Asian Biomedicine最新文献

{"title":"Intrabiliary ultrasound applied to endoscopic extraction of choledochal stones.","authors":"Liang Ye, Huaiyang Cai, Yingwei Wang, Weiqiang Guo","doi":"10.2478/abm-2026-0004","DOIUrl":"https://doi.org/10.2478/abm-2026-0004","url":null,"abstract":"<p><strong>Background: </strong>Although ERCP with endoscopic sphincterotomy is effective for choledocholithiasis, small residual stones may be missed by cholangiography, and intraductal ultrasound may improve detection and reduce recurrence.</p><p><strong>Objective: </strong>To observe the value of intraductal ultrasound (IDUS) in endoscopic extraction of choledocholithiasis.</p><p><strong>Methods: </strong>We retrospectively analyzed 148 patients with choledocholithiasis who underwent endoscopic retrograde cholangiopancreatography (ERCP) combined with endoscopic sphincterotomy (EST). IDUS was performed to observe whether there were any residual choledocholithiasis stones in those whose previous choledocholithiasis treatment indicated complete clearance; ERCP combined with EST was repeated to retrieve larger residual stones (≥3 mm). Postoperative follow-up was conducted to monitor the recurrence of choledocholithiasis and its influencing factors.</p><p><strong>Results: </strong>After 148 cases of endoscopic ERCP combined with EST, cholangiography confirmed the complete removal of choledochal stones. Notably, 61 cases were found to have residual stones, and 21 of them had residual stones ≥3 mm; these 21 cases were repeated until the stones were completely removed. After 3-24 months of follow-up, IDUS revealed that the stone recurrence rates were 8.33% (9/108) for 108 cases with complete stone removal and 62.50% (25/40) for 40 cases with residual stones. The difference was statistically significant (<i>P</i> < 0.01). The cumulative recurrence rates during the 24-month postoperative period were also significantly different (88.40% and 14.40%, respectively, <i>P</i> < 0.01). The results of multivariate analysis showed that choledocholithiasis, common bile duct (CBD) diameter, and angle were independent risk factors for stone recurrence, as indicated by IDUS (<i>P</i> < 0.05).</p><p><strong>Conclusions: </strong>IDUS can detect choledocholithiasis, particularly small stones (<3 mm), which are challenging to visualize with cholangiography. IDUS can assist in ERCP combined with EST to reduce the recurrence of postoperative stones.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"20 1","pages":"35-40"},"PeriodicalIF":0.9,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute kidney injury in urological conditions.","authors":"Kittisak Weerapolchai, Nuttha Lumlertgul, Nattachai Srisawat, Marlies Ostermann","doi":"10.2478/abm-2026-0002","DOIUrl":"https://doi.org/10.2478/abm-2026-0002","url":null,"abstract":"<p><p>Acute kidney injury (AKI) is a sudden deterioration of kidney function, typically diagnosed by a rise in serum creatinine (SCr) and/or a decrease in urine output. In urological conditions, AKI can result from a variety of factors such as an obstruction of the genitourinary tract, urological procedures, trauma, vascular causes, nephrotoxic drugs, or infection. Imaging plays an integral part in the diagnosis of post-renal AKI. Novel kidney biomarkers may have roles in the diagnosis and prognostication of urology-associated AKI. Finally, management consists of the correction of the underlying cause and supportive care. The prognosis of AKI in urological conditions depends on the underlying cause, the timeliness of intervention, and the patient's baseline kidney health.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"20 1","pages":"3-20"},"PeriodicalIF":0.9,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"E-selectin, but not CRP, partially mediates the association between metabolic indices and insulin resistance in older adults: a mediation analysis.","authors":"Laith Ashour, Tariq Albweitel, Juana Abu Rahmeh, Momen Alfawadleh, Afaf El Sharabi, Rahmah Ahmad Shareah, Zaid Alomari, Arar Alhawwari, Mohammad Alkalouti, Noura F Al-Nawaiseh, Malak S Ababneh, Abdelrahman Kaoukji","doi":"10.2478/abm-2026-0007","DOIUrl":"https://doi.org/10.2478/abm-2026-0007","url":null,"abstract":"<p><strong>Background: </strong>Evidence on the pathophysiology of insulin resistance (IR), particularly the mediating role of inflammatory markers, remains limited.