Asian Biomedicine最新文献

{"title":"Machine learning models for predicting hepatocellular carcinoma development in patients with chronic viral hepatitis B infection.","authors":"Warissara Kuaaroon, Thodsawit Tiyarattanachai, Terapap Apiparakoon, Sanparith Marukatat, Natthaporn Tanpowpong, Sombat Treeprasertsuk, Rungsun Rerknimitr, Pisit Tangkijvanich, Prooksa Ananchuensook, Watcharasak Chotiyaputta, Kittichai Samaithongcharoen, Roongruedee Chaiteerakij","doi":"10.2478/abm-2025-0007","DOIUrl":"https://doi.org/10.2478/abm-2025-0007","url":null,"abstract":"<p><strong>Background: </strong>Chronic hepatitis B (CHB) infection is the major risk factor for hepatocellular carcinoma (HCC).</p><p><strong>Objective: </strong>To develop machine-learning models for predicting an individual risk of HCC development in CHB-infected patients.</p><p><strong>Methods: </strong>Machine learning models were constructed using features from follow-up visits of CHB patients to predict the diagnosis of HCC development within 6 months after each index follow-up. We developed 4 model variants using all features, with alpha fetoprotein (AFP) (<i>AF ^A</i> ) and without AFP (<i>AF^N</i> ); and selected features, with AFP (<i>SF ^A</i> ) and without AFP (<i>SF^N</i> ). Performance was evaluated using 10-fold cross-validation on a derivation cohort and further validated on an independent cohort.</p><p><strong>Results: </strong>In the derivation cohort of 2,382 patients, of whom 117 developed HCC, <i>AF^A</i> achieved higher sensitivity (0.634, 95% confidence interval [CI]: 0.559-0.708) and specificity (0.836; 0.830-0.842) than <i>AF ^N</i> (sensitivity 0.553; 0.476-0.630 and specificity 0.786; 0.779-0.792). <i>SF^A</i> also achieved higher sensitivity (0.683; 0.611-0.755 vs. 0.658; 0.585-0.732) and specificity (0.756; 0.749-0.763 vs. 0.744; 0.737-0.751) than <i>SF^N</i> . Performance of <i>SF^A</i> and <i>SF^N</i> were tested in another cohort of 162 patients in which 57 patients developed HCC. <i>SF^A</i> achieved sensitivity and specificity of 0.634 (0.522-0.746) and 0.657 (0.615-0.699), while sensitivity and specificity of <i>SF^N</i> were 0.690 (0.583-0.798) and 0.651 (0.609-0.693), respectively.</p><p><strong>Conclusion: </strong>The machine learning models demonstrate good performance for predicting short-term risk for HCC development and may potentially be used for tailoring surveillance interval for CHB patients.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"19 1","pages":"51-59"},"PeriodicalIF":0.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the mechanisms underlying air pollution-induced dysfunction of the oral-gut-brain axis: implications for human health and well-being.","authors":"Sisi Chen, Wenlei Yu, Yiwen Shen, Linjie Lu, Xiangyong Meng, Jun Liu","doi":"10.2478/abm-2025-0002","DOIUrl":"https://doi.org/10.2478/abm-2025-0002","url":null,"abstract":"<p><p>Air pollution exposure has become an international health issue that poses many risks to life and health. The bidirectional regulatory network, known as the oral-gut-brain axis connects the oral cavity, intestine, and central nervous system, as well as its influence on health outcomes from exposure to air pollution is receiving increased attention. This article systematically details the epidemiological evidence linking air pollutants to diseases affecting the oral, respiratory, intestinal, and nervous systems, while also explaining the route of air pollutants via the oral-gut-brain axis. The oral-gut-brain axis anomalies resulting from air pollution and their underlying molecular processes are also covered. The study provides a fresh viewpoint on how exposure to air pollution affects health and investigates cutting-edge preventative and therapeutic techniques.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"19 1","pages":"21-35"},"PeriodicalIF":0.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of photobiomodulation in response to the microcirculation in arteriovenous fistula for hemodialysis patient.","authors":"Yi-Ping Chang, Chuan-Tsung Su, Ya-Hui Hsieh, Fan-Chieh Meng, Jih-Huah Wu","doi":"10.2478/abm-2025-0005","DOIUrl":"https://doi.org/10.2478/abm-2025-0005","url":null,"abstract":"<p><strong>Background: </strong>Management of blood flow in arteriovenous fistula (AVF) is a critical clinical issue for hemodialysis (HD) patients.