Asia Oceania Journal of Nuclear Medicine and Biology最新文献

{"title":"A Pilot Study of FDG-PET/CT in Polycythemia Vera Using Global Analysis Techniques.","authors":"Cyrus Ayubcha,&nbsp;Hitomi Hosoya,&nbsp;Siavash Mehdizadeh Seraj,&nbsp;Mahdi Zirakchian Zadeh,&nbsp;Thomas Werner M S E,&nbsp;Abass Alavi","doi":"10.22038/aojnmb.2019.41192.1278","DOIUrl":"https://doi.org/10.22038/aojnmb.2019.41192.1278","url":null,"abstract":"<p><strong>Objectives: </strong>Functional imaging presents a non-invasive process that may capture the hyper-metabolic nature of red bone marrow in myeloproliferative neoplasms, such as polycythemia vera (PV).</p><p><strong>Methods: </strong>This study analyzed the FDG-PET/CT scans (n=12) of six patients diagnosed with PV and six age-sex matched controls using a quantitative global analysis methodology.</p><p><strong>Results: </strong>All PV patients had elevated activities in the bone marrow of each skeletal structure as compared to matched controls with respect to mean standardized uptake value (femoral neck p=0.01, lumbar spine p=0.02, pelvis p=0.002, sternum p=0.04). Notable variations in splenic uptake were observed among the treated and untreated PV patients.</p><p><strong>Conclusion: </strong>Our study exemplifies the potential utility of PET in reflecting hyperactive bone marrow activity related to PV. Future studies may further substantiate and elaborate on the use of PET-derived metabolic data in PV.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"8 1","pages":"64-68"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37649180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inguino-scrotal bladder hernia: an unexpected finding on ⁶⁸Ga-PSMA-11 PET/CT.","authors":"Shirin Shahlaei,&nbsp;Sara Shakeri,&nbsp;Fatemeh Farahmandfar,&nbsp;Farshad Emami,&nbsp;Ramin Sadeghi","doi":"10.22038/AOJNMB.2020.45247.1305","DOIUrl":"https://doi.org/10.22038/AOJNMB.2020.45247.1305","url":null,"abstract":"<p><p>Bladder herniation is an uncommon condition mimicking suspicious metastasis on PET/CT imaging. We report a 67 y/o man with prostate cancer referred for recurrence evaluation with ⁶⁸Ga-PSMA-11 PET/CT. The scan showed an asymmetric site of intense tracer accumulation in the left inguino-scrotal region with the same SUV_max to the pelvic bladder. Reviewing cross sectional CT images with PET confirmed the inguino-scrotal bladder herniation.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"8 2","pages":"141-144"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354241/pdf/AOJNMB-8-141.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38195309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pericardial sarcoidosis presenting as PUO diagnosed on FDG PET CT scan.","authors":"Solav Shrikant Vasantrao,&nbsp;Patil Abhijit Mahaveer,&nbsp;Savale Shailendra Vasant,&nbsp;Salunke Deepak Vishnu","doi":"10.22038/aojnmb.2019.38132.1255","DOIUrl":"https://doi.org/10.22038/aojnmb.2019.38132.1255","url":null,"abstract":"<p><p>Pyrexia of unknown origin (PUO) is a common problem in day-to-day practice. FDG PET CT is an established investigation that aids in identifying the cause of PUO. Due to its high sensitivity PET detects an occult hypermetabolic focus in the body where CT helps in anatomical localization, vascularity, enhancement characteristics of the lesion detected on PET. It helps to differentiate benign versus malignant cause and target biopsy. Tuberculosis, lymphoma, pyelonephritis, thyroiditis appear hypermetabolic on FDG PET CT. Pericardial sarcoidosis is rare and not reported in literature as a cause of PUO. Presented here is a case of PUO secondary to pericardial granulomatosis diagnosed on PET CT. Cardiac MRI also helps in better tissue characterization and associated myocardial involvement of sarcoidosis. Histology confirmed the diagnosis of pericardial sarcoidosis in this case.