Asia Oceania Journal of Nuclear Medicine and Biology最新文献

{"title":"[¹⁸F]FMISO PET in metastatic neuroendocrine tumours: a pilot study.","authors":"David L Chan, Alice Conner, Nick Pavlakis, Elizabeth Bailey, Alireza Aslani, Kathy Willowson, Connie Diakos, Elizabeth J Bernard, Stephen Clarke, Alexander Engel, Paul J Roach, Dale L Bailey","doi":"10.22038/aojnmb.2025.83664.1611","DOIUrl":"https://doi.org/10.22038/aojnmb.2025.83664.1611","url":null,"abstract":"<p><strong>Objectives: </strong>The phenomenon of peripheral [⁶⁸Ga]DOTATATE avidity without central avidity (which we have termed a \"DONUT\") has been observed in neuroendocrine neoplasm (NEN) lesions. There has been speculation as to whether this is due to hypoxia, de-differentiated disease or other causes. The presence of hypoxia may have prognostic and therapeutic implications, and was evaluated in these lesions using the PET hypoxia imaging biomarker [¹⁸F]FMISO.</p><p><strong>Methods: </strong>Prospective pilot study in patients with metastatic NENs with at least one DONUT lesion (central [⁶⁸Ga]DOTATATE non-avidity). [¹⁸F]FDG and [¹⁸F]FMISO scans were acquired within 60 days of the [⁶⁸Ga]DOTATATE PET/CT. [¹⁸F]FMISO scans were acquired as a dynamic scan over 20 mins from injection with a delayed image at 2 hours. The dynamic acquisition was analysed quantitatively using a graphical approach yielding parametric images of Influx Rate Constant and Volume of Distribution. [¹⁸F]FMISO uptake within the identified DONUT hole on the 2 hr delayed scan was qualitatively scored by two experienced nuclear medicine physicians as: 0 (no uptake), 1 (uptake less than normal liver), 2 (uptake equal to normal liver), or 3 (uptake greater than normal liver).</p><p><strong>Results: </strong>Ten patients were enrolled with primary sites including pancreas (n=3), small bowel (n=3), rectum (n=2), duodenum (n=1) and lung (n=1). Six subjects were scored 1, three subjects were scored 2, and one subject was scored 3. All lesions evaluated were located in the liver. Quantitative [¹⁸F]FMISO parametric imaging showed evidence of increased uptake rate (Ki) in the photopenic areas of the DONUT lesions in 8/10 subjects. Surrounding uptake rate in normal liver was extremely low. In the qualitative delayed image assessment, only one subject demonstrated [¹⁸F]FMISO uptake greater than surrounding normal liver (small bowel primary, G2).</p><p><strong>Conclusion: </strong>Only one of ten patients with DONUT lesions demonstrated increased [¹⁸F]FMISO uptake rate on delayed static imaging. In contrast, dynamic imaging demonstrated increased [¹⁸F]FMISO uptake rate in the region of [⁶⁸Ga]DOTATATE photopenia on 8 of 10 patients. Future research using [¹⁸F]FMISO in NEN patients should incorporate dynamic imaging.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"13 2","pages":"117-125"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Focal radiotracer uptake in the falciform ligament; A rare lymphoscintigraphic pattern in breast cancer.","authors":"Amin Saber Tanha, Farid Jafari Zarrin Ghabaei, Pegah Sahafi, Mohammad Ahmadi, Ramin Sadeghi","doi":"10.22038/aojnmb.2024.80086.1564","DOIUrl":"10.22038/aojnmb.2024.80086.1564","url":null,"abstract":"<p><p>Breast cancer lymphoscintigraphy is a crucial tool in pre-operative assessment, typically revealing sentinel lymph node drainage patterns within axillary and extra-axillary regions. However, rare cases challenge conventional understanding. We report a 67-year-old woman with breast cancer, where lymphoscintigraphy revealed focal uptake within the falciform ligament of the liver, an exceedingly rare phenomenon. Clinical examination and imaging showed no axillary lymph node involvement. Lymphoscintigraphy and subsequent Single-photon emission computed tomography (SPECT)/computed tomography (CT) uncovered two axillary lymph nodes and an atypical focal uptake in the falciform ligament. Histopathology revealed no metastasis in sentinel nodes. The conventional understanding of breast lymphatic drainage primarily involves axillary and extra-axillary pathways, with the falciform ligament rarely implicated. This case suggests a unique lymphatic pathway connecting the breast and liver, possibly influencing metastasis. Factors such as lymphatic obstruction and valvular incompetency may contribute. This case highlights the importance of comprehensive lymphatic mapping in breast cancer evaluation and underscores the need for further research into atypical lymphatic pathways.