Khomsak Srilanchakon, Vichit Supornsilchai, Suttipong Wacharasindhu, Martin O Savage
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引用次数: 0
Abstract
Central precocious puberty (CPP) is characterized by early activation of the hypothalamic-pituitary-gonadal (HPG) axis, which is apparent in the form of breast development in girls and testicular enlargement in boys prior to the typical physiological age ranges. Although intracranial pathology, exposure to high levels of sex steroids, or environmental risk factors can precipitate CPP, the majority of cases are idiopathic. Monogenic causes have also been identified. We provide a concise summary of the pathophysiology, risk factors, diagnosis, and management of CPP in this review. A referral to pediatric endocrinology should be initiated when there is concern for CPP. The diagnosis is confirmed through clinical, biochemical, radiological, and genetic testing. The primary objectives of administering a gonadotropin-releasing hormone (GnRH) analog to patients with CPP are to increase adult height and postpone the development of secondary sexual characteristics until a later age that is more compatible with peer norms. Although the long-term results of treatment with GnRH analogs are encouraging, further research is required to investigate the psychological impact of CPP.
期刊介绍:
Asian Biomedicine: Research, Reviews and News (ISSN 1905-7415 print; 1875-855X online) is published in one volume (of 6 bimonthly issues) a year since 2007. [...]Asian Biomedicine is an international, general medical and biomedical journal that aims to publish original peer-reviewed contributions dealing with various topics in the biomedical and health sciences from basic experimental to clinical aspects. The work and authorship must be strongly affiliated with a country in Asia, or with specific importance and relevance to the Asian region. The Journal will publish reviews, original experimental studies, observational studies, technical and clinical (case) reports, practice guidelines, historical perspectives of Asian biomedicine, clinicopathological conferences, and commentaries
Asian biomedicine is intended for a broad and international audience, primarily those in the health professions including researchers, physician practitioners, basic medical scientists, dentists, educators, administrators, those in the assistive professions, such as nurses, and the many types of allied health professionals in research and health care delivery systems including those in training.