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"8 1","pages":"74-78"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37648103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"⁶⁸Ga-DOTATATE PET/CT Compared with ¹³¹I-MIBG SPECT/CT in the Evaluation of Neural Crest Tumors.","authors":"Pezhman Shahrokhi,&nbsp;Alireza Emami-Ardekani,&nbsp;Sara Harsini,&nbsp;Mohammad Eftekhari,&nbsp;Armaghan Fard-Esfahani,&nbsp;Babak Fallahi,&nbsp;Najme Karamzade Ziarati,&nbsp;Mehdi Akhlaghi,&nbsp;Saeed Farzanefar,&nbsp;Amir Pejman Hashemi Taheri,&nbsp;Davood Beiki","doi":"10.22038/aojnmb.2019.41343.1280","DOIUrl":"https://doi.org/10.22038/aojnmb.2019.41343.1280","url":null,"abstract":"<p><strong>Objectives: </strong>⁶⁸Ga-DOTATATE positron emission tomography (PET)/computed tomography (CT) has shown promising results in imaging of neural crest tumors (NCT). Herein, we compared the performance of ⁶⁸Ga-DOTATATE PET/CT and ¹³¹I-MIBG single photon emission computed tomography (SPECT)/CT in the initial diagnosis, staging and follow-up of patients with NCTs.</p><p><strong>Methods: </strong>Twenty-five patients (males:females=8:17; age range=2-71 years) with clinically proven or suspicious neuroblastoma, pheochromocytoma (PCC) or paraganglioma (PGL) were enrolled in this prospective study and underwent both ⁶⁸Ga-DOTATATE PET/CT and ¹³¹I-MIBG SPECT/CT. A composite reference standard derived from histopathological information, together with anatomical and functional imaging findings, was used to validate the results. Imaging findings were assessed on a per-patient and on a per-lesion basis. Sensitivity and accuracy were assessed using McNemar's test.</p><p><strong>Results: </strong>Referring to radiological imaging and histopathological findings as reference standard, ⁶⁸Ga-DOTATATE and ¹³¹I-MIBG scans showed a sensitivity and accuracy of (100%, 96%) and (86.7%, 88%), respectively, on a per-patient basis. In PCC/PGL patients, on a per-patient basis, the sensitivity of ⁶⁸Ga-DOTATATE was 100% and that of ¹³¹I-MIBG was 77.8%. In neuroblastoma patients, on a per-patient basis, the sensitivities of both ⁶⁸Ga-DOTATATE and ¹³¹I-MIBG were 100%. Overall, in this patient cohort, ⁶⁸Ga-DOTATATE PET/CT identified 52 lesions and ¹³¹I-MIBG SPECT/CT identified only 30 lesions. On a per-lesion analysis, ⁶⁸Ga-DOTATATE was found to be superior to ¹³¹I-MIBG in detecting lesions in all anatomical locations, particularly osseous lesions. According to the McNemar test results, differences were not statistically significant.</p><p><strong>Conclusion: </strong>This relatively small patient cohort suggests ⁶⁸Ga-DOTATATE PET/CT be superior to ¹³¹I-MIBG SPECT/CT in providing particularly valuable information for both primary staging and follow-up in patients with NCT.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"8 1","pages":"8-17"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37649682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peritoneal Super Scan on ¹⁸F-FDG PET/CT in two patients with Lymphoma.","authors":"Yassir Benameur,&nbsp;Sanâa Touil,&nbsp;Omar Ait Sahel,&nbsp;Salah Nabih Oueriagli,&nbsp;Abdelhamid Biyi,&nbsp;Abderrahim Doudouh","doi":"10.22038/AOJNMB.2020.44276.1296","DOIUrl":"https://doi.org/10.22038/AOJNMB.2020.44276.1296","url":null,"abstract":"<p><p>  Peritoneal lymphomatosis is an extremely rare presentation of lymphoma. Due to its relative low frequency, it receives much less attention than peritoneal carcinomatosis. The challenge is to differentiate between lymphomatosis and carcinomatosis, as well as peritoneal tuberculosis or other pathologic entities within the peritoneal cavity based essentially on radiologic features. ¹⁸F-FDG PET/CT is the main imaging modality for staging and monitoring response to treatment in lymphoma. Peritoneal lymphomatosis is most often associated to aggressive histological subtypes of high-grade lymphoma which are reputed high FDG uptake. We report two cases of Burkitt's lymphoma and diffuse large B cell lymphoma (DLBCL), with intense FDG uptake involving the entire peritoneum and decreased FDG activity of the rest of the body including brain and kidneys, giving it an appearance of \"peritoneal super scan\", follow up FDG PET/CT showed the disappearance of the peritoneal lymphomatosis and the reappearance of cerebral and urinary activity synonym of complete metabolic response.