Asian Journal of Pharmaceutical Sciences最新文献_第10页

Unleashing the healing potential: Exploring next-generation regenerative protein nanoscaffolds for burn wound recovery 释放愈合潜力:探索用于烧伤伤口恢复的下一代再生蛋白质纳米支架

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2023-11-01 DOI: 10.1016/j.ajps.2023.100856

Liangwei Si , Xiong Guo , Hriday Bera , Yang Chen , Fangfang Xiu , Peixin Liu , Chunwei Zhao , Yasir Faraz Abbasi , Xing Tang , Vito Foderà , Dongmei Cun , Mingshi Yang

{"title":"Unleashing the healing potential: Exploring next-generation regenerative protein nanoscaffolds for burn wound recovery","authors":"Liangwei Si , Xiong Guo , Hriday Bera , Yang Chen , Fangfang Xiu , Peixin Liu , Chunwei Zhao , Yasir Faraz Abbasi , Xing Tang , Vito Foderà , Dongmei Cun , Mingshi Yang","doi":"10.1016/j.ajps.2023.100856","DOIUrl":"10.1016/j.ajps.2023.100856","url":null,"abstract":"<div><p>Burn injury is a serious public health problem and scientists are continuously aiming to develop promising biomimetic dressings for effective burn wound management. In this study, a greater efficacy in burn wound healing and the associated mechanisms of α-lactalbumin (ALA) based electrospun nanofibrous scaffolds (ENs) as compared to other regenerative protein scaffolds were established. Bovine serum albumin (BSA), collagen type I (COL), lysozyme (LZM) and ALA were separately blended with poly(ε-caprolactone) (PCL) to fabricate four different composite ENs (LZM/PCL, BSA/PCL, COL/PCL and ALA/PCL ENs). The hydrophilic composite scaffolds exhibited an enhanced wettability and variable mechanical properties. The ALA/PCL ENs demonstrated higher levels of fibroblast proliferation and adhesion than the other composite ENs. As compared to PCL ENs and other composite scaffolds, the ALA/PCL ENs also promoted a better maturity of the regenerative skin tissues and showed a comparable wound healing effect to Collagen sponge<sup>Ⓡ</sup> on third-degree burn model. The enhanced wound healing activity of ALA/PCL ENs compared to other ENs could be attributed to their ability to promote serotonin production at wound sites. Collectively, this investigation demonstrated that ALA is a unique protein with a greater potential for burn wound healing as compared to other regenerative proteins when loaded in the nanofibrous scaffolds.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"18 6","pages":"Article 100856"},"PeriodicalIF":10.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1818087623000831/pdfft?md5=7dfd419d9ea04576804bc416881f1216&pid=1-s2.0-S1818087623000831-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136009507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leveraging immunoliposomes as nanocarriers against SARS-CoV-2 and its emerging variants 利用免疫脂质体作为纳米载体对抗SARS-CoV-2及其新变体

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2023-11-01 DOI: 10.1016/j.ajps.2023.100855

Nur Dini Fatini Mohammad Faizal , Nurul Afina Ramli , Nur Najihah Izzati Mat Rani , Nur Adania Shaibie , Aarti , Pattaporn Poonsawas , Sunil K. Sharma , Mohd Cairul Iqbal Mohd Amin

