Asia Oceania Journal of Nuclear Medicine and Biology最新文献

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Bio-distribution study of Tc-99m HMPAO labeled platelet in healthy volunteer. 健康志愿者体内 Tc-99m HMPAO 标记血小板的生物分布研究。
Asia Oceania Journal of Nuclear Medicine and Biology Pub Date : 2024-01-01 DOI: 10.22038/AOJNMB.2024.71620.1525
Mahdieh Parvizi, Mehrshad Abbasi, Hojjat Ahmadzadehfar, Abbas Tafakhori, Maryam Naseri, Ali Khalaj, Saeed Farzanehfar
{"title":"Bio-distribution study of Tc-99m HMPAO labeled platelet in healthy volunteer.","authors":"Mahdieh Parvizi, Mehrshad Abbasi, Hojjat Ahmadzadehfar, Abbas Tafakhori, Maryam Naseri, Ali Khalaj, Saeed Farzanehfar","doi":"10.22038/AOJNMB.2024.71620.1525","DOIUrl":"https://doi.org/10.22038/AOJNMB.2024.71620.1525","url":null,"abstract":"<p><strong>Objectives: </strong>The bio-distribution of Tc-99m HMPAO labeled platelets (LP), which could be used to image subtle thrombosis, is not reported in a human yet, which is the subject of the current study.</p><p><strong>Method: </strong>The platelets were extracted from 49 ml whole blood and labeled with Tc-99m HMPAO, then re-injected to the healthy volunteer. Anterior and posterior whole body imaging was done by a dual-head gamma camera 3, 18, 33, 46, 81, 124, 190 min and 15 hours after injection. Also a whole-body SPECT was done at 137 min post-injection. The area under the curves of the spleen, liver, left kidney, bladder, right lung, brain, and abdominal aorta ROIs was calculated to estimate the accumulation of labeled platelets within the organs.</p><p><strong>Results: </strong>The spleen was the target organ. The kidneys, liver, and heart were also remarkably visualized. The thyroid, stomach, bladder, or gastrointestinal (GI) uptake/activity was not significant. The stomach visualization was enhanced after ingestion at 60 min. The sagittal and lateral sinuses were delineated, and the background of the brain was very low. During the study, the area under the curve of activity was 738, 308, 302, 196, 230, 121, 79, 216, 529, 369, 162, and 54 counts. min/pixel for spleen, liver, heart, right lung, left kidney, right iliac artery, sagittal sinus, thyroid, bladder, stomach, GI, and background, respectively.</p><p><strong>Conclusion: </strong>The quality of the scan with low dose Tc-99m HMPAO LPs is optimal. We documented the bio-distribution of LPs. The optimal imaging time was 80-120 min post-injection when the free Tc-99m and GI transit were negligible. The sagittal and lateral sinuses were visualized enabling detection of possible clots in the vessels.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"12 2","pages":"142-148"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11263780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141756872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidental Finding of Triple Ectopic Thyroid: Case Report and Review of the Literature. 偶然发现的三异位甲状腺:病例报告与文献综述
Asia Oceania Journal of Nuclear Medicine and Biology Pub Date : 2024-01-01 DOI: 10.22038/AOJNMB.2024.75895.1532
Fatima Zeineddine, Gerard El-Hajj, Marie-Ange Hajj, Rita Chahinian
{"title":"Incidental Finding of Triple Ectopic Thyroid: Case Report and Review of the Literature.","authors":"Fatima Zeineddine, Gerard El-Hajj, Marie-Ange Hajj, Rita Chahinian","doi":"10.22038/AOJNMB.2024.75895.1532","DOIUrl":"https://doi.org/10.22038/AOJNMB.2024.75895.1532","url":null,"abstract":"<p><p>Ectopic thyroid tissue is a rare congenital anomaly, with the presence of three simultaneous ectopic foci being exceedingly rare. We describe a case of a totally asymptomatic 26-year-old male discovered to have triple ectopic thyroid following incidental elevated thyroid-stimulating hormone (TSH) levels. Subsequent ultrasonography of the neck showed an absent thyroid gland in its conventional location. A Technetium-99m pertechnetate (Tc-99m) thyroid scan showed three distinct foci of radiotracer uptake in the upper cervical, lingual, and sublingual regions, corresponding to triple ectopic thyroid. An extensive review of the literature was conducted to provide a broader understanding and deeper insights into this uncommon condition. This case underscores the pivotal role of Technetium-99m thyroid scanning in diagnosing triple ectopic thyroid, particularly in instances where the orthotopic thyroid gland is absent. A comprehensive understanding of this rare entity is indispensable for radiologists and clinicians, enabling accurate diagnosis and informed decision-making regarding the appropriate therapeutic strategies.