Asian Biomedicine最新文献

{"title":"Neonatal sevoflurane anesthesia can also affect rat medulla spinalis.","authors":"Elvan Ocmen, Hale Aksu Erdost, Osman Yilmaz, Alper Bagriyanik, Muge Kiray, Necati Gokmen","doi":"10.2478/abm-2025-0017","DOIUrl":"10.2478/abm-2025-0017","url":null,"abstract":"<p><strong>Background: </strong>Anesthesia has been linked to neuroapoptosis and prolonged neurocognitive disorders in the neonatal rat brain, but the full extent of damage induced by anesthesia on the central nervous system is still unknown.</p><p><strong>Objectives: </strong>We aim to investigate whether sevoflurane anesthesia affects the spinal cord.</p><p><strong>Methods: </strong>After the approval of the ethics committee, 24 Wistar albino rat pups, weighing between 9 g and 11 g, on the postnatal 7th day were included in the study. In the sevoflurane groups, rats breathed 2.5% sevoflurane in oxygen. The tail flick tests were performed on postnatal 8th, 15th, and 30th days to evaluate motor functions. At the end of the experiments, rats were sacrificed by decapitation, and their spinal cords were taken for histopathological evaluation.</p><p><strong>Results: </strong>There was a significant difference between the tail pulling times on the 8th and 30th days in both groups (<i>P</i> = 0.036). No significant difference was found between the control and sevoflurane groups (<i>P</i> = 0.053). In histopathological assessments, the chronic sevoflurane group showed a significant increase in apoptotic cell count (<i>P</i> < 0.001).</p><p><strong>Conclusions: </strong>This study showed that although there was a significant increase in apoptotic cells in the chronic sevoflurane group, motor function of the spinal cord was not affected. Further studies can be conducted to investigate the possible mechanisms.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"19 3","pages":"141-146"},"PeriodicalIF":0.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of garlic on the lowering of blood pressure in the patients with hypertension: an updated meta-analysis and trial sequential analysis.","authors":"Xiao Ma, Hongying Zhang, Jinhai Jia","doi":"10.2478/abm-2025-0016","DOIUrl":"10.2478/abm-2025-0016","url":null,"abstract":"<p><strong>Background: </strong>Garlic extracts have been demonstrated to be effective supplements for reducing blood pressure in hypertensive subjects. However, contradictory observations on the efficacy of garlic extracts have been reported in different studies.</p><p><strong>Objectives: </strong>To explore the efficacy of garlic, this study aimed to perform a meta-analysis of previously published controlled placebo trials and drew firm conclusions.</p><p><strong>Methods: </strong>We searched online databases, including Scopus, PubMed, and Science Direct, to obtain relevant articles on the role of garlic in reducing blood pressure in patients with hypertension. The literature search, data extraction, and analysis were performed independently by two researchers. Comprehensive Meta-Analysis Software v4 was used for all the analyses.</p><p><strong>Results: </strong>Twelve reports, comprising 405 patients treated with garlic derivatives and 333 receiving placebo, were included in this investigation. The results of the meta-analysis revealed a significant decrease in systolic blood pressure (mean difference: -8.121, 95% confidence interval [CI]: -10.95 to -5.28, <i>P</i> < 0.0001) and diastolic blood pressure (mean difference: -4.256, 95% CI: -5.99 to -2.52, <i>P</i> < 0.0001) in subjects treated with garlic extracts compared to those treated with placebo. Interestingly, trial sequential analysis also supports the observations of the meta-analysis and indicates that a sufficient number of trials have already been performed to reach a consensus conclusion, and further trials are not required. In addition, the GRADEing of evidence also supports the robustness of the observations.</p><p><strong>Conclusions: </strong>Garlic extracts significantly lower blood pressure and may be prescribed by clinicians for patients with hypertension.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"19 3","pages":"131-140"},"PeriodicalIF":0.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oculocutaneous albinism in a patient with an <i>OCA2</i> variant: molecular and clinical insights.","authors":"Mostafa Neissi, Sahar Kareem Al-Mozani, Ayoob Radhi Al-Zaalan, Samaneh Sanavi Shiri, Motahareh Sheikh-Hosseini, Adnan Issa Al-Badran, Elaheh Nekouei","doi":"10.2478/abm-2025-0019","DOIUrl":"10.2478/abm-2025-0019","url":null,"abstract":"<p><strong>Background: </strong>Albinism is a rare genetic condition characterized by hypopigmentation of the skin, hair, and eyes, as well as visual impairments. Oculocutaneous albinism type 2 (<i>OCA2</i>) is commonly associated with variants in the <i>OCA2</i> gene, which encodes a protein critical for melanosomal pH regulation and melanin biosynthesis. Exome sequencing, validated by Sanger sequencing, was employed to investigate the genetic basis of albinism in a consanguineous Iranian family. Bioinformatics analyses and structural modeling were conducted to assess the pathogenicity and impact of the detected variant.