Asian Biomedicine最新文献_第2页

Mesenchymal stem cells therapy for chronic ischemic stroke-a systematic review. 间充质干细胞治疗慢性缺血性中风--系统综述。

IF 0.4 4区医学

Asian Biomedicine Pub Date : 2024-10-31 eCollection Date: 2024-10-01 DOI: 10.2478/abm-2024-0027

Mohammad Kurniawan, Yetty Ramli, Nadira Deanda Putri, Salim Harris, Al Rasyid, Taufik Mesiano, Rakhmad Hidayat

{"title":"Mesenchymal stem cells therapy for chronic ischemic stroke-a systematic review.","authors":"Mohammad Kurniawan, Yetty Ramli, Nadira Deanda Putri, Salim Harris, Al Rasyid, Taufik Mesiano, Rakhmad Hidayat","doi":"10.2478/abm-2024-0027","DOIUrl":"10.2478/abm-2024-0027","url":null,"abstract":"Stroke represents a significant global health issue, primarily in the form of ischemic stroke. Despite the availability of therapeutic interventions, the recovery from chronic stroke, occurring 3 months post-initial stroke, poses substantial challenges. A promising avenue for post-acute stroke patients is mesenchymal stem cells (MSCs) therapy, which is derived from various sources and is globally recognized as the most utilized and extensively studied stem cell therapy. This systematic review, adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, aims to synthesize evidence regarding the impact of MSCs therapy on patients with chronic ischemic stroke. Employing an advanced search strategy across databases such as PubMed, PubMed Central, Google Scholar, the Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrial.gov, a total of 70 studies were identified, with 4studies meeting the inclusion criteria. Although positive outcomes were observed in terms of efficacy and safety, certain limitations, such as small sample sizes, study heterogeneity, and the absence of placebo groups, undermine the overall strength of the evidence. It is crucial to address these limitations in future research, highlighting the importance of larger sample sizes, standardized methodologies, and comparative trials to improve the assessment of MSCs' efficacy and safety. Moving forward, key priorities include exploring underlying mechanisms, determining optimal administration modes and dosages, and conducting comparative trials. By addressing these aspects, we can propel MSCs therapies toward greater efficacy, safety, and applicability across diverse patient populations.","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"18 5","pages":"194-203"},"PeriodicalIF":0.4,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors of cholangiocarcinoma: more than control of liver fluke. 胆管癌的风险因素：不仅仅是控制肝吸虫。

IF 0.4 4区医学

Asian Biomedicine Pub Date : 2024-10-31 eCollection Date: 2024-10-01 DOI: 10.2478/abm-2024-0026

引用次数: 0

TPH1 inhibits bladder tumorigenesis by targeting HIF-1α pathway in bladder cancer. TPH1 通过靶向膀胱癌中的 HIF-1α 通路抑制膀胱肿瘤发生。

IF 0.4 4区医学

Asian Biomedicine Pub Date : 2024-09-20 eCollection Date: 2024-08-01 DOI: 10.2478/abm-2024-0023

Jianwei Ren, Zhiting Mo, Xia Deng, Minghui Ren, Hailong Ren, Jie Jin, Huihui Zhang

{"title":"TPH1 inhibits bladder tumorigenesis by targeting HIF-1α pathway in bladder cancer.","authors":"Jianwei Ren, Zhiting Mo, Xia Deng, Minghui Ren, Hailong Ren, Jie Jin, Huihui Zhang","doi":"10.2478/abm-2024-0023","DOIUrl":"10.2478/abm-2024-0023","url":null,"abstract":"Background: BCa is the most common cancer of the urinary system. TPH1 has been reported to be associated with distinct tumorigenesis. However, the role of TPH1 in BCa remains to be clarified.Objectives: Our aim is to demonstrate the molecular mechanism of TPH1 in BCa carcinogenesis and development.Methods: In research, we explored the effect of TPH1 on T24 cells. Colony formation, soft agar, and cell proliferation assays were used to determine the survival and proliferative capacity of cells. Moreover, TPH1-/- cell lines were analyzed using CRISP-CAS9, and the recovery experiment was conducted. Realtime fluorescence quantitative PCR (qPCR) and Western blot were used to detect HIF-1α mRNA levels and TPH1 protein.Results: The TPH1 expression is lower in tumor tissues than in normal tissues. Colony formation, soft agar, and cell proliferation assays revealed that the overexpression of TPH1 declined cells survival. Moreover, the deficiency of TPH1 increased the number of clones. These results suggested that survival rate of TPH1 overexpression was repressed in cells. In addition, we found that HIF-1α activity was significantly downregulated with an increase in TPH1. The transcriptional activity of survivin was increased with TPH1-/- cells. Then, the proliferative ability of TPH1-/- cells was almost similar to the wild type levels with the treatment of LW6, TPH1 might play a major role to repress HIF-1α activity.Conclusions: Taken together, these results suggested that increasing TPH1 activity could inhibit survival and proliferation of cells via HIF-1α pathway. TPH1 may be a potential target for human BCa therapy.","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"18 4","pages":"171-179"},"PeriodicalIF":0.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11414775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the relationship between ACE2 G8790A and AT2R A1675G gene polymorphisms in COVID-19 patients with and without lung involvement. 评估有肺部受累和无肺部受累的 COVID-19 患者中 ACE2 G8790A 和 AT2R A1675G 基因多态性之间的关系。

