Archives of Virology最新文献_第7页

Molecular characterisation of novel reassortants of the G57 genotype of low-pathogenic avian influenza H9N2 virus isolated from poultry farms in Malaysia 从马来西亚家禽养殖场分离的低致病性禽流感H9N2病毒G57基因型新重组物的分子特征

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-12-07 DOI: 10.1007/s00705-024-06159-4

Erandi Gunasekara, M. Hair-Bejo, I. Aini, A. R. Omar

{"title":"Molecular characterisation of novel reassortants of the G57 genotype of low-pathogenic avian influenza H9N2 virus isolated from poultry farms in Malaysia","authors":"Erandi Gunasekara, M. Hair-Bejo, I. Aini, A. R. Omar","doi":"10.1007/s00705-024-06159-4","DOIUrl":"10.1007/s00705-024-06159-4","url":null,"abstract":"<div>In late 2017, Malaysia reported repeated outbreaks of low-pathogenic avian influenza virus (LPAI) H9N2 infections in commercial poultry flocks. Two H9N2 viruses, A/chicken/Malaysia/Negeri Sembilan/UPM994/2018 and A/chicken/Malaysia/Johore/UPM2033/2019, which were isolated from breeder and layer flocks in Peninsular Malaysia, were characterised in this study. Phylogenetic analysis revealed that both viruses were multiple-genotype reassortant strains with genes originating from Y280-like (HA gene), F/98-like (NS, NP and PA), G1-like (M and PB2), and Korean-like (PB1) lineages, indicating that they belong to a novel genotype that is divergent from the G57 lineage of Chinese origin. Both isolates were predicted to have a dibasic cleavage site (333-PSRSSRGLF-341) in the HA gene cleavage locations. Thus, the novel Malaysian H9N2 strain is a Y280-like virus resembling H9N2 isolates from Indonesia, Taiwan, Japan, and Cambodia. This virus is of the G57 lineage but has a novel genotype of the PB1 gene originating from a Korean-lineage H9N2 virus, which has not been detected before in the region.</div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142789368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complete genome sequence of Valeriana jatamansi cryptic virus 1: a novel member of the genus Alphapartitivirus infecting Valeriana jatamansi Jones 中华绒球孢子虫隐病毒1的全基因组序列：感染中华绒球孢子虫的一种新成员

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-12-05 DOI: 10.1007/s00705-024-06194-1

Chaorong Yang, Bifan Chu, Rex Frimpong Anane, Jianqin He, Dexi Wu, Yonghong Yang, Xuehua Li, Zhongan Liu, Jianhua Wang, Jinyan Shang, Mingfu Zhao

{"title":"Complete genome sequence of Valeriana jatamansi cryptic virus 1: a novel member of the genus Alphapartitivirus infecting Valeriana jatamansi Jones","authors":"Chaorong Yang, Bifan Chu, Rex Frimpong Anane, Jianqin He, Dexi Wu, Yonghong Yang, Xuehua Li, Zhongan Liu, Jianhua Wang, Jinyan Shang, Mingfu Zhao","doi":"10.1007/s00705-024-06194-1","DOIUrl":"10.1007/s00705-024-06194-1","url":null,"abstract":"<div>A new double-stranded RNA (dsRNA) virus, tentatively named \"Valeriana jatamansi cryptic virus 1\" (VJCV1, GenBank accession nos. PP482519 and PP482520), was isolated from diseased Valeriana jatamansi Jones plants exhibiting vein-banding in Yunnan. Its complete genome sequence was determined using metatranscriptomic and Sanger sequencing. The genome of VJCV1 consists of two dsRNA of different size, namely dsRNA1 (2,026 bp) and dsRNA2 (1,754 bp), which are predicted to encode an RNA-dependent RNA polymerase (RdRp, 616 aa) with molecular weight of 72.6 kDa and coat protein (CP, 491 aa) with molecular weight of 55.8 kDa, respectively. The non-coding region of dsRNA in VJCV1 is predicted to have a stem-loop structure and a poly(A) tail that are unique to the members of the genus Alphapartitivirus. Multiple sequence alignments showed that the RdRp and CP of VJCV1 shared the highest amino acid sequence identity (86.2% and 56.1%, respectively) with red clover cryptic virus 1 (RCCV1). These values are below the threshold for creating new species within the genus Alphapartitivirus. Phylogenetic analysis based on RdRp and CP sequences showed that VJCV1 clustered independently from members of the genus Alphapartitivirus, with RCCV1 being the closest relative. It is therefore suggested that VJCV1 should be considered a member of a new species of the genus Alphapartitivirus in the family Partitiviridae. This is the first report of a member of the genus Alphapartitivirus infecting a plant of the genus Valeriana.</div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142778117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the interaction of influenza a virus nucleoprotein with host cell nucleolin 甲型流感病毒核蛋白与宿主细胞核蛋白相互作用的分析