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"8 2","pages":"149-152"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354243/pdf/AOJNMB-8-149.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38195264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No needle to fear: An approach to needle phobic patients.","authors":"Lauren Hudswell,&nbsp;Joanne Pinson,&nbsp;Shakher Ramdave,&nbsp;Jason Bradley","doi":"10.22038/AOJNMB.2020.45184.1304","DOIUrl":"https://doi.org/10.22038/AOJNMB.2020.45184.1304","url":null,"abstract":"<p><p>¹⁸F-FDG is the most commonly used radioisotope in PET scanning and is administered intravenously. When patients cannot cannulated, there are limited options available for functional tumour assessment. A fifty year old male presented for investigation of a suspected lung carcinoma identified during investigation of pneumonia. The patient had a severe needle phobia, intellectual disabilities and multiple co-morbidities which made cannulation impossible. An alternative administration method was sought, with successful oral administration occurring in both staging and restaging scans. The scans demonstrated resolution of a suspected lung cancer indicating it was an inflammatory/infective process, preventing the need for more invasive investigative approaches. A non-invasive and positive experience allowed for accurate diagnosis and repeat imaging for this patient, enabling follow up imaging to occur. It is reported that oral administration of ¹⁸F-FDG may be useful for assessment of suspected cancers for patients where cannulation isn't possible, when limitations are taken into consideration.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"8 2","pages":"160-163"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354238/pdf/AOJNMB-8-160.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38195267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sectional Anatomy Quiz - V.","authors":"Rashid Hashmi","doi":"10.22038/aojnmb.2019.44526.1301","DOIUrl":"https://doi.org/10.22038/aojnmb.2019.44526.1301","url":null,"abstract":"<p><p>  In this series a pictorial quiz pertaining to identification of normal anatomical structures and landmarks at a given level on the computed tomography (CT) is presented. An image depicting normal anatomy is followed by a series of images showing different pathologies. Readers are expected to identify and appreciate variation and changes in the normal anatomy in presence of a given pathology. The series is intended to enhance understanding of sectional anatomy thus aiding interpretation of the CT component of the single photon emission computed tomography (SPECT) and positron emission tomography (PET) studies.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"8 1","pages":"88-94"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37648106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial damage of the entire ventricular region in a patient with acute myocardial infarction.","authors":"Hirofumi Kawamata,&nbsp;Tatsuya Kawasaki,&nbsp;Hiroki Sugihara,&nbsp;Satoaki Matoba","doi":"10.22038/aojnmb.2019.42134.1289","DOIUrl":"https://doi.org/10.22038/aojnmb.2019.42134.1289","url":null,"abstract":"<p><p> Technetium-99m-pyrophosphate (^99mTc-PYP) has been used, in combination with thallium-201, to estimate the site and extent of myocardial infarcts. We report a case of acute myocardial infarction with severe coronary disease in which the distribution of ^99mTc-PYP was extensive. A 78-year-old man presented with dyspnea, and a diagnosis of non-ST-segment elevation acute myocardial infarction was made. Emergency coronary angiography revealed total occlusion of the proximal portion of the right coronary artery and left circumflex coronary artery with collateral flow from the left anterior descending coronary artery, which also had severe stenoses. Given his comorbidities and preferences, subsequent angioplasty was waived. Dual myocardial scintigraphic imaging, which was performed four days after admission, demonstrated slightly reduced thallium-201 uptake in the inferior wall and apex, whereas ^99mTc-PYP was positive in the entire left ventricular subendocardial region and the free wall of the right ventricle. His clinical course was uneventful with conservative treatment and the patient was discharged 20 days after admission in a stable condition.