis, enhance T cell killing ability towards glioma cells <em>in vitro</em>, but also it showed higher accumulation in the glioma site, prolonged survival time, and potent immune responses as well as synergistic effects with temozolomide (TMZ) <em>in vivo</em>, offering a novel strategy for glioma immunotherapy.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 4","pages":"Article 101175"},"PeriodicalIF":12.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148645354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogel co-delivery of 5-fluorouracil and siRNA attenuates TGF-β1-mediated MMT to prevent postoperative peritoneal metastasis and adhesion in colorectal cancer","authors":"Jinpeng Wen,&nbsp;Jiangchuan He,&nbsp;Yunhe Zheng,&nbsp;Ting Wang,&nbsp;Kailai Liu,&nbsp;Hanchao Zhou,&nbsp;Yuchen Zhang,&nbsp;Yu Huang,&nbsp;Chen Zhang,&nbsp;Yue Zhang,&nbsp;Ke Wang","doi":"10.1016/j.ajps.2026.101166","DOIUrl":"10.1016/j.ajps.2026.101166","url":null,"abstract":"<div><div>Cytoreductive surgery is the treatment protocol for colorectal cancer. Nonetheless, a major medical challenge remains to fully eliminate malignant tumor cells, along with a number of complications such as peritoneal adhesion and tumor peritoneal metastasis. The occurrence of peritoneal adhesions compromises not only the ability to do subsequent surgery, but also the efficacy of adjunct chemotherapy. More and more evidence suggest that the process of mesothelial-mesenchymal transition (MMT) influenced by transforming growth factor-β1 (TGF-β1) has a role to play in these disturbances, therefore making TGF-β1 a viable target for therapy. This study has designed a hydrogel-based physical barrier drug delivery system loaded with RNA interference technology, designated as FC@MT. The 5-fluorouracil (5-FU), which is known for its antitumor effects, was firmly linked to the FCGCM hydrogel matrix through the formation of hydrogen bonds. Meanwhile, APTES-modified mesoporous silica nanoparticle (AMSN)/TGF-β1 siRNA complexes were incorporated to facilitate the cellular uptake of siRNA and enable their escape from lysosomes. The localized co-delivery of 5-FU and TGF-β1 siRNA induces residual tumor cells killing by silencing TGF-β1 expression and reverses MMT. The combination of FC@MTs was shown to have a synergistic anti-peritoneal metastasis and anti-adhesion effects, which could be an effective strategy to enhance the clinical therapeutics of CRC.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 4","pages":"Article 101166"},"PeriodicalIF":12.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148732816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A drug-repurposing nanotheranostic for synergistic management of resistant bacterial pneumonia","authors":"Xianbin Sun,&nbsp;Xinyi Wang,&nbsp;Fangying Zheng,&nbsp;Ruofei Xu,&nbsp;Xinyi Shen,&nbsp;Ding Tan,&nbsp;Xudong Li,&nbsp;Ya Wang,&nbsp;Kaiming Peng,&nbsp;Haijun Chen,&nbsp;Xiumei Li,&nbsp;Yu Gao","doi":"10.1016/j.ajps.2026.101185","DOIUrl":"10.1016/j.ajps.2026.101185","url":null,"abstract":"<div><div>The rising threat of antibiotic resistance severely compromises the treatment of bacterial pneumonia, underscoring the urgent need for innovative and comprehensive therapeutic strategies. Here, we developed an innovative theranostic nanoplatform (Dex/BTGd) through the coordinated assembly of tetracycline, gadolinium ion (Gd³⁺) and baicalin, which acts synergistically to combat infection, enable non-invasive magnetic resonance imaging (MRI), and regulate the lung microenvironment. Dex/BTGd demonstrated potent antibacterial activity against clinically relevant pathogens, effectively disrupting biofilms and overcoming tetracycline resistance. The incorporated Gd³⁺ allowed targeted visualization of pulmonary infection sites by MRI, facilitating timely disease assessment. Beyond its direct antibacterial effects, the nanoplatform modulated the inflammatory microenvironment by scavenging reactive oxygen species, promoting macrophage polarization from the pro-inflammatory to the anti-inflammatory phenotype, and suppressing profibrotic transforming growth factor-β signaling. In a murine model of tetracycline-resistant <em>Pseudomonas aeruginosa</em> pneumonia, Dex/BTGd significantly reduced bacterial load, alleviated pulmonary edema and fibrosis, and enabled targeted MRI visualization of infected lesions. This integrated strategy of pathogen clearance, microenvironment modulation, and tissue repair offers a multifaceted solution to drug-resistant bacterial pneumonia, providing a promising blueprint for next-generation anti-infective systems.