Archives of Virology最新文献_第7页

Alpha- and Betagymnorhavirus: two new genera of gymnosperm-infecting viruses in the family Rhabdoviridae, subfamily Betarhabdovirinae α-和Betagymnorhavirus：Rhabdoviridae科、Betarhabdovirinae亚科中两个新的裸子植物感染病毒属。

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-09-06 DOI: 10.1007/s00705-024-06119-y

Nicolas Bejerman, Humberto Debat

引用次数: 0

Graphene oxide nanoparticles inhibit H9N2 influenza A virus infectivity by destroying viral coat proteins 氧化石墨烯纳米粒子通过破坏病毒衣壳蛋白抑制 H9N2 甲型流感病毒的感染性。

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-09-03 DOI: 10.1007/s00705-024-06117-0

Hui Wang, Jiao Wang, Jieqiong Zhang, Jingdong Song, Dayan Wang, Jie Dong, Hongtu Liu

{"title":"Graphene oxide nanoparticles inhibit H9N2 influenza A virus infectivity by destroying viral coat proteins","authors":"Hui Wang, Jiao Wang, Jieqiong Zhang, Jingdong Song, Dayan Wang, Jie Dong, Hongtu Liu","doi":"10.1007/s00705-024-06117-0","DOIUrl":"10.1007/s00705-024-06117-0","url":null,"abstract":"<div><p>Nanoparticles have gained attention as potential antiviral agents, but the effects of graphene oxide nanoparticles (GONPs) on influenza virus remain unclear. In this study, we evaluated the antiviral activity of GONPs against influenza virus strain A/Hunan-Lengshuitan/11197/2013(H9N2). Our results show that GONPs with a diameter of 4 nm exerted an antiviral effect, whereas those with a diameter of 400 nm had no effect. Treatment with 4-nm GONPs reduced viral titers by more than 99% and inhibited viral nucleoprotein expression in a dose-dependent manner. We also confirmed that 4-nm GONPs inhibited the infectivity of H9N2 in MDCK cells. A transmission electron microscopic analysis revealed morphological abnormalities in the GONP-treated virus, including the destruction of the envelope glycoprotein spikes and an irregular shape, suggesting that GONPs cause the destruction of the viral coat proteins. Our results highlight the potential utility of GONPs in the prevention and treatment of viral infections, especially those of emerging and re-emerging viruses.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"169 9","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection and molecular characterization of a novel mitovirus associated with Passiflora edulis Sims 西番莲有丝分裂病毒的检测和分子鉴定

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-09-02 DOI: 10.1007/s00705-024-06115-2

Yam Sousa Santos, Andreza Henrique Vidal, Emanuel Felipe Medeiros Abreu, Isadora Nogueira, Fábio Gelape Faleiro, Cristiano Castro Lacorte, Fernando L. Melo, Magnólia de Araújo Campos, Rafael Reis de Rezende, Tulio Morgan, Arvind Varsani, Poliane Alfenas-Zerbini, Simone Graça Ribeiro

{"title":"Detection and molecular characterization of a novel mitovirus associated with Passiflora edulis Sims","authors":"Yam Sousa Santos, Andreza Henrique Vidal, Emanuel Felipe Medeiros Abreu, Isadora Nogueira, Fábio Gelape Faleiro, Cristiano Castro Lacorte, Fernando L. Melo, Magnólia de Araújo Campos, Rafael Reis de Rezende, Tulio Morgan, Arvind Varsani, Poliane Alfenas-Zerbini, Simone Graça Ribeiro","doi":"10.1007/s00705-024-06115-2","DOIUrl":"10.1007/s00705-024-06115-2","url":null,"abstract":"<div><p>Mitoviruses are cryptic capsidless viruses belonging to the family <i>Mitoviridae</i> that replicate and are maintained in the mitochondria of fungi. Complete mitovirus-like sequences were recently assembled from plant transcriptome data and plant leaf tissue samples. Passion fruit (<i>Passiflora</i> spp.) is an economically important crop for numerous tropical and subtropical countries worldwide, and many virus-induced diseases impact its production. From a large-scale genomic study targeting viruses infecting <i>Passiflora</i> spp. in Brazil, we detected a <i>de novo</i>-assembled contig with similarity to other plant-associated mitoviruses. The contig is ∼2.6 kb long, with a single open reading frame (ORF) encoding an RNA-dependent RNA polymerase (RdRP). This contig has been named \"<u>p</u>assion <u>f</u>ruit <u>m</u>itovirus-like 1\" (PfMv1). An alignment of the predicted amino acid sequence of the RdRP of PfMv1 and those of other plant-associated mitoviruses revealed the presence of the six conserved motifs of mitovirus RdRPs. PfMv1 has 79% coverage and 50.14% identity to Humulus lupulus mitovirus 1. Phylogenetic analysis showed that PfMV1 clustered with other plant-associated mitoviruses in the genus <i>Duamitovirus</i>. Using RT-PCR, we detected a PfMv1-derived fragment, but no corresponding DNA was identified, thus excluding the possibility that this is an endogenized viral-like sequence. This is the first evidence of a replicating mitovirus associated with <i>Passiflora edulis</i>, and it should be classified as a member of a new species, for which we propose the name \"<i>Duamitovirus passiflorae</i>\".</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"169 9","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular characterization of avian metapneumovirus subtype C associated with hydrosalpinx fluid and egg drop syndrome in Jinding ducks 与金定鸭肾积水和落蛋综合征有关的禽偏肺病毒 C 亚型的分子特征。