</p><p><strong>Objectives: </strong>To determine the effect of microcirculation of AVF in HD patients with photobiomodulation (PBM).</p><p><strong>Methods: </strong>Twenty HD patients were enrolled in this study. PBM was used to radiate the palm of HD patients at a total dose of 126 J, and the microcirculatory analysis in AVF was investigated.</p><p><strong>Results: </strong>Among the patients <65 years old, there is an increase of 2.31% and 1.37% in the average velocity and flux in AVF, respectively. This increase is higher than those observed in patients aged >65 years old. Additionally, the cumulative effect of the 830 nm laser was observed for at least 10 min, resulting in continuous increases of 3.16% in velocity and 1.59% in flux for HD patients <65 years old. On the contrary, the average velocity and flux in AVF increased in patients who had undergone HD for <6 years.</p><p><strong>Conclusions: </strong>In this study, the age and the duration of HD treatment are the two factors that influence microcirculation in HD patients with PBM. The results suggest that PBM could be used to improve the average velocity and flux in AVF, particularly for younger patients with shorter HD treatment durations.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"19 1","pages":"3-13"},"PeriodicalIF":0.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia: the need for early detection, early treatment, and the identification of sensitive measures for predicting treatment response.","authors":"","doi":"10.2478/abm-2025-0001","DOIUrl":"https://doi.org/10.2478/abm-2025-0001","url":null,"abstract":"","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"19 1","pages":"1-2"},"PeriodicalIF":0.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between blood cadmium levels and the risk of chronic kidney disease in Korea, based on the Korea National Health and Nutrition Examination Survey 2016-2017.","authors":"Jieun Yeon, Suji Kang, Jiyeon Park, Jin Hee Ahn, Eun-Ah Cho, Sung Hyun Lee, Kyoung-Ho Ryu, Jae-Geum Shim","doi":"10.2478/abm-2025-0004","DOIUrl":"https://doi.org/10.2478/abm-2025-0004","url":null,"abstract":"<p><strong>Background: </strong>Exposure to environmental cadmium can have harmful effects on the human kidneys. The relationship between the degree of exposure to cadmium and the risk of chronic kidney disease (CKD) in the general population is unclear.</p><p><strong>Objectives: </strong>To investigate the association between blood cadmium levels and CKD risk using samples from the Korea National Health and Nutrition Examination Survey (KNHANES) VII data, which included heavy metal and serum creatinine levels.</p><p><strong>Methods: </strong>We analyzed the data of 4,222 adults from January 1, 2016, to December 31, 2017. Multiple logistic regression analysis was conducted on weighted data using complex sampling to assess the relationship between blood cadmium levels and CKD. We performed a stratified analysis in the presence of comorbidities such as diabetes or hypertension.</p><p><strong>Results: </strong>There was a positive association between blood cadmium level and the risk of CKD in hypertensive or nondiabetic participants after adjustment, but not between blood cadmium level and CKD in normotensive or diabetic participants. The corresponding odds ratios (OR) of cadmium for CKD were 2.70 (95% confidence interval [CI], 1.49-4.90, <i>P</i> = 0.001) in samples with hypertension and 2.40 (95% CI, 1.56-3.70, <i>P</i> < 0.001) in samples without diabetes.</p><p><strong>Conclusions: </strong>Our findings suggest an association between blood cadmium level and the risk of CKD in hypertensive or nondiabetic participants. Additional research is necessary to elucidate the relationship between cadmium exposure and CKD risk, particularly in individuals with comorbidities.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"19 1","pages":"60-66"},"PeriodicalIF":0.