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"13 1","pages":"114-116"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11682471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of diagnostic performance of [⁶⁸Ga]-Ga-FAPI-46 and [¹⁸F]-FDG PET/CT imaging for the detection of lesions and disease staging in patients with breast cancer.","authors":"Kiana Radmehr, Saeed Farzanefar, Mehrshad Abbasi, Yalda Salehi, Najme Karamzade-Ziarati, Alireza Emami-Ardekani, Reyhaneh Manafi-Farid, Nasim Vahidfar, Davood Beiki","doi":"10.22038/aojnmb.2024.80845.1573","DOIUrl":"10.22038/aojnmb.2024.80845.1573","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the diagnostic performance of [⁶⁸Ga]-Ga-FAPI-46 and [¹⁸F]-FDG PET/CT imaging for the detection of lesions and disease staging in breast cancer.</p><p><strong>Methods: </strong>Twelve female patients with breast cancer (mean age= 49.2±13.29 years) and previous [¹⁸F]-FDG PET/CT were recruited in the study. [⁶⁸Ga]Ga-FAPI-46 imaging performed in all patients within one month after [¹⁸F]-FDG PET/CT imaging. The acquired PET/CT data with both tracers were reconstructed. Tracer avid lesions with each PET tracer were identified and the semi-quantitative parameters i.e. SUV_max, lesion counts and target-to-background ratio (TBR_max) were analyzed.</p><p><strong>Results: </strong>Physiologic distribution of [⁶⁸Ga]-Ga-FAPI-46 was observed in the liver, blood pool and kidneys, whereas no tracer uptake was noted in the brain and heart. The mean liver SUV_max for [⁶⁸Ga] Ga-FAPI-46 was 1.5±0.1 which was lower than that noted for [¹⁸F]-FDG PET/CT (2.9±0.2). Likewise, the mean blood pool SUV_max value for [⁶⁸Ga]-Ga-FAPI-46 was lower than [¹⁸F]-FDG PET/CT (1.7±0.1 versus 2.0±0.1). [⁶⁸Ga]-Ga-FAPI-46 PET/CT demonstrated higher tracer uptake in the lesions detected in the brain, bone, internal mammary and lymph nodes in 4/12 patients. The overall lesions detections and the mean SUV_max values did not differ significantly between the two techniques. On the other hand, [⁶⁸Ga]-Ga-FAPI-46 demonstrated higher mean TBR_max than [¹⁸F] FDG PET/CT particularly for lesions detected in kidneys, chest wall, mediastinum, and musculoskeletal lesions. However, both techniques offered identical TNM staging.</p><p><strong>Conclusion: </strong>The findings of this preliminary study demonstrated that [⁶⁸Ga]-Ga-FAPI-46 and [¹⁸F]-FDG PET/CT offered identical disease staging in the breast cancer patients. [⁶⁸Ga]-Ga-FAPI-46 showed lower liver and blood pool uptake and an enhanced tumor-to-background ratio, thereby suggesting its potential for improved lesions detection. This may open opportunity for emerging FAP based radioligand for therapeutic applications in advanced stage breast cancers. However, this needs validation in a larger number of patients.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"13 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11682476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement of image quality for small lesion sizes in ¹⁸F-FDG prone breast silicon photomultiplier-based PET/CT imaging.","authors":"Nobuhiro Yada, Hiroyuki Kuroda, Toshihiko Kawamura, Mizuki Fukuda, Yoshinori Miyahara, Takeshi Yoshizako, Yasushi Kaji","doi":"10.22038/aojnmb.2024.78080.1553","DOIUrl":"10.22038/aojnmb.2024.78080.1553","url":null,"abstract":"<p><strong>Objectives: </strong>We investigated image quality and standardized uptake values (SUVs) for different lesion sizes using clinical data generated by ¹⁸F-FDG-prone breast silicon photomultiplier (SiPM)-based positron emission tomography/computed tomography (PET/CT).</p><p><strong>Methods: </strong>We evaluated the effect of point-spread function (PSF) modeling and Gaussian filtering (Gau) and determined the optimal reconstruction conditions. We compared the signal-to-noise ratio (SNR), contrast, %coefficient of variation (%CV), SUV, and Likert scale score between ordered-subset expectation maximization (OSEM) time-of-flight (TOF) and OSEM+TOF+PSF in phantom and clinical studies. The conventional image was generated with OSEM+TOF_Gau 6 mm. The National Electrical Manufacturers Association body phantom with 10-mm hot sphere data was acquired for 5 min. Twenty-six patients (40 lesions, ranging from 3.7 to 63.0 mm) were examined using prone breast PET/CT with a breast positioner for breast cancer staging. PET data were acquired 125±9.7 min after intravenous injection of 220±16.1 MBq at 5 min/bed.