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 4","pages":"Article 101185"},"PeriodicalIF":12.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148732204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive hydrogels for bone tissue engineering: Design strategies, bioactive cargo delivery, and artificial intelligence–assisted clinical translation","authors":"Chongzheng Yan,&nbsp;Yuxue Pan,&nbsp;Yu Tian,&nbsp;Peng Sun,&nbsp;Xinyi Jiang,&nbsp;Yuankai Zhang","doi":"10.1016/j.ajps.2026.101188","DOIUrl":"10.1016/j.ajps.2026.101188","url":null,"abstract":"<div><div>The functional reconstruction of bone defects caused by trauma, infection, surgical resection and degenerative diseases poses substantial clinical challenges. Bone tissue engineering (BTE) holds immense potential for treating bone defects while avoiding complications commonly associated with conventional autografts, allografts and internal fixation. Bioactive hydrogels with exceptional drug delivery capabilities, excellent biocompatibility and tunable physicochemical properties have emerged as promising biomaterial scaffolds for BTE. This review provides a comprehensive overview of recent advancements in bioactive hydrogel–based strategies for BTE applications. An initial introduction to bone physiology is followed by a critical discussion of the design considerations for hydrogel platforms, specifically biomaterial selection, innovative crosslinking mechanisms and bioactive functionalization. Furthermore, hydrogel engineering for the controlled delivery of bioactive cargo is critically examined, with an emphasis on spatiotemporally programmable release behaviors that coordinate osteogenesis, angiogenesis and immunomodulation. Finally, key translational challenges are discussed, and the emerging role of artificial intelligence–assisted design is explored as a transformative approach for facilitating the clinical translation of next-generation bioactive hydrogels for BTE.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 4","pages":"Article 101188"},"PeriodicalIF":12.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148844489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carrier-free doxorubicin nanomedicine integrates chemotherapy and chemodynamic therapy to achieve anti-tumor efficacy","authors":"Min Liu,&nbsp;Xin Hu,&nbsp;Siyi Liu,&nbsp;Jingya Xiu,&nbsp;Dan Li,&nbsp;Jiulong Zhang,&nbsp;Xiuli Zhao","doi":"10.1016/j.ajps.2026.101174","DOIUrl":"10.1016/j.ajps.2026.101174","url":null,"abstract":"<div><div>Nanomedicines have been constructed to enhance the efficacy and safety of traditional anti-cancer drugs. However, the clinical translation of these nanomedicines was hindered by the complexity of carrier materials and functional integration. In this study, a carrier-free nanomedicine composed of doxorubicin (DOX), Cu²⁺ and siRNA of GPX4 was constructed for combination therapy of tumors. DOX, Cu²⁺ and siRNA were assembled through multiple forces and decorated with hyaluronic acid (HA) to prepare tumor targeted carrier-free nanomedicines (HDCS). The HA coating on the surface of HDCS ensured specific tumor targeting, and the released drugs triggered by acidity could eliminate tumor cells. The nanomedicine showed significant anti-cancer efficiency and quite reduced side effects in the breast cancer model when compared with DOX solution. HDCS treatment led to significant accelerated production of ROS, reduced GPX4 expression, and sustained decrease in GSH at tumor sites, ultimately forming a powerful chemodynamic effect enhancing circuit. The HDCS provides an effective strategy for tumor combination therapy with good clinical translation and application potential.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"21 4","pages":"Article 101174"},"PeriodicalIF":12.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148732203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}