Archives of Virology最新文献

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Isolation, characterization, and genomic analysis of phage MY02 targeting extended-spectrum beta-lactamase-producing Klebsiella pneumoniae 针对广谱β -内酰胺酶产生肺炎克雷伯菌的噬菌体MY02的分离、鉴定和基因组分析
IF 2.5 4区 医学
Archives of Virology Pub Date : 2025-04-09 DOI: 10.1007/s00705-025-06281-x
Mengya Wang, Hailin Jiang, Chuhan Wang, Chunyan Zhao, Jinghua Li, Yanbo Sun, Xin Yu, Honglan Huang
{"title":"Isolation, characterization, and genomic analysis of phage MY02 targeting extended-spectrum beta-lactamase-producing Klebsiella pneumoniae","authors":"Mengya Wang,&nbsp;Hailin Jiang,&nbsp;Chuhan Wang,&nbsp;Chunyan Zhao,&nbsp;Jinghua Li,&nbsp;Yanbo Sun,&nbsp;Xin Yu,&nbsp;Honglan Huang","doi":"10.1007/s00705-025-06281-x","DOIUrl":"10.1007/s00705-025-06281-x","url":null,"abstract":"<div><p>Abuse of antibiotics has led to increased rates of resistance in extended-spectrum beta-lactamase (ESBL)-producing <i>Klebsiella pneumoniae</i> and an acceleration in the emergence of drug-resistant strains, which can have serious consequences for nosocomial infections. In this study, phage MY02, which infects ESBL-producing <i>Klebsiella pneumoniae</i>, was isolated from sewage and characterized. Phage MY02 was found to have an optimal multiplicity of infection of 0.001, with a lysis period of up to 40 minutes and an average burst of about 80 plaque-forming units per cell. The phage was found to be stable over a temperature range of -20 to 60°C and a pH range of 3–11 and to have a broad host range. Whole-genome sequencing showed that the genome of phage MY02 is ??171,821?? bp in length and contains 293 open reading frames. Sequence comparisons and phylogenetic analysis showed that phage MY02 belongs to the genus <i>Marfavirus</i> in the class <i>Caudoviricetes</i>. This novel broad-spectrum <i>Klebsiella pneumoniae</i> phage has potential applications against bacterial infections.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Porcine circovirus type 2 (PCV2) in Brazil in the past 55 years (1967-2022): evolutionary rates and patterns 过去55年(1967-2022年)巴西猪圆环病毒2型(PCV2):进化速率和模式
IF 2.5 4区 医学
Archives of Virology Pub Date : 2025-04-09 DOI: 10.1007/s00705-025-06276-8
I. L. F. Rodrigues, A. C. M. Cruz, A. E. Souza, F. B. Knackfuss, C. H. C. Costa, B. V. Lago, R. L. Silveira, T. X. Castro
{"title":"Porcine circovirus type 2 (PCV2) in Brazil in the past 55 years (1967-2022): evolutionary rates and patterns","authors":"I. L. F. Rodrigues,&nbsp;A. C. M. Cruz,&nbsp;A. E. Souza,&nbsp;F. B. Knackfuss,&nbsp;C. H. C. Costa,&nbsp;B. V. Lago,&nbsp;R. L. Silveira,&nbsp;T. X. Castro","doi":"10.1007/s00705-025-06276-8","DOIUrl":"10.1007/s00705-025-06276-8","url":null,"abstract":"<div><p>Porcine circovirus type 2 (PCV2) is a common virus that infects pigs. It exhibits marked genetic variability, which is affected by factors such as vaccination and commercial trade. In this study, a retrospective analysis of PCV2 was performed based on molecular characterization, Bayesian inference, and haplotype networks in tissue samples obtained from Brazilian pig herds from 1967 to 2018. A nested PCR targeting a 225-nucleotide fragment of the PCV2 capsid gene was performed, followed by bidirectional sequencing. Out of 178 samples tested, 39 (21.9%) were positive for PCV2. Phylogenetic analysis showed that strains from this study collected before the introduction of a PCV2 vaccine clustered with genotype 2d reference strains. The mean substitution rate was 1.54 × 10<sup>-3</sup> substitutions per site per year (s/s/y). The haplotype diversity of PCV2 was 0.98, which shows a high mutation rate compatible with the topology found in the haplotype network. Our study shows that most of the Brazilian isolates, including those obtained before the introduction of the PCV2 vaccine, were similar to PCV2d reference strains, suggesting that this genotype was already circulating before the introduction of the vaccine in Brazil. One of the PCV2 sequences was from an isolate from 1967, making it the oldest sequenced isolate from the Americas, and the second oldest worldwide. Phylogenetic analysis and haplotype network analysis indicated a high degree of diversity of PCV2 as well as a high rate of evolution. These results increase our knowledge about the genetic diversity, evolution, and dispersal patterns of PCV2 in Brazil.