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-09-02 DOI: 10.1007/s00705-024-06122-3

Ruiluan Yu, Xuefeng Zhong, Yintao Zeng, Xiaoyan Wang, Dabing Zhang

引用次数: 0

Whole-genome sequence analysis of canine parvovirus reveals replacement with a novel CPV-2c strain throughout India 犬细小病毒的全基因组序列分析表明，印度各地都出现了新型 CPV-2c 株系的替代。

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-08-27 DOI: 10.1007/s00705-024-06096-2

Harish Reddy, Mouttou Vivek Srinivas, Jayalakshmi Vasu, Abiramy Prabavathy, Rahul Dhodapkar, Hirak Kumar Mukhopadhyay

{"title":"Whole-genome sequence analysis of canine parvovirus reveals replacement with a novel CPV-2c strain throughout India","authors":"Harish Reddy, Mouttou Vivek Srinivas, Jayalakshmi Vasu, Abiramy Prabavathy, Rahul Dhodapkar, Hirak Kumar Mukhopadhyay","doi":"10.1007/s00705-024-06096-2","DOIUrl":"10.1007/s00705-024-06096-2","url":null,"abstract":"<div><p>Canine parvovirus (CPV) infection causes severe gastroenteritis in canines, with high mortality in puppies. This virus evolved from feline panleukopenia virus by altering its transferrin receptor (TfR), followed by the emergence of CPV-2 variants in subsequent years with altered immunodominant amino acid residues in the VP2 protein. While previous studies have focused on the VP2 gene, there have been fewer studies on non-structural protein (NS1 and NS2) genes. In the present study, CPV genome sequences from clinical samples collected from canines throughout India in 2023, previous Indian CPV isolates from 2009–2019, and the current Indian CPV vaccine strain were compared. The study showed that the CPV-2c (N426E) variant had almost completely replaced the previously dominant CPV-2a variant (N426) in India. The Q370R mutation of VP2 was the most common change in the recent CPV-2c strain (CPV-2c 370Arg variant). Phylogenetic analysis showed the existence of three clades among the recent CPV-2c strains, and sequence analysis identified several new sites of positive selection in the VP1 (N-terminus), VP2, NS1, and NS2 protein-encoding genes in recent CPV strains, indicating the emergence of new CPV-2c variants with varied antigenic and replication properties. The predominant ‘CPV-2c 370Arg variants’ were grouped with the Chinese and Nigerian CPV-2c strains but were separate from the CPV vaccine strain and earlier isolates from our repository. VP2 epitope analysis predicted nine amino acid variations (including two new variations) in four potential linear B-cell epitopes in the CPV-2c 370Arg variants that might make vaccine failure more likely. This pan-Indian study lays the foundation for further research concerning the dynamics of virus evolution and understanding genetic mutations.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"169 9","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142079013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular characterization of a novel gammapartitivirus infecting the fungus Nigrospora oryzae 一种感染黑孢子菌的新型伽马巴氏病毒的分子特征。

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-08-26 DOI: 10.1007/s00705-024-06111-6

Zhijuan Yang, Baolin Zhang, Yang Hu, Lianjing Zhao, Zengmin Chen, Jie Zhong, Jiaen Su, Yi Chen

引用次数: 0

Orthohantavirus infections in South America: a systematic review and meta-analysis 南美洲的正表型病毒感染：系统回顾和荟萃分析。

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-08-26 DOI: 10.1007/s00705-024-06104-5

Sílvia C.S. Oloris, Valquíria F. Neves, Felipe C.M. Iani, Cristiane Faria de Oliveira Scarponi