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"12 2","pages":"179-184"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11263775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141756876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
18F-FDG PET/CT imaging of IgG4-producing MALT lymphoma with multiple site involvement. 多部位受累的 IgG4 型 MALT 淋巴瘤的 18F-FDG PET/CT 成像。
Asia Oceania Journal of Nuclear Medicine and Biology Pub Date : 2024-01-01 DOI: 10.22038/AOJNMB.2023.73477.1512
Kodai Kawaji, Seiji Kurata, Katsuhisa Matsuo, Hiroaki Miyoshi, Jun Akiba, Fumihiko Mouri, Akiko Sumi, Kiminori Fujimoto, Toshi Abe
{"title":"<sup>18</sup>F-FDG PET/CT imaging of IgG4-producing MALT lymphoma with multiple site involvement.","authors":"Kodai Kawaji, Seiji Kurata, Katsuhisa Matsuo, Hiroaki Miyoshi, Jun Akiba, Fumihiko Mouri, Akiko Sumi, Kiminori Fujimoto, Toshi Abe","doi":"10.22038/AOJNMB.2023.73477.1512","DOIUrl":"10.22038/AOJNMB.2023.73477.1512","url":null,"abstract":"<p><p><sup>18</sup>F-FDG PET/CT is regarded as a modality utilized for the purpose of lesion localization, staging and assessment of treatment response in patients with lymphoma. However, it is difficult that we diagnose among multifocal lymphoma, IgG4-related disease (IgG4-RD), or a combination of both conditions when confronted with multiple sites of <sup>18</sup>F-FDG uptake with heightened serum IgG4 levels. We present a case of a 72-year-old male who was suspected of Sjögren's syndrome based on symptoms of xerostomia accompanied by swelling of the bilateral upper eyelid and salivary glands. Following a diagnostic biopsy that revealed mucosa-associated lymphoid tissue (MALT) lymphoma as a possible finding, <sup>18</sup>F-FDG PET/CT was conducted, which demonstrated multiple sites of <sup>18</sup>F-FDG accumulation. While multifocal MALT lymphoma was initially suspected, the coexistence of IgG4-RD could not be definitively ruled out due to the elevated serum IgG4 levels. Subsequent histopathological and immunohistochemical examinations confirmed the diagnosis of IgG4-producing MALT lymphoma. After receiving systemic therapy with rituximab, the swelling of the bilateral upper eyelid and parotid glands resolved upon visual examination, and the serum IgG4 levels returned to within the normal range in a few months. No new lesions were detected during the subsequent follow-up examinations conducted over a period of 3 years.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"12 1","pages":"52-56"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10757051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139073265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Formulating a national position statement and guide on modern theranostics in the Philippines. 制定菲律宾关于现代治疗学的国家立场声明和指南。
Asia Oceania Journal of Nuclear Medicine and Biology Pub Date : 2024-01-01 DOI: 10.22038/AOJNMB.2023.72838.1508
Patricia A Bautista-Peñalosa, Francis Gerard M Estrada, Emerita A Barrenechea, Teofilo O L San Luis
