Electrically conductive “SMART” hydrogels for on-demand drug delivery

IF 11.9 1区医学 Q1 PHARMACOLOGY & PHARMACY

Asian Journal of Pharmaceutical Sciences Pub Date : 2025-02-01 DOI:10.1016/j.ajps.2024.101007

Soumajyoti Ghosh , Nikhil Kumar , Santanu Chattopadhyay

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Abstract

In the current transformative era of biomedicine, hydrogels have established their presence in biomaterials due to their superior biocompatibility, tuneability and resemblance with native tissue. However, hydrogels typically exhibit poor conductivity due to their hydrophilic polymer structure. Electrical conductivity provides an important enhancement to the properties of hydrogel-based systems in various biomedical applications such as drug delivery and tissue engineering. Consequently, researchers are developing combinatorial strategies to develop electrically responsive “SMART” systems to improve the therapeutic efficacy of biomolecules. Electrically conductive hydrogels have been explored for various drug delivery applications, enabling higher loading of therapeutic cargo with on-demand delivery. This review emphasizes the properties, mechanisms, fabrication techniques and recent advancements of electrically responsive “SMART” systems aiding on-site drug delivery applications. Additionally, it covers prospects for the successful translation of these systems into clinical research.

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用于按需给药的导电“SMART”水凝胶

在当前生物医学的变革时代，水凝胶由于其优越的生物相容性、可调节性和与天然组织的相似性而在生物材料中建立了自己的存在。然而，由于其亲水性聚合物结构，水凝胶通常表现出较差的导电性。导电性为水凝胶系统在各种生物医学应用（如药物输送和组织工程）中的性能提供了重要的增强。因此，研究人员正在开发组合策略来开发电响应“SMART”系统，以提高生物分子的治疗效果。导电性水凝胶已被探索用于各种药物递送应用，使按需递送的治疗货物负载更高。本文综述了电响应“SMART”系统的特性、机制、制造技术和最新进展，以辅助现场给药应用。此外，它还涵盖了这些系统成功转化为临床研究的前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Journal of Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

18.30

自引率

2.90%

发文量

审稿时长

14 days

期刊介绍： The Asian Journal of Pharmaceutical Sciences (AJPS) serves as the official journal of the Asian Federation for Pharmaceutical Sciences (AFPS). Recognized by the Science Citation Index Expanded (SCIE), AJPS offers a platform for the reporting of advancements, production methodologies, technologies, initiatives, and the practical application of scientific knowledge in the field of pharmaceutics. The journal covers a wide range of topics including but not limited to controlled drug release systems, drug targeting, physical pharmacy, pharmacodynamics, pharmacokinetics, pharmacogenomics, biopharmaceutics, drug and prodrug design, pharmaceutical analysis, drug stability, quality control, pharmaceutical engineering, and material sciences.