Artificial organs最新文献

{"title":"Baseline Ventricular-Arterial Coupling Modifies Left Atrial Pressure Response to Venoarterial Extracorporeal Membrane Oxygenation In Vitro","authors":"Christian Said,&nbsp;Christopher Hayward,&nbsp;Ricardo Deveza,&nbsp;Sumita Barua,&nbsp;Kavitha Muthiah,&nbsp;Pankaj Jain","doi":"10.1111/aor.70168","DOIUrl":"10.1111/aor.70168","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Venoarterial extracorporeal membrane oxygenation (VA-ECMO) increases systemic afterload, potentially elevating mean left atrial pressure (mLAP). How baseline ventricular-arterial coupling modifies this effect remains unclear. Our aim was to determine how baseline cardiac power output (CPO) and systemic vascular resistance (SVR) modify the mLAP response to VA-ECMO, with or without valvular regurgitation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using a biventricular mock circulatory loop with peripheral VA-ECMO cannulation, we simulated 12 cardiogenic shock states. Measurements were obtained at baseline and at VA- ECMO pump speeds of 2000–4000 RPM. Results were stratified by baseline SVR (&lt; 20 vs. ≥ 20 Wood units), CPO (&lt; 0.20 vs. ≥ 0.20 W) and valve competence. Severe aortic and mitral regurgitation were tested independently as additional conditions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>With competent valves, mLAP decreased from 27.0 ± 0.2 mmHg at baseline to 19.0 ± 0.6 mmHg at 3000 RPM, then increased to 22.0 ± 0.9 mmHg at 4000 RPM. High baseline SVR produced greater mLAP reduction at 3000 RPM (15.0 ± 0.6 vs. 20.0 ± 0.7 mmHg, <i>p</i> &lt; 0.001) but steeper rebound at 4000 RPM (26.0 ± 1.1 vs. 20.0 ± 0.9 mmHg, <i>p</i> &lt; 0.001) compared to low SVR. Higher baseline CPO (≥ 0.20 W) maintained lower mLAP at higher speeds (16.0 ± 0.6 vs. 21.0 ± 0.7 mmHg at 3500 RPM; <i>p</i> &lt; 0.001). Aortic regurgitation (AR) elevated mLAP above baseline (36.0 ± 1.5 vs. 22.0 ± 0.9 mmHg at 4000 RPM; <i>p</i> &lt; 0.001), amplified by high SVR (47.0 ± 1.1 vs. 29.0 ± 0.8 mmHg at 4000 RPM). Mitral regurgitation elevated mLAP above baseline at higher pump speeds (32.0 ± 1.4 vs. 22.0 ± 0.9 mmHg at 4000 RPM; <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Baseline ventricular–arterial coupling modifies mLAP response to VA-ECMO. Low CPO with high SVR, particularly with AR, narrows the safe pump speed window and may require early left ventricular unloading, inotropic support, or vascular resistance optimization. These findings support phenotype-guided VA-ECMO titration.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"50 9","pages":"1228-1236"},"PeriodicalIF":2.2,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147940001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Texture Analysis Using Indocyanine Green Fluorescence Measurement During Porcine Hypothermic Oxygenated Machine Perfusion.","authors":"Yuga Okazawa, Hiromichi Obara, Taiki Mori, Satoshi Muto, Mio Takashima, Masafumi Furukawa, Hiroki Kaneko, Tetsuya Nakajo, Shohei Ishizawa, Seisuke Sakamoto, Naoto Matsuno","doi":"10.1111/aor.70199","DOIUrl":"https://doi.org/10.1111/aor.70199","url":null,"abstract":"<p><strong>Background: </strong>Development of novel organ viability assessment methods during MP under hypothermic conditions is important to expand the donor pool with DCD donors for transplantation. This study proposed a novel quantitative method using Indocyanine Green (ICG) fluorescence image for assessing organ viability during hypothermic oxygenated machine perfusion (HOPE), specifically focusing on homogeneous flow distribution analyzed with the gray-scale level co-occurrence matrix (GLCM) method, which is one of the most effective texture analysis method.</p><p><strong>Method: </strong>The proposed method quantifies ICG image uniformity using GLCM's 'contrast' feature, defining an evaluation index h as the average contrast (𝑐𝑜𝑛𝑡𝑟𝑎𝑠𝑡_𝑎𝑣𝑒) after 200 s of ICG inflow. Experiments involved porcine livers with 0 min (WIT0) or 45 min (WIT45) of warm ischemia, preserved by dual-hypothermic oxygenated machine perfusion (HOPE), then evaluated using autologous blood reperfusion under normothermic conditions with an Isolated Reperfusion Model (IRM).</p><p><strong>Results: </strong>Qualitatively, WIT45 livers showed more heterogeneous perfusion with \"localized non-fluorescent regions\". Quantitatively, the evaluation index h indicated a strong positive correlation with portal vein resistance at 120 min during IRM (r = 0.70, p = 0.015). A correlation with hepatic artery (HA) resistance (r = 0.40) was also investigated. This method enables quantitative prediction of ischemic injury status before transplantation, which is crucial for making informed decisions about DCD and marginal organs. It could expand the possibilities for HOPE perfusion.