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Avian influenza A(H5N6) virus detected during live-poultry market surveillance linked to a human infection in Changsha, China, from 2020 to 2023 在2020年至2023年中国长沙活禽市场监测期间发现与一起人间感染有关的甲型禽流感(H5N6)病毒
IF 2.5 4区 医学
Archives of Virology Pub Date : 2025-04-09 DOI: 10.1007/s00705-025-06280-y
Zheng Huang, Rusheng Zhang, Dong Yao, Huiyuan Fu, Lingzhi Li, Shan Xiao, Xinhua Ou, Mingzhong Xu, Qing-Bin Lu, Xuewen Yang
{"title":"Avian influenza A(H5N6) virus detected during live-poultry market surveillance linked to a human infection in Changsha, China, from 2020 to 2023","authors":"Zheng Huang,&nbsp;Rusheng Zhang,&nbsp;Dong Yao,&nbsp;Huiyuan Fu,&nbsp;Lingzhi Li,&nbsp;Shan Xiao,&nbsp;Xinhua Ou,&nbsp;Mingzhong Xu,&nbsp;Qing-Bin Lu,&nbsp;Xuewen Yang","doi":"10.1007/s00705-025-06280-y","DOIUrl":"10.1007/s00705-025-06280-y","url":null,"abstract":"<div><p>In November 2022, we reported a fatal case of human infection caused by a highly pathogenic avian influenza A(H5N6) virus bearing a clade 2.3.4.4b HA gene in Changsha City. We investigated the transmission route and distribution of the H5N6 virus in the largest live-poultry market (LPM), which is linked to the human infection. A total of 1357 samples from the LPM were collected for avian influenza A virus detection from 2020 to 2023. The proportion of LPM samples positive for H5 subtype avian influenza virus was 14.30% (194/1357). Sequences of H5N6 (n = 10) and H5N1 (n = 4) avian influenza viruses were obtained from the LPM samples using next-generation sequencing. The complete genome sequence of the H5N6 virus from the human infection case, A/Changsha/1/2022(EPI_ISL_16466440), was determined and analyzed. The PB1 and PB2 segments shared 99.65% and 99.23% sequence identity with A/duck/Hunan/S40199/2021(H5N6) and A/Whooper swan/Sanmenxia/H615/2020(H5N8), respectively. The other segments showed the highest sequence similarity to strain A/Guangdong/1/2021(H5N6), which was isolated in Guangzhou. L89V and I292V substitutions in the PB2 protein were predicted from the A/Changsha/1/2022 genome sequence. Phylogenetic analysis based on the HA gene showed that A/Changsha/1/2022 and other H5 subtype isolates obtained from the LPM grouped together in the 2.3.4.4b branch. Bayesian evolutionary analysis of the HA gene showed that clade 2.3.4.4b of the H5N6 virus is likely to have been prevalent in Hunan Province around October 2021. In conclusion, we confirmed that the clade 2.3.4.4b HA gene of A/Changsha/1/2022 virus recombined with those of local strains. These results demonstrate the importance of continuous surveillance of H5N6 influenza viruses.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of a recombinant GII.13[P21] norovirus strain: molecular dynamic simulations indicate that gene mutations shifted its spectrum of binding to host receptor glycans 重组GII.13[P21]诺如病毒株的鉴定:分子动力学模拟表明基因突变改变了其与宿主受体聚糖的结合谱
IF 2.5 4区 医学
Archives of Virology Pub Date : 2025-04-01 DOI: 10.1007/s00705-025-06277-7
Yunfei Chen, Zexian Zhou, Lei Dong, Miao Jin, Yongjie Wang, Yongxin Yu