</p><p><strong>Objectives: </strong>Prior studies suggest associations of C-reactive protein (CRP) and E-selectin with IR, generally examined independently of other risk factors. This study evaluates their potential mediation roles.</p><p><strong>Methods: </strong>Using biomarker data from the Midlife in the United States 3 (MIDUS3) 2017-2022 cohort, we conducted cross-sectional bias-corrected bootstrapping mediation analyses to assess whether CRP and E-selectin mediate associations between established risk factors-body mass index (BMI), waist-hip ratio (WHR), total cholesterol/HDL ratio, age, glycated hemoglobin A (HbA1c), smoking status, dietary habits, physical activity, medication use, and sex-and IR measured by log-transformed homeostatic model assessment of IR (HOMA-IR).</p><p><strong>Results: </strong>The study included 708 participants (57% female; mean age 66.2 ± 9.65 years). CRP did not mediate associations between covariates and HOMA-IR. In contrast, E-selectin showed indirect-only mediation for sex and HOMA-IR (% change in HOMA-IR [%CHIR] in females = 2.4; 95% CI: [0.46, 5.80]). Partial mediation by E-selectin was observed for HbA1c (%CHIR = 9.26; 95% CI: [3.40, 18.66]), BMI (%CHIR = 2.72; 95% CI: [0.97, 5.54]), and total/HDL cholesterol ratio (%CHIR = 1.92; 95% CI: [0.34, 4.49]). Indirect-only mediation was also found for age (%CHIR = -1.11; 95% CI: [-2.58, -0.27]), non-smoking (%CHIR = -1.55; 95% CI: [-4.09, -0.13]), and higher healthy eating index score (%CHIR = -7.87; 95% CI: [-17.48, -2.43]).</p><p><strong>Conclusion: </strong>E-selectin, but not CRP, mediates relationships between metabolic risk factors and IR, highlighting endothelial dysfunction as a key pathway.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"20 1","pages":"60-69"},"PeriodicalIF":0.9,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of clinical characteristics and liver stiffness measurement with liver viscosity measured by shear wave elastography in patient with non-alcoholic fatty liver disease.","authors":"Anchasa Opasatian, Natthaporn Tanpowpong, Pisit Tangkijvanich","doi":"10.2478/abm-2026-0006","DOIUrl":"https://doi.org/10.2478/abm-2026-0006","url":null,"abstract":"<p><strong>Background: </strong>Viscosity plane-wave ultrasound (Vi.PLUS) measures tissue viscosity by using shear wave dispersion within tissues. The tissue viscosity is associated with the degree of liver necroinflammation, which is an important mechanism that leads to the development of liver fibrosis (LF).</p><p><strong>Objectives: </strong>This study aimed to examine the association of clinical characteristics and liver stiffness measurement (LSM) by magnetic resonance elastography (MRE) with liver viscosity measurement by shear wave elastography (SWE) in patients with non-alcoholic fatty liver disease.</p><p><strong>Methods: </strong>This monocentric cross-sectional study with retrospective data collection included 164 patients. The medical records of patients aged ≥18 years with non-alcoholic fatty liver disease (NAFLD) and who underwent MRE and Vi.PLUS at King Chulalongkorn Memorial Hospital were reviewed. The viscosity measurements were performed according to guidelines.</p><p><strong>Results: </strong>Of the 164 patients, 11 (6.7%) had invalid or unreliable measurements by elastographic technique and 4 (2.4%) were excluded due to incomplete clinical data. This resulted in 149 subjects being included in the final analysis. The study found good correlation between viscosity measurements by shear wave elastography and LSM by MRE (<i>r</i> = 0.74, <i>P</i> < 0.001). Multivariate regression analysis found that body mass index (<i>P</i> = 0.032) and LSM by MRE (<i>P</i> < 0.001) were independently associated with Vi.PLUS values.</p><p><strong>Conclusion: </strong>In conclusion, viscosity measured by shear wave elastography is a non-invasive method of assessing liver inflammation with good correlation to LF. This may aid the early diagnosis of liver inflammation in patients with NAFLD.