</p><p><strong>Case presentation: </strong>A 27-year-old male from a consanguineous Iranian family presented with features of oculocutaneous albinism, including white hair, blue eyes, strabismus, sun-sensitive skin, reduced visual acuity, and significant photophobia, resulting in functional limitations in bright environments. Genetic analysis identified a novel homozygous missense variant in the <i>OCA2</i> gene, NM_000275.3:c.1274T>G (p.Met425Arg), located in exon 13. The genomic coordinates of the variant are chr15:g.27985154A>C (GRCh38/hg38). In silico tools classified the variant as likely pathogenic based on its evolutionary conservation, absence in population databases, and structural modeling predictions. Segregation analysis confirmed autosomal recessive inheritance, with both parents being heterozygous carriers.</p><p><strong>Conclusion: </strong>The identified <i>OCA2</i> variant, c.1274T>G; p.Met425Arg, disrupts protein function, impairing melanosomal activity and melanin biosynthesis. This study underscores the importance of genetic analysis in characterizing <i>OCA2</i> variants and highlights the need for further exploration of molecular mechanisms and phenotypic variability in <i>OCA2</i>-related albinism to improve diagnosis and counseling.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"19 3","pages":"154-163"},"PeriodicalIF":0.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk scores to guide the use of anticoagulant in atrial fibrillation.","authors":"","doi":"10.2478/abm-2025-0008","DOIUrl":"10.2478/abm-2025-0008","url":null,"abstract":"","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"19 2","pages":"67-68"},"PeriodicalIF":0.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the molecular mechanism of Xiao Ji (<i>Cirsium setosum</i>) in treating bladder cancer using network pharmacology and molecular docking.","authors":"Hui Yu, Yang Dong, Gui-Cheng Zou, Yun-Jie Yang, Meng-Zhen Liu, Cong-Hui Han","doi":"10.2478/abm-2025-0012","DOIUrl":"10.2478/abm-2025-0012","url":null,"abstract":"<p><strong>Background: </strong>In China, Xiao Ji decoction has been used to treat hematuria. However, pharmacological studies on its effects against bladder cancer (BC) remain limited.</p><p><strong>Objective: </strong>This study aims to explore the potential mechanisms of Xiao Ji in treating BC using network pharmacology and molecular docking.</p><p><strong>Methods: </strong>The active constituents of Xiao Ji and their corresponding molecular targets were identified through the utilization of the Traditional Chinese Medicine Systems Pharmacology Database. Genes associated with BC were screened by employing resources including the Online Mendelian Inheritance in Man (OMIM) and GeneCards databases. Furthermore, protein-protein interaction (PPI) networks and networks illustrating the connections between ingredients and their ingredient-target (I-T) were established. The related genes underwent gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Ultimately, molecular docking experiments were conducted to substantiate and reinforce the proposed hypotheses.</p><p><strong>Results: </strong>Four compounds were identified, along with 82 target genes that exhibited associations with BC. In the I-T network, quercetin exhibited the highest degree of association with multiple targets. Within the PPI network, interleukin (IL)IL-6, hypoxia inducible factor 1 subunit alpha (HIF1A), epidermal growth factor receptor (EGFR), and myelocytomatosis oncogene (MYC) were discerned as pivotal genes. The enrichment analysis of the critical genes led to the identification of 92 GO terms and 105 pathways. Furthermore, the results of molecular docking analyses revealed that the active compounds, including acacetin, sitosterol, and stigmasterol, exhibited strong binding affinities with IL-6, EGFR, and MYC.</p><p><strong>Conclusions: </strong>Xiao Ji acts on BC through multiple targets and pathways. This study elucidates the potential mechanisms of Xiao Ji in treating BC, providing new options for BC therapy.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"19 2","pages":"94-105"},"PeriodicalIF":0.