{"title":"Leveraging immunoliposomes as nanocarriers against SARS-CoV-2 and its emerging variants","authors":"Nur Dini Fatini Mohammad Faizal , Nurul Afina Ramli , Nur Najihah Izzati Mat Rani , Nur Adania Shaibie , Aarti , Pattaporn Poonsawas , Sunil K. Sharma , Mohd Cairul Iqbal Mohd Amin","doi":"10.1016/j.ajps.2023.100855","DOIUrl":"10.1016/j.ajps.2023.100855","url":null,"abstract":"<div><p>The global COVID-19 pandemic arising from SARS-CoV-2 has impacted many lives, gaining interest worldwide ever since it was first identified in December 2019. Till 2023, 752 million cumulative cases and 6.8 million deaths were documented globally. COVID-19 has been rapidly evolving, affecting virus transmissibility and properties and contributing to increased disease severity. The Omicron is the most circulating variant of concern. Although success in its treatment has indicated progress in tackling the virus, limitations in delivering the current antiviral agents in battling emerging variants remain remarkable. With the latest advancements in nanotechnology for controlling infectious diseases, liposomes have the potential to counteract SARS-CoV-2 because of their ability to employ different targeting strategies, incorporating monoclonal antibodies for the active and passive targeting of infected patients. This review will present a concise summary of the possible strategies for utilizing immunoliposomes to improve current treatment against the occurrence of SARS-CoV-2 and its variants.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"18 6","pages":"Article 100855"},"PeriodicalIF":10.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S181808762300082X/pdfft?md5=e8406d12085f6381f6578dc836e21539&pid=1-s2.0-S181808762300082X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136009861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An infection-microenvironment-targeted and responsive peptide-drug nanosystem for sepsis emergency by suppressing infection and inflammation 一种针对感染微环境的反应性肽药物纳米系统，通过抑制感染和炎症来治疗败血症

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2023-11-01 DOI: 10.1016/j.ajps.2023.100869

Wei He , Daan Fu , Yongkang Gai , Xingxin Liu , Chang Yang , Zhilan Ye , Xu Chen , Jia Liu , Bingcheng Chang

{"title":"An infection-microenvironment-targeted and responsive peptide-drug nanosystem for sepsis emergency by suppressing infection and inflammation","authors":"Wei He , Daan Fu , Yongkang Gai , Xingxin Liu , Chang Yang , Zhilan Ye , Xu Chen , Jia Liu , Bingcheng Chang","doi":"10.1016/j.ajps.2023.100869","DOIUrl":"10.1016/j.ajps.2023.100869","url":null,"abstract":"<div><p>Sepsis is a life-threatening emergency that causes millions of deaths every year due to severe infection and inflammation. Nevertheless, current therapeutic regimens are inadequate to promptly address the vast diversity of potential pathogens. Omiganan, an antimicrobial peptide, has shown promise for neutralizing endotoxins and eliminating diverse pathogens. However, its clinical application is hindered by safety and stability concerns. Herein, we present a nanoscale drug delivery system (Omi-hyd-Dex@HA NPs) that selectively targets infectious microenvironments (IMEs) and responds to specific stimuli for efficient intervention in sepsis. The system consists of omiganan-dexamethasone conjugates linked by hydrazone bonds which self-assemble into nanoparticles coated with a hyaluronic acid (HA). The HA coating not only facilitates IMEs-targeting through interaction with intercellular-adhesion-molecule-1 on inflamed endotheliocytes, but also improves the biosafety of the nanosystem and enhances drug accumulation in primary infection sites triggered by hyaluronidase. The nanoparticles release dual drugs in IMEs through pH-sensitive cleavage of hydrazone bonds to eradicate pathogens and suppress inflammation. In multiple tissue infection and sepsis animal models, Omi-hyd-Dex@HA NPs exhibited rapid source control and comprehensive inflammation reduction, thereby preventing subsequent fatal complications and significantly improving survival outcomes. The bio-responsive and self-delivering nanosystem offers a promising strategy for systemic sepsis treatment in emergencies.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"18 6","pages":"Article 100869"},"PeriodicalIF":10.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S181808762300096X/pdfft?md5=8466c895246022bda0325d9709016e7d&pid=1-s2.0-S181808762300096X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138544269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contact lens as an emerging platform for ophthalmic drug delivery: A systematic review 隐形眼镜作为眼科给药的新兴平台:系统综述

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2023-09-27 DOI: 10.1016/j.ajps.2023.100847

Hongyu Yang , Ming Zhao , Dandan Xing, Jian Zhang, Ting Fang, Faxing Zhang, Zhihao Nie, Yaming Liu, Lihua Yang, Ji Li, Dongkai Wang

