Artificial organs最新文献_第7页

Recent Progress in Artificial Organs 人造器官研究进展。

IF 2.2 3区医学

Artificial organs Pub Date : 2025-01-17 DOI: 10.1111/aor.14946

引用次数: 0

Isogenic Transplantation of Hybrid Artificial Pleural Tissue Consisting of Rat Cells and Polyglycolic Acid Nanofiber Sheet Induces Restoration of Mesothelial Defects in Rat Model. 由大鼠细胞和聚乙醇酸纳米纤维片组成的杂交人工胸膜组织等基因移植诱导大鼠间皮缺损模型的修复。

IF 2.2 3区医学

Artificial organs Pub Date : 2025-01-16 DOI: 10.1111/aor.14947

Kengo Tani, Daisuke Kimura, Yoshiya Asano, Cheng-Yang Song, Hiroshi Shimoda, Masahito Minakawa

{"title":"Isogenic Transplantation of Hybrid Artificial Pleural Tissue Consisting of Rat Cells and Polyglycolic Acid Nanofiber Sheet Induces Restoration of Mesothelial Defects in Rat Model.","authors":"Kengo Tani, Daisuke Kimura, Yoshiya Asano, Cheng-Yang Song, Hiroshi Shimoda, Masahito Minakawa","doi":"10.1111/aor.14947","DOIUrl":"https://doi.org/10.1111/aor.14947","url":null,"abstract":"Background: Impairment of the visceral pleura following thoracic surgery often leads to air leaks and intrathoracic adhesions. For preventing such complications, mesothelial cell proliferation at the pleural defects can be effective. To develop new materials for pleural defects restoration, we constructed a hybrid artificial pleural tissue (H-APLT) combining polyglycolic acid (PGA) nanofiber sheets with a three-dimensional culture of mesothelial cells and fibroblasts and evaluated its therapeutic efficacy in a rat pleural defect model.Methods: After rat lungs were harvested, pleural mesothelial cells and lung fibroblasts were cultured separately. To construct H-APLT, the cells were then coated with multiple layers of fibronectin and gelatin, followed by a single layer of mesothelial cells on top of multiple layers of fibroblasts accumulated onto a collagen-coated PGA nanofiber sheet. Left lateral thoracotomy was performed, and H-APLTs were transplanted into a rat model with pleural defects (N = 8). After 2-12 weeks of transplantation, lung resection and histological analyses were performed.Results: H-APLTs exhibited a pleural structure with a highly integrated mesothelial layer in vitro. After transplantation, all eight rats survived until sacrifice. At 12 weeks post-transplantation, the mesothelial layer on the lung surface was observed to be without defects with no intrathoracic adhesions detected.Conclusion: Successful isogenic engraftment of H-APLTs was achieved in a rat model of pleural defects. The combination of accumulated fibroblasts and collagen-coated PGA nanofiber sheets contributed to the maintenance of the mesothelial layer's structure and function, potentially preventing air leaks and intrathoracic adhesions.","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early and Late Effects of Medium Cutoff Dialyzer on Arterial Stiffness in Maintenance Hemodialysis Patients. 中截止透析器对维持性血液透析患者动脉硬度的早期和晚期影响。

IF 2.2 3区医学

Artificial organs Pub Date : 2025-01-16 DOI: 10.1111/aor.14948

Yelda Deligoz Bildaci, Berfu Korucu, Efe Erbay, Ege Erbay, Akif Vural, Saime Betul Caylan, Barkın Yigitbasi, Mehmet Asi Oktan, Ayse Colak, Caner Cavdar, Serpil Muge Deger

