难治性院内心脏骤停体外心肺复苏的结果。

IF 2.2 3区 医学 Q3 ENGINEERING, BIOMEDICAL
Thays Sokolov, Thomas Varin, Maxime Zimmermann, Xavier Armoiry, Bertrand Scheppler, Matthias Jacquet-Lagrèze, Philippe Portran, Anais Schwab, Jean Luc Fellahi, Martin Ruste, Matteo Pozzi
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引用次数: 0

摘要

背景:体外心肺复苏(ECPR)是难治性院内心脏骤停(IHCA)的潜在干预措施。本研究旨在评估一所大学附属三级护理中心难治性IHCA患者ECPR的结果。方法:我们对2007年1月至2023年12月接受ECPR治疗难治性IHCA的成人患者的机构数据库进行了回顾性观察分析。主要终点是存活至出院时神经系统预后良好,定义为脑功能分类(CPC)得分为1或2。CPC评分为1-2分的患者与CPC评分≥3分的患者进行比较。结果:研究期间,147例难治性IHCA患者接受ECPR治疗(平均年龄51.0岁,男性64.6%)。两组的基线特征具有可比性。两组患者的平均无流时间、低流时间和震荡节律率具有可比性。89例(60.5%)患者死于临时机械循环支持。在56例(38.1%)脱离机械循环支持的患者中,24例(16.3%)在出院前死亡。总生存率为22.4%,其中20.4%达到CPC 1-2分。结论:由于难治性IHCA总是致命的,ECPR在这类危重患者群体中提供了合理的生存率和良好的神经预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Outcomes of Extracorporeal Cardiopulmonary Resuscitation for Refractory In-Hospital Cardiac Arrest.

Background: Extracorporeal cardiopulmonary resuscitation (ECPR) is a potential intervention for refractory in-hospital cardiac arrest (IHCA). This study aimed to evaluate the outcomes of ECPR in patients with refractory IHCA at a university-affiliated tertiary care center.

Methods: We performed a retrospective, observational analysis of an institutional database of adult patients who received ECPR for refractory IHCA from January 2007 to December 2023. The primary endpoint was survival to hospital discharge with a favorable neurological outcome, defined as a Cerebral Performance Category (CPC) score of 1 or 2. Patients with a CPC score of 1-2 were compared to those with a CPC score ≥ 3.

Results: During the study period, 147 patients received ECPR for refractory IHCA (mean age 51.0 years, 64.6% male). Baseline characteristics were comparable between both groups. Mean no-flow time and low-flow time and the rate of shockable rhythms were comparable between both groups. Eighty-nine (60.5%) patients died during temporary mechanical circulatory support. Among the 56 (38.1%) patients who were weaned from mechanical circulatory support, 24 (16.3%) died before hospital discharge. The overall survival to discharge was 22.4%, with 20.4% achieving a CPC score of 1-2.

Conclusions: Owing to the invariably fatal nature of refractory IHCA, ECPR offered a reasonable survival with a favorable neurological outcome in this critically ill patients' population.

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来源期刊
Artificial organs
Artificial organs 工程技术-工程:生物医学
CiteScore
4.30
自引率
12.50%
发文量
303
审稿时长
4-8 weeks
期刊介绍: Artificial Organs is the official peer reviewed journal of The International Federation for Artificial Organs (Members of the Federation are: The American Society for Artificial Internal Organs, The European Society for Artificial Organs, and The Japanese Society for Artificial Organs), The International Faculty for Artificial Organs, the International Society for Rotary Blood Pumps, The International Society for Pediatric Mechanical Cardiopulmonary Support, and the Vienna International Workshop on Functional Electrical Stimulation. Artificial Organs publishes original research articles dealing with developments in artificial organs applications and treatment modalities and their clinical applications worldwide. Membership in the Societies listed above is not a prerequisite for publication. Articles are published without charge to the author except for color figures and excess page charges as noted.
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