{"title":"Formulating a national position statement and guide on modern theranostics in the Philippines.","authors":"Patricia A Bautista-Peñalosa, Francis Gerard M Estrada, Emerita A Barrenechea, Teofilo O L San Luis","doi":"10.22038/AOJNMB.2023.72838.1508","DOIUrl":"10.22038/AOJNMB.2023.72838.1508","url":null,"abstract":"<p><p>Barriers to the establishment of advanced technologies in developing countries were overcome when modern theranostics pertaining to the use of Ga-68 and Lu-177 PSMA and DOTATATE were first offered to patients in the Philippines in early 2018. However, significant growth was not experienced at St. Luke's Medical Center for five years and lutetium was not yet distributed to other institutions by a radiopharmaceutical supplier. Due to the relative novelty and rapid expansion of theranostics worldwide, position statements were released by the Australasian Association of Nuclear Medicine Specialists, European Association of Nuclear Medicine, Society of Nuclear Medicine and Molecular Imaging, and International Atomic Energy Agency primarily to uphold patient safety and ensure a level of standard among its practitioners. Subsequently in the latter half of 2022, these were adopted and modified according to what is feasible and applicable locally within the Philippine Society of Nuclear Medicine, considering the current status and future possibilities. Different representatives were involved, and several groups were mobilized for successful implementation. A liability clause was incorporated to discourage unprofessional acts.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"12 1","pages":"69-72"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10757056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139073283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the diagnostic value of Sentinel Lymph Node in patients with gastric adenocarcinoma. 评估前哨淋巴结对胃腺癌患者的诊断价值。
Asia Oceania Journal of Nuclear Medicine and Biology Pub Date : 2024-01-01 DOI: 10.22038/AOJNMB.2023.70461.1491
Ramin Sadeghi, Reza Taheri, Ali Jangjoo, Akbar Pakdel, Mohammad-Hassan Arjmand, Mohammad Reza Motiei, Bahram Memar, Mohsen Aliakbarian
{"title":"Evaluation of the diagnostic value of Sentinel Lymph Node in patients with gastric adenocarcinoma.","authors":"Ramin Sadeghi, Reza Taheri, Ali Jangjoo, Akbar Pakdel, Mohammad-Hassan Arjmand, Mohammad Reza Motiei, Bahram Memar, Mohsen Aliakbarian","doi":"10.22038/AOJNMB.2023.70461.1491","DOIUrl":"10.22038/AOJNMB.2023.70461.1491","url":null,"abstract":"<p><strong>Objectives: </strong>Sentinel lymph node biopsy (SLNB) has been proven as a safe and efficient procedure in some cancers like breast cancer and melanoma with a reduction of complications and side effects of unnecessary lymphadenectomy in many patients. However, the diagnostic value of SLNB in gastric cancer is a point of debate. This study evaluated the diagnostic value of SLNB using radiotracer and isosulphan blue dye injection in patients with Gastric Adenocarcinomas (GA).</p><p><strong>Methods: </strong>This descriptive study was performed at Imam-Reza HOSPITAL on 39 patients diagnosed with GA with no lymphatic metastasis using two methods: the combination of radionuclide with isosulphan together (R&I) method compared with the isosulphan alone method. Lymphatic dissection was performed in all patients. The pathological results were compared between the sentinel lymph nodes (SLN) and other lymph nodes and their accordance rate was calculated.</p><p><strong>Results: </strong>In the T1 group, the sentinel lymph node biopsy detection rate was 100% for the combination of the R&I method and 60% for the isosulphan method and the false negative rate was zero. These values respectively were 88.8% and 88.8% in the T2 group with a false negative rate of 75%. In the T3 group, the values were 100% for the combination of the R&I method and 93.7% for the isosulphan method with a false negative rate of 40%. In the combination of the R&I method, the sensitivity, specificity, and positive and negative predictive values were 57.9, 100, 100, and 69.2 percent respectively.</p><p><strong>Conclusion: </strong>Based on the false negative rate (47.4%), SLNB by injection of isosulphan blue dye alone is not a diagnostic enough value for predicting lymph node metastasis in GA. Although, SLNB by combination of the R&I had better accuracy compared to the isosulphan alone, more studies with larger samples are needed to prove this result.