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of dexpanthenol on 5-fluorouraci-induced nephrotoxicity, hepatotoxicity, and intestinal mucositis in rats: a clinical, biochemical, and pathological study.","authors":"Şeyma Taştemur, Mehmet Ekĭcĭ, Ali Sefa Mendĭl, Mustafa Özkaraca, Hilmi Ataseven","doi":"10.2478/abm-2025-0006","DOIUrl":"https://doi.org/10.2478/abm-2025-0006","url":null,"abstract":"<p><strong>Background: </strong>5-fluorouracil (5-FU) is a broad-spectrum drug that has a wide range of side effects. Patients may experience severe comorbidities as a result of these toxic side effects, making it impossible for them to continue chemotherapy. Despite the fact that various molecules have been experimented, there is no literature data on the efficacy of dexpanthenol (DXP) for mitigating the toxic effects of 5-FU.</p><p><strong>Objective: </strong>To investigate the protective effects of DXP on nephrotoxicity, hepatotoxicity, and intestinal toxicity induced by 5-FU in rats.</p><p><strong>Methods: </strong>Twenty-eight male Wistar-Albino rats aged 16 weeks were randomly assigned to four groups. We created a rat model of intestinal mucositis, nephrotoxicity, and hepatotoxicity through intraperitoneal 5-FU (35 mg/kg for 4 d) injection. 500 mg/kg and 1000 mg/kg of DXP were administered to the treatment groups. The effects of dexpanthenol were evaluated clinically, biochemically, histopathologically, and immunohistochemically (inducible nitric oxide synthase [iNOS], cyclooxygenase-2 [COX-2], 8-hydroxyguanosine [8-OHdG], and nuclear factor kappa B [NF-κB]).</p><p><strong>Results: </strong>5-FU caused a decrease in body weight and food intake, and an increase in diarrhea scores in rats. 5-FU led to significant disruptions in the hepatic biochemical markers (aspartate transaminase [AST], alanine transaminase [ALT], alkaline phosphatase [ALP], total bilirubin, direct bilirubin, and lactate dehydrogenase [LDH]), renal biochemical markers (blood urea nitrogen [BUN], creatinine, and uric acid), and protein and albumin, which are markers of both hepatic and renal functions. Severe pyknosis and mononuclear cell infiltrations were observed in the liver, and mononuclear cell infiltration and tubular degeneration in the kidneys. Jejunum and colon showed villous hyperemia and hemorrhage, respectively, along with mononuclear cell infiltration. Furthermore, 5-FU increased the immunohistochemical expressions of iNOS, COX-2, 8-OHdG, and NF-κB in the examined tissues. The administration of DXP at doses of 500 mg/kg and 1000 mg/kg demonstrated significant mitigation of the toxic effects induced by 5-FU on the liver, kidney, jejunum, and colon.</p><p><strong>Conclusion: </strong>DXP showed protective effects against nephrotoxicity, hepatotoxicity, and intestinal toxicity caused by 5-FU. These findings suggest that DXP may serve as a potential therapeutic agent to alleviate the severe side effects of 5-FU chemotherapy, thereby improving patient tolerance and quality of life. Further clinical studies are warranted to validate these results and explore the translational potential of DXP in human cancer therapy.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"19 1","pages":"36-50"},"PeriodicalIF":0.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into sarcopenia awareness among trainee physicians: a survey-based analysis of a university hospital, Thailand.","authors":"Manchumad Manjavong, Panita Limpawattana, Khanyanut Ojongpien, Nutwara Saengwijit, Prapassawan Tanlawan","doi":"10.2478/abm-2025-0003","DOIUrl":"https://doi.org/10.2478/abm-2025-0003","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenia is associated with a decline in functionality and disability among older adults. Extensive research has been conducted on the subject matter of sarcopenia; nevertheless, there is a paucity of studies documenting the extent to which practicing physicians are integrating sarcopenia into their clinical practice in the Asian context.</p><p><strong>Objectives: </strong>To examine trainee physicians' attitude and knowledge in sarcopenia and factors associated with higher scores on knowledge in sarcopenia.</p><p><strong>Methods: </strong>An electronic survey of trainee physicians of the Faculty of Medicine, Khon Kaen University, Thailand was conducted from November 2022 to December 2023. The survey consisted of questionnaires designed to assess both attitude and knowledge toward sarcopenia. All trainees were invited to participate, and the completed questionnaires were subsequently returned to the researchers for analysis.