{"title":"Contact lens as an emerging platform for ophthalmic drug delivery: A systematic review","authors":"Hongyu Yang , Ming Zhao , Dandan Xing, Jian Zhang, Ting Fang, Faxing Zhang, Zhihao Nie, Yaming Liu, Lihua Yang, Ji Li, Dongkai Wang","doi":"10.1016/j.ajps.2023.100847","DOIUrl":"https://doi.org/10.1016/j.ajps.2023.100847","url":null,"abstract":"<div><p>The number of people with eye diseases has increased with the use of electronics. However, the bioavailability of eye drops remains low owing to the presence of the ocular barrier and other reasons. Although many drug delivery systems have been developed to overcome these problems, they have certain limitations. In recent years, the development of contact lenses that can deliver drugs for long periods with high bioavailability and without affecting vision has increased the interest in using contact lenses for drug delivery. Hence, a review of the current state of research on drug delivery contact lenses has become crucial. This article reviews the key physical and chemical properties of drug-laden contact lenses, development and classification of contact lenses, and features of the commonly used materials. A review of the methods commonly used in current research to create contact lenses has also been presented. An overview on how drug-laden contact lenses can overcome the problems of high burst and short release duration has been discussed. Overall, the review focuses on drug delivery methods using smart contact lenses, and predicts the future direction of research on contact lenses.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"18 5","pages":"Article 100847"},"PeriodicalIF":10.2,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49709820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Remodeling the tumor immune microenvironment via siRNA therapy for precision cancer treatment 通过siRNA疗法重塑肿瘤免疫微环境，实现精准癌症治疗

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2023-09-01 DOI: 10.1016/j.ajps.2023.100852

Lingxi Jiang , Yao Qi , Lei Yang , Yangbao Miao , Weiming Ren , Hongmei Liu , Yi Huang , Shan Huang , Shiyin Chen , Yi Shi , Lulu Cai

{"title":"Remodeling the tumor immune microenvironment via siRNA therapy for precision cancer treatment","authors":"Lingxi Jiang , Yao Qi , Lei Yang , Yangbao Miao , Weiming Ren , Hongmei Liu , Yi Huang , Shan Huang , Shiyin Chen , Yi Shi , Lulu Cai","doi":"10.1016/j.ajps.2023.100852","DOIUrl":"https://doi.org/10.1016/j.ajps.2023.100852","url":null,"abstract":"<div><p>How to effectively transform the pro-oncogenic tumor microenvironments (TME) surrounding a tumor into an anti-tumoral never fails to attract people to study. Small interfering RNA (siRNA) is considered one of the most noteworthy research directions that can regulate gene expression following a process known as RNA interference (RNAi). The research about siRNA delivery targeting tumor cells and TME has been on the rise in recent years. Using siRNA drugs to silence critical proteins in TME was one of the most efficient solutions. However, the manufacture of a siRNA delivery system faces three major obstacles, <em>i.e.</em>, appropriate cargo protection, accurately targeted delivery, and site-specific cargo release. In the following review, we summarized the pharmacological actions of siRNA drugs in remolding TME. In addition, the delivery strategies of siRNA drugs and combination therapy with siRNA drugs to remodel TME are thoroughly discussed. In the meanwhile, the most recent advancements in the development of all clinically investigated and commercialized siRNA delivery technologies are also presented. Ultimately, we propose that nanoparticle drug delivery siRNA may be the future research focus of oncogene therapy. This summary offers a thorough analysis and roadmap for general readers working in the field.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"18 5","pages":"Article 100852"},"PeriodicalIF":10.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49709959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of virus-capsid mimicking biologic-shell based versus polymeric-shell nanoparticles for enhanced oral insulin delivery 模拟病毒衣壳的生物壳纳米颗粒与聚合物壳纳米颗粒增强口服胰岛素递送的比较

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2023-09-01 DOI: 10.1016/j.ajps.2023.100848

Zhixiang Cui , Shuman Cui , Lu Qin , Yalin An , Xin Zhang , Jian Guan , Tin Wui Wong , Shirui Mao