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-12-05 DOI: 10.1007/s00705-024-06189-y

Shruti Mishra, Achyut Pandey, Jyoti Verma, Maitreyi S. Rajala

引用次数: 0

Predicting the conserved folds and putative homologs of the hypothetical proteins of the giant Marseillevirus 预测巨大马赛病毒的假设蛋白质的保守折叠和假定同源物

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-12-03 DOI: 10.1007/s00705-024-06181-6

Jay C. Brown

引用次数: 0

Complete genome sequence of a new poacevirus infecting wild oat (Avena fatua L.) in France 感染法国野生燕麦（Avena fatua L.）的一种新poacevirus的完整基因组序列

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-11-28 DOI: 10.1007/s00705-024-06187-0

Aijun Huang, Armelle Marais, Zhixiang Zhang, Thierry Candresse

{"title":"Complete genome sequence of a new poacevirus infecting wild oat (Avena fatua L.) in France","authors":"Aijun Huang, Armelle Marais, Zhixiang Zhang, Thierry Candresse","doi":"10.1007/s00705-024-06187-0","DOIUrl":"10.1007/s00705-024-06187-0","url":null,"abstract":"<div>Using a high-throughput sequencing (HTS) approach, we report the discovery of a new poacevirus (family Potyviridae) in symptomatic wild oat (Avena fatua L.) plants collected near Bordeaux, France, in June 2023. A nearly complete genome sequence of 10,292 nucleotides (nt) was obtained. The genome encodes a large 3189-amino-acid (aa) polyprotein with all of the expected hallmarks of those of Potyviridae members. The 3' untranslated region (UTR) is 195 nt long, and the 5' UTR, whose sequence is likely missing a few terminal nucleotides despite repeated efforts at 5' RACE, is unusually long (531 nt), like that of triticum mosaic virus (TrMV). Pairwise sequence comparisons and phylogenetic analysis showed that the new virus is most closely related to TrMV and to Poaceae Liege poacevirus, a virus that was identified recently in Poaceae members in Belgium by metagenomics. The common name \"wild oat poacevirus 1\" (WOPV1) is proposed for this novel virus, which should be accommodated in a new species in the genus Poacevirus. Given that WOPV1 was identified in plants that were coinfected by several other viruses, no conclusions can be drawn at this stage about its potential pathogenicity.</div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"169 12","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142737225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation and characterization of Salmonella enterica- and Escherichia coli-specific bacteriophages of the genus Epseptimavirus from wastewater in Minnesota 从明尼苏达州的废水中分离出肠炎沙门氏菌和大肠埃希氏菌特异性噬菌体，并确定其特征。

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-11-27 DOI: 10.1007/s00705-024-06190-5

Estephany Cortes-Ortega, Eleanore G. Hansen, Irem Iskender, Meredith L. Farmer, Juan M. Martinez-Villalobos, Jacob D. Vitt, Steven D. Bowden

引用次数: 0

Calcitriol reduces Newcastle disease virus replication by modulating galectin 3 and pro-inflammatory cytokines 骨化三醇通过调节半整联蛋白 3 和促炎细胞因子减少新城疫病毒的复制。

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-11-27 DOI: 10.1007/s00705-024-06183-4