{"title":"Early and Late Effects of Medium Cutoff Dialyzer on Arterial Stiffness in Maintenance Hemodialysis Patients.","authors":"Yelda Deligoz Bildaci, Berfu Korucu, Efe Erbay, Ege Erbay, Akif Vural, Saime Betul Caylan, Barkın Yigitbasi, Mehmet Asi Oktan, Ayse Colak, Caner Cavdar, Serpil Muge Deger","doi":"10.1111/aor.14948","DOIUrl":"https://doi.org/10.1111/aor.14948","url":null,"abstract":"Introduction: Removing uremic toxins from the body is one of the most critical points in the maintenance hemodialysis (MHD) population. This study aimed to evaluate the effects of medium cutoff (MCO) membranes on pulse wave velocity (PWV) and augmentation index (AIx), early markers of arterial stiffness, in MHD patients over both short- and long-term periods.Methods: Twenty MHD patients were included in this study. Patients were switched from low-flux to MCO membranes. Hemodynamic parameters and laboratory results were recorded in the low-flux membrane as baseline and the second week and the sixth month after switching to the MCO membranes. PWV and AIx were measured using the IME Mobil-O-Graph.Findings: The median was 69.5 years old, with 60% female predominance. 35% of the patients were diabetic, 70% had hypertension, and 21.1% were smokers. The median systolic, diastolic blood pressure, mean arterial pressure, and pulse were similar at all study time points. The pulse pressure tended to decrease with a significant reduction in the sixth month (p = 0.73 and p = 0.03). We did not observe any significant differences regarding the PWV measurements (p = 0.71 and p = 0.62) and total vascular resistance (p = 0.23 and p = 0.79). The median AIx decreased during the study time points, with a significant difference between the second-week MCO and the sixth-month MCO measurements (p = 0.04).Discussion: Our findings underscore the potential benefits of MCO membranes to provide a favorable cardiovascular profile in conventional HD setting.","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancement of the Dragon Heart 7-Series for Pediatric Patients With Heart Failure. 龙心7系列治疗小儿心力衰竭的进展。

IF 2.2 3区医学

Artificial organs Pub Date : 2025-01-10 DOI: 10.1111/aor.14935

Giselle C Matlis, Thomas C Palazzolo, Jonathan E M Lawley, Steven W Day, Emily Woodland, Vakhtang Tchantchaleishvili, Randy M Stevens, Amy L Throckmorton

{"title":"Advancement of the Dragon Heart 7-Series for Pediatric Patients With Heart Failure.","authors":"Giselle C Matlis, Thomas C Palazzolo, Jonathan E M Lawley, Steven W Day, Emily Woodland, Vakhtang Tchantchaleishvili, Randy M Stevens, Amy L Throckmorton","doi":"10.1111/aor.14935","DOIUrl":"https://doi.org/10.1111/aor.14935","url":null,"abstract":"Background: Safe and effective pediatric blood pumps continue to lag far behind those developed for adults. To address this growing unmet clinical need, we are developing a hybrid, continuous-flow, magnetically levitated, pediatric total artificial heart (TAH). Our hybrid TAH design, the Dragon Heart (DH), integrates both an axial flow and centrifugal flow blood pump within a single, compact housing. The axial pump is embedded in the central hub region of the centrifugal pump, and both pumps rotate around a common central axis, while maintaining separate fluid domains.Methods: In this work, we concentrated our design and development effort on the centrifugal blood pump by performing computational modeling. An iterative process was employed to improve the DH design. The pressure generation, scalar stress levels, and fluid forces exerted on the magnetically levitated impellers were computationally estimated. A shaft driven centrifugal prototype was also manufactured and tested using a hydraulic flow loop circulating a water-glycerol blood analog. Pressure and flow performance of the pump prototype was measured for a given rotational speed for comparison to computational predictions.Results: Our design achieved the target pump pressures of 60-140 mm Hg for flow rates of 1-5 L/min, and strong agreement in pressure rise was demonstrated between the experimental data and simulation results (less than 10% deviation on average). Fluid stress levels were, however, found to exceed thresholds in the outflow region of the pump, and fluid residence times were less than 600 ms.Conclusion: The findings of this work demonstrate that the more compact, next-gen DH's centrifugal pump design is able to achieve pressure-capacity requirements. Next steps will require a focused strategy to reduce hemolytic potential and to integrate magnetic suspension components for full rotor levitation.","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Pivotal Role of an Early Post-Acute Cardiac Rehabilitation as an Evidence-Based Management of Left Ventricular Assist Device Patients. 早期急性后心脏康复作为左心室辅助装置患者循证管理的关键作用。