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precocious puberty: a comprehensive review of diagnosis and clinical presentation, etiology, and treatment.","authors":"Khomsak Srilanchakon, Vichit Supornsilchai, Suttipong Wacharasindhu, Martin O Savage","doi":"10.2478/abm-2025-0009","DOIUrl":"10.2478/abm-2025-0009","url":null,"abstract":"<p><p>Central precocious puberty (CPP) is characterized by early activation of the hypothalamic-pituitary-gonadal (HPG) axis, which is apparent in the form of breast development in girls and testicular enlargement in boys prior to the typical physiological age ranges. Although intracranial pathology, exposure to high levels of sex steroids, or environmental risk factors can precipitate CPP, the majority of cases are idiopathic. Monogenic causes have also been identified. We provide a concise summary of the pathophysiology, risk factors, diagnosis, and management of CPP in this review. A referral to pediatric endocrinology should be initiated when there is concern for CPP. The diagnosis is confirmed through clinical, biochemical, radiological, and genetic testing. The primary objectives of administering a gonadotropin-releasing hormone (GnRH) analog to patients with CPP are to increase adult height and postpone the development of secondary sexual characteristics until a later age that is more compatible with peer norms. Although the long-term results of treatment with GnRH analogs are encouraging, further research is required to investigate the psychological impact of CPP.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"19 2","pages":"69-77"},"PeriodicalIF":0.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the potential of herbal drugs for treating liver fibrosis: a computational screening approach.","authors":"Tanya Ralli, Abdulsalam Alhalmi","doi":"10.2478/abm-2025-0010","DOIUrl":"10.2478/abm-2025-0010","url":null,"abstract":"<p><strong>Background: </strong>With the increasing prevalence of metabolic disorders such as obesity and hyperlipidemia, there is a heightened tendency for inflammation in the hepatocytes, which can eventually progress to liver fibrosis. Despite its high incidence, no approved treatment currently exists for liver fibrosis.</p><p><strong>Objectives: </strong>This study aims to identify potential herbal drugs with anti-fibrotic activity by targeting multiple pathways involved in liver fibrosis, particularly focusing on the Tumour growth factor-beta (TGF-β) and tumor necrosis factor-alpha (TNF-α) proteins.</p><p><strong>Methods: </strong>We conducted in silico studies on 9 widely used herbal drugs to evaluate their binding affinities for TGF-β and TNF-α receptors. The herbal drugs analyzed included ginseng, danshen, silymarin, resveratrol, berberine, anthocyanin, ginger, curcumin, and tocopherol.</p><p><strong>Results: </strong>Our results indicate that ginseng and danshen exhibit the strongest anti-fibrotic potential, with the most favorable binding energies for both TGF-β and TNF-α receptors. Silymarin, resveratrol, berberine, and anthocyanin also demonstrated comparable or superior activity to the reference drug and pirfenidone. Conversely, ginger, curcumin, and tocopherol showed relatively lower activity.</p><p><strong>Conclusions: </strong>Herbal drugs such as ginseng and danshen present promising candidates for the treatment of liver fibrosis due to their strong binding affinity to key fibrosis-related proteins and their lower side effect profile compared with synthetic drugs. The appropriate selection and combination of these herbal drugs could offer a viable therapeutic approach for managing liver fibrosis.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"19 2","pages":"78-85"},"PeriodicalIF":0.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The novel risk score model for predicting the poor anticoagulation control in patients with atrial fibrillation taking warfarin.","authors":"Komsing Methavigul, Rungroj Krittayaphong","doi":"10.2478/abm-2025-0013","DOIUrl":"10.2478/abm-2025-0013","url":null,"abstract":"<p><strong>Background: </strong>Previous trials have shown that the C-statistics of SAMe-TT₂R₂ score in the prediction of suboptimal time in therapeutic range (TTR) is very low.</p><p><strong>Objectives: </strong>To propose the novel risk score model for predicting the poor anticoagulation control in atrial fibrillation (AF) patients compared with the SAMe-TT₂R₂ score.</p><p><strong>Methods: </strong>We prospectively recruited AF patients from 27 hospitals between 2014 and 2017 in the COOL AF Thailand registry. The poor anticoagulation control was defined as TTR <65%. Multivariate logistic regression analysis was performed for the prediction of poor anticoagulation control. The novel risk score model was then generated. Receiver operating characteristic (ROC) curve analysis was performed to calculate the C-statistics and to compare between the novel risk score model and the SAMe-TT₂R₂ score. Net Reclassification Index (NRI) and Integrated Discrimination Index (IDI) were performed.</p><p><strong>Results: </strong>Of 3,461 patients, 2,233 patients taking warfarin having available TTR data were retrieved. There were 1,432 patients having poor anticoagulation control (TTR < 65%) and 801 patients having good anticoagulation control (TTR ≥ 65%). Symptomatic AF, diabetes, heart failure, and a history of bleeding were associated with increased risk while obesity, AF duration, and paroxysmal AF were associated with decreased risk of poor anticoagulation control. SHOB-D₂AF score was created. The C-statistics of SHOB-D₂AF score was greater than the SAMe-TT₂R₂ score (0.584 vs 0.506, <i>P</i> < 0.001). NRI of the SHOB-D₂AF score was 17.82% compared with the SAMe-TT₂R₂ score.