{"title":"Identification of a recombinant GII.13[P21] norovirus strain: molecular dynamic simulations indicate that gene mutations shifted its spectrum of binding to host receptor glycans","authors":"Yunfei Chen,&nbsp;Zexian Zhou,&nbsp;Lei Dong,&nbsp;Miao Jin,&nbsp;Yongjie Wang,&nbsp;Yongxin Yu","doi":"10.1007/s00705-025-06277-7","DOIUrl":"10.1007/s00705-025-06277-7","url":null,"abstract":"<div><p>Human norovirus is a pervasive pathogen that causes global outbreaks of viral gastroenteritis. Previous studies have suggested that histo-blood group antigens (HBGAs) can interact with human norovirus, facilitating its entry of host cells and significantly affecting its evolution. In this study, the complete genome sequence of recombinant GII.13[P21] norovirus from fecal samples was analyzed. Molecular dynamics simulations of GII.13 norovirus P proteins from 1978 to 2019 showed changes in their capacity to bind to HBGAs. Initially, GII.13 proteins bound A or B/H-type HBGAs, but subsequent mutations resulted in a loss of this binding capacity, favoring binding to the HBGA type I precursor (Lewis c) over A or B/H and Lewis antigens.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complete genome sequences of two different broad bean stain virus isolates 两种不同蚕豆染色病毒分离株的全基因组序列
IF 2.5 4区 医学
Archives of Virology Pub Date : 2025-04-01 DOI: 10.1007/s00705-025-06273-x
Fumino Nito, Yuya Imamura, Yuji Fujiwara, Takayuki Matsuura, Hironobu Yanagisawa
{"title":"Complete genome sequences of two different broad bean stain virus isolates","authors":"Fumino Nito,&nbsp;Yuya Imamura,&nbsp;Yuji Fujiwara,&nbsp;Takayuki Matsuura,&nbsp;Hironobu Yanagisawa","doi":"10.1007/s00705-025-06273-x","DOIUrl":"10.1007/s00705-025-06273-x","url":null,"abstract":"<div><p>Here, the complete genome sequences of two broad bean stain virus (BBSV; genus <i>Comovirus</i>) strains – Tunisia (RNA1, 5,965 nt; RNA2, 3,467 nt) and Syria (RNA1, 5,976 nt; RNA2, 3,449 nt) – were determined using next-generation sequencing (NGS) and rapid amplification of cDNA ends (RACE). These strains showed 79.2% and 71.6% nucleotide sequence identity to each other in RNA1 and RNA2, respectively. The predicted amino acid sequence identity was 95.2% in the proteinase-polymerase and 93.9% in the coat protein, indicating that these strains belong to the same species in the genus <i>Comovirus</i>. Phylogenetic analysis showed that both strains are closely related to red clover mottle virus (genus <i>Comovirus</i>). This is the first report of the complete genome sequences of two BBSV strains.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143740629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complete genome sequence of a novel mitovirus identified in the phytopathogenic fungus Puccinia triticina 小麦锈菌中鉴定的一种新型有丝分裂病毒的全基因组序列
IF 2.5 4区 医学
Archives of Virology Pub Date : 2025-03-27 DOI: 10.1007/s00705-025-06272-y
Yanhui Zhang, Nuoheng Wang, Jinyang Li, Bingtao Chen, Zhensheng Kang, Pengyu Song, Wenming Zheng
{"title":"Complete genome sequence of a novel mitovirus identified in the phytopathogenic fungus Puccinia triticina","authors":"Yanhui Zhang,&nbsp;Nuoheng Wang,&nbsp;Jinyang Li,&nbsp;Bingtao Chen,&nbsp;Zhensheng Kang,&nbsp;Pengyu Song,&nbsp;Wenming Zheng","doi":"10.1007/s00705-025-06272-y","DOIUrl":"10.1007/s00705-025-06272-y","url":null,"abstract":"<div><p>Wheat leaf rust is caused by the obligate biotrophic fungus <i>Puccinia triticina</i> f. sp. <i>tritici</i>, which seriously affects wheat production. In this study, a novel mitovirus was identified in <i>Puccinia triticina</i> strain HN-1 and designated as \"Puccinia triticina mitovirus 1\" (PtMV1). The genome of PtMV1 consists of a single RNA molecule with a length of 2,380 nt and an A + U content of 54.7% that contains a single open reading frame (ORF). The ORF is predicted to encode a putative RNA-dependent RNA polymerase (RdRp) of 653 amino acids with a molecular mass of 74.77 kDa, containing six conserved motifs. The RdRp amino acid sequence of PtMV1 has a high degree of sequence similarity to the RdRps of unuamitoviruses. Phylogenetic analysis indicated that PtMV1 is a new member of the genus <i>Unuamitovirus</i> within the family <i>Mitoviridae</i>. To our knowledge, this is the first report of a fungal virus in <i>Puccinia triticina.</i></p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00705-025-06272-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic and biological characterization of African swine fever virus clones selected at the early stages of adaptation in Vero cells 在Vero细胞适应的早期阶段选择的非洲猪瘟病毒克隆的遗传和生物学特性