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"12 1","pages":"21-26"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10757058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139073282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On the Optimization of the Protocol for Automated Radiosyntheses of [68Ga]Ga-Pentixafor, [68Ga]Ga-FAPI-4 and [68Ga]Ga-DOTATATE in a Modular-Lab Standard. 在模块化实验室标准中优化[68Ga]Ga-Pentixafor、[68Ga]Ga-FAPI-4 和 [68Ga]Ga-DOTATATE 的自动放射合成程序。
Asia Oceania Journal of Nuclear Medicine and Biology Pub Date : 2024-01-01 DOI: 10.22038/AOJNMB.2024.77059.1545
Sreeja Raj Menon, Arpit Mitra, Sudeep Sahu, Sangita Lad, Avik Chakraborty, Mukti Kanta Ray, Sharmila Banerjee
{"title":"On the Optimization of the Protocol for Automated Radiosyntheses of [<sup>68</sup>Ga]Ga-Pentixafor, [<sup>68</sup>Ga]Ga-FAPI-4 and [<sup>68</sup>Ga]Ga-DOTATATE in a Modular-Lab Standard.","authors":"Sreeja Raj Menon, Arpit Mitra, Sudeep Sahu, Sangita Lad, Avik Chakraborty, Mukti Kanta Ray, Sharmila Banerjee","doi":"10.22038/AOJNMB.2024.77059.1545","DOIUrl":"https://doi.org/10.22038/AOJNMB.2024.77059.1545","url":null,"abstract":"<p><strong>Objectives: </strong>The present work describes the automated radiochemical synthesis of different PET tracers like [<sup>68</sup>Ga]Ga-Pentixafor, [<sup>68</sup>Ga]Ga-FAPI-4 and [<sup>68</sup>Ga]Ga-DOTATATE using optimized single protocol in the non-cassette based Eckert & Ziegler (EZ) Modular Lab (fixed tubing system) without any modification in the inbuilt human machine interface (HMI) software. Recently, PET agents viz. [<sup>68</sup>Ga]Ga-Pentixafor and [<sup>68</sup>Ga]Ga-FAPI-4 are gaining prominence for the diagnosis of overexpressed Chemokine Receptor-4 (CXCR4) and Fibroblast Activation Protein (FAP) receptor, respectively, in the microenvironment of numerous cancer types. The promising results observed with the clinical usage of [<sup>68</sup>Ga]Ga-DOTATATE produced using the automated protocol, provided impetus for the clinical translation of [<sup>68</sup>Ga]Ga-Pentixafor and [<sup>68</sup>Ga]Ga-FAPI-4 using the in-house developed automated radiolabeling protocol.</p><p><strong>Methods: </strong>Herein we report a single radiolabeling protocol for the automated preparation of [<sup>68</sup>Ga]Ga-Pentixafor and [<sup>68</sup>Ga]Ga-FAPI-4 in the non-cassette based EZ Modular-Lab Standard radiochemistry module, without any changes in schematic, graphical user interface (GUI) software and time list, from that used for routine production of [<sup>68</sup>Ga]Ga-DOTATATE in our centre, since 2015. Physico-chemical quality control and in-vitro stability analyses were carried out using radio-TLC and radio-HPLC.</p><p><strong>Results: </strong>The automated protocol yielded reliable and consistent non-decay corrected (ndc) radiochemical yield (RCY) of (84.4%±0.9%) and (85.5%±1.4%) respectively, for [<sup>68</sup>Ga]Ga-Pentixafor and [<sup>68</sup>Ga]Ga-FAPI-4, with RCP>98%, which are comparable to the RCY of (84.4%±1.2%) and RCP (99.1%±0.3%) for [<sup>68</sup>Ga]Ga-DOTATATE. The biological quality control studies confirmed the formulations to be of ready-to-use pharmaceutical grade.</p><p><strong>Conclusion: </strong>The consistent and reliable RCY and RCP of multiple <sup>68</sup>Ga-labeled PET tracers by single automated radiochemistry protocol exhibits the versatility of the EZ Modular Lab.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"12 2","pages":"149-160"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11263773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141756877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
18F-FDG PET CT in cardiac device infections - A Case series. 18F-FDG PET CT 在心脏设备感染中的应用--病例系列。
Asia Oceania Journal of Nuclear Medicine and Biology Pub Date : 2024-01-01 DOI: 10.22038/AOJNMB.2024.77504.1547