</p><p><strong>Conclusion: </strong>In conclusion, the evaluation index h obtained from GLCM analysis of ICG fluorescence images in organs during MP can predict portal vein resistance induced by ischemic reperfusion injury before transplantation and is a method that can expand the possibilities of HOPE perfusion.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148849716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Autologous Tissue Sources and Optimization of a Treatment Method for Intraoperative Manufacturing of Heart Valve Constructs","authors":"Marvin Steitz,&nbsp;Mahamuda Badhon Khan,&nbsp;Katharina Fritsch,&nbsp;Alexander Breitenstein-Attach,&nbsp;Jana Katharina Betty Korbacher,&nbsp;Jordi Joaquin Modolell Y Mainou,&nbsp;Katrin Schrimpf,&nbsp;Robert Ramm,&nbsp;Sara Knigge,&nbsp;Katja Eildermann,&nbsp;Georg Arlt,&nbsp;Antonia Schulz,&nbsp;Jonathan Frederik Sebastian Kiekenap,&nbsp;Boris Warnack,&nbsp;Peter Kramer,&nbsp;Frank Edelmann,&nbsp;Felix Berger,&nbsp;Boris Schmitt","doi":"10.1111/aor.70151","DOIUrl":"10.1111/aor.70151","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Valvular heart disease remains a leading cause of morbidity and mortality. Current biological and mechanical heart valve prostheses have significant limitations and fail to address the patient's needs. Most of the limitations arise from the use of foreign materials, which can largely be addressed by utilizing autologous pericardial tissue. However, not all patients have usable pericardium due to previous interventions. This study investigates peritoneum as a potential alternative to pericardium and evaluates an optimized treatment method for intraoperative tissue treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A previously established cross-linking method was optimized and applied to pericardial and peritoneal tissues. The tissues were characterized with respect to biochemical composition, cross-linking degree, biomechanical properties, and structural organization. Furthermore, the feasibility of valve shaping was assessed, and constructs were subjected to acute hydrodynamic testing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Tissue treated with the optimized cross-linking method showed high cytocompatibility and was successfully applied to peritoneal tissue. Compared to pericardium, peritoneum exhibited a higher elastin content and a looser structural organization, resulting in distinct mechanical behavior. Both tissues could be shaped into valve constructs showing adequate acute hydrodynamic behavior under the applied test conditions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The findings suggest that the peritoneum is a promising candidate material for further investigation as a heart valve scaffold. However, differences in microstructure and mechanical behavior highlight the need for further testing, particularly regarding long-term durability, cyclic loading behavior, and tissue remodeling capacity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"50 9","pages":"1237-1253"},"PeriodicalIF":2.2,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aor.70151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Device-Induced Blood Damage in Pump-Assisted Circulation: A Comparative Study of HeartMate III and BrioVAD Pumps","authors":"Wenji Sun,&nbsp;Kiersten P. Clark,&nbsp;Douglas Tran,&nbsp;John C. Vandenberge,&nbsp;Nancy Kim,&nbsp;Shigang Wang,&nbsp;Anik Tarafder,&nbsp;Randy Perez,&nbsp;Bartley P. Griffith,&nbsp;Dong Han","doi":"10.1111/aor.70166","DOIUrl":"10.1111/aor.70166","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Mechanical circulatory support (MCS) has emerged as a life-saving intervention and may be a potential alternative to organ transplant for patients with end-stage heart failure. The Heartmate III (HM3) left ventricular assist device (LVAD) is a magnetically levitated centrifugal pump and the most advanced LVAD on the current MCS market. The BrioVAD is a newly developed LVAD featuring a fully magnetically suspended blood pump and has recently been approved by the FDA for the INNOVATE trial in the US. However, device-related complications, which are highly related to blood damage by the pump, remain a major concern for patients with MCS. This study aimed to compare device-induced blood damage by the HM3 and BrioVAD pumps in vitro in a circulatory loop.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The device-assisted circulatory loop was filled with fresh, healthy human blood. Both pumps were operated under the same clinically relevant condition, i.e., a blood flow rate of 4.5 L/min and an afterload pressure head of 75 mmHg, for 4 h. Hourly blood samples were collected to assess device-induced damage to blood components, including red blood cells, platelets, neutrophils, and von Willebrand factor (VWF).