</p><p><strong>Conclusions: </strong>SHOB-D₂AF score was the novel risk score which was better than the SAMe-TT₂R₂ score in predicting poor anticoagulation control.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"19 2","pages":"106-113"},"PeriodicalIF":0.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of clinicopathological parameters with the presence of Epstein-Barr virus and the absence of DNA mismatch repair proteins in gastric adenocarcinomas.","authors":"Özge Eyeoğlu, Serra Kayaçetin","doi":"10.2478/abm-2025-0011","DOIUrl":"10.2478/abm-2025-0011","url":null,"abstract":"<p><strong>Background: </strong>High mortality and poor prognosis are seen in gastric adenocarcinomas (GAs). Therefore, investigation of the factors related to GA prognosis is important.</p><p><strong>Objective: </strong>To investigate the association between clinicopathological parameters and DNA mismatch repair (MMR) proteins as well as Epstein-Barr virus (EBV) in GAs.</p><p><strong>Methods: </strong>Expression of MMR proteins and EBV positivity of 77 patients diagnosed with GA were evaluated using immunohistochemistry. Survival data of the patients were also considered.</p><p><strong>Results: </strong>Significant correlations were found between EBV positivity and gender, perineural invasion (PNI), and histological type. PNI was less common in EBV-positive patients, and EBV positivity was highly correlated with lymphoid stromal adenocarcinoma. Tumor budding was significantly correlated with histological type and grade, lymphovascular invasion (LVI), PNI, lymph node metastasis, and post-diagnosis survival time. Moreover, tumor-stroma ratio was correlated with tumor stage. Additionally, tumor location, histological grade, tumor budding, PNI, and pathological stage were associated with survival. Also, EBV positivity was significantly associated with histological type, PNI, tumor location, and gender. However, MMR and EBV positivity were not significantly correlated to tumor microenvironment and prognosis. It was noteworthy that the mortality rate was much higher in patients with PNI compared with those without PNI.</p><p><strong>Conclusion: </strong>Our findings support that the tumor microenvironment is significantly associated with GA prognosis.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"19 2","pages":"86-93"},"PeriodicalIF":0.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning models for predicting hepatocellular carcinoma development in patients with chronic viral hepatitis B infection.","authors":"Warissara Kuaaroon, Thodsawit Tiyarattanachai, Terapap Apiparakoon, Sanparith Marukatat, Natthaporn Tanpowpong, Sombat Treeprasertsuk, Rungsun Rerknimitr, Pisit Tangkijvanich, Prooksa Ananchuensook, Watcharasak Chotiyaputta, Kittichai Samaithongcharoen, Roongruedee Chaiteerakij","doi":"10.2478/abm-2025-0007","DOIUrl":"https://doi.org/10.2478/abm-2025-0007","url":null,"abstract":"<p><strong>Background: </strong>Chronic hepatitis B (CHB) infection is the major risk factor for hepatocellular carcinoma (HCC).</p><p><strong>Objective: </strong>To develop machine-learning models for predicting an individual risk of HCC development in CHB-infected patients.</p><p><strong>Methods: </strong>Machine learning models were constructed using features from follow-up visits of CHB patients to predict the diagnosis of HCC development within 6 months after each index follow-up. We developed 4 model variants using all features, with alpha fetoprotein (AFP) (<i>AF ^A</i> ) and without AFP (<i>AF^N</i> ); and selected features, with AFP (<i>SF ^A</i> ) and without AFP (<i>SF^N</i> ). Performance was evaluated using 10-fold cross-validation on a derivation cohort and further validated on an independent cohort.</p><p><strong>Results: </strong>In the derivation cohort of 2,382 patients, of whom 117 developed HCC, <i>AF^A</i> achieved higher sensitivity (0.634, 95% confidence interval [CI]: 0.559-0.708) and specificity (0.836; 0.830-0.842) than <i>AF ^N</i> (sensitivity 0.553; 0.476-0.630 and specificity 0.786; 0.779-0.792). <i>SF^A</i> also achieved higher sensitivity (0.683; 0.611-0.755 vs. 0.658; 0.585-0.732) and specificity (0.756; 0.749-0.763 vs. 0.744; 0.737-0.751) than <i>SF^N</i> . Performance of <i>SF^A</i> and <i>SF^N</i> were tested in another cohort of 162 patients in which 57 patients developed HCC. <i>SF^A</i> achieved sensitivity and specificity of 0.634 (0.522-0.746) and 0.657 (0.615-0.699), while sensitivity and specificity of <i>SF^N</i> were 0.690 (0.583-0.798) and 0.651 (0.609-0.693), respectively.</p><p><strong>Conclusion: </strong>The machine learning models demonstrate good performance for predicting short-term risk for HCC development and may potentially be used for tailoring surveillance interval for CHB patients.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"19 1","pages":"51-59"},"PeriodicalIF":0.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}