{"title":"Comparison of virus-capsid mimicking biologic-shell based versus polymeric-shell nanoparticles for enhanced oral insulin delivery","authors":"Zhixiang Cui , Shuman Cui , Lu Qin , Yalin An , Xin Zhang , Jian Guan , Tin Wui Wong , Shirui Mao","doi":"10.1016/j.ajps.2023.100848","DOIUrl":"https://doi.org/10.1016/j.ajps.2023.100848","url":null,"abstract":"<div><p>Virus-capsid mimicking mucus-permeable nanoparticles are promising oral insulin carriers which surmount intestinal mucus barrier. However, the impact of different virus-capsid mimicking structure remains unexplored. In this study, utilizing biotin grafted chitosan as the main skeleton, virus-mimicking nanoparticles endowed with biologic-shell (streptavidin coverage) and polymeric-shell (hyaluronic acid/alginate coating) were designed with insulin as a model drug by self-assembly processes. It was demonstrated that biologic-shell mimicking nanoparticles exhibited a higher intestinal trans-mucus (>80%, 10 min) and transmucosal penetration efficiency (1.6–2.2-fold improvement) than polymeric-shell counterparts. Uptake mechanism studies revealed caveolae-mediated endocytosis was responsible for the absorption of biologic-shell mimicking nanoparticles whereas polymeric-shell mimicking nanoparticles were characterized by clathrin-mediated pathway with anticipated lysosomal insulin digestion. Further, <em>in vivo</em> hypoglycemic study indicated that the improved effect of regulating blood sugar levels was virus-capsid structure dependent out of which biologic-shell mimicking nanoparticles presented the best performance (5.1%). Although the findings of this study are encouraging, much more work is required to meet the standards of clinical translation. Taken together, we highlight the external structural dependence of virus-capsid mimicking nanoparticles on the muco-penetrating and uptake mechanism of enterocytes that in turn affecting their <em>in vivo</em> absorption, which should be pondered when engineering virus-mimicking nanoparticles for oral insulin delivery.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"18 5","pages":"Article 100848"},"PeriodicalIF":10.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49709939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nano transdermal system combining mitochondria-targeting cerium oxide nanoparticles with all-trans retinoic acid for psoriasis 结合线粒体靶向氧化铈纳米颗粒与全反式维甲酸治疗银屑病的纳米透皮系统

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2023-09-01 DOI: 10.1016/j.ajps.2023.100846

Wei Wang , Xinyi Xu , Yanling Song , Lan Lan , Jun Wang , Xinchang Xu , Yongzhong Du

{"title":"Nano transdermal system combining mitochondria-targeting cerium oxide nanoparticles with all-trans retinoic acid for psoriasis","authors":"Wei Wang , Xinyi Xu , Yanling Song , Lan Lan , Jun Wang , Xinchang Xu , Yongzhong Du","doi":"10.1016/j.ajps.2023.100846","DOIUrl":"https://doi.org/10.1016/j.ajps.2023.100846","url":null,"abstract":"<div><p>Psoriasis is an inflammatory skin disease that is intricately linked to oxidative stress. Antioxidation and inhibition of abnormal proliferation of keratinocytes are pivotal strategies for psoriasis. Delivering drugs with these effects to the site of skin lesions is a challenge that needs to be solved. Herein, we reported a nanotransdermal delivery system composed of all-trans retinoic acid (TRA), triphenylphosphine (TPP)-modified cerium oxide (CeO<sub>2</sub>) nanoparticles, flexible nanoliposomes and gels (TCeO<sub>2</sub>-TRA-FNL-Gel). The results revealed that TCeO<sub>2</sub> synthesized by the anti-micelle method, with a size of approximately 5 nm, possessed excellent mitochondrial targeting ability and valence conversion capability related to scavenging reactive oxygen species (ROS). TCeO<sub>2</sub>-TRA-FNL prepared by the film dispersion method, with a size of approximately 70 nm, showed high drug encapsulation efficiency (>96%). TCeO<sub>2</sub>-TRA-FNL-Gel further showed sustained drug release behaviors, great transdermal permeation ability, and greater skin retention than the free TRA. The results of <em>in vitro</em> EGF-induced and H<sub>2</sub>O<sub>2</sub>-induced models suggested that TCeO<sub>2</sub>-TRA-FNL effectively reduced the level of inflammation and alleviated oxidative stress in HaCat cells. The results of <em>in vivo</em> imiquimod (IMQ)-induced model indicated that TCeO<sub>2</sub>-TRA-FNL-Gel could greatly alleviate the psoriasis symptoms. In summary, the transdermal drug delivery system designed in this study has shown excellent therapeutic effects on psoriasis and is prospective for the safe and accurate therapy of psoriasis.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"18 5","pages":"Article 100846"},"PeriodicalIF":10.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49709938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic biomineralization nanoplatform-mediated differentiation therapy and phototherapy for cancer stem cell inhibition and antitumor immunity activation 仿生生物矿化纳米平台介导的分化和光疗对肿瘤干细胞抑制和抗肿瘤免疫激活的作用