</p><p><strong>Results: </strong>In the phantom study, a high SNR was obtained from a 3- to 5-mm Gaussian filter for OSEM+TOF+PSF. The contrast obtained with OSEM+TOF without Gaussian filtering was superior to that obtained with OSEM+TOF+PSF_Gau 4 mm. In the clinical study, the image quality depended on lesion size. The average SNR was significantly higher at 40.8% for lesions >20 mm with OSEM+TOF_Gau 6 mm than with OSEM+TOF without Gaussian filtering. The average contrast for lesions ≤10 mm was significantly higher by 42.0% with OSEM+TOF without Gaussian filtering than with OSEM+TOF_Gau 6 mm. The average SUV_max of OSEM+TOF without Gaussian filtering significantly increased by 53.3% for lesions ≤10 mm.</p><p><strong>Conclusion: </strong>OSEM+TOF without Gaussian filtering provided good contrast and quantitative value for small lesions.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"13 1","pages":"77-86"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11682473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unexplained Cardiac Uptake on ^99mTc-MDP Bone Scan in a Patient with Prostate Cancer.","authors":"Malik E Juweid, Baraa Alsyouf, Nour Kasasbeh, Waleed Mahafza, Serin Moghrabi, Hanna Al-Makhamreh, Akram Saleh","doi":"10.22038/aojnmb.2025.85251.1609","DOIUrl":"https://doi.org/10.22038/aojnmb.2025.85251.1609","url":null,"abstract":"<p><p>This case report presents a case of unusual diffuse cardiac uptake (Peruguni 3: uptake greater than rib uptake) on a ^99mTc-methylene diphosphonate bone scan in an 83-year-old patient with metastatic prostate cancer which is almost resolved (Peruguni 1: uptake less than rib uptake) on a follow up bone scan about 4.4 months later. Laboratory values and imaging were negative for cardiac amyloidosis and a thorough review of the patient's medical chart did not reveal any other possible causes, pharmacologic or otherwise, thus deeming the uptake non-specific. While increased non-specific cardiac ^99mTc-diphosphanate uptake has been previously reported in elderly prostate cancer patients, possibly attributable to asymptomatic atherosclerosis, this explanation is unlikely considering that the uptake almost resolved within a relatively short period of time. It is clinically important to rule out amyloidosis in patients with increased cardiac uptake on bone scans. However, we believe that clinicians should also consider the possibility of non-specific uptake as a cause for cardiac uptake on bone scan, which would only require follow-up rather than medical intervention.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"13 2","pages":"198-202"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain metastasis from differentiated thyroid carcinoma responding to radioiodine therapy.","authors":"Leo Hashimoto, Shiro Watanabe, Mungunkhuyag Majigsuren, Kenji Hirata, Junki Takenaka, Rina Kimura, Hiroshi Ishii, Kohsuke Kudo","doi":"10.22038/aojnmb.2025.86276.1618","DOIUrl":"https://doi.org/10.22038/aojnmb.2025.86276.1618","url":null,"abstract":"<p><p>Brain metastasis (BM) occurs only in about 1% of differentiated thyroid carcinoma (DTC) cases. Although DTC generally has a good prognosis, once BM develops, the mortality rate significantly increases up to 78%. BM is usually treated by surgical resection or external radiotherapy, whereas radioactive iodine therapy (RAIT) using I-131 is much less often chosen because BM often shows poor uptake of I-131. In addition, even in case I-131 accumulates in the BM, RAIT could cause adverse effects such as brain hemorrhage and cerebral edema. We present a case of BM from DTC that showed response to I-131 therapy with no severe adverse effects. The brain lesion was very small and asymptomatic, and was only found after a post-therapy I-131 scintigraphy. There are a few case reports where BM was cured by RAIT with little to no side effects. We theorize that BM that is small in size, asymptomatic and show I-131 accumulation could be successfully treated with RAIT.