IF 0.4 4区医学

Asian Biomedicine Pub Date : 2024-09-20 eCollection Date: 2024-08-01 DOI: 10.2478/abm-2024-0022

Raziye Akcilar, Fatma Emel Kocak, Fatih Kar, Ozben Ozden Isiklar, Sahinde Atlanoglu, Ozlem Genc, Fatima Yaman

{"title":"Evaluation of the relationship between ACE2 G8790A and AT2R A1675G gene polymorphisms in COVID-19 patients with and without lung involvement.","authors":"Raziye Akcilar, Fatma Emel Kocak, Fatih Kar, Ozben Ozden Isiklar, Sahinde Atlanoglu, Ozlem Genc, Fatima Yaman","doi":"10.2478/abm-2024-0022","DOIUrl":"10.2478/abm-2024-0022","url":null,"abstract":"Background: The SARS-CoV-2 virus produces severe acute respiratory syndrome. The severity of coronavirus disease 2019 (COVID-19) infection is determined by a number of factors, including inherited ones.Objectives: Our goal is to investigate the link between ACE2 G8790A (rs2285666) and AT2R A1675G (rs14035430) gene polymorphisms in COVID-19 patients with and without lung involvement.Methods: A total of 160 COVID-19 patients were divided into 2 groups based on their clinical symptoms: those without lung involvement (control group) and those with lung involvement (infected group). The ACE2 G8790A and AT2R A1675G gene polymorphisms were analyzed using the PCR-RFLP methods.Results: The GG genotype, G allele of ACE2 G8790A, and GG genotype of AT2R A1675G were significantly higher in the control group and had a protective effect against COVID-19 as well as decreased the development of lung involvement (OR = 0.29, 95% CI = 0.10-0.84; OR = 0.40, 95% CI = 0.22-0.72; and OR = 0.33, 95% CI = 0.14-0.78, respectively). Moreover, we found that the AA genotype, A allele of ACE2 G8790A, and AG genotype of AT2R A1675G increased the risk of COVID-19 in the infected group (OR = 3.50, 95% CI = 1.18-10.3; OR = 2.49, 95% CI = 1.39-4.48; and OR = 3.08, 95% CI = 1.28-7.38, respectively).Conclusions: These results revealed that a greater frequency of COVID-19 lung involvement in the Turkish population was connected with the AA genotype, the A allele of ACE2 G8790A, and the AG genotype of AT2R A1675G.","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"18 4","pages":"157-170"},"PeriodicalIF":0.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11414776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Whole exome sequencing in relapsed or refractory childhood cancer: case series. 复发或难治性儿童癌症的全外显子组测序：病例系列。

IF 0.4 4区医学

Asian Biomedicine Pub Date : 2024-09-20 eCollection Date: 2024-08-01 DOI: 10.2478/abm-2024-0025

Rungroj Thangpong, Pattarin Nuwongsri, Chupong Ittiwut, Rungnapa Ittiwut, Chureerat Phokaew, Piti Techavichit, Kanya Suphapeetiporn