{"title":"Orthohantavirus infections in South America: a systematic review and meta-analysis","authors":"Sílvia C.S. Oloris, Valquíria F. Neves, Felipe C.M. Iani, Cristiane Faria de Oliveira Scarponi","doi":"10.1007/s00705-024-06104-5","DOIUrl":"10.1007/s00705-024-06104-5","url":null,"abstract":"<div><p>Orthohantaviruses are zoonotic pathogens that cause acute and severe syndromes in humans. This review was performed to estimate the occurrence of human orthohantaviruses in South America between 2010 and 2022. A careful evaluation of the eligibility and quality of the articles was carried out after a systematic bibliographic search of four databases. The pooled frequency of human orthohantaviruses was calculated using a random effects model meta-analysis. The heterogeneity of estimates (resulting from the chi2 test and I2 statistics) was investigated by subgroup analysis and meta-regression. 1,962 confirmed cases of orthohantavirus infections were diagnosed among 35,548 individuals from seven South American countries. The general occurrence of orthohantaviruses was estimated to be 4.4% (95% confidence interval: 2.9–6.2%) based on general pooling of human cases from 32 studies. In a subgroup analysis considering the study design and method of diagnosis, the percentages of diagnosed orthohantavirus infections differed substantially (I2 = 97.8%, p = 0.00) among South American countries. Four genetic variants of orthohantavirus have been identified circulating in Argentina, Brazil, Bolivia, Chile, Colombia, and Peru. Although laboratory diagnosis of orthohantaviruses is not performed in many countries in South America, there is evidence that four different orthohantaviruses are circulating in the region. The pooled occurrence of viral infection was approximately 4.0% in more than half of the South American countries. Updated information on the occurrence of human infections is essential for monitoring the territorial spread and determining the frequency of this zoonosis.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"169 9","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142071847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptional kinetics of NADC34-like porcine reproductive and respiratory syndrome virus during cellular infection 猪繁殖与呼吸综合征病毒 NADC34-like 在细胞感染过程中的转录动力学。

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-08-24 DOI: 10.1007/s00705-024-06113-4

Riteng Zhang, Hui Li, Honglin Xie, Peixin Wang, Chenfei Yu, Junda Li, Zengqi Yang, Basit Zeshan, Aiqiao Cao, Xinglong Wang

{"title":"Transcriptional kinetics of NADC34-like porcine reproductive and respiratory syndrome virus during cellular infection","authors":"Riteng Zhang, Hui Li, Honglin Xie, Peixin Wang, Chenfei Yu, Junda Li, Zengqi Yang, Basit Zeshan, Aiqiao Cao, Xinglong Wang","doi":"10.1007/s00705-024-06113-4","DOIUrl":"10.1007/s00705-024-06113-4","url":null,"abstract":"<div><p>NADC34-like porcine reproductive and respiratory syndrome virus (PRRSV) employs complex strategies to synthesize subgenomic RNAs (sgRNAs); however, their plasticity and temporal dynamics remain largely unexplored. Using next-generation sequencing (NGS), we examined the high-resolution landscape of the PRRSV subgenome, highlighting considerable heterogeneity in temporal kinetics and transcriptional control and revealing extensive coordination between TRS<sub>L</sub>-dependent and TRS<sub>L</sub>-independent sgRNAs. In addition, a comprehensive re-annotation of transcription regulatory sequence (TRS) locations was conducted, clarifying that their usage involved canonical, alternative, and non-canonical splicing events for annotated genes. These insights emphasize that the coding of genetic material in PRRSV is far more intricate than previously anticipated. Collectively, the altered sgRNA phenotype offers distinctive insights into PRRSV transcription and gives additional impetus for mining the functional short- and long-range RNA-RNA interactome at active viral replication sites.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"169 9","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Prevalence, clinico-epidemiological features, and molecular characterization of bovine papular stomatitis virus in cattle in Iraq 更正：伊拉克牛乳头状口炎病毒的流行率、临床流行病学特征和分子特征。

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-08-23 DOI: 10.1007/s00705-024-06089-1

Yahia Ismail Khudhair, Atiaf Ghanim Rhyif, Khetam Qaid Mayea, Mourad Ben Said

引用次数: 0

2024 Smacoviridae family update: 59 new species in seven genera 2024 Smacoviridae 科更新：7 个属中的 59 个新种。

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-08-21 DOI: 10.1007/s00705-024-06116-1

Arvind Varsani, Mart Krupovic

引用次数: 0