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"8 1","pages":"69-73"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37649181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"⁶⁸Ga-Prostate-Specific Membrane Antigen, A Potential Radiopharmaceutical in PET/CT To detect primary Cholangiocarcinoma.","authors":"Rita Chahinian,&nbsp;Ahmad El-Amine,&nbsp;Sayed Matar,&nbsp;Mostafa Annan,&nbsp;Ali Shamseddine,&nbsp;Mohamad Haidar","doi":"10.22038/AOJNMB.2020.46939.1314","DOIUrl":"https://doi.org/10.22038/AOJNMB.2020.46939.1314","url":null,"abstract":"<p><p>  ⁶⁸Ga Prostate-specific membrane antigen (PSMA) is an increasingly popular radiopharmaceutical tracer in prostate cancer and is becoming increasingly researched in other cancers such as breast cancer, renal cell carcinoma, glioblastoma multiforme, among others. Cholangiocarcinoma is the second most common primary hepatic malignant tumor; it is an aggressive tumor with a 5-year survival rate of less than 5 %. We herein report a case of primary cholangiocarcinoma detected on ⁶⁸Ga-PSMA PET-CT conducted as part of follow up for prostate cancer and confirmed by biopsy and immunohistochemistry.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"8 2","pages":"136-140"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354244/pdf/AOJNMB-8-136.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38195308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct comparison of ^99mTc-PSMA SPECT/CT and ⁶⁸Ga-PSMA PET/CT in patients with prostate cancer.","authors":"Batool Albalooshi,&nbsp;Mouza Al Sharhan,&nbsp;Fariborz Bagheri,&nbsp;Shabna Miyanath,&nbsp;Bhavna Ray,&nbsp;Muhammed Muhasin,&nbsp;Seyed Rasoul Zakavi","doi":"10.22038/aojnmb.2019.43943.1293","DOIUrl":"https://doi.org/10.22038/aojnmb.2019.43943.1293","url":null,"abstract":"<p><strong>Objectives: </strong>^99mTc-PSMA SPECT/CT is a cost effective alternative for ⁶⁸Ga-PSMA PET/CT. The aim of this study was to directly compare these two techniques in patients with prostate cancer.</p><p><strong>Methods: </strong>28 man with prostate cancer were studied using ^99mTc-PSMA SPECT/CT and ⁶⁸Ga-PSMA PET/CT in a short time period (<60 days). No intervention was done between the studies. Whole body PET/CT was done 60 minutes after IV injection of 2 MBq/Kg of ⁶⁸Ga-PSMA. ^99mTc-PSMA kit (PSMA I+S) was used for SPECT/CT and whole body imaging was performed 4 hours after IV injection of 740 MBq of ^99mTc-PSMA. Images were interpreted independently and the results of each imaging were recorded.</p><p><strong>Results: </strong>The mean age of the patients was 64.7±9.6 years old and the mean time difference between two sets of images was 16.6±13.5 days. Abnormal uptake was seen in 25 (89.2%) patients by ⁶⁸Ga-PSMA PET/CT and 20 (71.4%) patients with ^99mTc-PSMA SPECT/CT. No patients with positive ^99mTc-PSMA SPECT/CT had negative ⁶⁸Ga-PSMA PET/CT. The mean number of detected lesions was 26.07±27.5 by ⁶⁸Ga-PSMA PET/CT and 10.52±10.99 by ^99mTc-PSMA SPECT/CT (P<0.001). Detection of lymph nodes and bone metastases were not significantly different between two sets of imaging (P>0.05), however ⁶⁸Ga-PSMA PET/CT were more successful in detection of prostate bed lesions compared to ^99mTc-PSMA scan. Interestingly, no patient with PSA level of >2.1 ng/ml had discordant result between two sets of images.</p><p><strong>Conclusion: </strong>^99mTc-PSMA SPECT/CT is as accurate as ⁶⁸Ga-PSMA PET/CT in M staging, however ⁶⁸Ga-PSMA PET/CT detected more lesions compared to ^99mTc-PSMA SPECT/CT. Detection rate was not significantly different between two techniques in patients with PSA levels>2.1 ng/ml.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"8 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37649680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}