Awiral Saxena, Manjit Sarma, Bhagirath Bhad, Ramkesh Ratheesan, Padma Subramanyam, P Shanmuga Sundaram
{"title":"<sup>18</sup>F-FDG PET CT in cardiac device infections - A Case series.","authors":"Awiral Saxena, Manjit Sarma, Bhagirath Bhad, Ramkesh Ratheesan, Padma Subramanyam, P Shanmuga Sundaram","doi":"10.22038/AOJNMB.2024.77504.1547","DOIUrl":"https://doi.org/10.22038/AOJNMB.2024.77504.1547","url":null,"abstract":"<p><p>With the increasing number of interventional cardiology procedures, the number of cardiac device infections (including pacemakers, prosthetic valves, coronary and aortic stents) have also increased. These infections can cause significant morbidity and can even lead to mortality if not managed promptly. If suspected clinically the first-line imaging modality is Trans-Thoracic Echocardiography, while Transesophageal Echocardiography is also used in selected cases. The confirmation of a cardiac device infection is mostly done with the help of blood or pus culture. Even though Echocardiography is a very efficient technique for the evaluation of the heart, it cannot differentiate infection from thrombus or fibrosis. With the increasing availability of Positron Emission Tomography CT (PET CT) machines worldwide, the use of <sup>18</sup>F-FDG PET CT for infection imaging has gained traction, especially for cardiac device infection. Most of the recent studies show a good diagnostic accuracy of <sup>18</sup>F-FDG PET CT with many of the recent diagnostic and management guidelines now acknowledging its role, especially in equivocal cases. We present six such cases where <sup>18</sup>F-FDG PET CT provided valuable information either for diagnosis, confirming the presence of infection, delineating extent, therapy response or sometimes even helping appropriate treatment decision making in patients with suspected cardiac device infection.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"12 2","pages":"161-169"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11263774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141756870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of an automated region-of-interest-setting method based on a deep neural network for brain perfusion single photon emission computed tomography quantification methods. 为脑灌注单光子发射计算机断层扫描量化方法开发基于深度神经网络的兴趣区自动设定方法。
Asia Oceania Journal of Nuclear Medicine and Biology Pub Date : 2024-01-01 DOI: 10.22038/AOJNMB.2024.75375.1528
Taeko Tomimatsu, Kosuke Yamashita, Takumi Sakata, Ryosuke Kamezaki, Ryuji Ikeda, Shinya Shiraishi, Yoshikazu Uchiyama, Shigeki Ito
{"title":"Development of an automated region-of-interest-setting method based on a deep neural network for brain perfusion single photon emission computed tomography quantification methods.","authors":"Taeko Tomimatsu, Kosuke Yamashita, Takumi Sakata, Ryosuke Kamezaki, Ryuji Ikeda, Shinya Shiraishi, Yoshikazu Uchiyama, Shigeki Ito","doi":"10.22038/AOJNMB.2024.75375.1528","DOIUrl":"https://doi.org/10.22038/AOJNMB.2024.75375.1528","url":null,"abstract":"<p><strong>Objectives: </strong>A simple noninvasive microsphere (SIMS) method using <sup>123</sup>I-IMP and an improved brain uptake ratio (IBUR) method using <sup>99m</sup>Tc-ECD for the quantitative measurement of regional cerebral blood flow have been recently reported. The input functions of these methods were determined using the administered dose, which was obtained by analyzing the time activity curve of the pulmonary artery (PA) for SIMS and the ascending aorta (AAo) for the IBUR methods for dynamic chest images. If the PA and AAo regions of interest (ROIs) can be determined using deep convolutional neural networks (DCNN) for segmentation, the accuracy of these ROI-setting methods can be improved through simple analytical operations to ensure repeatability and reproducibility. The purpose of this study was to develop new PA and AAo-ROI setting methods using a DCNN (DCNN-ROI method).