Synergistic chemotherapy/PTT/oxygen enrichment by multifunctional liposomal polydopamine nanoparticles for rheumatoid arthritis treatment

IF 10.7 1区医学 Q1 PHARMACOLOGY & PHARMACY

Asian Journal of Pharmaceutical Sciences Pub Date : 2024-02-01 DOI:10.1016/j.ajps.2024.100885

Xiaoling Fu , Yutong Song , Xianquan Feng , Zhihong Liu , Wenhao Gao , Hongtao Song , Qian Zhang

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引用次数: 0

Abstract

Amultifunctional liposomal polydopamine nanoparticle (MPM@Lipo) was designed in this study, to combine chemotherapy, photothermal therapy (PTT) and oxygen enrichment to clear hyperproliferating inflammatory cells and improve the hypoxic microenvironment for rheumatoid arthritis (RA) treatment. MPM@Lipo significantly scavenged intracellular reactive oxygen species and relieved joint hypoxia, thus contributing to the repolarization of M1 macrophages into M2 phenotype. Furthermore, MPM@Lipo could accumulate at inflammatory joints, inhibit the production of inflammatory factors, and protect cartilage in vivo, effectively alleviating RA progression in a rat adjuvant-induced arthritis model. Moreover, upon laser irradiation, MPM@Lipo can elevate the temperature to not only significantly obliterate excessively proliferating inflammatory cells but also accelerate the production of methotrexate and oxygen, resulting in excellent RA treatment effects. Overall, the use of synergistic chemotherapy/PTT/oxygen enrichment therapy to treat RA is a powerful potential strategy.

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利用多功能脂质体多巴胺纳米颗粒的协同化疗/PTT/富氧作用治疗类风湿性关节炎

本研究设计了一种多功能脂质体多巴胺纳米粒子（MPM@Lipo），将化疗、光热疗法（PTT）和富氧结合起来，清除过度增殖的炎症细胞，改善缺氧微环境，用于类风湿性关节炎（RA）的治疗。MPM@Lipo 能明显清除细胞内的活性氧，缓解关节缺氧，从而促使 M1 巨噬细胞重新极化为 M2 表型。此外，在大鼠佐剂诱导的关节炎模型中，MPM@Lipo 能在炎症关节处聚集，抑制炎症因子的产生，保护软骨，有效缓解 RA 的进展。此外，在激光照射下，MPM@Lipo 还能升高温度，不仅能显著清除过度增殖的炎症细胞，还能加速甲氨蝶呤和氧气的产生，从而产生良好的 RA 治疗效果。总之，使用协同化疗/PTT/富氧疗法治疗RA是一种强有力的潜在策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Journal of Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

18.30

自引率

2.90%

发文量

审稿时长

14 days

期刊介绍： The Asian Journal of Pharmaceutical Sciences (AJPS) serves as the official journal of the Asian Federation for Pharmaceutical Sciences (AFPS). Recognized by the Science Citation Index Expanded (SCIE), AJPS offers a platform for the reporting of advancements, production methodologies, technologies, initiatives, and the practical application of scientific knowledge in the field of pharmaceutics. The journal covers a wide range of topics including but not limited to controlled drug release systems, drug targeting, physical pharmacy, pharmacodynamics, pharmacokinetics, pharmacogenomics, biopharmaceutics, drug and prodrug design, pharmaceutical analysis, drug stability, quality control, pharmaceutical engineering, and material sciences.