{"title":"Whole exome sequencing in relapsed or refractory childhood cancer: case series.","authors":"Rungroj Thangpong, Pattarin Nuwongsri, Chupong Ittiwut, Rungnapa Ittiwut, Chureerat Phokaew, Piti Techavichit, Kanya Suphapeetiporn","doi":"10.2478/abm-2024-0025","DOIUrl":"10.2478/abm-2024-0025","url":null,"abstract":"Background: The prognosis for relapsed or refractory childhood cancer is approximately 20%. Genetic alterations are one of the significant contributing factors to the prognosis of patients.Objective: To investigate the molecular profile of relapsed or refractory childhood cancers in Thai cases.Methods: The study design is a descriptive study of patients <18 years old, suspected or diagnosed of relapsed or refractory childhood cancer who underwent whole exome sequencing (WES).Results: WES was successfully performed in both the tumor and the blood or saliva samples obtained from 4 unrelated patients. Six different variants were identified in the NCOR2, COL6A3, TP53, and SMAD4 genes. These alterations were found to be associated with tumor aggressiveness.Conclusion: This study is the first one to demonstrate genetic alterations by using WES in relapsed or refractory childhood cancer in Thai cases.","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"18 4","pages":"186-191"},"PeriodicalIF":0.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11414774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive model for left main coronary artery or triple vessel disease in patients with chronic coronary syndromes. 慢性冠状动脉综合征患者左冠状动脉主干或三支血管疾病的预测模型。

IF 0.4 4区医学

Asian Biomedicine Pub Date : 2024-09-20 eCollection Date: 2024-08-01 DOI: 10.2478/abm-2024-0024

Piyanop Nuchanat, Komsing Methavigul

{"title":"Predictive model for left main coronary artery or triple vessel disease in patients with chronic coronary syndromes.","authors":"Piyanop Nuchanat, Komsing Methavigul","doi":"10.2478/abm-2024-0024","DOIUrl":"10.2478/abm-2024-0024","url":null,"abstract":"Background: Data about prediction of left main coronary artery disease (LMCAD)/three-vessel disease (TVD) in patients with chronic coronary syndromes (CCS) are lacking.Objectives: This study aimed to develop a model for predicting patients at risk of LMCAD/TVD.Methods: This study used retrospective data from patients with CCS scheduled for invasive coronary angiography (ICA) and who were retrospectively recruited between January 2018 and December 2020. Predictors were obtained and analyzed by using logistic regression analysis, and generated the prediction score. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated. The cut-off value and area under the curve (AUC) were analyzed by using the receiver operating characteristic (ROC) curve.Results: We recruited 162 patients with CCS. There were 75 patients in the non-LMCAD/TVD and 87 patients in the LMCAD/TVD groups. After the multivariate analysis, new onset of heart failure (HF) or left ventricular systolic dysfunction (LVSD) and suspected CAD, ST elevation (STE) in aVR, STE in V1 and lateral ST depression (STD) were associated with increased risk of LMCAD/TVD. Based on these 4 predictors, the prediction score was created. The cut-off value of the prediction score by using ROC curve analysis was 3.0. The sensitivity, specificity, PPV, and NPV were 71.26%, 86.67%, 86.11%, and 72.22%, respectively, with an AUC of 0.855.Conclusions: The CCS patients with new onset of HF or LVSD and suspected CAD, STE in aVR, and STE in V1 and lateral STD were associated with increased risk of LMCAD/TVD. The novel prediction score could predict LMCAD/TVD in those patients with acceptable sensitivity, specificity, PPV, and NPV.","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"18 4","pages":"180-185"},"PeriodicalIF":0.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11414772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of the severity of patients with chronic coronary syndrome. 预测慢性冠状动脉综合征患者的严重程度。

IF 0.4 4区医学

Asian Biomedicine Pub Date : 2024-09-20 eCollection Date: 2024-08-01 DOI: 10.2478/abm-2024-0020

引用次数: 0

Exploring pathogenesis, prevalence, and genetic associations in Chiari malformation type 1: a contemporary perspective. 探索 Chiari 畸形 1 型的发病机制、发病率和遗传关联：当代视角。

IF 0.4 4区医学

Asian Biomedicine Pub Date : 2024-09-20 eCollection Date: 2024-08-01 DOI: 10.2478/abm-2024-0021

Siti Nornazihah Mohd Rosdi, Suzuanhafizan Omar, Mazira Mohamad Ghazali, Ab Rahman Izaini Ghani, Abdul Aziz Mohamed Yusoff