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"20 1","pages":"1-7"},"PeriodicalIF":0.9,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biosynthesis of fosfomycin-loaded CuO nanoparticles: evaluation of antibacterial, antibiofilm properties and molecular docking analysis against biofilm-associated proteins in MDR bacteria.","authors":"Zukhra Abbasi, Fehmida Fasim, Sehrish Abbas, Rabia Shafique, Barkat Ali Khan, Amna Nisar, Sultan M Alshahrani, Bushra Uzair","doi":"10.2478/abm-2026-0003","DOIUrl":"https://doi.org/10.2478/abm-2026-0003","url":null,"abstract":"<p><strong>Background: </strong>Infectious diseases caused by antibiotic-resistant bacteria pose a significant challenge in healthcare. The development of new antibiotics, while essential, is often hindered by the complexity, cost, and time involved in the process. An alternative approach gaining traction is the conjugation of existing antibiotics with potent antimicrobial agents to improve their efficacy against resistant pathogens.</p><p><strong>Objective: </strong>This study aimed to develop environmentally sustainable and cost-effective copper oxide nanoparticles (CuO NPs) synthesized using bioactive compounds extracted from <i>Curcuma zedoaria</i>.</p><p><strong>Methods: </strong>These nanoparticles were subsequently conjugated with fosfomycin. Physicochemical characterization was carried out using XRD, scanning electron microscopy (SEM), FTIR, and UV-Visible spectroscopy. Release was studied using Franz diffusion cell. Antibacterial efficacy of the pure and fosfomycin-conjugated copper oxide nanoparticles (Fos-CuO NPs) was evaluated against multidrug-resistant (MDR) strains of <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, and <i>Pseudomonas aeruginosa</i> using the disk diffusion method. The minimum inhibitory concentration (MIC) and antibiofilm activity were determined using the microbroth dilution method. Additionally, molecular docking analysis was performed to examine the interaction of Fos-CuO NPs with biofilm-associated proteins (LecA, CdrA, PslA, PslD, GacA, CupA, DipA, PelA, PelB) in <i>P. aeruginosa</i>.</p><p><strong>Results: </strong>The physicochemical analysis confirmed successful CuO NPs synthesis and their conjugation with fosfomycin. XRD results confirmed the crystalline structure of the nanoparticles, while SEM revealed some agglomerated, irregular spherical shapes. Fos-CuO NPs exhibited greater antibacterial activity against MDR <i>S. aureus</i> (42 mm), <i>E. coli</i> (45 mm), and <i>P. aeruginosa</i> (39 mm) compared with pure CuO NPs (39 mm, 27 mm, and 41 mm, respectively). The docking results showed that the fosfomycin-conjugated nanoparticle exhibited the highest binding affinity for the biofilm-associated proteins Lec A and Pel A, with docking scores of -4.4 kcal/mol and -4.9 kcal/mol, respectively, compared with blank CuO NPs, supporting their potential application as a novel antimicrobial strategy.</p><p><strong>Conclusion: </strong>This research offers significant insights into the green synthesis of fosfomycin-conjugated nanoparticles for addressing the growing challenge of multidrug-resistant bacterial infections.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"20 1","pages":"21-34"},"PeriodicalIF":0.9,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role and advantages of intraductal ultrasound for the management of gallstones.","authors":"","doi":"10.2478/abm-2026-0001","DOIUrl":"https://doi.org/10.2478/abm-2026-0001","url":null,"abstract":"","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"20 1","pages":"1-2"},"PeriodicalIF":0.9,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of GnRH-a in combination with dienogest therapy in endometriosis and its effects in recurrence and pregnancy status.","authors":"Ke Zhou, Rong Zhu, Yue Jin","doi":"10.2478/abm-2026-0005","DOIUrl":"https://doi.org/10.2478/abm-2026-0005","url":null,"abstract":"<p><strong>Background: </strong>Endometriosis (EMT) is a common gynecologic and hormone-dependent disease that seriously affects patients' quality of life and currently faces certain challenges in clinical treatment.</p><p><strong>Objective: </strong>To observe the clinical efficacy of gonadotropin-releasing hormone agonists (GnRH-a) in combination with Dienogest treatment in EMT and its effects on recurrence and pregnancy.