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2023-09-01 DOI: 10.1016/j.ajps.2023.100851

Shan Gao, Meng Liu, Dongzhu Liu, Xinru Kong, Yuelin Fang, Yingying Li, Hang Wu, Jianbo Ji, Xiaoye Yang, Guangxi Zhai

{"title":"Biomimetic biomineralization nanoplatform-mediated differentiation therapy and phototherapy for cancer stem cell inhibition and antitumor immunity activation","authors":"Shan Gao, Meng Liu, Dongzhu Liu, Xinru Kong, Yuelin Fang, Yingying Li, Hang Wu, Jianbo Ji, Xiaoye Yang, Guangxi Zhai","doi":"10.1016/j.ajps.2023.100851","DOIUrl":"https://doi.org/10.1016/j.ajps.2023.100851","url":null,"abstract":"<div><p>Growing evidence suggests that the presence of cancer stem cells (CSCs) is a major challenge in current tumor treatments, especially the transition from non-CSCs to differentiation of CSCs for evading conventional therapies and driving metastasis. Here we propose a therapeutic strategy of synergistic differentiation therapy and phototherapy to induce differentiation of CSCs into mature tumor cells by differentiation inducers and synergistic elimination of them and normal cancer cells through phototherapy. In this work, we synthesized a biomimetic nanoplatform loaded with IR-780 and all-trans retinoic acid (ATRA) <em>via</em> biomineralization. This method can integrate aluminum ions into small-sized protein carriers to form nanoclusters, which undergo responsive degradation under acidic conditions and facilitate deep tumor penetration. With the help of CSC differentiation induced by ATRA, IR-780 inhibited the self-renewal of CSCs and cancer progression by generating hyperthermia and reactive oxygen species in a synergistic manner. Furthermore, ATRA can boost immunogenic cell death induced by phototherapy, thereby strongly causing a systemic anti-tumor immune response and efficiently eliminating CSCs and tumor cells. Taken together, this dual strategy represents a new paradigm of targeted eradication of CSCs and tumors by inducing CSC differentiation, improving photothermal therapy/photodynamic therapy and enhancing antitumor immunity.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"18 5","pages":"Article 100851"},"PeriodicalIF":10.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49709877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-temperature photothermal-induced alkyl radical release facilitates dihydroartemisinin-triggered “valve-off” starvation therapy 低温光热诱导的烷基自由基释放促进了双氢青蒿素触发的“关阀”饥饿治疗

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2023-09-01 DOI: 10.1016/j.ajps.2023.100850

Xiaomin Su , Boshu Ouyang , Yao Liu , Yang Wang , Ruizhe Xu , Lili Niu , NanNan Li , Ce Xu , Zanya Sun , Huishu Guo , Zhiqing Pang , Xiangrong Yu