IF 2.2 3区医学

Artificial organs Pub Date : 2025-01-10 DOI: 10.1111/aor.14940

Massimo Pistono, Andrea Giordano, Marco Gnemmi, Fabiana Isabella Gambarin, Mario Granata, Alessandro Imparato, Pier Luigi Temporelli, Letizia Mannucci, Silvia Prolo, Ugo Corrà

{"title":"The Pivotal Role of an Early Post-Acute Cardiac Rehabilitation as an Evidence-Based Management of Left Ventricular Assist Device Patients.","authors":"Massimo Pistono, Andrea Giordano, Marco Gnemmi, Fabiana Isabella Gambarin, Mario Granata, Alessandro Imparato, Pier Luigi Temporelli, Letizia Mannucci, Silvia Prolo, Ugo Corrà","doi":"10.1111/aor.14940","DOIUrl":"https://doi.org/10.1111/aor.14940","url":null,"abstract":"Background: Left Ventricular Assist Device (LVAD) implantation is an important treatment option for patients with advanced CHF. Referral to an early, intensive cardiac rehabilitation (CR) program in these patients seems still underused. This observational descriptive study aimed to evaluate the feasibility and efficacy of an early intensive CR program in LVAD recipients, also comparing results with a matched group of advanced HFrEF patients.Methods: The study involved patients with LVAD implantation due to HFrEF who were admitted to our intensive post-acute CR program from several surgery wards from 2009 to 2023. They underwent a twice-a-day individualized exercise program and physiotherapeutic treatment, according to clinical stability and functional assessment. The study exclusively focused on the in-hospital rehabilitation period and documented cardiac and non-cardiac complications, including the Hemocompatibility-Related Adverse Events (HRAEs). The Barthel index (BI) was used to assess functional recovery from admission to discharge. Results in a subgroup of 210 LVAD patients matched on a 1:1 basis with an HFrEF population were also analyzed.Results: One patient died during the inward rehabilitation period (respiratory failure). The majority (70.0%) of patients improved their disability (BI 67 ± 24 to 84 ± 23, p < 0.001). HRAEs occurred in 25 patients (9.1%). Compared to the HFrEF group, LVAD patients showed similar improvement in disability (p = 0.54).Conclusions: The study suggests that an early intensive post-acute CR program can significantly improve functional capacity and disability in LVAD patients, similar to HFrEF patients admitted to the same program. Our data support scientific recommendations suggesting participation of LVAD to a CR.","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Third Genetically Modified Kidney Xenotransplantation in Living Human Recipient 第三例活体受体的基因修饰肾脏异种移植。

IF 2.2 3区医学

Artificial organs Pub Date : 2025-01-10 DOI: 10.1111/aor.14945

Maria C. Beyer

引用次数: 0

CFD-Based Hemolysis Study of Fontan Cavopulmonary Assist Device Using Kriging Surrogate Modeling. 基于cfd的Fontan腔体肺辅助装置溶血研究。

IF 2.2 3区医学

Artificial organs Pub Date : 2025-01-06 DOI: 10.1111/aor.14938

Shreyas Sarfare, Alan Palazzolo, Muhammad Afaq, George Ghali, Guruprasad Giridharan, Mark Rodefeld