</p><p><strong>Methods: </strong>In a retrospective study, 254 patients with EMT from The First Affiliated Hospital, College of Medicine, Zhejiang University were selected between October 2020 and December 2021, and were divided into DT group (Dienogest treatment group) and GD group (GnRH-a combined with dienogest treatment group) according to the treatment modality, both groups were treated with Dienogest, and the GD group was additionally treated with GnRH-a. The primary assessment of both groups was clinical efficacy, recurrence rate and pregnancy (cumulative pregnancy rate, live birth rate, miscarriage rate, multiple pregnancy rate, and ectopic pregnancy rate). Secondary outcomes included the antibody indicator positive rate (anti-endometrial antibodies [AEmAb], anti-sperm antibodies [AsAb], and anti-zona pellucida antibodies [AZpAb]), sex hormone levels (luteinizing hormone [LH], follicle-stimulating hormone [FSH], and estradiol [E2]), serum inflammatory indicator levels (Interleukin-6 [IL-6], C-reactive protein [CRP], tumor necrosis factor-α [TNF-α]), visual analog scale (VAS) scores, and adverse reactions.</p><p><strong>Results: </strong>After treatment, all indicators improved in both groups (<i>P</i> < 0.05). The clinical efficacy, cumulative pregnancy rate, and live birth rate of patients in the GD group were markedly higher than those in the DT group (<i>P</i> < 0.05). The recurrence rate, positive rate of antibody indicator, sex hormone level, serum inflammation indicator, VAS score, and incidence of adverse reactions of patients in the GD group were remarkably below the DT group (<i>P</i> < 0.05). No marked discrepancies were found in the rates of miscarriage, multiple pregnancy, and ectopic pregnancy in both groups (<i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>The efficacy of GnRH-a combined with Dienogest in the treatment of EMT is remarkable, which can effectively reduce the inflammatory response, sex hormone levels, and recurrence rate, and markedly improve pregnancy, which is worth promoting its use in the clinic.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"20 1","pages":"41-52"},"PeriodicalIF":0.9,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2024 Thai guidelines on the treatment of hypertension.","authors":"Sirisawat Kunanon, Praew Kotruchin, Pairoj Chattranukulchai, Chavalit Chotruangnapa, Weranuj Roubsanthisuk, Prin Vathesatogkit, Tada Kunavisarut, Songkwan Silaruks, Sirakarn Tejavanija, Tuangsit Wataganara, Piengbulan Yapan, Nijasri Suwanwela, Pongamorn Bunnag, Buncha Satirapoj, Surapun Sitthisook, Rapeephon Kunjara Na Ayudhya, Apichard Sukonthasarn","doi":"10.2478/abm-2025-0034","DOIUrl":"https://doi.org/10.2478/abm-2025-0034","url":null,"abstract":"<p><p>The committee of the 2024 Thai Guidelines on the Treatment of Hypertension has reviewed new developments in the body of knowledge, combined with expertise in real-life clinical practice and evidence collected from clinical studies worldwide. The Guidelines consist of newly highlighted key topics to be up to date and suitable for the country's context. We still maintained the current office blood pressure (BP) cut-point of 140/90 mmHg for hypertension diagnosis. The new BP category, \"BP at risk,\" i.e., BP of 130-139/80-89 mmHg, was introduced. The out-of-office BP measurements, including home BP monitoring (HBPM) or ambulatory blood pressure monitoring (ABPM), are also advocated to confirm the diagnosis of hypertension. Target BP levels depend on the age of the patients i.e., 120-130/70-79 mmHg for patients age 18-65 years, 130-139/70-79 mmHg for patients over 65 years of age. There are 5 main groups of antihypertensive medication, that is, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, betablockers, calcium-channel blockers, and diuretics (thiazides and thiazide-like diuretics such as chlorthalidone and indapamide). Two types of medications should be started for most patients, except for frail elderly patients, patients with relatively low initial BP (140-149/90-99 mmHg), and low-risk patients; only 1 type of starting medication should be selected. Medication that is a combination of 2 types in 1 pill should be selected. Patient empowerment can be useful in sharing decisions in goal setting, provision of feedback channels, self-monitoring, education, and motivation, which the use of telemedicine and mobile health technologies can assist.