Bacterial isolates and their antimicrobial susceptibility profile of superficial and deep-seated skin and soft tissue infections.

IF 0.4 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Asian Biomedicine Pub Date : 2023-04-01 DOI:10.2478/abm-2023-0045

Rao Muhammad Abid Khan, Sunil Kumar Dodani, Ali Nadeem, Sana Jamil, Mirza Naqi Zafar

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引用次数: 2

Abstract

Background: Skin and soft tissue infections (SSTIs) are caused by microbial invasion of healthy or damaged skin. SSTIs are difficult to manage and contribute to chronicity and emergence of antimicrobial resistance.

Objectives: To ascertain the prevalence of bacteria causing SSTIs and their antimicrobial susceptibility patterns.

Methods: A prospective study between November 2020 and May 2021. A total of 447 samples from SSTIs were analyzed.

Results: A total of 347 samples revealed mono-bacterial growth, of which 67% were male. SSTIs are common among patients aged 21-50 years with the dominance (78%) of gram-negative rods (GNRs). Escherichia coli (36%), Klebsiella spp. (22%), Staphylococcus aureus (16%), and Pseudomonas aeruginosa (11%) were predominant organisms. GNRs were highly resistant (>65%) to ciprofloxacin and trimethoprim-sulfamethoxazole. For injectable antibiotics, the highest resistance was determined against ceftriaxone, and the least resistance was determined against amikacin. Resistance against carbapenem was the highest among P. aeruginosa (53%) and Klebsiella spp. (32%). S. aureus showed the highest resistance against ciprofloxacin, and the least resistance was determined against clindamycin. Of 57 S. aureus isolates, 86% isolates were methicillin-resistant Staphylococcus aureus (MRSA). All isolates of P. aeruginosa and S. aureus were sensitive to polymyxin B and vancomycin, respectively. The prevalence of multidrug-resistant E. coli and Klebsiella spp. was higher among deep-seated SSTIs (dSSTIs).

Conclusions: The predominant etiology of SSTIs is GNR. Currently, there is very high resistance against oral antibiotics. Antimicrobial resistance against carbapenem has also increased. Moreover, there is a high frequency of MRSA. MDR E. coli and Klebsiella spp. isolates are frequently involved in dSSTIs.

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浅表和深层皮肤和软组织感染的细菌分离株及其抗生素敏感性分析。

背景:皮肤和软组织感染(SSTIs)是由微生物侵入健康或受损皮肤引起的。性传播感染难以控制，并导致抗菌素耐药性的长期性和出现。目的:了解引起SSTIs的细菌的流行情况及其药敏模式。方法:2020年11月至2021年5月进行前瞻性研究。共分析了447份ssti样本。结果:共有347份样本发现单细菌生长，其中男性占67%。ssti常见于21-50岁的患者，其中革兰氏阴性棒(gnr)占主导地位(78%)。优势菌为大肠杆菌(36%)、克雷伯氏菌(22%)、金黄色葡萄球菌(16%)和铜绿假单胞菌(11%)。gnr对环丙沙星和甲氧苄啶-磺胺甲恶唑高度耐药(>65%)。注射用抗生素中，头孢曲松耐药最高，阿米卡星耐药最低。铜绿假单胞菌(P. aeruginosa)和克雷伯菌(Klebsiella spp)对碳青霉烯的耐药率最高(53%)。金黄色葡萄球菌对环丙沙星的耐药性最高，对克林霉素的耐药性最低。57株金黄色葡萄球菌中，86%为耐甲氧西林金黄色葡萄球菌(MRSA)。铜绿假单胞菌和金黄色葡萄球菌分别对多粘菌素B和万古霉素敏感。多重耐药大肠杆菌和克雷伯氏菌的流行率在深层感染中较高。结论:GNR是SSTIs的主要病因。目前，对口服抗生素的耐药性非常高。对碳青霉烯的抗菌素耐药性也有所增加。此外，耐甲氧西林金黄色葡萄球菌的发病率很高。耐多药大肠杆菌和克雷伯氏杆菌分离株经常涉及dssti。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Biomedicine 医学-医学：研究与实验

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Asian Biomedicine: Research, Reviews and News (ISSN 1905-7415 print; 1875-855X online) is published in one volume (of 6 bimonthly issues) a year since 2007. [...]Asian Biomedicine is an international, general medical and biomedical journal that aims to publish original peer-reviewed contributions dealing with various topics in the biomedical and health sciences from basic experimental to clinical aspects. The work and authorship must be strongly affiliated with a country in Asia, or with specific importance and relevance to the Asian region. The Journal will publish reviews, original experimental studies, observational studies, technical and clinical (case) reports, practice guidelines, historical perspectives of Asian biomedicine, clinicopathological conferences, and commentaries Asian biomedicine is intended for a broad and international audience, primarily those in the health professions including researchers, physician practitioners, basic medical scientists, dentists, educators, administrators, those in the assistive professions, such as nurses, and the many types of allied health professionals in research and health care delivery systems including those in training.