{"title":"Exploring pathogenesis, prevalence, and genetic associations in Chiari malformation type 1: a contemporary perspective.","authors":"Siti Nornazihah Mohd Rosdi, Suzuanhafizan Omar, Mazira Mohamad Ghazali, Ab Rahman Izaini Ghani, Abdul Aziz Mohamed Yusoff","doi":"10.2478/abm-2024-0021","DOIUrl":"10.2478/abm-2024-0021","url":null,"abstract":"Chiari malformation type 1 (CM 1) entails a structural defect in the cerebellum, involving the herniation of cerebellar tonsils toward the foramen magnum. The symptomatic or asymptomatic nature of CM 1 is contingent upon the condition of malformation in the spinal cord. This review presents an updated perspective on the prevalence of CM 1, its pathogenesis, genetic associations, and treatment. CM 1 exhibits a higher prevalence in adult females than males. Despite the incomplete understanding of the exact cause of CM 1, recent research suggests the involvement of both genetic and environmental factors in its development. One of the reasons for the occurrence of CM 1 in individuals is the smaller posterior cranial fossa, which manifests as typical morphological features. Additionally, environmental factors can potentially interact with genetic factors, modifying the observable characteristics of the disease and affecting the symptoms, severity, and development of the condition. Notably, headaches, neck pain, dizziness, and neurological deficits may be exhibited by individuals with CM 1, highlighting the importance of early diagnosis. Magnetic resonance imaging (MRI) serves as an alternative diagnostic technique for monitoring the symptoms of CM 1. Multiple genetic factors are likely to contribute to a cascade of abnormalities in CM 1. Early studies provided evidence, including clustering within families, bone development, and co-segregation with known genetic syndromes, establishing CM 1's association with a genetic basis. Furthermore, surgery is the only available treatment option to alleviate symptoms or hinder the progression of damage to the central nervous system (CNS) in CM 1 cases.","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"18 4","pages":"148-156"},"PeriodicalIF":0.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11414777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Control of parenteral blood stream infections in patients who need parenteral nutrition. 控制需要肠外营养的病人的肠外血流感染。

IF 0.4 4区医学

Asian Biomedicine Pub Date : 2024-06-28 eCollection Date: 2024-06-01 DOI: 10.2478/abm-2024-0014

引用次数: 0

The prooxidant-antioxidant balance in diagnosis and developmental prognosis of premature neonates with asphyxia. 早产新生儿窒息诊断和发育预后中的原氧化剂-抗氧化剂平衡。

IF 0.4 4区医学

Asian Biomedicine Pub Date : 2024-06-28 eCollection Date: 2024-06-01 DOI: 10.2478/abm-2024-0017

Maryam Zakerihamidi, Boskabadi Hassan, Amirkhani Samin

{"title":"The prooxidant-antioxidant balance in diagnosis and developmental prognosis of premature neonates with asphyxia.","authors":"Maryam Zakerihamidi, Boskabadi Hassan, Amirkhani Samin","doi":"10.2478/abm-2024-0017","DOIUrl":"10.2478/abm-2024-0017","url":null,"abstract":"Background: The antioxidant system in a preterm neonate is premature. The imbalance between the prooxidant and antioxidant systems can make these neonates prone to oxidative stress. Birth asphyxia is one of the factors that can disturb this balance.Objective: We studied the prooxidant-antioxidant balance (PAB) in the diagnosis and developmental prognosis of preterm neonates with asphyxia.Methods: This cohort study has been conducted between 2016 and 2022 with 2 years follow-up on 183 premature neonates admitted to Ghaem Hospital Mashhad, by using a convenience sampling method. The data-collection tool and the researcher-made checklist included the mothers' and the neonate's information, and the third segment included laboratory information. PAB was studied by using standard solutions and the Enzyme immunoassays (ELISA) method. After discharging the newborns from the hospital, they were under follow-up at 6 months, 12 months, 18 months, and 24 months, by using the Denver II test. PAB was compared among newborns with asphyxia, those without asphyxia, and also newborns with normal and abnormal outcomes in both groups.Results: The mean ± standard deviation of the PAB factor reported is as follows: in newborns without asphyxia (21.00 ± 18.14 HK), those with asphyxia (31.00 ± 45.42 HK), in newborns with asphyxia having abnormal outcomes (40.00 ± 60.84 HK), and those having normal outcomes (21.00 ± 18.67 HK) (P ≤ 0.05). PAB results >25 HK have been used for the diagnosis of asphyxia prognosis in newborns, with 83.3% sensitivity and 81% specificity.Conclusion: The PAB index showed a significant increase after asphyxia. It can be used as a diagnostic marker for the prognosis of premature newborns with asphyxia. Thus, diagnosis and prognosis of asphyxia in premature newborns can be predicted by using the PAB index.","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"18 3","pages":"116-124"},"PeriodicalIF":0.4,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11338270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0