</p><p><strong>Results: </strong>A total of 211 trainees enrolled; most of them were familiar with \"sarcopenia\" (70.1%) but lack of confidence in diagnosis, prevention, and management. The total scores on general knowledge about sarcopenia were 22 out of 30 (73.3%). They scored well in the area of \"etiology\" (75%) and \"terminology and importance\" (70%) but fair in \"diagnosis\" (62.5%) and \"management and prevention\" (62.5%). The lower age of the trainee physicians, increased years of practice, and \"training in internal medicine\" were associated with higher scores.</p><p><strong>Conclusions: </strong>Trainee physicians were aware of the term \"sarcopenia\" but had limited knowledge in diagnosis, prevention, and management. Certain factors related to better scores on the knowledge evaluation were identified.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"19 1","pages":"14-20"},"PeriodicalIF":0.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2024 The Royal College of Physicians of Thailand (RCPT) clinical practice guidelines on management of dyslipidemia for atherosclerotic cardiovascular disease prevention.","authors":"Praween Lolekha, Weerapan Khovidhunkit, Chaicharn Deerochanawong, Nuntakorn Thongtang, Thananya Boonyasirinant, Chatchalit Rattarasarn, Aurauma Chutinet, Vuddhidej Ophascharoensuk, Nicha Somlaw, Surapun Sitthisook, Surajit Suntorntham, Wannee Nitiyanant, Rungroj Krittayaphong","doi":"10.2478/abm-2024-0033","DOIUrl":"10.2478/abm-2024-0033","url":null,"abstract":"<p><strong>Background: </strong>The Royal College of Physicians of Thailand (RCPT) published a Clinical Practice Guideline on Pharmacologic Therapy of Dyslipidemia for Atherosclerotic Cardiovascular Disease (ASCVD) Prevention in 2016. The availability of newer classes of medications for dyslipidemia, supported by extensive clinical research findings, indicates a significant need for the updating of the existing clinical practice guideline.</p><p><strong>Objectives: </strong>To serve as guidelines on the management of dyslipidemia for Thai adults.</p><p><strong>Methods: </strong>The RCPT Dyslipidemia Guidelines Committee was established with representatives from selected professional societies to revise the 2016 Guideline by critically reviewing the latest evidence. Meetings were conducted from August to December 2023, culminating in a public hearing that engaged various stakeholders in January 2024. The final Thai version received approval in April 2024, while the English translation was completed in October 2024.</p><p><strong>Results: </strong>Lifestyle modifications and statins remain the cornerstone of therapy for dyslipidemia in adults across various clinical settings. Emerging evidence regarding newer classes of lipid-lowering medications indicates that these treatments are effective in lowering LDL-cholesterol levels and reducing atherosclerotic cardiovascular events. This suggests that they may serve as an add-on therapy for individuals who cannot achieve target levels or who are at high risk for future cardiovascular events. The Thai CV Risk Score is recommended due to its specificity for the Thai population.</p><p><strong>Conclusions: </strong>The 2024 updated clinical practice guidelines establish a framework, provide recommendations, and serve as a comprehensive resource for the contemporary management of dyslipidemia in adults, with the goal of preventing ASCVD in Thailand.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"18 6","pages":"246-267"},"PeriodicalIF":0.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of radiofrequency ablation for secondary hyperparathyroidism: a systematic review and meta-analysis.","authors":"Mengyuan Li, Hongwei Jiang, Yunchang Wang, Fujun Li","doi":"10.2478/abm-2024-0036","DOIUrl":"10.2478/abm-2024-0036","url":null,"abstract":"<p><strong>Background: </strong>Secondary hyperparathyroidism (SHPT) is a common complication of chronic kidney disease (CKD) that affects approximately 90% of end-stage renal disease and poses a significant threat to long-term survival and quality of life in patients.