Comparison of clinicopathological parameters with the presence of Epstein-Barr virus and the absence of DNA mismatch repair proteins in gastric adenocarcinomas.
{"title":"Comparison of clinicopathological parameters with the presence of Epstein-Barr virus and the absence of DNA mismatch repair proteins in gastric adenocarcinomas.","authors":"Özge Eyeoğlu, Serra Kayaçetin","doi":"10.2478/abm-2025-0011","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>High mortality and poor prognosis are seen in gastric adenocarcinomas (GAs). Therefore, investigation of the factors related to GA prognosis is important.</p><p><strong>Objective: </strong>To investigate the association between clinicopathological parameters and DNA mismatch repair (MMR) proteins as well as Epstein-Barr virus (EBV) in GAs.</p><p><strong>Methods: </strong>Expression of MMR proteins and EBV positivity of 77 patients diagnosed with GA were evaluated using immunohistochemistry. Survival data of the patients were also considered.</p><p><strong>Results: </strong>Significant correlations were found between EBV positivity and gender, perineural invasion (PNI), and histological type. PNI was less common in EBV-positive patients, and EBV positivity was highly correlated with lymphoid stromal adenocarcinoma. Tumor budding was significantly correlated with histological type and grade, lymphovascular invasion (LVI), PNI, lymph node metastasis, and post-diagnosis survival time. Moreover, tumor-stroma ratio was correlated with tumor stage. Additionally, tumor location, histological grade, tumor budding, PNI, and pathological stage were associated with survival. Also, EBV positivity was significantly associated with histological type, PNI, tumor location, and gender. However, MMR and EBV positivity were not significantly correlated to tumor microenvironment and prognosis. It was noteworthy that the mortality rate was much higher in patients with PNI compared with those without PNI.</p><p><strong>Conclusion: </strong>Our findings support that the tumor microenvironment is significantly associated with GA prognosis.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":"19 2","pages":"86-93"},"PeriodicalIF":0.9000,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189990/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Biomedicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2478/abm-2025-0011","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Background: High mortality and poor prognosis are seen in gastric adenocarcinomas (GAs). Therefore, investigation of the factors related to GA prognosis is important.
Objective: To investigate the association between clinicopathological parameters and DNA mismatch repair (MMR) proteins as well as Epstein-Barr virus (EBV) in GAs.
Methods: Expression of MMR proteins and EBV positivity of 77 patients diagnosed with GA were evaluated using immunohistochemistry. Survival data of the patients were also considered.
Results: Significant correlations were found between EBV positivity and gender, perineural invasion (PNI), and histological type. PNI was less common in EBV-positive patients, and EBV positivity was highly correlated with lymphoid stromal adenocarcinoma. Tumor budding was significantly correlated with histological type and grade, lymphovascular invasion (LVI), PNI, lymph node metastasis, and post-diagnosis survival time. Moreover, tumor-stroma ratio was correlated with tumor stage. Additionally, tumor location, histological grade, tumor budding, PNI, and pathological stage were associated with survival. Also, EBV positivity was significantly associated with histological type, PNI, tumor location, and gender. However, MMR and EBV positivity were not significantly correlated to tumor microenvironment and prognosis. It was noteworthy that the mortality rate was much higher in patients with PNI compared with those without PNI.
Conclusion: Our findings support that the tumor microenvironment is significantly associated with GA prognosis.
期刊介绍：
Asian Biomedicine: Research, Reviews and News (ISSN 1905-7415 print; 1875-855X online) is published in one volume (of 6 bimonthly issues) a year since 2007. [...]Asian Biomedicine is an international, general medical and biomedical journal that aims to publish original peer-reviewed contributions dealing with various topics in the biomedical and health sciences from basic experimental to clinical aspects. The work and authorship must be strongly affiliated with a country in Asia, or with specific importance and relevance to the Asian region. The Journal will publish reviews, original experimental studies, observational studies, technical and clinical (case) reports, practice guidelines, historical perspectives of Asian biomedicine, clinicopathological conferences, and commentaries
Asian biomedicine is intended for a broad and international audience, primarily those in the health professions including researchers, physician practitioners, basic medical scientists, dentists, educators, administrators, those in the assistive professions, such as nurses, and the many types of allied health professionals in research and health care delivery systems including those in training.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
