Asian Biomedicine最新文献

{"title":"Multivariable analysis of clinical and laboratory data manifestations predicting severity and mortality risk in patients with Coronavirus disease 2019 in the mountainous west of Iran: a retrospective single-center study.","authors":"Zahra Naderi Beni,&nbsp;Afsaneh Naderi Beni,&nbsp;Fereidoun Rahmani Samani,&nbsp;Mohammad Ali Dayani,&nbsp;Fariba Naderi Beni,&nbsp;Hamed Radmehr,&nbsp;Pegah Noorshargh","doi":"10.2478/abm-2022-0005","DOIUrl":"https://doi.org/10.2478/abm-2022-0005","url":null,"abstract":"<p><strong>Background: </strong>Few reports have addressed the clinical and laboratory features of patients with coronavirus disease-2019 (COVID-19) in mountainous areas, especially in Iran.</p><p><strong>Objectives: </strong>To report the clinical and laboratory data and manifestations predicting mortality of patients with COVID-19 in the west of Iran.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of 286 patients hospitalized with COVID-19 between 25 February 2020 and 12 May 2020 to describe their clinical symptoms and laboratory test findings when they were admitted at the Hajar Hospital affiliated with the Shahrekord University of Medical Sciences, and a multivariable analysis of factors that predict their disease severity and mortality.</p><p><strong>Results: </strong>After hospital admission, 18 patients died and 268 were discharged. Older age [odds ratio (OR) = 1.02, 95% confidence interval (CI) = 1.01-1.04, <i>P</i> = 0.001], presence of underlying diseases (OR = 1.86, 95% CI = 1.01-3.45, <i>P</i> = 0.04), elevated hematocrit (OR = 1.08, 95% CI = 1.03-1.13, <i>P</i> = 0.002), and increase in red blood cell distribution width (RDW) coefficient of variation (OR = 1.18, 95% CI = 1.02-1.36, <i>P</i> = 0.02) were significantly associated with disease severity. Older age (OR = 1.00, 95% CI = 1.00-1.07, <i>P</i> = 0.03), hypocalcemia (OR = 0.20, 95% CI = 0.09-0.58, <i>P</i> = 0.002), hypophosphatemia (OR = 0.50, 95% CI = 0.26-1.02, <i>P</i> = 0.04), and increase in platelet-larger cell ratio (P-LCR; OR = 1.10, 95% CI = 1.00-1.15, <i>P</i> = 0.04) were significantly associated with mortality. The areas under the receiver operating characteristic curves were as follows: calcium 0.759; lactate dehydrogenase (LDH) 0.731; phosphorus 0.725; bilirubin 0.689; C-reactive protein 0.679; and RDW - standard deviation (RDW-SD) 0.624.</p><p><strong>Conclusions: </strong>Those who did not survive tended to be elderly and had a greater incidence of comorbidities. Elevated LDH, decreased levels of calcium and phosphorus, and anemia at diagnosis were associated with greater risk of death for these Iranian patients hospitalized with COVID-19. Regular assessment of these markers would help to manage patients with COVID-19.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9959378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Propofol effects in rodent models of traumatic brain injury: a systematic review.","authors":"Riyadh Firdaus,&nbsp;Sandy Theresia,&nbsp;Ryan Austin,&nbsp;Rani Tiara","doi":"10.2478/abm-2021-0032","DOIUrl":"https://doi.org/10.2478/abm-2021-0032","url":null,"abstract":"<p><strong>Background: </strong>Traumatic brain injury (TBI) causes high mortality and disability worldwide. Animal models have been developed to explore the complex processes in TBI. Propofol is used to manage head injuries during surgical intervention and mechanical ventilation in patients with TBI. Many studies have investigated the neuroprotective effect of propofol on TBI. However, other studies have shown neurotoxic effects.</p><p><strong>Objectives: </strong>To review systematically the literature regarding the neuroprotective and neurotoxic effects of propofol in rodent models of TBI.</p><p><strong>Methods: </strong>Data from rodents as models of TBI with propofol as one of the intervention agents, and/or comparing the neuroprotective effects of propofol with the other substances in rodent models of TBI, were obtained from PubMed, EBSCO Host, and ProQuest databases. The PRISMA 2020 statement recommendations were followed and research questions were developed based on PICOS guidelines. Data was extracted from the literature using a standardized Cochrane method.</p><p><strong>Results: </strong>We analyzed data from 12 articles on physiological changes of experimental animals before and after trauma, the effects of propofol administration, and the observed neurotoxic effects. The effects of propofol administration were observed in terms of changes in traumatic lesion volume, the release of antioxidants and inflammatory factors, and the neurological function of rodent models of TBI.</p><p><strong>Conclusion: </strong>Propofol has neuroprotective and neurotoxic effects via several mechanisms, and various doses have been used in research to determine its effects. The timing of administration, the dose administered, and the duration of administration contribute to determine the effect of propofol in rodent models of TBI. However, the doses that produce neuroprotective and neurotoxic effects are not yet clear and further research is needed to determine them.