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"13 2","pages":"208-212"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-pyloric botulinum toxin injection improves liquid gastric emptying using ^99mTc DTPA scintigraphy: a case report in a 2 years- old girl with idiopathic gastroparesis.","authors":"Khadijah R Sumitro, Andy Darma, Tri P Sucianti, Stepanus Massora, Alpha F Athiyyah, Reza G Ranuh, Subijanto M Sudarmo","doi":"10.22038/aojnmb.2025.84182.1599","DOIUrl":"https://doi.org/10.22038/aojnmb.2025.84182.1599","url":null,"abstract":"<p><p>Gastroparesis, characterized by delayed gastric emptying in the absence of mechanical obstruction, is a challenging condition to diagnose and treat in children due to limited pediatric-specific data. This case report presents a 15-month-old girl with recurrent and chronic vomiting since infancy, which worsened upon the introduction of solid foods. Initial diagnostic evaluations, including esophagogastroduodenoscopy (EGD) and upper gastrointestinal contrast study, ruled out structural abnormalities. A gastric emptying scintigraphy (GES) with ^99mTc DTPA confirmed significant gastric retention, leading to a diagnosis of idiopathic gastroparesis. Endoscopic intra-pyloric botulinum toxin injection (IPBI) was performed and resulting in significant symptom improvement. Post-procedure assessments revealed improved gastric emptying, with reduced retention at 60 and 180 minutes and a markedly decreased half-time (t_1/2) was shown following the procedure. These findings highlight that IPBI may be a promising therapeutic option for pediatric idiopathic gastroparesis unresponsive to standard treatments. Further research is warranted to refine treatment protocols and evaluate long-term outcomes.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"13 2","pages":"190-194"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of the specific binding ratio distribution to characterise multiple system atrophy in advanced iodine-123-labelled N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane serotonin transporter imaging.","authors":"Kazuya Takahashi, Masanobu Ishiguro, Yoshitaka Inui, Takashi Ichihara, Cong Shang, Ryunosuke Nagao, Yasuaki Mizutani, Mizuki Ito, Hirohisa Watanabe, Nobutoku Motomura, Hiroshi Toyama","doi":"10.22038/aojnmb.2024.78274.1557","DOIUrl":"10.22038/aojnmb.2024.78274.1557","url":null,"abstract":"<p><strong>Objectives: </strong>Sudden death in multiple system atrophy (MSA) is caused by decreased serotonergic innervation, but there is no routine test method for this decrease. In addition to dopamine transporters, iodine-123-labelled N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane (¹²³I-FP-CIT) binds serotonin transporters (SERTs). We noted a binding potential to quantify the total quantity of ¹²³I-FP-CIT binding to its receptors.Following Mintun's binding-potential concept, this study aimed to evaluate the relationship between the specific binding ratio (SBR) and total SERT tissue amount, but not SERT binding, and to develop an SBR imaging method to measure brain-stem SERT. We sought to establish a binding-potential imaging procedure using SBR images to examine differences in the brain-stem SERT distribution between healthy subjects and MSA patients.</p><p><strong>Methods: </strong>Single-photon emission computed tomography (SPECT) and T1-weighted magnetic resonance (MR) images were aligned. The MR (T1) images were used to set a reference site for the occipital-lobe SBR in each subject, and measurements were made from the SPECT image at the same position. The pixel values and accumulation ratios compared with the occipital lobe were calculated, and a regional SBR distribution image was created. We identified areas with SERT accumulation above a certain level.</p><p><strong>Results: </strong>The SERT accumulation site was visualised as an SBR value on MR images. The accumulation distribution (SERT distribution) on the SBR images significantly differed between the healthy subjects and patients with MSA.</p><p><strong>Conclusion: </strong>SERT accumulation was noted in the brain-stem region, indicating that SBR imaging was useful for viewing and quantifying SERT accumulation.