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Both pumps had comparable impacts on blood components, with no statistically significant difference between them in all the measured parameters (except one neutrophil activation marker). After the four hours of device-assisted circulation, both pumps caused minimal hemolysis and moderate platelet damage but had significant impacts on VWF and neutrophils.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study provides a comprehensive comparative in vitro analysis of blood damage caused by the HM3 and BrioVAD pumps under a clinically relevant condition. The results provide valuable insight into the potential implications for clinical use of the two devices and guidance for the design of new LVADs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"50 9","pages":"1295-1304"},"PeriodicalIF":2.2,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aor.70166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracorporeal Albumin Dialysis (OPAL) as Novel Therapeutic Bridging Option in Posthepatectomy Liver Failure","authors":"Dorian Marckmann,&nbsp;Emely Wack,&nbsp;Luisa Schäfer,&nbsp;H. Christian Hillebrecht,&nbsp;Francesca Reimer,&nbsp;Gabriel Stöger,&nbsp;Klara Krötzsch,&nbsp;Magdalena Menzel,&nbsp;Lampros Kousoulas,&nbsp;Stefan Utzolino,&nbsp;Stefan Fichtner-Feigl,&nbsp;Dawid L. Staudacher,&nbsp;Frederic Arnold,&nbsp;Thomas Welte,&nbsp;Philipp Holzner,&nbsp;Felix A. Rottmann,&nbsp;Christopher Berlin","doi":"10.1111/aor.70187","DOIUrl":"10.1111/aor.70187","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Posthepatectomy liver failure (PHLF) remains a major cause of mortality after liver resection, with limited therapeutic options. PHLF can be categorized into primary (small-for-size) and secondary forms, the latter resulting from complications such as sepsis or hemorrhage. Extracorporeal albumin dialysis (ECAD), including open albumin dialysis (OPAL), may support hepatic detoxification by removing albumin-bound toxins. While most studies focus on primary PHLF, data on secondary PHLF are scarce.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort study includes all patients receiving OPAL after liver surgery until February 2026 at the Medical Center of the University of Freiburg, Germany. A detailed chart review was performed. The primary endpoint was bilirubin reduction per filter cycle. Survival and changes in laboratory parameters were analyzed as secondary endpoints.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eighteen patients were included, predominantly with secondary PHLF (15/18, 83.3%). Sepsis was the leading cause of secondary liver failure (8/15, 53.3%), followed by hemorrhage (6/15, 40.0%). Median bilirubin reduction per filter cycle was 1.52 mg/dL (relative reduction 14.64%; <i>p</i> &lt; 0.0001), with greater reductions at higher prefilter levels (<i>p</i> &lt; 0.0001). Relative reductions were also observed in creatinine (16.84%) and urea (14.75%; both <i>p</i> &lt; 0.0001). Platelet count and hemoglobin showed minor decreases, while MELD 3.0 scores improved modestly. Multiple consecutive filters did not increase overall bilirubin reduction. Thirty-day survival after surgery was 66.7% and 38.9% after OPAL initiation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>OPAL effectively reduces bilirubin levels and improves related parameters in PHLF. It may provide temporary detoxification support, particularly in secondary PHLF. Prospective studies are needed to assess its impact on patient survival.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"50 9","pages":"1254-1263"},"PeriodicalIF":2.2,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aor.70187","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148248832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Patients' Treatment Expectations in Ventricular Assist Device Support: Results From a Convergent Mixed Methods Study","authors":"Simon Felix Zerth,&nbsp;Bernd Niemann,&nbsp;Miriam Salzmann-Djufri,&nbsp;Sandra Semmig-Könze,&nbsp;Katharina Tigges-Limmer,&nbsp;Yvonne Brocks,&nbsp;Monika Sadlonova,&nbsp;Anna Markser,&nbsp;Tanja Zimmermann,&nbsp;Lara Kristin Oldach,&nbsp;Stefan Salzmann","doi":"10.1111/aor.70175","DOIUrl":"10.1111/aor.70175","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Treatment expectations influence patient-reported outcomes in chronic conditions; however, their role in ventricular assist device (VAD) therapy remains poorly understood. This study aimed to: (i) identify treatment expectations held by individuals with a VAD, (ii) assess the extent to which these expectations have been met, and (iii) examine how treatment expectations relate to VAD-specific health-related quality of life (HRQoL).