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"19 6","pages":"316-357"},"PeriodicalIF":0.9,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12919385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer potential of fused heterocycles: structural insights and mechanistic advances.","authors":"Aaysha Pandey, Shubham Sharma, Kamal Kishore, Swati Rani, Man Vir Singh, Gangotri Pemawat","doi":"10.2478/abm-2025-0035","DOIUrl":"https://doi.org/10.2478/abm-2025-0035","url":null,"abstract":"<p><p>β-lactam derivatives, carbazoles, isatin derivatives, pyrrolo-benzodiazepines (PBDs), and pyrido[2,3-d]pyrimidines have demonstrated potential as anticancer agents among organic compounds. They exhibit substantial anticancer efficacy across several cancer cell lines, such as HL-60, THP-1, U-937, HeLa, PANC1, MDA-MB-231, and A549 cell lines. These compounds display a significant anticancer profile via diverse biological pathways such as DNA interaction, kinase inhibition, microtubule disruption, and enzyme inhibition. Their low IC50 values across various cell lines suggest their viability as strong candidates for targeted and multi-mechanistic cancer therapy, warranting further in vivo and clinical exploration. This review thoroughly summarized the anticancer efficacy of <i>β</i>-lactam derivatives, carbazoles, isatins, PBDs, and pyrido[2,3-d]pyrimidine derivatives.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"19 6","pages":"358-374"},"PeriodicalIF":0.9,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12919380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial functional ingredients used in hand hygiene products: a cross-sectional survey on regional e-commerce platforms in Wuhan area of China.","authors":"Xintong Chen, Jun Wang","doi":"10.2478/abm-2025-0037","DOIUrl":"https://doi.org/10.2478/abm-2025-0037","url":null,"abstract":"<p><strong>Background: </strong>Hand hygiene products containing antimicrobial functional ingredients have become daily products for many people during the post-pandemic period. However, their current market scenarios have not been well explored.</p><p><strong>Objective: </strong>To provide an overview of antimicrobial functional ingredients in hand sanitizer products marketed to the public in Wuhan, China.</p><p><strong>Methods: </strong>This cross-sectional product survey was conducted in September 2023. Information about existing hand hygiene products available online for household use was obtained from 2 major local e-commerce platforms in the Wuhan area of China: Tmall Supermarket and Jingdong Supermarket.</p><p><strong>Results: </strong>A total of 674 hand sanitizer products were included in the survey, which were evenly divided into alcohol-based and alcohol-free sanitizers. More than 22 non-alcoholic compounds were used in alcohol-free hand sanitizer products, among which the top 5 major ingredients were benzalkonium chloride (BAC), iodine-based compounds, chloroxylenol (CX), hypochlorous acid, and polyhexamethylene biguanide. A majority (83.2%) of hand sanitizer products available on e-commerce platforms were single-ingredient formulations, with the remaining 16.8% containing sanitizers in combination. Triclosan (TCS)/triclocarban (TCC)-containing products accounted for 4.2% of all the included products and 8.3% of alcohol-free products; their recognized alternatives BAC/benzethonium chloride/CX had replaced the role of TCS/TCC in hand sanitization, especially in liquid hand rubs, antiseptic hand wipes, and liquid soaps. A total of 13 natural antimicrobial ingredients were identified in 2.1% of all the products.</p><p><strong>Conclusion: </strong>There was a booming and diversified hand sanitizer market in Wuhan, China during the post-pandemic era. A market shift from alcohol-based to alcohol-free hand sanitizers has emerged.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"19 6","pages":"383-393"},"PeriodicalIF":0.9,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12919381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}