{"title":"CFD-Based Hemolysis Study of Fontan Cavopulmonary Assist Device Using Kriging Surrogate Modeling.","authors":"Shreyas Sarfare, Alan Palazzolo, Muhammad Afaq, George Ghali, Guruprasad Giridharan, Mark Rodefeld","doi":"10.1111/aor.14938","DOIUrl":"https://doi.org/10.1111/aor.14938","url":null,"abstract":"Background: Predicting hemolysis numerically based on the power-law model using idealized coefficients obtained from simplified devices yields a large variability in hemolysis index predictions. A computational fluid dynamics (CFD)-based Kriging surrogate modeling approach, developed by Craven et al. at the US Food & Drug Administration (FDA), was applied to a Fontan cavopulmonary assist device (CPAD) to generate device-specific hemolysis power-law coefficients.Methods: The hemolysis index of a CPAD was measured using tests in a mock loop and simulated using CFD. The Kriging surrogate modeling approach was employed for the Lagrangian and Eulerian formulations of the stress-based hemolysis power-law model. The CPAD-specific power-law coefficients obtained from one design of the CPAD were used in predicting the Modified Index of Hemolysis (MIH) for an alternate design of the CPAD.Results: The MIH CFD predictions with the CPAD-specific coefficients deviate by 16%-20% using the Eulerian approach, and 7%-15% using the Lagrangian approach, compared with experimental results for the alternate design. This vastly improves over the use of idealized empirical coefficients, which yield variation in MIH predictions up to two orders of magnitude.Conclusion: The presented power-law approach shows good correlation between CFD and tests in predicting MIH for CPAD design modifications. The hemolysis power-law coefficients obtained in this study may be useful in predicting hemolysis in similar rotary blood pumps.","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine perfusion organ preservation: Highlights from the American transplant congress 2024 机器灌注器官保存：2024年美国移植大会的亮点。

IF 2.2 3区医学

Artificial organs Pub Date : 2025-01-06 DOI: 10.1111/aor.14923

Maheswaran Pitchaimuthu, Carol Crochet, Narendra R. Battula, Isabella Faria, Paulo N. Martins

引用次数: 0

Perfusion Pressures and Weight Loss During Normothermic Machine Perfusion of Human Donor Livers. 人供肝常温机器灌注过程中的灌注压力和体重减轻。

IF 2.2 3区医学

Artificial organs Pub Date : 2024-12-31 DOI: 10.1111/aor.14939

Bianca Lascaris, Silke B Bodewes, Adam M Thorne, Marius C van den Heuvel, Robbert J de Haas, Maarten W N Nijsten, Vincent E de Meijer, Robert J Porte

{"title":"Perfusion Pressures and Weight Loss During Normothermic Machine Perfusion of Human Donor Livers.","authors":"Bianca Lascaris, Silke B Bodewes, Adam M Thorne, Marius C van den Heuvel, Robbert J de Haas, Maarten W N Nijsten, Vincent E de Meijer, Robert J Porte","doi":"10.1111/aor.14939","DOIUrl":"https://doi.org/10.1111/aor.14939","url":null,"abstract":"Background: Normothermic machine perfusion (NMP) is increasingly used to preserve and assess donor livers prior to transplantation. Due to its success, it is expected that more centers will start using this technology. However, NMP may also cause adverse effects.Methods: In this retrospective, observational study, we investigated the effect of NMP pressures on donor liver weight, post-transplant outcomes, and hepatic perfusion characteristics. A total of 36 livers were transplanted after NMP. NMP perfusion pressure settings were lowered from a median (IQR) of 47 mmHg (42-54) to 34 mmHg (30-39) for the hepatic artery (HA), and from 8 mmHg (7-10) to 7 mmHg (6-8) for the portal vein (PV) to diminish potential edema formation inside the liver.Results: This change appeared to lead to a reduction of liver weight after NMP (-22 g to -143 g, p = 0.02), without affecting the PV flow velocity (35.5 to 48.0 cm/s, p = 0.54), or hepatocellular injury markers during NMP (AST 1511-1148 U/L, p = 0.44; ALT 318-849 U/L, p = 0.35), and post-transplantation outcomes. Changes in liver weight correlated significantly with the applied PV pressure during NMP (r = 0.52, p < 0.01) and the HA flow (r = 0.38, p < 0.05).Conclusion: NMP can lead to a reduction in liver weight, which might be masked by edema when high perfusion pressures are used. We encourage applying the lowest perfusion pressures possible to reach adequate flows and oxygen supply during liver NMP.","PeriodicalId":8450,"journal":{"name":"Artificial organs","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Upcoming meetings

IF 2.2 3区医学

Artificial organs Pub Date : 2024-12-31 DOI: 10.1111/aor.14920

引用次数: 0