{"title":"Low-temperature photothermal-induced alkyl radical release facilitates dihydroartemisinin-triggered “valve-off” starvation therapy","authors":"Xiaomin Su , Boshu Ouyang , Yao Liu , Yang Wang , Ruizhe Xu , Lili Niu , NanNan Li , Ce Xu , Zanya Sun , Huishu Guo , Zhiqing Pang , Xiangrong Yu","doi":"10.1016/j.ajps.2023.100850","DOIUrl":"https://doi.org/10.1016/j.ajps.2023.100850","url":null,"abstract":"<div><p>The high nutrient and energy demand of tumor cells compared to normal cells to sustain rapid proliferation offer a potentially auspicious avenue for implementing starvation therapy. However, conventional starvation therapy, such as glucose exhaustion and vascular thrombosis, can lead to systemic toxicity and exacerbate tumor hypoxia. Herein, we developed a new “valve-off” starvation tactic, which was accomplished by closing the valve of glucose transporter protein 1 (GLUT1). Specifically, dihydroartemisinin (DHA), 2,20-azobis [2-(2-imidazolin-2-yl) propane] dihydrochloride (AI), and Ink were co-encapsulated in a sodium alginate (ALG) hydrogel. Upon irradiation with the 1064 nm laser, AI rapidly disintegrated into alkyl radicals (R<sup>•</sup>), which exacerbated the DHA-induced mitochondrial damage through the generation of reactive oxygen species and further reduced the synthesis of adenosine triphosphate (ATP). Simultaneously, the production of R<sup>•</sup> facilitated DHA-induced starvation therapy by suppressing GLUT1, which in turn reduced glucose uptake. Systematic <em>in vivo</em> and <em>in vitro</em> results suggested that this radical-enhanced “valve-off” strategy for inducing tumor cell starvation was effective in reducing glucose uptake and ATP levels. This integrated strategy induces tumor starvation with efficient tumor suppression, creating a new avenue for controlled, precise, and concerted tumor therapy.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"18 5","pages":"Article 100850"},"PeriodicalIF":10.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49709892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted hyperalkalization with NaOH-loaded starch implants enhances doxorubicin efficacy in tumor treatment 用NaOH负载的淀粉植入物进行靶向超碱性化可增强阿霉素在肿瘤治疗中的疗效。

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2023-09-01 DOI: 10.1016/j.ajps.2023.100853

Changkyu Lee

{"title":"Targeted hyperalkalization with NaOH-loaded starch implants enhances doxorubicin efficacy in tumor treatment","authors":"Changkyu Lee","doi":"10.1016/j.ajps.2023.100853","DOIUrl":"10.1016/j.ajps.2023.100853","url":null,"abstract":"<div><p>High-alkali treatment using sodium hydroxide (NaOH) injection can be a therapeutic approach for killing tumor cells. Alkalization can damage cellular structures and lead to cell death. Increased alkalinity can also enhance the efficacy of certain chemotherapeutic drugs such as doxorubicin (DOX). In this study, NaOH-loaded starch implants (NST implants) were used to induce hyperalkalization (increase pH) in the tumor environment, thereby inducing necrosis and enhancing the effects of DOX. NaOH is a strongly alkaline substance that can increase the pH when injected into a tumor. However, the administration of NaOH can have toxic side effects because it increases the pH of the entire body, not just at the tumor site. To overcome this problem, we developed an injectable NST implant, in which NaOH can be delivered directly into the tumor. This study showed that NST implants could be easily administered intratumorally in mice bearing 4T1 tumors and that most of the NaOH released from the NST implants was delivered to the tumors. Although some NaOH from NST implants can be systemically absorbed, it is neutralized by the body's buffering effect, thereby reducing the risk of toxicity. This study also confirmed both <em>in vitro</em> and <em>in vivo</em> that DOX is more effective at killing 4T1 cells when alkalized. It has been shown that administration of DOX after injection of an NST implant can kill most tumors. Systemic absorption and side effects can be reduced using an NST implant to deliver NaOH to the tumor. In addition, alkalinization induced by NST implants not only exerts anticancer effects but can also enhance the effect of DOX in killing cancer cells. Therefore, the combination of NaOH-loaded starch implants and DOX treatment has the potential to be a novel therapy for tumors.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"18 5","pages":"Article 100853"},"PeriodicalIF":10.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71420179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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