</p><p><strong>Objectives: </strong>To assess whether radiofrequency ablation (RFA) is a productive and low-risk treatment for hyperparathyroidism secondary to CKD.</p><p><strong>Methods: </strong>Embase, Web of Science, Cochrane Library, and PubMed were searched independently by two authors. The results after RFA and baseline biochemical indicators were compared, and parathyroid hormone (PTH), serum calcium, and serum phosphorus levels were the major outcomes.</p><p><strong>Results: </strong>Four retrospective studies were screened out from 147 original literature and involved 118 cases. After RFA, serum PTH levels (1 d standardized mean difference [SMD] = -2.30, 95% confidence interval [CI] = from -3.04 to -1.56, <i>P</i> < 0.0001; 6 months SMD = -2.15, 95% CI = from -3.04 to -1.26, <i>P</i> < 0.0001; 12 months SMD = -2.35, 95% CI = from -3.52 to -1.17, <i>P</i> < 0.0001), serum calcium levels (1 d SMD = -1.49, 95% CI = from -2.18 to -0.81, <i>P</i> = 0.0001; 6 months SMD = -1.09, 95% CI = from -1.51 to -0.68, <i>P</i> < 0.0001), and serum phosphorus levels (1 d SMD = -1.37, 95% CI = from -1.67 to -1.07, <i>P</i> < 0.0001; 6 months SMD = -1.06, 95% CI = from -1.35 to -0.78, <i>P</i> < 0.0001) decreased significantly.</p><p><strong>Conclusions: </strong>RFA, the newest thermal ablation technique, can effectively and safely treat hyperparathyroidism secondary to CKD. Hoarseness is the most common complication but is reversed within 6 months.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"18 6","pages":"287-296"},"PeriodicalIF":0.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of blood thiosulfate produced by postmortem changes for the diagnosis of hydrogen sulfide poisoning in forensic autopsy.","authors":"Masaaki Suzuka, Shigeki Jin, Akiko Takeuchi, Manabu Murakami, Keiko Takahashi, Kotaro Matoba","doi":"10.2478/abm-2024-0035","DOIUrl":"10.2478/abm-2024-0035","url":null,"abstract":"<p><strong>Background: </strong>Thiosulfate concentration in blood is an important indicator for the diagnosis of hydrogen sulfide poisoning. It may also be detected at high levels in postmortem decomposition cases.</p><p><strong>Objectives: </strong>To determine the effect of postmortem decomposition on blood thiosulfate concentration and define precautions for diagnosing hydrogen sulfide poisoning based on thiosulfate concentration.</p><p><strong>Methods: </strong>A total of 57 cadavers (37 males and 20 females) of non-hydrogen sulfide poisoning-related deaths that underwent forensic autopsy in our department between 2016 and 2019 were classified into the non-decomposed (19 cases), partially decomposed (19 cases), and severely decomposed (19 cases) groups based on forensic findings. Blood samples collected from each case were analyzed for thiosulfate concentration using liquid chromatography-tandem mass spectrometry.</p><p><strong>Results: </strong>The mean concentration of thiosulfate detected in the blood was 70.9 (10.5-266.6) μmol/L in the severely decomposed group, 16.3 (0.1-52.7) μmol/L in the partially decomposed group, and 1.1 (0.1-3.6) μmol/L in the non-decomposed group. There was a statistically significant difference between each of the 3 groups (<i>P</i> < 0.01).</p><p><strong>Conclusions: </strong>Previous studies have reported a blood thiosulfate concentration of >14 μmol/L in hydrogen sulfide poisoning cases and <4 μmol/L in normal cases. Thus, thiosulfate concentration is believed to have a significant impact on the diagnosis of hydrogen sulfide poisoning. This study revealed that postmortem decomposition produced thiosulfate in the blood, and the concentration of thiosulfate was often as high as that observed in cases of hydrogen sulfide poisoning-related death. In addition to cases of advanced decomposition, an increase in thiosulfate concentration was also observed in cases of partial decomposition. Therefore, when measuring thiosulfate concentration as an indicator of hydrogen sulfide poisoning, it is necessary to carefully consider the influence of decomposition.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"18 6","pages":"281-286"},"PeriodicalIF":0.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}