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional convergent mixed methods design with equal weighting of the qualitative and quantitative parts was employed. Quantitative questionnaire data (<i>N</i> = 47) from adult individuals with a VAD were analyzed using descriptive statistics and Bayesian multiple linear regression. Qualitative data (<i>N</i> = 8) were obtained through semi-structured interviews and analyzed using reflexive thematic analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Participants reported having had high positive treatment expectations and moderate negative treatment expectations, on average. Approximately half of the participants indicated that they felt better than expected, while one-third felt worse than expected. Bayesian multiple linear regression analysis revealed strong evidence for several expectation domains and expectation violation as relevant for HRQoL. The thematic analysis resulted in three themes: “No choice: survival as context for expectations,” “Shared experience and social support as mechanisms for coping and expectation adjustment,” and “Setting expectations through provider communication.”</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This mixed methods study suggests that treatment expectations play a significant role in VAD therapy and may be associated with HRQoL. Assessing and, in some cases, managing treatment expectations may improve VAD care and enable more informed decision-making.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"50 9","pages":"1305-1314"},"PeriodicalIF":2.2,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aor.70175","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148040956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Failure of Tricuspid Bioprosthetic Valve After Concomitant Use With a Continuous Flow Temporary Right Heart Pump","authors":"Fabian Jimenez Contreras,&nbsp;Lindsey Brinkley,&nbsp;Patrick D. Kohtz,&nbsp;Luke Landolt,&nbsp;Tomas D. Martin,&nbsp;Eric Jeng","doi":"10.1111/aor.70176","DOIUrl":"10.1111/aor.70176","url":null,"abstract":"<div>\u0000 \u0000 <p>Managing right ventricular heart failure (RVHF) is a challenging issue, requiring balancing volume status, increasing right ventricular (RV) contractility, and reducing RV afterload. When RVHF is refractory to medical management, surgical intervention is required. Current studies have documented the success of Impella RP for RVHF. However, there are no reports regarding the concomitant implantation of an Impella RP and a bioprosthetic tricuspid valve. A 79-year-old man presented with a pseudoaneurysm of the left atrioventricular junction. On physical exam he had 4+ diffuse pitting edema and ascites. Transesophageal echo (TEE) confirmed the presence of the pseudoaneurysm while also showing severe right ventricular systolic dysfunction, severe tricuspid regurgitation, dilated right and left atriums, with preserved left ventricular systolic function. Due to the poor function of the right ventricle, it was decided to repair the pseudoaneurysm, replace the tricuspid valve, and place an Impella RP flex. While mechanical circulatory support is an option for patients with RVHF, there is a risk of tricuspid valve damage, particularly in patients who have a concomitant bioprosthetic tricuspid valve replacement. Therefore, other MCS strategies could be more useful in RVHF patients who have a newly implanted bioprosthetic valve.</p>\u0000 </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"50 9","pages":"1322-1324"},"PeriodicalIF":2.2,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148052264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Intra-Aortic Balloon Pump Support and Whole Blood Viscosity Following Cardiopulmonary Bypass","authors":"Mehmet Emre Elci,&nbsp;Gozde Tekin,&nbsp;Selen Ozturk","doi":"10.1111/aor.70165","DOIUrl":"10.1111/aor.70165","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The present study aimed to evaluate the association between intra-aortic balloon pump (IABP) support and whole blood viscosity (WBV) following cardiopulmonary bypass (CPB).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this prospective observational study, 80 patients undergoing CPB were included. Of these, 40 patients received perioperative IABP support, while 40 patients served as the control group. Whole blood viscosity was measured preoperatively and postoperatively across a range of shear rates (0.6–60 s⁻¹). Postoperative viscosity values and changes in viscosity (ΔWBV) were compared between groups. Multivariable linear regression analysis was performed to assess the independent association between IABP use and postoperative WBV, adjusting for key clinical variables.