IF 2.5 4区 医学
Archives of Virology Pub Date : 2025-03-24 DOI: 10.1007/s00705-025-06269-7
Tae-Young Suh, Ji-Hoon Park, Chae-Rin Park, Ji-Eun Kim, Jun Young Park, Seong Yun Hwang, Yong-Joo Kim, Hae-Eun Kang, Dae-Yong Kim, Jun-Gu Choi
{"title":"Genetic and biological characterization of African swine fever virus clones selected at the early stages of adaptation in Vero cells","authors":"Tae-Young Suh,&nbsp;Ji-Hoon Park,&nbsp;Chae-Rin Park,&nbsp;Ji-Eun Kim,&nbsp;Jun Young Park,&nbsp;Seong Yun Hwang,&nbsp;Yong-Joo Kim,&nbsp;Hae-Eun Kang,&nbsp;Dae-Yong Kim,&nbsp;Jun-Gu Choi","doi":"10.1007/s00705-025-06269-7","DOIUrl":"10.1007/s00705-025-06269-7","url":null,"abstract":"<div><p>African swine fever is a highly contagious viral disease affecting domestic pigs and wild boars, caused by African swine fever virus (ASFV). ASFV exhibits highly restricted cell tropism, primarily targeting porcine macrophages for efficient and stable replication. This strict requirement for a specific cell type has posed significant challenges in ASFV research and remains a critical obstacle to vaccine development. Although several cell lines have been reported to support ASFV replication, significant genetic changes occur during passages in cell lines in unpredictable ways. In this study, we adapted a highly virulent Korean ASFV isolate to Vero cells, and plaque purification was employed during the early stages of cell adaptation to eliminate the competitive pressure between viral subpopulations. Three viral clones with distinct genetic properties were obtained and passaged independently up to 30 times. The three clones replicated efficiently in porcine alveolar macrophages (PAMs) and Vero cells even after 30 passages, while the parent virus did not grow in Vero cells. Genetic analysis revealed that the cell-adapted viral clones shared multiple single-nucleotide polymorphisms (SNPs) but also had unique SNPs and large deletions in their genome. This diversity of mutations in these clones could provide a valuable model for exploring gene functions and their effects on phenotypic properties. Future studies will focus on evaluating the phenotypic effects of these SNPs <i>in vivo</i> to support vaccine development.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Description of two novel bacteriophages of the class Caudoviricetes that infect Ralstonia solanacearum and Ralstonia pseudosolanacearum 描述了两种新型的茎状菌类噬菌体,它们可以感染龙舌兰菌和假龙舌兰菌
IF 2.5 4区 医学
Archives of Virology Pub Date : 2025-03-24 DOI: 10.1007/s00705-025-06271-z
Beatriz Dias Januário, Rafael Reis de Rezende, Tulio Morgan, Poliane Alfenas-Zerbini
{"title":"Description of two novel bacteriophages of the class Caudoviricetes that infect Ralstonia solanacearum and Ralstonia pseudosolanacearum","authors":"Beatriz Dias Januário,&nbsp;Rafael Reis de Rezende,&nbsp;Tulio Morgan,&nbsp;Poliane Alfenas-Zerbini","doi":"10.1007/s00705-025-06271-z","DOIUrl":"10.1007/s00705-025-06271-z","url":null,"abstract":"<div><p>Here, we describe the isolation and characterization of two novel phages from Brazilian soil that infect <i>Ralstonia solanacearum</i> and <i>Ralstonia pseudosolanacearum</i>, which we have named “RS phage AB1 and RS phage CA1. Genome sequencing and phylogenetic analysis revealed that RS phage AB1 is a novel member of the family <i>Peduoviridae</i>, while RS phage CA1 could not be classified as part of any established family. Thus, we propose a new viral family, “<i>Anamaviridae</i>”, with two subfamilies, “<i>Kantovirinae</i>” and “<i>Mascarenevirinae</i>”, with the latter including RS phage CA1. We propose the species names “<i>Cocadavirus alagoinhas</i>” and “<i>Acarajevirus bahia</i>” for RS phage CA1 and RS phage AB1, respectively. These findings increase our understanding of the diversity of phages infecting plant pathogens of the genus <i>Ralstonia</i>.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of inactivated COVID-19 vaccine against symptom severity in hospitalized COVID-19 patients infected with the Omicron variant COVID-19灭活疫苗对感染欧米克隆变异的住院患者症状严重程度的影响