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"13 1","pages":"33-41"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11682478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ventilation/Perfusion Mismatch in Pulmonary Vein Stenosis Secondary to Atrial Fibrillation Ablation.","authors":"Leah Anne Christine L Bollos, Ryosuke Kasai, Hideki Otsuka, Yoichi Otomi, Tomomi Matsuura, Tamaki Otani, Koji Yamaguchi, Takanori Bando, Yuya Ueki, Noritake Matsuda, Satoru Takashi, Shota Azane, Yamato Kunikane, Shoichiro Takao, Shusuke Yagi, Masataka Sata, Hitoshi Ikushima, Masafumi Harada","doi":"10.22038/aojnmb.2024.79650.1561","DOIUrl":"10.22038/aojnmb.2024.79650.1561","url":null,"abstract":"<p><p>We present two patients with a history of paroxysmal atrial fibrillation who developed pulmonary vein stenosis (PVS) following atrial fibrillation (AF) ablation. Case 1 involved a female patient in her 50s who was asymptomatic for pulmonary symptoms but was found to have a high degree of left superior PVS 15 months after AF ablation. This was demonstrated using contrast-enhanced computed tomography (CE-CT) and supported by findings of perfusion defects on ventilation-perfusion (V/Q) scan. Case 2 was a male patient in his 60s who developed progressive left superior PVS nine months after AF ablation, evidenced by serial CE-CT and V/Q scans. PVS is a rare but well-known complication of pulmonary vein ablation for the treatment of AF that can lead to severe complications if left untreated. V/Q scans effectively assess the functional significance of PVS by detecting abnormal blood flow segments. Although a V/Q mismatch characterized by reduced perfusion defects is more commonly used in evaluating pulmonary embolism, PVS should not be disregarded as a differential diagnosis. Few studies emphasize the utility of V/Q scans in managing PVS and highlight V/Q mismatch as a notable finding. This case report aimed to highlight their significance.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"13 1","pages":"62-69"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11682475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of shortened scan acquisition time with IQ-SPECT technology using SMARTZOOM(TM) collimator in myocardial perfusion imaging.","authors":"Saranya Thiruvengadam, Dinesh Kumar Gauthaman, Nikita Sampathirao, Indirani Elangovan, Shelley Simon","doi":"10.22038/aojnmb.2025.78149.1551","DOIUrl":"https://doi.org/10.22038/aojnmb.2025.78149.1551","url":null,"abstract":"<p><strong>Objectives: </strong>IQ-SPECT technology uses cardiac-specific SMARTZOOM(TM) collimator that can reduce the time required to acquire myocardial perfusion images to half (14 seconds/view) of a standard SPECT procedure. This study aimed to further shorten the scan acquisition time (7 seconds/view) using the SMARTZOOM(TM) collimator without compromising the image quality.</p><p><strong>Methods: </strong>This prospective observational study involved 50 patients (39 men and 11 women) who underwent myocardial perfusion studies using the SMARTZOOM(TM) collimator. The scans were acquired in 7 seconds/view (Group A) and 14 seconds/view (Group B). Attenuation-corrected (AC), non-attenuation-corrected (NAC), and polar maps were generated for both groups using the QGS/QPS software. The groups were qualitatively and quantitatively compared in terms of image quality, relative uptake score, summed scores, total perfusion deficit, and left ventricular ejection fraction (LVEF).</p><p><strong>Results: </strong>The image quality of both groups was comparable in the AC studies, whereas Group B was superior to Group A in the NAC studies. All images exhibited an image quality score of ≥3, which suggested adequate image quality. The mean LVEF values were 62.16 and 64.34 in Groups A and B, respectively (p-value 0.326). A strong positive correlation was observed between the two datasets (Pearson's r=0.59). The mean summed score in the AC images was 7.5 in both groups (p-value 0.49), and in the NAC images, the scores were 7.68 in Group A and 7.46 in Group B (p-value 0.46). The mean total perfusion deficits calculated using the 17-segment models were 11% and 16% in Group A and Group B, respectively, for the AC images (p-value 0.143) and 11.2% and 16.5% in Group A and Group B, respectively, for the NAC images (p-value 0.135). Significant differences were not noted in the calculation of the relative uptake score in segments 1- 17 for the AC and NAC images in Groups A and B.</p><p><strong>Conclusion: </strong>The findings from this study indicate that further shortening of the scan acquisition time to 7 seconds/view is possible in myocardial perfusion imaging using the SMARTZOOM(TM) collimator without compromising the scan quality and the results, thus improving patient comfort.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"13 2","pages":"138-145"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}