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9960150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraventricular tuberculosis abscess in an immunocompromised patient: clinical vignette.","authors":"Mohamad Hanafiah,&nbsp;Shahizon A Mohamed Mukhari,&nbsp;Aida M Mustapha,&nbsp;Nazimah Ab Mumin","doi":"10.2478/abm-2021-0036","DOIUrl":"https://doi.org/10.2478/abm-2021-0036","url":null,"abstract":"<p><p>Tuberculosis is caused by <i>Mycobacterium tuberculosis</i>. Tuberculosis of the central nervous system is common and manifestations include meningeal and intraparenchymal diseases. However, intraventricular tuberculous abscess is a rare manifestation of intracranial tuberculous infection. We present a case of an immunocompromised female patient with high-grade fever and signs of meningism. The computed tomography and magnetic resonance imaging (MRI) of the brain showed hydrocephalus with rim-enhancing lesion in the right lateral ventricle. The MRI demonstrated a hypointense signal on T1-weighted imaging, hyperintense signal on T2-weighted imaging, and mild restricted diffusion in diffusion-weighted imaging. She underwent emergency external ventricular drainage and frank pus was drained. Diagnosis of tuberculosis was made via polymerase chain reaction analysis and culture. Understanding the intracranial manifestation of neurotuberculosis is imperative to arrive at the diagnosis correctly and ensure prompt treatment.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10013539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and attitude of dental professionals toward COVID-19 in Riyadh, Saudi Arabia: a cross-sectional survey.","authors":"Darshan Devang Divakar,&nbsp;Shruti Basavaraj Nimbeni,&nbsp;Abdulaziz A Al-Kheraif,&nbsp;Aftab Ahmed Khan,&nbsp;Sachin Naik,&nbsp;Sanjeev Balappa Khanagar,&nbsp;Chitra Jhugroo,&nbsp;Basavaraj Nimbeni","doi":"10.2478/abm-2021-0034","DOIUrl":"https://doi.org/10.2478/abm-2021-0034","url":null,"abstract":"<p><strong>Background: </strong>Coronavirus disease-2019 (COVID-19) is a life-threatening global pandemic. The dental profession is considered a high-risk group in the transmission of the responsible virus.</p><p><strong>Objective: </strong>To assess the knowledge and attitude among dental professionals in response to the COVID-19 pandemic.</p><p><strong>Methods: </strong>We conducted a cross-sectional study of dental graduates, interns, postgraduates, and dental faculty from May to July 2020. A standardized questionnaire was developed to assess knowledge and attitude of 650 participants. The questionnaire comprised 14 questions to assess general knowledge about COVID-19, 11 questions regarding knowledge about prevention of COVID-19 in dental practice, and 10 questions regarding the attitude toward preventing COVID-19.</p><p><strong>Results: </strong>Among the study population, only 376 (57.8%) knew the causative virus for COVID-19. Only 425 (65.3%) knew about rinsing the mouth with an antimicrobial solution or 1% hydrogen peroxide before the dental procedure. Regarding the hand hygiene guidelines, 357 (54.9%) had knowledge of the Centers for Disease Control and Prevention (CDC) and 377 (58.0%) about World Health Organization (WHO) guidelines. At the time of our survey, 72% of the participants showed sufficient knowledge, while 28% had low or insufficient knowledge about COVID-19.</p><p><strong>Conclusion: </strong>While there was a lack of knowledge among dental professionals in Riyadh, Saudi Arabia about COVID-19, there was an excellent positive attitude toward preventing disease. Greater awareness is needed to control the spread of this disease.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9960147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulatory roles of lncRNA <i>PANDAR</i> in breast cancer cell proliferation.","authors":"Qinnuan Sun,&nbsp;Xiumei Wang","doi":"10.2478/abm-2021-0035","DOIUrl":"https://doi.org/10.2478/abm-2021-0035","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer represents the second most deadly malignancy in women, and long noncoding RNAs (lncRNAs) have crucial functions in its development.</p><p><strong>Objective: </strong>To investigate effects of the promoter of <i>CDKN1A</i> antisense DNA damage-activated RNA (<i>PANDAR</i>) on epithelial-mesenchymal transition (EMT) in breast cancer cells and their proliferation.</p><p><strong>Methods: </strong>lncRNAs potentially regulating the transcriptional activity of the E-cadherin (E-cad, an epithelial cell marker) gene promoter were screened using a dual-luciferase reporter assay. <i>PANDAR</i> was overexpressed in Michigan cancer foundation 7 (MCF-7) breast cancer cells. E-cad and N-cadherin (N-cad, a mesenchymal cell marker) levels were detected by immunoblotting. Cell viability was assessed using a cell counting kit-8.