</p><p><strong>Methods: </strong>A U-Net architecture based on convolutional neural networks was used to determine the PA and AAo candidate regions. Images of 290 patients who underwent <sup>123</sup>I-IMP RI-angiography and 108 patients who underwent <sup>99m</sup>Tc-ECD RI-angiography were used. The PA and AAo-ROI results for the DCNN-ROI method were compared to those obtained using manual methods. The counts for the input function on the PA and AAo-ROI were determined by integrating the area under the curve (AUC) counts of the time-activity curve of PA and AAo-ROI, respectively. The effectiveness of the DCNN-ROI method was elucidated through a comparison with the integrated AUC counts of the DCNN-ROI and the manual ROI.</p><p><strong>Results: </strong>The coincidence ratio for the locations of the PA and AAo-ROI obtained using the DCNN method and that for the manual method was 100%. Strong correlations were observed between the AUC counts using the DCNN and manual methods.</p><p><strong>Conclusion: </strong>New ROI- setting programs were developed using a deep convolution neural network DCNN to determine the input functions for the SIMS and IBUR methods. The accuracy of these methods is comparable to that of the manual method.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"12 2","pages":"120-130"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11263778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141756873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Graves' disease post-COVID-19 m-RNA vaccine in pediatric age group. 儿科年龄组接种COVID-19 m-RNA疫苗后出现的巴塞杜氏病。
Asia Oceania Journal of Nuclear Medicine and Biology Pub Date : 2024-01-01 DOI: 10.22038/AOJNMB.2023.73051.1510
Abhaa Sulaiyam Al-Jahhafi, Asma Ali Al-Sawaai, Zamzam Khalifa Al-Bimani, Naima Khamis Al-Bulushi
{"title":"Graves' disease post-COVID-19 m-RNA vaccine in pediatric age group.","authors":"Abhaa Sulaiyam Al-Jahhafi, Asma Ali Al-Sawaai, Zamzam Khalifa Al-Bimani, Naima Khamis Al-Bulushi","doi":"10.22038/AOJNMB.2023.73051.1510","DOIUrl":"10.22038/AOJNMB.2023.73051.1510","url":null,"abstract":"<p><p>The surge of the COVID-19 pandemic (December / 2019 - May/2023) and its catastrophic effect worldwide have necessitated emergent intervention to reduce its influence on people's health and life. To eliminate and reduce the impact of COVID-19 infection, COVID-19 vaccination was emergently authorized in December 2020 which has established good safety and efficacy. Having said that, some adverse effects merged in a few individuals. We are reporting an adolescent patient a 17-year-old female who has been diagnosed with Graves' disease after post-COVID-19 vaccinations. In addition, she was a confirmed case of COVID-19 infection three months earlier. The patient presented with typical features of hyperthyroidism 30 days post receiving the first dose of the vaccination. Based on the patient's presentation relative to the administration of the vaccine and prior infection of the virus. We proposed the synergistic effect of both factors to induce Graves' disease in this young healthy female with no family history of autoimmune disease. We are reporting this case for pediatric endocrinologists to be aware of the interaction and possible impact of the COVID-19 vaccine on thyroid function.</p>","PeriodicalId":8503,"journal":{"name":"Asia Oceania Journal of Nuclear Medicine and Biology","volume":"12 1","pages":"65-68"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10757064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139073284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tubarial salivary glands on PSMA ligands based PET imaging and post 177Lu PSMA therapy scan: reiterating its importance. 基于 PSMA 配体的 PET 成像和 177Lu PSMA 治疗后扫描中的管状唾液腺:重申其重要性。
Asia Oceania Journal of Nuclear Medicine and Biology Pub Date : 2024-01-01 DOI: 10.22038/AOJNMB.2023.72138.1505
Srinivas Ananth Kumar, Anjali Meena, Ashwani Sood, Rajender Kumar, Bhagwant Rai Mittal
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