IF 2.5 4区 医学
Archives of Virology Pub Date : 2025-03-24 DOI: 10.1007/s00705-025-06275-9
Qing-Yan Ye, Zhi-Tian Jiang, Yun Jiang, Jing-Wen Cai, Zhen Zhou, Jie Song, Qian Wang, Qi-Qi Wu, Gang Zhao, Jia Chen, Qi-Hua Ling
{"title":"Effectiveness of inactivated COVID-19 vaccine against symptom severity in hospitalized COVID-19 patients infected with the Omicron variant","authors":"Qing-Yan Ye,&nbsp;Zhi-Tian Jiang,&nbsp;Yun Jiang,&nbsp;Jing-Wen Cai,&nbsp;Zhen Zhou,&nbsp;Jie Song,&nbsp;Qian Wang,&nbsp;Qi-Qi Wu,&nbsp;Gang Zhao,&nbsp;Jia Chen,&nbsp;Qi-Hua Ling","doi":"10.1007/s00705-025-06275-9","DOIUrl":"10.1007/s00705-025-06275-9","url":null,"abstract":"<div><p>In this study, we analysed the outcomes of 1165 symptomatic patients infected with the SARS-CoV-2 Omicron BA.2 variant and their response to Sinovac-CoronaVac vaccination. We assessed the effectiveness of vaccination against adverse outcomes (severe, critical, or fatal cases). Of these patients, 504 (43.3%) were men, the median age was 71 years, and 391 patients (66.4%) had received the Sinovac-CoronaVac COVID-19 vaccine (Sino Pharma, Beijing, China). The percentages of severe, critical, and fatal cases were 3.9%, 2.8%, and 3.7%, respectively, with significantly lower rates among vaccinated patients (2.8% vs. 14.2%; adjusted odds ratio [aOR], 0.306; 95% confidence interval [95% CI], 0.129–0.727). Age ≥ 70 years and a CRP level &gt; 8 mg/L were independent predictors of an adverse outcome. Out of 630 patients aged ≥ 70 years, 107 (17.0%) were vaccinated. Seven vaccinated patients (6.5%) and 94 unvaccinated patients (18.0%) experienced adverse outcomes. Multivariate analysis indicated that vaccination (OR, 0.401; 95% CI 0.162–0.991) and CRP levels &gt; 8 mg/L (OR, 3.262; 95% CI 1.754–6.067) were independently associated with adverse outcomes in patients aged ≥ 70 years. Inactivated vaccines were effective against symptomatic and severe COVID-19. Even in symptomatic Omicron infections, full vaccination with inactivated vaccines significantly reduced the number of adverse cases, especially in patients aged ≥ 70 years. Systemic inflammation (as measured by the CRP level) was independently correlated with adverse outcomes in patients infected with Omicron BA.2.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular characterization of a novel gammascleroulivirus from the rice blast fungus Magnaporthe oryzae isolate ES155 来自稻瘟病真菌 Magnaporthe oryzae ES155 分离物的一种新型甘马氏硬核病毒的分子鉴定
IF 2.5 4区 医学
Archives of Virology Pub Date : 2025-03-23 DOI: 10.1007/s00705-025-06267-9
Cong Li, Yuxin Wu, Xinyi Li, Hongliu An, Shouguo Fang, Songbai Zhang, Qingchao Deng
{"title":"Molecular characterization of a novel gammascleroulivirus from the rice blast fungus Magnaporthe oryzae isolate ES155","authors":"Cong Li,&nbsp;Yuxin Wu,&nbsp;Xinyi Li,&nbsp;Hongliu An,&nbsp;Shouguo Fang,&nbsp;Songbai Zhang,&nbsp;Qingchao Deng","doi":"10.1007/s00705-025-06267-9","DOIUrl":"10.1007/s00705-025-06267-9","url":null,"abstract":"<div><p>A novel single-stranded (+ss) RNA mycovirus, designated as \"Magnaporthe oryzae botourmiavirus 14\" (MoBV14), was identified in the rice blast fungus <i>Magnaporthe oryzae</i> isolate ES155. The viral genome is 2,336 nucleotides in length and contains a single open reading frame (ORF) that is predicted to encode an RNA-dependent RNA polymerase (RdRp). Genome sequence comparisons and phylogenetic analysis indicated that MoBV14 is a new member of the genus <i>Gammascleroulivirus</i> in the family <i>Botourmiaviridae</i>.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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