</p><p><strong>Results: </strong><i>PANDAR</i> and <i>TCONS00068220</i>/<i>LOC105375819</i> conservatively regulated the promoter activity of <i>E-cad</i>. <i>PANDAR</i> overexpression in MCF-7 inhibited E-cad expression, but upregulated N-cad. The enhanced expression of <i>PANDAR</i> promoted cell proliferation.</p><p><strong>Conclusion: </strong><i>PANDAR</i> is a key transcriptional repressor of <i>E-cad</i> and has regulatory effects on the promotion of cell proliferation. <i>PANDAR</i> is an oncogene in breast cancer, potentially facilitating the EMT process and promoting cell proliferation.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9962152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital heart disease: magnitude of problem and possible interventions.","authors":"","doi":"10.2478/abm-2021-0031","DOIUrl":"https://doi.org/10.2478/abm-2021-0031","url":null,"abstract":"","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9960148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental risk factors associated with congenital heart disease in a Thai population: multivariable analysis.","authors":"Chayamon Suwansumrit,&nbsp;Worawan Jittham","doi":"10.2478/abm-2021-0033","DOIUrl":"https://doi.org/10.2478/abm-2021-0033","url":null,"abstract":"<p><strong>Background: </strong>Congenital heart diseases (CHDs) are the most common types of birth defects and contribute to a large proportion of infant morbidities and mortalities worldwide. These defects may require multiple surgical interventions impacting the infant's quality of life.</p><p><strong>Objectives: </strong>To identify risk factors associated with CHD in a population of Thai children.</p><p><strong>Methods: </strong>We conducted a case-control study of patients attending the Pediatric Clinic, Naresuan University Hospital, Thailand. We included data from pediatric patients diagnosed with CHDs as cases, and patients without cardiovascular abnormalities as controls. Risk data were collected from July 2019 to April 2020 using face-to-face interviews. Multiple logistic regression was used to analyze parental factors associated with CHDs.</p><p><strong>Results: </strong>We included 249 cases classified into 2 groups according to severity and 304 patients as controls. For those less-severely affected (155 patients, 62.2%), ventricular septal defect (27.7%) was the most prevalent, whereas for those with severe CHDs, tetralogy of Fallot was the most prevalent (14.0%). There was no difference in sex distribution or maternal obstetric history between the groups. In multivariable analysis, a family history of CHDs (adjusted odds ratio [AOR] 4.67, 95% confidence interval (CI) 1.61-13.57, <i>P</i> = 0.005) and maternal exposure to second-hand cigarette smoke (AOR 1.58, 95% CI 1.03-2.42, <i>P</i> = 0.002) were identified as significant risk factors for CHDs.</p><p><strong>Conclusion: </strong>A family history of CHDs and maternal exposure to second-hand cigarette smoke are associated with having offspring with CHDs in the population studied. These findings help us to encourage affected parents to obtain a fetal echocardiogram.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9960149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low bone mineral density in Thai children with systemic lupus erythematosus: prevalence and risk factors.","authors":"Ankanee Chanakul,&nbsp;Suriyaphon Khunrattanaphon,&nbsp;Tawatchai Deekajorndech","doi":"10.2478/abm-2021-0030","DOIUrl":"https://doi.org/10.2478/abm-2021-0030","url":null,"abstract":"<p><strong>Background: </strong>Improvement of disease recognition and management has increased the survival of children with systemic lupus erythematosus (SLE), but has shifted the morbidity focus toward long-term complications, such as low bone mass and osteoporosis. Studies in adults with SLE show older age, chronic inflammation, and corticosteroid therapy are risk factors for low bone mineral density (BMD) and osteoporosis.</p><p><strong>Objectives: </strong>To determine the prevalence of and identify risk factors associated with low BMD in Thai children with SLE.</p><p><strong>Methods: </strong>We conducted a retrospective review of demographic data and clinical variables for a cohort of 60 Thai children with SLE who underwent 2 dual-energy X-ray absorptiometry (DXA) at their initial examination and later follow-up. We considered a BMD <i>z</i> score ≤ -2.0 to indicate low BMD. Binary logistic regression was used to assess risk factors potentially associated with low BMD.</p><p><strong>Results: </strong>The prevalence of low BMD at the first visit was 40% and increased to 55% over follow-up. We found a significantly decreased hip BMD <i>z</i> score (median difference -0.25, 95% confidence interval [CI] -0.40 to -0.05; <i>P</i> = 0.016) and lumbar BMD <i>z</i> score (median difference -0.49, 95% CI -0.69 to -0.28; <i>P</i> < 0.001) over time. The cumulative steroid dose tended to be higher for patients with low BMD (adjusted odds ratio [OR] = 1.08, 95% CI 1.00 to 1.17; <i>P</i> = 0.050).