用于治疗性基因传递的高分子纳米载体

IF 10.7 1区医学 Q1 PHARMACOLOGY & PHARMACY

Asian Journal of Pharmaceutical Sciences Pub Date : 2025-02-01 DOI:10.1016/j.ajps.2025.101015

Jiayuan Zhang , Xinyu Yang , Zhichao Chang , Wenwei Zhu , Yuhua Ma , Haisheng He

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引用次数: 0

摘要

最近基因产品的商业化引发了人们对基因治疗的极大兴趣，需要通过各种载体高效和精确地传递基因。目前，病毒载体和基于脂质的纳米载体是主要的选择，并得到了广泛的研究和综述。除了这些载体之外，聚合物纳米载体由于其多功能，如提高核酸药物的稳定性、细胞吸收和内体逃逸，以及精确递送到目标组织，在治疗性基因递送方面也有希望。本文综述了用于治疗性基因传递的新型高分子纳米载体的研究现状，重点介绍了主要的阳离子聚合物、纳米载体类型和制备方法。它还强调了目标疾病，提高递送效率的策略，以及该研究领域潜在的未来方向。该综述希望对高效高分子纳米载体的开发、优化和临床转化提供启发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Polymeric nanocarriers for therapeutic gene delivery

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Polymeric nanocarriers for therapeutic gene delivery

The recent commercialization of gene products has sparked significant interest in gene therapy, necessitating efficient and precise gene delivery via various vectors. Currently, viral vectors and lipid-based nanocarriers are the predominant choices and have been extensively investigated and reviewed. Beyond these vectors, polymeric nanocarriers also hold the promise in therapeutic gene delivery owing to their versatile functionalities, such as improving the stability, cellar uptake and endosomal escape of nucleic acid drugs, along with precise delivery to targeted tissues. This review presents a brief overview of the status quo of the emerging polymeric nanocarriers for therapeutic gene delivery, focusing on key cationic polymers, nanocarrier types, and preparation methods. It also highlights targeted diseases, strategies to improve delivery efficiency, and potential future directions in this research area. The review is hoped to inspire the development, optimization, and clinical translation of highly efficient polymeric nanocarriers for therapeutic gene delivery.

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来源期刊

Asian Journal of Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

18.30

自引率

2.90%

发文量

审稿时长

14 days

期刊介绍： The Asian Journal of Pharmaceutical Sciences (AJPS) serves as the official journal of the Asian Federation for Pharmaceutical Sciences (AFPS). Recognized by the Science Citation Index Expanded (SCIE), AJPS offers a platform for the reporting of advancements, production methodologies, technologies, initiatives, and the practical application of scientific knowledge in the field of pharmaceutics. The journal covers a wide range of topics including but not limited to controlled drug release systems, drug targeting, physical pharmacy, pharmacodynamics, pharmacokinetics, pharmacogenomics, biopharmaceutics, drug and prodrug design, pharmaceutical analysis, drug stability, quality control, pharmaceutical engineering, and material sciences.