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A decrease in whole blood viscosity was observed after CPB in both groups. Postoperative viscosity values were significantly lower in the IABP group at lower shear rates (0.6 s⁻¹: 5.35 ± 1.19 vs. 6.71 ± 1.96, <i>p</i> &lt; 0.001; 0.8 s⁻¹: 4.77 ± 1.07 vs. 5.64 ± 1.52, <i>p</i> &lt; 0.001; 1 s⁻¹: 4.08 ± 0.93 vs. 5.05 ± 1.22, <i>p</i> &lt; 0.001). In multivariable analysis, IABP use remained independently associated with lower WBV at both 0.6 s⁻¹ (<i>β</i> = −1.58, <i>p</i> = 0.007) and 1 s⁻¹ (<i>β</i> = −0.94, <i>p</i> = 0.016). No consistent differences were observed at higher shear rates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>IABP support is independently associated with reduced whole blood viscosity at lower shear conditions following CPB. These findings may reflect alterations in hemorheological behavior and may have implications for microcirculatory flow and tissue perfusion.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":"50 9","pages":"1278-1284"},"PeriodicalIF":2.2,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147969763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental Extracorporeal Circulation System: A Pilot Study in Rats.","authors":"Akira T Kawaguchi, Kaori Inukai, Mayuko Shibata, Gen T Kawaguchi, Kazuaki Sato, Taiga Aburaya, Jacob Bergsland, Yoshiyuki Yamada","doi":"10.1111/aor.70222","DOIUrl":"https://doi.org/10.1111/aor.70222","url":null,"abstract":"<p><strong>Background: </strong>Extracorporeal circulation (ECC) has become an important component in cardiac surgery, for cardiopulmonary support, and as a bridge to transplantation. Optimization of systems, components, and management requires further refinements using relevant ECC models.</p><p><strong>Methods: </strong>A miniature silicone membrane oxygenator with a surface area of 134 cm² and a pump-head tube with internal dimension, ID 2.0 mm, was connected to the rat with a double-lumen tube, where the inner silicone tube (ID 1.0 mm) was irrigated with temperature-controlled water, serving as a heat-exchanger.</p><p><strong>Results: </strong>The ECC system had a priming volume less than 1.5 mL yet developed a pulsatile flow up to 11.6 mL/min, or 40 mL/min/kg, for a 290-g animal. The system kept sufficient gas exchange, sustained stable hemodynamics in heart failure, and induced hyperthermia (40°C) and hypothermia (20°C) successfully with long-term survival.</p><p><strong>Conclusion: </strong>A silicone-based closed ECC system for rodents was developed as an experimental platform to address controversies, optimize management, and test the feasibility of new systems, components, or concepts in ECC.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148849599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress Toward a Portable Artificial Lung: A Systematic Review.","authors":"Maja Munk Svendsen, Clara Kjær Hendriksen, Lars Folkersen, Peter Juhl-Olsen, Leila Louise Benhassen, Søren Nielsen Skov","doi":"10.1111/aor.70230","DOIUrl":"https://doi.org/10.1111/aor.70230","url":null,"abstract":"<p><strong>Background: </strong>Chronic respiratory diseases are the third leading global cause of death. As lung transplantation is a definitive treatment for highly selected candidates, extracorporeal membrane oxygenation (ECMO) can be a life-sustaining therapy. Standard ECMO therapy immobilizes the patient, which increases morbidity and mortality. There is a need for a portable venovenous (VV)-ECMO device that allows hospital ambulation and ultimately home use.</p><p><strong>Aim: </strong>This systematic review aims to identify clinically utilized and preclinical portable respiratory assist devices and describe their efficiency, progress, and innovative design features.</p><p><strong>Method: </strong>A comprehensive systematic search was conducted in six databases: PubMed, Cochrane, EMBASE, Inspect Engineering Village, ScienceDirect, and Journal of Heart and Lung Transplantation until July 25, 2025. A total of 562 articles were screened, and 16 were included.</p><p><strong>Results: </strong>Eight portable respiratory assist devices were identified. Among these, the CE-marked MobyBox and the FDA-approved Breethe OXY-1 system are in clinical use. Two devices, the APL and the PAAL, are no longer in active development but have each laid the foundation for the Breethe OXY-1 system and the ModELAS device. Additionally, implementation of the PAL machine was not completed but led to the development of the double-lumen cannula. The remaining three portable ECMO devices are still undergoing preclinical testing.</p><p><strong>Conclusion: </strong>Several different portable ECMO devices have been developed, demonstrating substantial progress toward portable extracorporeal support. However, optimized anticoagulation strategies and safe mobilization require further investigation before widespread clinical adaptation.</p><p><strong>Trial registration: </strong>PROSPERO registration number: CRD420251051796.</p>","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148838893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}