</p><p><strong>Conclusion: </strong>Low BMD has a 40% prevalence in Thai children newly diagnosed with SLE and progresses significantly over time. Higher cumulative corticosteroid dose tended to be associated with a low BMD, but we did not find a significant risk in this small sample.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9959367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydraulic expansion facilitates remodeling of arteriovenous fistulas without increasing venous intimal hyperplasia in rabbits.","authors":"Wanjun Ren,&nbsp;Jiyuan Niu,&nbsp;Yuejuan Du,&nbsp;Huili Jiang","doi":"10.2478/abm-2021-0028","DOIUrl":"https://doi.org/10.2478/abm-2021-0028","url":null,"abstract":"<p><strong>Background: </strong>An arteriovenous fistula (AVF) is considered essential for chronic hemodialysis.</p><p><strong>Objective: </strong>To determine the effects of hydraulic expansion on the intimal hyperplasia of an AVF.</p><p><strong>Methods: </strong>We divided 12 healthy male New Zealand white rabbits into a control group (vein without special handling and direct anastomosis with an artery, n = 6) and a hydraulic expansion group (vein dilated by hydraulic pressure before anastomosis, n = 6). Histopathomorphology was examined with hematoxylin and eosin staining and immunohistochemistry. Analysis of covariance (ANCOVA) was used to compare the data between the groups.</p><p><strong>Results: </strong>Immediately and 1 day after surgery, the diameter of the fistula vein in rabbits in the hydraulic expansion group was significantly larger than it was in the control group (<i>P</i> = 0.02 and 0.03 respectively), but not on subsequent days. After hydraulic expansion and before construction of the fistula, the wall of vein was noticeably thinner on macroscopic observation, and the anterior and posterior walls were indistinguishable. At 3 weeks after surgery in the hydraulic expansion group, cells in the vein wall were disordered, there were fewer elastic fibers, tissues from the endothelium to tunica externa were less dense, and there was less extracellular matrix than in the control group. Expression of connective tissue growth factor in the hydraulic expansion group was significantly less than that in the control group (<i>P</i> = 0.01). No differences were found in intimal thickness or immunohistochemistry scores for transforming growth factor-β1 between the groups.</p><p><strong>Conclusion: </strong>Hydraulic expansion did not increase intimal hyperplasia of an AVF, but facilitates remodeling of AVFs in rabbits.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10013545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the burden of dengue among household members in Alaminos, Laguna, the Philippines: a prospective cohort study.","authors":"Maria Rosario Capeding,&nbsp;Melanie de Boer,&nbsp;Silvia Damaso,&nbsp;Adrienne Guignard","doi":"10.2478/abm-2021-0027","DOIUrl":"https://doi.org/10.2478/abm-2021-0027","url":null,"abstract":"<p><strong>Background: </strong>The incidence of dengue is increasing rapidly and is a challenging health issue in the Philippines. Epidemiological data are largely based on a passive-surveillance reporting system, which leads to substantial under-reporting of cases.</p><p><strong>Objectives: </strong>To estimate dengue infection and disease incidence prospectively at the community level in an endemic area of the Philippines using an active surveillance strategy.</p><p><strong>Methods: </strong>We implemented active surveillance in the highly endemic community of Alaminos, Laguna. The study consisted of a 1-year follow-up with 2 visits scheduled at the start and end of the study, as well as regular active surveillance in between and unscheduled visits for suspected cases. Blood samples were collected and analyzed to detect dengue during the first scheduled visit and all unscheduled visits, and clinical examination was performed at all visits (registered at clinicaltrials.gov NCT02766088).</p><p><strong>Results: </strong>We enrolled 500 participants, aged from 6 months to 50 years; 76.2% were found positive for immunoglobulin G (95% confidence interval [CI], 71.9-80.0), with 92.0% among those aged 9-17 years. Active (weekly) surveillance identified 4 virologically confirmed cases of dengue (incidence proportion 0.8; 95% CI 0.3-2.1); all in participants aged ≤14 years.</p><p><strong>Conclusions: </strong>Routine surveillance programs such as sentinel sites are needed to characterize the entire clinical spectrum of symptomatic dengue, disease incidence, and transmission in the community.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10013542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}