Polymorphism of fucosyltransferase 3 gene is associated with inflammatory bowel disease: a systematic review.

IF 0.4 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Asian Biomedicine Pub Date : 2023-04-01 DOI:10.2478/abm-2023-0044

Jiansheng Zheng, Tang Zhu

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引用次数: 0

Abstract

Background: Inflammatory bowel disease (IBD) is a condition with an unclear genetic basis. Fucosyltransferase 3 (FUT3) could potentially be linked to IBD susceptibility.

Objective: To investigate the association between FUT3 gene polymorphisms and IBD.

Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 checklist and Population, Intervention, Comparison, Outcomes, and Study (PICOS) guidelines, case-control studies published until April 30, 2020 was searched. Two independent reviewers conducted screening, data extraction, and quality assessment using the Newcastle-Ottawa Scale. Meta-analysis, sensitivity analysis, and Egger tests were performed using RevMan and Stata12.0.

Results: The review included 5 articles and 12 case-control studies involving 1712 IBD patients and 1903 controls. The meta-analysis revealed the following combined odds ratios [95% confidence intervals]: rs3745635 genotype (GA+AA vs GG) 0.84 (0.72-0.97), (GG+GA vs AA) 1.93 (1.23-3.05), (GG vs AA) 2.38 (1.52-3.74), (A vs G) 0.84 (0.73-0.96); rs3894326 genotype (TA+AA vs TT) 1.03 (0.87-1.23), (TT+TA vs AA) 1.19 (0.56-2.51), (TT vs AA) 1.19 (0.56-2.51), (A vs T) 1.02 (0.86-1.20); rs28362459 genotype (TG+GG vs TT) 0.98 (0.85-1.12), (TT+TG vs GG) 1.20 (0.90-1.61), (TT vs GG) 1.21 (0.90-1.62), (G vs T) 0.96 (0.86-1.07). Sensitivity analysis indicated the stability of the results, and Egger analysis showed no significant publication bias.

Conclusions: The rs3745635 gene polymorphism may be associated with IBD susceptibility, whereas the rs3894326 and rs28362459 gene polymorphisms may not be associated with IBD.

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focusyltransferase 3基因多态性与炎症性肠病相关:一项系统综述

背景:炎症性肠病(IBD)是一种遗传基础不明确的疾病。focusyltransferase 3 (FUT3)可能与IBD易感性有关。目的:探讨FUT3基因多态性与IBD的关系。方法:根据系统评价和荟萃分析首选报告项目(PRISMA) 2020清单和人群、干预、比较、结果和研究(PICOS)指南，检索截至2020年4月30日发表的病例对照研究。两名独立审稿人使用纽卡斯尔-渥太华量表进行筛选、数据提取和质量评估。采用RevMan和Stata12.0进行meta分析、敏感性分析和Egger检验。结果:纳入5篇文献和12项病例对照研究，涉及1712例IBD患者和1903例对照。meta分析显示，rs3745635基因型(GA+AA vs GG)的组合优势比为0.84 (0.72-0.97)，(GG+GA vs AA) 1.93 (1.23-3.05)， (GG vs AA) 2.38 (1.52-3.74)， (A vs G) 0.84 (0.73-0.96);rs3894326基因型(TA+AA对TT) 1.03(0.87 ~ 1.23)、(TT+TA对AA) 1.19(0.56 ~ 2.51)、(TT对AA) 1.19(0.56 ~ 2.51)、(A对T) 1.02 (0.86 ~ 1.20);rs28362459基因型(TG+GG vs TT) 0.98 (0.85-1.12)， (TT+TG vs GG) 1.20 (0.90-1.61)， (TT vs GG) 1.21 (0.90-1.62)， (G vs T) 0.96(0.86-1.07)。敏感性分析显示结果的稳定性，Egger分析显示没有明显的发表偏倚。结论:rs3745635基因多态性可能与IBD易感性相关，而rs3894326和rs28362459基因多态性可能与IBD易感性无关。

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来源期刊

Asian Biomedicine 医学-医学：研究与实验

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Asian Biomedicine: Research, Reviews and News (ISSN 1905-7415 print; 1875-855X online) is published in one volume (of 6 bimonthly issues) a year since 2007. [...]Asian Biomedicine is an international, general medical and biomedical journal that aims to publish original peer-reviewed contributions dealing with various topics in the biomedical and health sciences from basic experimental to clinical aspects. The work and authorship must be strongly affiliated with a country in Asia, or with specific importance and relevance to the Asian region. The Journal will publish reviews, original experimental studies, observational studies, technical and clinical (case) reports, practice guidelines, historical perspectives of Asian biomedicine, clinicopathological conferences, and commentaries Asian biomedicine is intended for a broad and international audience, primarily those in the health professions including researchers, physician practitioners, basic medical scientists, dentists, educators, administrators, those in the assistive professions, such as nurses, and the many types of allied health professionals in research and health care delivery systems including those in training.