Shaurya Dumka, Chinmaya Panda, Sachin Kumar

{"title":"Calcitriol reduces Newcastle disease virus replication by modulating galectin 3 and pro-inflammatory cytokines","authors":"Shaurya Dumka, Chinmaya Panda, Sachin Kumar","doi":"10.1007/s00705-024-06183-4","DOIUrl":"10.1007/s00705-024-06183-4","url":null,"abstract":"<div>Calcitriol, or vitamin D (Vit D), is known for promoting strong bones and its ability to modulate inflammation and support the immune system. It has also been reported to be a potent antiviral agent, but the underlying mechanisms behind the mode of action are still unclear. Newcastle disease virus (NDV) belongs to the family Paramyxoviridae and causes infectious diseases in numerous avian species. In the present study, we explored the use of calcitriol as an antiviral agent against NDV infection. Post-treatment with calcitriol (the most active form of Vit D) was found to inhibit NDV replication in chicken embryo fibroblast cells (DF-1) in a time-of-addition- and concentration-dependent manner. The titer of NDV in allantoic fluid exhibited a substantial decrease after administration of cholecalciferol (the less active form of Vit D) to a 9-day-old chicken embryo. In addition, the results demonstrated a significant modulation of galectin 3 gene expression after NDV infection. Cytokine profiling of DF-1 cells treated with calcitriol and aloe-emodin, a known modulator of galectin 3, revealed significant upregulation of pro-inflammatory cytokines. The study indicates that calcitriol modulates host proteins, affecting NDV replication. These findings suggest that calcitriol or Vit D has the potential to be developed as an alternative antiviral drug against NDV, warranting further investigation.</div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"169 12","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142725068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of two Campylobacter jejuni phages and evaluation of their antibacterial efficacy with EDTA 两种空肠弯曲杆菌噬菌体的特征及其与 EDTA 的抗菌效果评估

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-11-20 DOI: 10.1007/s00705-024-06169-2

Su Zar Chi Lwin, Aye Thida Maung, Khin Zar Linn, Miku Hirono, Cunkuan Shen, Mohamed El-Telbany, Marwa Nabil Sayed Abdelaziz, Tahir Noor Mohammadi, Yoshimitsu Masuda, Ken-ichi Honjoh, Takahisa Miyamoto

{"title":"Characterization of two Campylobacter jejuni phages and evaluation of their antibacterial efficacy with EDTA","authors":"Su Zar Chi Lwin, Aye Thida Maung, Khin Zar Linn, Miku Hirono, Cunkuan Shen, Mohamed El-Telbany, Marwa Nabil Sayed Abdelaziz, Tahir Noor Mohammadi, Yoshimitsu Masuda, Ken-ichi Honjoh, Takahisa Miyamoto","doi":"10.1007/s00705-024-06169-2","DOIUrl":"10.1007/s00705-024-06169-2","url":null,"abstract":"<div>Campylobacter jejuni is a leading cause of foodborne illness worldwide. The application of bacteriophages offers a promising approach to specifically target and reduce C. jejuni contamination in food products. In this study, two C. jejuni phages were characterized, and their ability to inhibit bacterial growth in combination with ethylenediaminetetraacetic acid (EDTA) was investigated. Both phages exhibited tolerance to a wide range of temperature (4–60 °C) and pH (3-9). Phage vB_CjeM-PC10 and vB_CjeM-PC22 were found to have a latent period of 30 min and 20 min and a burst size of 7 and 35 PFU/cell, respectively. Phage vB_CjeM-PC10 has a linear double-stranded DNA (dsDNA) genome of 51,148 bp with 77 ORFs and 29% GC content. Phage vB_CjeM-PC22 has a circular dsDNA genome of 32,543 bp with 56 ORFs and 28% GC content. At 42 °C, the combination of these phages (MOI = 10) and EDTA decreased the count of viable C. jejuni by 5.2 log10 and inhibited the regrowth of resistant cells for 48 h. At 4 °C, phage vB_CjeM-PC10 alone (MOI = 1000) reduced the count of viable C. jejuni by 3 log10 in brain heart infusion (BHI) broth and 2 log10 on chicken skin after incubation for 48 h. Although these phages were effective against C. jejuni, they cannot be utilized directly for food safety applications because they are lysogenic. Nevertheless, these findings expand the genome library of C. jejuni phages and enrich data resources by highlighting potential strategies for controlling C. jejuni infections.</div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"169 12","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142672556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can viral proteins be retooled for chimeric toxin development? 病毒蛋白能否重新用于嵌合毒素的开发？

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-11-20 DOI: 10.1007/s00705-024-06173-6

Caroline Ismeurt-Walmsley, Eric J. Kremer

引用次数: 0

Complete genome sequence of a rare recombinant GII.5[P16] norovirus found in Russian Siberia 俄罗斯西伯利亚发现的罕见重组 GII.5[P16]诺如病毒的完整基因组序列

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-11-19 DOI: 10.1007/s00705-024-06176-3

E. Zhirakovskaia, A. Tikunov, B. Kravchuk, N. Tikunova

引用次数: 0